Clinical trials: Knee Arthritis
Osteoarthritis, Knee
STepped Exercise Program for Knee OsteoArthritis
Knee osteoarthritis (OA) is one of the most common chronic conditions and a leading cause of disability among Veterans. Although exercise is known to improve pain, physical abilities, and other outcomes for patients who have knee…
- Trial name
- STEP-KOA (NCT02653768)
- Testing
- Stepped Exercise Program, Arthritis Education
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- VA Office of Research and Development
Knee Osteoarthritis
Evaluating the Efficacy of Lateral Heel Wedges of Osteoarthritis of the Knee
This study is looking at the efficacy of a sloped insole in patients with knee osteoarthritis. Regularly wearing a sloped insole over the course of one year will result in a wider joint space by x-ray in 60% of the subjects, a…
- Trial name
- NCT02254473
- Testing
- Wedge Insert, Flat Insert
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Anterior Cruciate Ligament Injuries, Knee Osteoarthritis
Optimizing Movement After Anterior Cruciate Ligament Injury
Fifty percent of teenagers and young adults who suffer an anterior cruciate ligament (ACL) injury develop knee osteoarthritis (OA) within 15 years.
- Trial name
- NCT05363683
- Testing
- Squat Biofeedback, Standard Care
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Nebraska
Osteoarthritis, Knee, Knee Osteoarthritis
AP-003-C Study to Confirm the Efficacy of Ampion™ in Adults With Pain Due to Severe Osteoarthritis of the Knee
This is a phase 3 randomized study to confirm the efficacy of an intra-articular injection of Ampion™ in adults with pain due to severe osteoarthritis of the knee.
- Conditions
- Osteoarthritis, Knee, Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
- Trial name
- NCT03182686
- Testing
- 4 mL injection of Ampion
- Where
- 13 sites in United States
- Volunteers
- 168 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Osteoarthritis
Single-use Efficiency Instruments With Patient Specific Technique (MyKnee®) Versus Traditional Metal Instruments With Conventional Surgical Technique
To compare economic factors and the rate of adverse events between two types of instrumentation used for total knee replacement: Single-use Efficiency Instruments with Patient Specific Technique (MyKnee®) Traditional Metal…
- Trial name
- NCT03148379
- Testing
- Customized patient instruments, Traditional Metal Instruments
- Where
- 5 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Knee Osteoarthritis
Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Knee Osteoarthritis (STRIDES)
This phase 3 study was a multicenter, randomized, double-blind, placebo-controlled study of lorecivivint injected intra-articularly (IA) into the target (most painful) knee joint of moderately to severely symptomatic…
- Trial name
- NCT05603754
- Testing
- Lorecivivint
- Where
- 44 sites in United States
- Volunteers
- 499 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteoarthritis
A Study of Hyaluronate Injectable Viscosupplement for Treatment of Osteoarthritis of the Knee
The study is a prospective, multi-center, randomized, three-arm, parallel group, clinical study to evaluate the superiority of 3 weekly intra-articular (IA) doses of 2 mL of Investigational hyaluronate as compared to placebo…
- Trial name
- NCT02495857
- Testing
- Hyaluronate Injectable Viscosupplement, Euflexxa IA injection
- Where
- 2 sites in United States
- Volunteers
- 599 people
- Sponsor
- Actavis Inc.
Osteoarthritis
Educational Intervention for Knee Pain
The purpose of this study is to demonstrate the efficacy of interventions to improve understanding of knee replacement risks, benefits, and expected outcomes among AA primary care patients, increase willingness to consider knee…
- Trial name
- NCT00324857
- Testing
- Decision Aid Video, Motivational Interviewing, MI plus Decision aid
- Where
- 3 sites in United States
- Volunteers
- 663 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis
Extension Study Of Tanezumab In Osteoarthritis
Safety extension study of Phase 3 Osteoarthritis trials with Tanezumab
- Trial name
- NCT00809783
- Testing
- tanezumab
- Where
- 226 sites in United States
- Volunteers
- 2,147 people
- Sponsor
- Pfizer
Knee Osteoarthritis
To Look at the Characteristics of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection
The purpose of this study is to identify novel imaging markers for characterizing the biochemical profiles in synovial fluid and cartilage matrix in OA knee joints after intra-articular HA (Euflexxa) injection using high field…
- Trial name
- NCT01895959
- Testing
- Euflexxa, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Osteoarthritis
Physical Activity Pathway for Patients With Osteoarthritis in Primary Care (OA-PCP) (R33)
The purpose of this study is to test an osteoarthritis (OA) primary care Physical activity Care Pathway (OA-PCP), a scalable intervention that includes: 1) a practical process for physical inactivity screening in primary care, 2)…
- Trial name
- OA-PCP (NCT04533711)
- Testing
- OA-PCP Intervention, Attention Control
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis, Knee
Optimum Radiographic Assessment of the Knee
X-rays are the most frequently used imaging test when evaluating the knee for joint replacement. They are non-invasive, safe and cost effective.
