Clinical trials: Kinetics
Hodgkin Lymphoma
A Phase II Study to Determine Pembrolizumab as Frontline Treatment of Patients With Hodgkin Lymphoma
The purpose of this study is to test how safe and effective the research study drug, pembrolizumab is as a treatment for patients with Hodgkin lymphoma who have not previously been treated for this disease and are unsuitable for…
- Trial name
- PLIMATH (NCT03331731)
- Testing
- pembrolizumab
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 27 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Dyskinesias
Comparison of Open Chain Kinetic Exercises and Forward Head Posture Correction in Type II Scapular Dyskinesia
The objective of this study is to compare the effect of open chain kinetic exercises and forward head posture correction on scapular symmetry and glenohumeral disability in office workers with type II scapular dyskinesis.
- Trial name
- NCT05044572
- Testing
- Open chain kinetic exercises, Forward head posture correction exercises
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Hemophilia B
The Efficacy and Safety of ZS801 in Chinese Hemophilia B Patients.
A non-randomized, open-label study to evaluate the safety, kinetics and efficacy of a single intravenous infusion of ZS801 in hemophilia B subjects with endogenous FIX ≤2%.
- Trial name
- NCT05630651
- Testing
- ZS801
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Influenza, Vaccine Virus Shedding
Nasal and Systemic Immune Responses to Nasal Influenza Vaccine
Intranasal live attenuated influenza vaccine (LAIV; trade name FluMist/Fluenz-Tetra, manufactured by AstraZeneca/Medimmune) is the standard influenza vaccine given to children aged 2-17 years of age in the UK.
- Trial name
- Flu-M3 (NCT04110366)
- Testing
- Live attenuated influenza vaccine, Vehicle control
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Choline Uptake, Kinetics
Choline Uptake Study
The study is a randomised, cross-over, double blind, controlled trial in which study participants will visit the research facility on two occasions under fasting conditions with a washout period of one week.
- Trial name
- CUP (NCT03822169)
- Testing
- Choline added as a phospholipid, Choline added as a salt
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Wageningen University and Research
Protein Digestion Kinetics
Postprandial Plasma Amino Acid Concentrations After Dairy Consumption
This study was designed to obtain information about the change in postprandial amino acids in blood over time, after consumption of different dairy products, in an elderly population and how this relates to gastric emptying rate…
- Trial name
- PARROT (NCT02546141)
- Testing
- skimmed milk (UHT), skimmed milk (pasteurized), skimmed yoghurt
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- NIZO Food Research
Motor Control Retraining, Close Kinetic Chain Exercises
Motor Control Retraining vs Close Kinetic Chain Exercises for Pain, Function and Vastus Medialis Oblique Strength in Patients With Patellofemoral Pain Syndrome
This study compares two treatments - motor control retraining and close kinetic chain exercises - to improves the pain, VMO strength, knee function.
- Conditions
- Motor Control Retraining, Close Kinetic Chain Exercises, Patellofemoral Pain Syndrome
- Trial name
- MCR VS CKC (NCT07766083)
- Testing
- Motor Control Retraining, Close Kinetic Chain Exercises
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Faisalabad
Tuberculosis
Study in Healthy Adults to Evaluate Gene Activation After Vaccination With GlaxoSmithKline (GSK) Biologicals' Candidate Tuberculosis (TB) Vaccine GSK 692342
The purpose of this study is to assess the safety and immunogenicity of two doses of the TB vaccine administered according to a 0, 1 month schedule.
- Trial name
- NCT01669096
- Testing
- GSK Biologicals' investigational TB vaccine GSK 692342
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Relapsed/Refractory Multiple Myeloma
A Clinical Study of CT0596 CAR-T in Relapsed/Refractory Multiple Myeloma
This is a Phase I/II, single-arm, open-label, multicenter clinical trial in patients with relapsed/refractory multiple myeloma (R/R MM).
- Trial name
- NCT07760454
- Testing
- CT0596
- Where
- 2 sites in China
- Volunteers
- 68 people
- Sponsor
- UCARsgen Biotech Limited
Vestibular Rehabilitation in MS
Effect of Vestibular Rehabilitation on Trunk Kinetic and Kinematic Parameters in Patients With Multiple Sclerosis
The Cawthorne Cooksey exercises and conventional program of physical therapy were administered.
