Clinical trials: Kidney Replacement Disorder
Acute Kidney Injury
Biomarker Guided Intervention for Prevention of Acute Kidney Injury
This study evaluates the impact of a biomarked guided intervention on the development of acute kidney injury in high risk surgical patients.
- Trial name
- BigpAK (NCT02500394)
- Testing
- Ionosteril
- Where
- Germany
- Volunteers
- 135 people
- Sponsor
- University Hospital Regensburg
Arthroplasty, Replacement, Knee, Acute Kidney Injury
After Surgery Acute Renal Failure Incidence in Total Knee Arthroplasty With and Without Tourniquet
This study analize the incidence of acute renal failure after performing total knee arthroplasty with or without use of tourniquet limb cuff (half of patients for each group) in a randomized clinical trial
- Conditions
- Arthroplasty, Replacement, Knee, Acute Kidney Injury, Tourniquets, Knee Osteoarthritis
- Trial name
- NCT03795805
- Testing
- total knee arthroplasty, Tourniquet limb cuff, Intaarticular lidocain
- Where
- Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
End Stage Renal Disease
Use of a Bimodal Solution for Peritoneal Dialysis
Peritoneal dialysis (PD) is the method of renal replacement therapy used by close to 200,000 end stage renal disease patients worldwide to help replace the functions that are no longer performed by their kidneys.
- Trial name
- NCT01242904
- Testing
- bimodal solution, icodextrin
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
End-stage Renal Disease
Effect of Different Dialysis Dosage on Prognosis in Maintenance Peritoneal Dialysis Patients
Peritoneal dialysis (PD) is an important model of renal replacement therapy for end-stage renal disease (ESRD) patients. Thus far, evidence for the initiation dosage of PD treatment is lacking, most patients begin their PD with…
- Trial name
- NCT00912821
- Testing
- 6 L dialysate, 8 L dialysate
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Continuous Renal Replacement Therapy, Intensive Care Unit
Diagnosis Accuracy of Hemoconcentration to Detect Hypovolemia During CRRT
The aim of the study is to analyze if blood protein concentration variation during continuous renal replacement therapy (CRRT) with fluid removal can predict a decrease of 15 % of cardiac index in intensive care unit (ICU)…
- Conditions
- Continuous Renal Replacement Therapy, Intensive Care Unit, Hypovolemia, Fluid Overload
- Trial name
- NCT03144349
- Where
- 2 sites in France
- Volunteers
- 52 people
- Sponsor
- Hopital Louis Pradel
Acute Kidney Injury
IHD Versus CRRT for Severe Acute Kidney Injury in Critically Ill Patients
Intermittent hemodialysis (IHD) and continuous RRT (CRRT) provided as continuous hemofiltration or hemodiafiltration are the main RRT modalities in ICU.
- Trial name
- ICRAKI (NCT06032884)
- Testing
- continuous renal replacement therapy (CRRT), Intermittent hemodialysis (IHD)
- Where
- France
- Volunteers
- 554 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Failures, Acute
Intra-Renal Therapy of Diuretic Unresponsive Acute Kidney Injury
Randomized prospective trial of patients with diuretic unresponsive acute kidney injury where patients will receive standard supportive therapy with diuretics versus intra-renal delivery of the vasodilator fenoldopam mesylate.
- Trial name
- IR-FTA (NCT01073189)
- Testing
- Intra-Renal Fenoldopam, Furosemide
- Where
- United States
- Sponsor
- Southeast Renal Research Institute
Endstage Kidney Disease
Implementing "Explore Transplant"- A Pilot Study
Patients with End Stage Kidney Disease (ESKD) require Renal Replacement Therapy (RRT) in order to survive, be it dialysis or kidney transplantation (KT).