- Trial name
- NCT03685019
- Testing
- Valgus Stress, Varus stress, 0 degree flexion radiograph
- Volunteers
- 8 people
- Sponsor
- Oxford University Hospitals NHS Trust
Osteoarthritis, Knee
Home Monitoring After Primary Total Knee Arthroplasty
Home monitoring technologies have recently emerged in many different areas of healthcare. These technologies are being used to provide rehabilitation to patients, and to prevent, identify, and manage complications.
- Trial name
- NCT03032068
- Testing
- At-Home Monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Cleveland Clinic
Osteoarthritis, Arthritis
Efficacy And Safety Study Of Tanezumab Subcutaneous Administration In Osteoarthritis - A Subcutaneous/Intravenous Bridging Study
This is an efficacy and safety study of 3 doses (2.5 mg, 5 mg and 10mg) of tanezumab administered subcutaneously versus placebo.
- Conditions
- Osteoarthritis, Arthritis, Pain
- Trial name
- NCT01089725
- Testing
- Tanezumab SC, Tanezumab IV
- Where
- 91 sites in United States
- Volunteers
- 385 people
- Sponsor
- Pfizer
Osteoarthritis, Post-traumatic Arthritis
ATTUNE Single-Use Instrumentation vs. ATTUNE Reusable Instrumentation in Primary Total Knee Arthroplasty
This post-marketing investigation will evaluate the mechanical axis alignment achieved with the ATTUNE Single-Use Instrumentation (SUI) as compared to the mechanical axis alignment achieved with the ATTUNE Reusable…
- Trial name
- SOLO (NCT02574312)
- Testing
- ATTUNE TKA with ATTUNE RUI, ATTUNE TKA with ATTUNE SUI
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 88 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis, Knee
lIfestyle iNterventionS for PaIn ReliEf (INSPIRE)
This is a 2x2 factorial design randomised controlled trial in which participants with knee pain will be grouped into the diet intervention, exercise intervention, diet and exercise intervention or placebo arm.
- Trial name
- INSPIRE (NCT05670314)
- Testing
- Inulin Fibre supplement, Exercise
- Where
- United Kingdom
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Osteoarthritis, Knee
Orthosensor vs Conventional Total Knee Arthroplasty
In a randomized-controlled fashion, this investigation will evaluate the use of the Verasense technology to achieve optimal TKA balance.
- Trial name
- NCT03628378
- Testing
- Verasense
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- Columbia University
Osteoarthritis of the Knee
Dose Escalation Study Of Chinese Herbs In Osteoarthritis Of The Knee
The purpose of this study is to determine if the traditional Chinese herbal compound (Huo-Luo-Xiao-Ling Dan, or HLXL) is effective in treating OA of the knee in addition to participants current OA of the knee treatment(s) and…
- Trial name
- TCM-OAK (NCT00755326)
- Testing
- HLXL
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Maryland, Baltimore
Osteoarthritis, Knee, Arthritis of Knee
Treatment of Knee Osteoarthritis With Allogenic Mesenchymal Stem Cells
In this study we want to evaluate the clinical use of allogenic mesenchymal stem cells (MSC), obtained from bone marrow of healthy donors, for treatment of knee osteoarthritis.
- Conditions
- Osteoarthritis, Knee, Arthritis of Knee, Knee Osteoarthritis
- Trial name
- MSV_allo (NCT01586312)
- Testing
- Allogenic mesenchymal stromal cells injection, Hyaluronic Acid
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Red de Terapia Celular
Osteoarthritis, Knee
Bioequivalence Study With Clinical Endpoint for Diclofenac Sodium Topical Gel 1%
A Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Three-Arm, Multi-Site Study to Evaluate the Therapeutic Equivalence of Diclofenac Sodium Topical Gel 1% (Hi-Tech Pharmacal Co., Inc.) With Voltaren® Gel (Diclofenac…
- Trial name
- NCT02913521
- Testing
- Diclofenac Sodium Gel 1%, Voltaren Gel
- Where
- 51 sites in Estonia, Latvia and 4 more
- Volunteers
- 934 people
- Sponsor
- Akorn, Inc.