Clinical trials: Kidney Insufficiency
Hyperphosphatemia, End-stage Renal Disease
Trial of a New Formulation of KRX-0502 (Ferric Citrate) in Patients With End-Stage Renal Disease
The objective of this study is to see if KRX-0502 (ferric citrate) is safe and effective as a dietary phosphate binder in controlling and managing serum phosphorus levels in patients with end-stage renal disease (ESRD).
- Conditions
- Hyperphosphatemia, End-stage Renal Disease, Renal Failure Chronic Requiring Hemodialysis
- Trial name
- NCT00967993
- Testing
- ferric citrate
- Where
- 3 sites in Israel
- Volunteers
- 22 people
- Sponsor
- Keryx Biopharmaceuticals
End-stage Kidney Disease, End-stage Renal Disease
The Optiflow Patency and Maturation Study
The objective of this study is to assess the performance and safety of the Optiflow Anastomotic Connector (Optiflow) when used to facilitate the creation of autogenous arteriovenous fistula (AVF) anastomoses.
- Trial name
- OPEN (NCT01921933)
- Testing
- Optiflow
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Bioconnect Systems, Inc
Diabetic Nephropathies, Diabetes Mellitus, Type 2
Comparing The Effect Of Empagliflozin With Dapagliflozin In Reducing Proteinuria In Diabetic Patients With Chronic Kidney Disease With eGFR More Than 45ml/Min/1.73m²
This study was designed to compare empagliflozin and dapagliflozin in reducing protein leakage into the urine in adults with type 2 diabetes and chronic kidney disease.
- Conditions
- Diabetic Nephropathies, Diabetes Mellitus, Type 2, Renal Insufficiency, Chronic
- Trial name
- NCT07866235
- Testing
- Dapagliflozin, Empagliflozin (EMPA)
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- Lahore General Hospital
Renal Insufficiency, Chronic
Short-term Metabolic Effects of Ketosteril® Supplemented Low Protein Diet in Pre-dialysis Chronic Kidney Disease (CKD) Patients
Supplementation of ketoanalogues of essential amino acids improves the protein quality of protein restricted diets without burdening the kidneys.
- Trial name
- CKD (NCT03077048)
- Testing
- Ketosteril®
- Where
- Czechia
- Volunteers
- 23 people
- Sponsor
- Fresenius Kabi
Acute Kidney Insufficiency, Anti-Infective Agent Toxicity
Computer-based Dosage Calculation for Antibiotics
Adequate dosing of antiinfective therapy in critically ill patients with impaired or lost renal function or continuous renal replacement therapy is nearly impossible without measuring the drug concentration in blood samples.
- Trial name
- NCT03036826
- Testing
- Piperacillin/tazobactam, Meropenem
- Where
- Germany
- Sponsor
- University Hospital Tuebingen
End Stage Renal Disease
Safety and Efficacy of Empagliflozin in Hemodialysis
A 12-week, phase II, randomized, double-blind, placebo-controlled, multi-center study to assess the safety, tolerability, and preliminary efficacy of empagliflozin versus placebo among patients initiating hemodialysis (n=60) for…
- Trial name
- SEED (NCT05786443)
- Testing
- Empagliflozin 10 MG
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Chronic Kidney Disease (CKD)
Kidney Awareness Registry and Education
The purpose of this study is to evaluate the feasibility and acceptability of two different interventions aimed at improving health outcomes among patients with chronic kidney disease (CKD), who are at high risk of CKD…
- Trial name
- KARE (NCT01530958)
- Testing
- CKD Registry, ATSM + Health Coach, Usual care
- Where
- 2 sites in United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Acute Kidney Injury, Immune Deficiency
Immunoparalysis in Acute Kidney Injury After Cardiac Surgery
Infection and sepsis are common after acute kidney injury (AKI) and increase mortality. In this study, the investigators will determine whether patients with acute kidney injury after cardiac surgery have immunosuppression as…
- Trial name
- NCT03922958
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Acute Kidney Injury
Recovery After Dialysis-Requiring Acute Kidney Injury
The Recovery After Dialysis-Requiring Acute Kidney Injury (RAD-AKI) Pilot Study is a 2-arm randomized clinical trial of hospitalized patients with dialysis-requiring acute kidney injury (RAD-AKI), comparing conventional…
- Trial name
- RAD-AKI (NCT03305549)
- Testing
- Conservative dialysis strategy, TIW dialysis strategy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
End Stage Renal Disease, Hemodialysis
Oxidative Stress and Hemodialysis Access Failure
Complications of hemodialysis access are the most frequent single reason for hospitalization among patients with End Stage Renal Disease (ESRD).