- Trial name
- NCT03046732
- Testing
- Implementing "Explore Transplant" Education
- Where
- 2 sites in Canada
- Volunteers
- 227 people
- Sponsor
- University Health Network, Toronto
Acute Kidney Injury, Sepsis
Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury
The goal of this clinical trial is to learn if adding the iron-binding drug MEX-CD1 to dialysis fluid can help remove excess iron in adults with sepsis-associated acute kidney injury (AKI) requiring dialysis who are in the…
- Trial name
- IRON-IC (NCT07236463)
- Testing
- Continuous veino-veinous dialysis with iron-chelator supplemented dialysate
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Kidney Injury
Online Hemodiafiltration vs Conventional Hemodialysis in Acute Kidney Injury
Only limited data exist on the benefit of online hemodiafiltration in patient with Acute kidney injury. The objective of this pilot RCT is to assess the feasibility of a large multicentre RCT to determine whether, in patients…
- Trial name
- HDFAKI (NCT04525092)
- Testing
- Online Pre-dilution Hemodiafiltration, Conventional Hemodialysis, Online Post-dilution Hemodiafiltration
- Where
- 2 sites in Canada, Ireland
- Volunteers
- 45 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Continuous Renal Replacement Therapy (CRRT), End Stage Kidney Disease (ESRD)
Prospective Analysis of Arteriovenous Access (AVA) Use in Continuous Renal Replacement Therapy: A Feasibility Project
This study will test whether patients who already have a permanent dialysis access (an arteriovenous fistula or graft) can safely use that access for continuous dialysis (CRRT) while they are critically ill in the intensive care…
- Trial name
- CRRT (NCT07447128)
- Testing
- Cannulation of permanent dialysis access, for the purpose of delivering continuous renal replacement therapy.
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- East Carolina University
Renal Insufficiency, Chronic
Living With Chronic Kidney Disease Without Renal Replacement Therapy: Experience of Women of Childbearing Age
Chronic kidney disease (CKD) affects approximately 13% of the global population. This condition is often associated with comorbidities such as diabetes and hypertension.
- Trial name
- IMAJE (NCT07690202)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Caen
Chronic Kidney Disease
Impact of HemoDiaFIltration on Physical Activity and Self- Reported Outcomes
This is a randomized controlled clinical trial that will analyze the impact of high volume online HDF in comparison to high-flux HD on measured physical activity.
- Trial name
- HDFIT (NCT02787161)
- Testing
- Hemodiafiltration, Hemodialysis
- Where
- 13 sites in Brazil
- Volunteers
- 195 people
- Sponsor
- Pontifícia Universidade Católica do Paraná
Chronic Kidney Diseases, Protein-Energy Malnutrition
Effect of a Specialized Oral Supplement on Nutritional Status and Quality of Life in Non-dialysis CKD
Patients whit chronic kidney disease (CKD) there is a high prevalence of nutritional disorders and negative changes in body composition, which is strongly associated with an increased risk of morbidity and mortality.
- Trial name
- NCT06576479
- Testing
- Nutritious Shake, Nutritional counseling
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- NIN Institute
Acute Liver Failure, Acute on Chronic Liver Failure (ACLF)
Continuous Renal Replacement Therapy Intensity in Hyperammonemia
Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) are life-threatening conditions often associated with hyperammonemia, hepatic encephalopathy, and multi-organ dysfunction.
- Conditions
- Acute Liver Failure, Acute on Chronic Liver Failure (ACLF), Acute Kidney Injury, Ammonia Metabolism
- Trial name
- CRITICAL (NCT06987604)
- Testing
- High-dose continuous renal replacement therapy, Conventional-dose continuous renal replacement therapy
- Where
- Brazil
- Volunteers
- 152 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Multi Organ Failure
Early Renal Replacement Therapy in COVID 19 Patients With AKI Does it Improve the Outcome?
patients will be divided into two equal groups, each group including 50 adult patients with a confirmed diagnosis of covid, patients with acute kidney injury, the first group will be treated with early hemodialysis, second group…
- Trial name
- NCT05274685
- Testing
- haemodialysis
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University