Clinical trials: Kidney Replacement Disorder
End Stage Renal Disease
Study to Evaluate the Safety of Chronic Administration of Simulect to Subjects Receiving a First Kidney Transplant
The study is undertaken to explore the safety of using Simulect at monthly dose intervals to reduce the need of high dose/level CNI's such as Prograf.
- Trial name
- Simulect (NCT00928811)
- Testing
- basiliximab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Drexel University College of Medicine
Acute Kidney Injury
IHD Versus CRRT for Severe Acute Kidney Injury in Critically Ill Patients
Intermittent hemodialysis (IHD) and continuous RRT (CRRT) provided as continuous hemofiltration or hemodiafiltration are the main RRT modalities in ICU.
- Trial name
- ICRAKI (NCT06032884)
- Testing
- continuous renal replacement therapy (CRRT), Intermittent hemodialysis (IHD)
- Where
- France
- Volunteers
- 554 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury
FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU
Ischemic acute tubular necrosis (ATN) is one of the main cause of acute kidney injury (AKI) in intensive care units (ICU). Sepsis and cardio-pulmonary bypass (CPB) are major providers.
- Trial name
- FURTHER (NCT03731117)
- Testing
- Furosemide
- Where
- 3 sites in France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury, Cardiac Surgery
Outcome of Patients Treated With RRT
Acute Kidney Injury (AKI) is a common serious complication after cardiac surgery. AKI not only prolongs the hospitalization time of patients undergoing cardiac surgery and increases the cost of treatment, but also is an…
- Trial name
- NCT04405830
- Testing
- Renal replacement therapy
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Nanjing Medical University
Acute Kidney Injury, Acute Kidney Failure
HEmoFiltration With Citric Acid Anticoagulation
Prospective observational study of all consecutive cardio-vascular surgical patients treated with post-dilution hemofiltration with regional citrate anticoagulation as first-choice anticoagulation method.
- Conditions
- Acute Kidney Injury, Acute Kidney Failure, Renal Replacement Therapy, Hemofiltration
- Trial name
- HEFCAA (NCT03836742)
- Testing
- Hemofiltration with regional citrate anticoagulation
- Where
- Poland
- Volunteers
- 54 people
- Sponsor
- Medical University of Gdansk
Acute Kidney Injury, Citrate
Citrate Versus Heparin in Continuous Renal Replacement Therapy :
This study is a prospective, multicenter, open-label randomized trial comparing regional citrate anticoagulation (RCA) with heparin-free protocol.
- Conditions
- Acute Kidney Injury, Citrate, Cytokines, Hemodynamic Responses
- Trial name
- NCT04865510
- Testing
- Regional citrate anticoagulation
- Where
- Thailand
- Volunteers
- 41 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Acute Kidney Injury
Metabolic Complications Using a Low- Versus High Concentration Citrate Solution for Regional Anticoagulation in Continuous Kidney Replacement Therapy: A Pragmatic Randomized Trial.
This study is a pragmatic, randomized trial comparing two commercially available citrate solutions to determine their impact on metabolic complications in critically ill patients with acute kidney injury receiving continuous…
- Trial name
- LEON1 (NCT07751861)
- Testing
- low concentrated citrate solution (18 mmol/L), high concentrated citrate solution (136 mmol/L)
- Where
- Belgium
- Volunteers
- 176 people
- Sponsor
- University Hospital, Antwerp
Acute Renal Failure, Dialysis; Complications
New Protocol With Diluted Citrate in Continuous Techniques
The investigators designed a monitoring and control table of a citrate treatment on a specific monitor. This is the Baxter "Prismaflex" monitor, with 8.2 software version.
- Conditions
- Acute Renal Failure, Dialysis; Complications, Citrate Poisoning
- Trial name
- NCT04062812
- Testing
- the same citrate dosification in both types
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Intradialytic Hypotension, Cardiac Event
BIA Versus Physician Adjustment in Acute Kidney Injury Patients Requiring Renal Replacement Therapy
This study was designed to compare the efficacy of BIA and physician adjustment to prevent intradialytic hypotension in patients with acute kidney injury who received renal replacement therapy.