- Trial name
- NCT00410449
- Testing
- Alpha tocopherol
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Chronic Kidney Disease
A Study to Examine Past Estimated Glomerular Filtration Rate (eGFR) Slope as a Risk Marker for Rapid Kidney Function Decline in People With Chronic Kidney Disease
This study is intended to investigate the usefulness of estimated glomerular filtration rate (eGFR) slopes derived from retrospective routine clinical practice data, compare those retrospective slopes with those generated in a…
- Trial name
- NCT04881448
- Testing
- collection of serum/capillary creatinine values
- Where
- 25 sites in United States, Germany and 2 more
- Volunteers
- 223 people
- Sponsor
- Boehringer Ingelheim
Diabetic Nephropathies, Diabetic Glomerulosclerosis
Transformative Research in Diabetic Nephropathy
This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy.
- Trial name
- TRIDENT (NCT02986984)
- Testing
- There is no intervention
- Where
- 17 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Pennsylvania
Heart Failure, Chronic Obstructive Pulmonary Disease
Effects of Remote Patient Monitoring on Chronic Disease Management
Remote patient monitoring is a potential component for the management of chronic conditions that may provide reliable and real-time physiological measurements for clinical decision support, alerting, and patient self-management.
- Conditions
- Heart Failure, Chronic Obstructive Pulmonary Disease, Chronic Kidney Disease, Uncontrolled Hypertension
- Trial name
- NCT03127852
- Testing
- Medly
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University Health Network, Toronto
Hypertension With Renal Dysfunction
Safety and Tolerability and Efficacy of LCZ696 in Japanese Hypertensive Patients With Renal Dysfunction
This study assessed the safety, tolerability, and efficacy of LCZ696 in hypertensive patients with renal dysfunction.
- Trial name
- NCT01593787
- Testing
- LCZ696
- Where
- 13 sites in Japan
- Volunteers
- 32 people
- Sponsor
- Novartis Pharmaceuticals
End Stage Renal Disease, Inflammation
Permeability Enhancement to Reduce Chronic Inflammation
Chronic dialysis patients with end stage renal disease have an increased mortality rate as compared to the age matched healthy population.
- Trial name
- PERCI (NCT01582893)
- Testing
- HCO1100, P210H
- Where
- 2 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Vantive Health LLC
Chronic Kidney Disease
Low-protein Formula Supplements in Chronic Kidney Disease
Prospective randomized contorl study.Comparing clinical outcome between chronic kidney disease who were prescribed 6% low-protein nutrition supplement along with dietatian regular nutrition education and those without oral…
- Trial name
- NCT05318014
- Testing
- Intervention group, Regular nutrition education
- Where
- Taiwan
- Volunteers
- 95 people
- Sponsor
- Taichung Veterans General Hospital
AKI - Acute Kidney Injury
Renal Cell Arrest and Damage Biomarkers in Progression and Outcome of Septic AKI
The aim of the current study is to assess the predictive value of renal cell arrest biomarkers (urinary TIMP2 and IGFBP7), renal damage biomarkers (urinary KIM-1) and microscopic examination of urinary sediment in progression and…
- Trial name
- NCT06064487
- Testing
- renal cell arrest and damage biomarkers assessment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Chronic Kidney Disease
The Effect of Correction of Metabolic Acidosis in CKD on Intrarenal RAS Activity
This study evaluates the effect of oral sodium bicarbonate treatment on the intrarenal renin-angiotensin-system in adult patients with a metabolic acidosis and chronic kidney disease.
- Trial name
- BIC (NCT02896309)
- Testing
- Sodium bicarbonate, Sodium chloride
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Erasmus Medical Center
Chronic Kidney Disease, Hyperparathyroidism, Secondary
Safety and Efficacy of CTAP101 to Treat Secondary Hyperparathyroidism in Stage 3 or 4 CKD and Vitamin D Insufficiency
This study will evaluate the efficacy of CTAP101 Capsules versus placebo in reducing intact parathyroid hormone (iPTH) by at least 30% from pretreatment baseline; safety and tolerability of CTAP101 will also be evaluated
- Conditions
- Chronic Kidney Disease, Hyperparathyroidism, Secondary, Vitamin D Deficiency
- Trial name
- NCT01651000
- Testing
- CTAP101 30 μg capsules, Sugar pill to CTAP101 30 μg capsules
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- OPKO IP Holdings II, Inc.
Ischemic Heart Disease, Heart Failure
Trial of an Internet-based Platform for Managing Chronic Diseases at a Distance
In 2005, more then one-third of Canadians were burdened with one or more chronic diseases. Patients with one chronic disease often have, or are at risk for, another chronic disease.
- Conditions
- Ischemic Heart Disease, Heart Failure, Chronic Kidney Disease, Diabetes
- Trial name
- iCDM (NCT01342263)
- Testing
- iCDM
- Where
- Canada
- Volunteers
- 234 people
- Sponsor
- Simon Fraser University
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