- Trial name
- NCT05635890
- Testing
- Cawthorne Cooksey exercise protocol, conventional vestibular rehabilitation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- October 6 University
HIV Infections
Safety of and Immune Response to Two Different HIV Vaccines, Each Followed by a Adenoviral Vaccine Boost, in HIV Uninfected Adults
The purpose of this study is to determine the safety of and immune response to an adenoviral vector HIV vaccine or a DNA HIV vaccine, each followed by an adenoviral vector HIV vaccine boost, in HIV uninfected adults.
- Trial name
- NCT00270218
- Testing
- VRC-HIVADV014-00-VP, VRC-HIVDNA009-00-VP, FFB
- Where
- 7 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy
The Effect of Rifapentine on Raltegravir
The aim of this study is to study the effect of rifapentine on plasma concentrations of raltegravir.
- Trial name
- NCT00809718
- Testing
- Raltegravir and rifapentine
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
One-carbon Metabolism in Healthy Individuals
Impact of High-dose Folic Acid Supplementation on Pathways Linked to DNA Formation
Periconceptional supplementation with folic acid - the synthetic form of the B-vitamin folate - reduces the occurrence of adverse pregnancy outcomes such as spina bifida.
- Trial name
- NCT01687127
- Testing
- Folic acid, 5-methyltetrahydrofolate, calcium salt
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cholesterol Absorption
GPur- Luminating Oral Cholesterol Kinetics Pilot Study
In healthy subjects not receiving or requiring lipid lowering therapy and who do not have diabetes, the use of clinoptilolite (GPUR) will result in a reduction of absorbed dietary cholesterol observed over 6 days of therapy.
- Trial name
- GLOCK-pilot (NCT03090542)
- Testing
- clinoptilolite
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Canadian Collaborative Research Network
Bacterial Infection
Increase in Procalcitonin Kinetics May be a Good Indicator of Starting Empirical Antibiotic Treatment in Critically Ill Patients
The value of procalcitonin change from the day before to the day when infection was suspected in predicting bacterial infection in intensive care patients.
- Trial name
- NCT02311816
- Where
- Hungary
- Volunteers
- 114 people
- Sponsor
- Domonkos Trásy
Coronary Heart Disease, Cardiovascular Disease
Physiological Study of Human Cholesterol Metabolism and Excretion
The underlying hypothesis is that whole body cholesterol - including cholesterol present in tissues that cannot be measured by standard blood tests - is related to heart disease risk.
- Conditions
- Coronary Heart Disease, Cardiovascular Disease, Dyslipidemia, Disorder of Cholesterol Metabolism
- Trial name
- NCT01603758
- Testing
- Ezetimibe
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Richard E. Ostlund Jr., MD
Brain Injuries, Traumatic, Brain Injuries, Acute
Critical Hyperacute Assessment Research On Neurobiomarker Kinetics in Acute Brain Injury
Traumatic brain injury (TBI) and other conditions that reduce blood flow to the brain - such as cardiac arrest (CA) - are life-threatening medical emergencies.
- Conditions
- Brain Injuries, Traumatic, Brain Injuries, Acute, Hypoxia, Brain, Cardiac Arrest (CA)
- Trial name
- CHARON (NCT07782216)
- Where
- 4 sites in Hungary
- Volunteers
- 477 people
- Sponsor
- University of Pecs
Common Cold
Experimental Human Rhinovirus Infection
Our primary objective is to set up the Human Rhinovirus (HRV)-model in our centre. In addition, to facilitate future clinical trials, we want to determine optimal read-out parameters and read-out time points for experimental HRV…
- Trial name
- EHRVI (NCT01823640)
- Testing
- Human Rhinovirus strain 16 (HRV-16)
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Genitourinary Cancer
Parametric PET of Genitourinary Cancer
Metastatic kidney cancer is usually treated with targeted therapy or immunotherapy which is costly and has low response rate. The current standard care is to perform anatomical imaging studies after a few cycles (months) of…
- Trial name
- NCT04020978
- Testing
- Parametric PET/CT
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Davis
LUMBAR RADICULOPATHY, Lumbar Radiculopathy Due to Spinal Nerve Compression
Maitland Mobilization Effect On Gait Kinetics And Kinematics Parameters In Patients With Lumbosacral Radiculopathy
Effect Of Maitland Mobilization On Selected Gait Kinetic And Kinematic Parameters In Patients With Lumbosacral Radiculopathy
- Conditions
- LUMBAR RADICULOPATHY, Lumbar Radiculopathy Due to Spinal Nerve Compression, Lumbar Disc Prolapse With Radiculopathy, Lumbosacral Radiculopathy
- Trial name
- NCT07448311
- Testing
- MAITHLEND MOBILIZATION, transcutaneous electrical neuromuscular stimulation, stretching hamstrings
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Cairo University