- Conditions
- Intradialytic Hypotension, Cardiac Event, Renal Insufficiency, Hospital Length of Stay
- Trial name
- NCT03916861
- Testing
- Bioelectrical Impedance Analysis, Physician-guided
- Where
- Thailand
- Volunteers
- 9 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Acute Renal Failure
Acute Renal Failure Trial Network (ATN) Study
This is a multi-center, prospective, randomized, parallel-group trial of an intensive strategy vs conventional strategy of renal replacement therapy for the treatment of acute renal failure secondary to acute tubular necrosis in…
- Trial name
- ATN (NCT00076219)
- Testing
- renal replacement therapy
- Where
- 22 sites in United States
- Volunteers
- 1,124 people
- Sponsor
- US Department of Veterans Affairs
Anemia
A Study of Treatment With NeoRecormon (Epoetin Beta) in Patients With Chronic Renal Anemia
This study will evaluate whether anemia prevention with NeoRecormon has an additional impact on reducing cardiovascular risk over conventional anemia treatment in patients mostly with stage IV chronic kidney disease and renal…
- Trial name
- NCT00321919
- Testing
- epoetin beta [NeoRecormon]
- Where
- 93 sites in Austria, Belgium and 20 more
- Volunteers
- 605 people
- Sponsor
- Hoffmann-La Roche
Acute Renal Failure
Clearance of Inflammatory Cytokines During Renal Replacement Therapy Using the EMIC®2 Filter
This study will be conducted in patients with sepsis and acute kidney injury needing renal replacement therapy. The aim is to investigate whether continuous renal replacement therapy with the EMIC®2 filter leads to removal of…
- Trial name
- ClicAKI (NCT03231748)
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Kidney Injury
Tunneled Dialysis Catheters Versus Non-tunneled Dialysis Catheters as First-line for Renal Replacement Therapy in the ICU
The investigators propose a randomized controlled trial to examine whether tunneled dialysis catheters should be first-line for acute kidney injury requiring renal replacement therapy (AKI-RRT) in the critical care setting…
- Trial name
- BACKDOOR (NCT03496935)
- Testing
- Tunneled versus non-tunneled dialysis catheter insertion
- Volunteers
- 102 people
- Sponsor
- Brigham and Women's Hospital
Influenza, Renal Failure
Pharmacokinetic Assessment of Peramivir in Hospitalized Adults Undergoing Continuous Renal Replacement Therapy
Pharmacokinetics for peramivir have not been well characterized in patients undergoing continuous renal replacement therapy CRRT - either Continuous veno-venous hemofiltration (CVVH) +/- dialysis (CVVHD).
- Trial name
- NCT01146353
- Where
- United States
- Sponsor
- Midwestern University
Acute Kidney Injury
Biomarker Guided Intervention for Prevention of Acute Kidney Injury
This study evaluates the impact of a biomarked guided intervention on the development of acute kidney injury in high risk surgical patients.
- Trial name
- BigpAK (NCT02500394)
- Testing
- Ionosteril
- Where
- Germany
- Volunteers
- 135 people
- Sponsor
- University Hospital Regensburg
Acute on Chronic Liver Failure (ACLF)
Study About Hepatic Toxins Kinetic and Evaluation of Organ Damage in Acute on Chronic Liver Failure (ACLF) Patients
Spontaneous Observational Prospective Multicenter study of all patients admitted to Intensive Care with a diagnosis of Acute on Chronic Liver Failure (ACLF) of grade ≥ 2 for which the use of the system will be authorized…
- Trial name
- BILIVER2020 (NCT06837766)
- Where
- 3 sites in Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Citrate Toxicity, Regional Citrate Anticoagulation
Citrate Pharmacokinetics in Critically Ill Liver Failure Patients Receiving CRRT
Citrate has been proposed as anticoagulation of choice in continuous renal replacement therapy (CRRT). However, little is known about the pharmacokinetics (PKs) and metabolism of citrate in liver failure patients who require CRRT…
- Conditions
- Citrate Toxicity, Regional Citrate Anticoagulation, Liver Failure, Acute, Liver Failure, Acute on Chronic
- Trial name
- Citrate PK (NCT04959110)
- Testing
- Pharmacokinetic study
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Chulalongkorn University
Acute Kidney Injury, ICU Patients
Validation of a Regional Citrate Anticoagulation Protocol in Critically Ill Patients on Continuous Renal Replacement Therapy
The objective of this study is to evaluate the effectiveness of a modified continuous renal replacement therapy (CRRT) protocol in maintaining electrolyte balance in adult patients with acute kidney injury (AKI) admitted to the…
- Conditions
- Acute Kidney Injury, ICU Patients, Continuous Renal Replacement Therapy (CRRT), Electrolytes
- Trial name
- CRRT (NCT07514650)
- Testing
- continuous renal replacement therapy
- Where
- Spain
- Volunteers
- 43 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Humoral Rejection, Guillain-Barre Syndrome
Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation
Plasma exchange procedures remove procoagulant and anticoagulant factors. Every procedure increases the risk of bleeding and repeated procedures increase the risk of bleeding mostly because lower fibrinogen levels.
- Conditions
- Humoral Rejection, Guillain-Barre Syndrome, Miller Fisher Syndrome, CIDP
- Trial name
- NCT03801135
- Testing
- Fibrinogen concentrate, Fresh Frozen Plasma
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Liver Cirrhosis
Impact of Continuous Renal Replacement Therapy on Systemic Hemodynamics and Lactate Clearance in Critically Ill Cirrhotics With Septic Shock.
Consecutive critically ill cirrhotics with septic shock and AKI who give written informed consent will be included in this prospective study.
- Trial name
- NCT04949178
- Testing
- No intervention
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India