Clinical trials: Knee Arthritis Disease
Osteoarthritis of the Knee
A Study of the Efficacy and Safety of CF101 to Patients With Osteoarthritis of the Knee
This study will test the effectiveness of CF101 in treating the symptoms of osteoarthritis (OA) of the knee. Eligible patients will be given either CF101 or matching placebo tablets and their symptoms will be evaluated over the…
- Trial name
- NCT00837291
- Testing
- CF101
- Where
- Israel
- Sponsor
- Can-Fite BioPharma
Osteoarthritis, Knee, Knee Osteoarthritis
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
Patients with degenerative joint disease can effectively be treated with a primary total knee replacement to reduce pain and improve function in their daily lives.
- Conditions
- Osteoarthritis, Knee, Knee Osteoarthritis, Osteoarthritis Knees Both, Osteoarthritis Knee Left
- Trial name
- NCT04814082
- Testing
- MicroPort Evolution Medial-Pivot Knee System (Cruciate-substituting), Stryker Triathlon Tritanium Knee System (Condylar Stabilizing)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- LifeBridge Health
Osteoarthritis, Knee
Comparison of Surgical Time and Efficiency of Total Knee Arthroplasty
This study is designed to compare the surgical efficiency of TruMatch® Personalized Solutions surgical technique compared to conventional surgical technique.
- Trial name
- NCT01301950
- Testing
- Custom Patient Instrumentation, Conventional Instruments
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- DePuy Orthopaedics
Metalloproteinase SNPs -1575 G/A MMP-2, 836 A/G MMP-9 and -77 A/G MMP-13 and Risk for Developing Knee Osteoarthritis in Greek Population
Association of Single Nucleotide Polymorphisms (SNPs) in Metalloproteinases (MMPs) Genes With the Risk of Primary Knee Osteoarthritis in Greek Population.
Does the presence of gene polymorphisms -1575G / A in the MMP-2 gene, 836A / G in the MMP-9 gene and -77A / G in the MMP-13 gene, affect the risk of developing idiopathic knee osteoarthritis in the Greek population?
- Trial name
- NCT04463290
- Testing
- No intervention, Patients selection based on clinical symptoms and radiological imaging
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Osteoarthritis, Knee, Obesity
Effect Of The Use Of Navigation In The Alignment Obtained When Performing A Total Knee Arthroplasty In Obese Patients
NAOBE is a randomized, open and prospective clinical trial that evaluates the accuracy to achieve an adequate mechanical axis of the lower extremity in obese patients after total knee replacement.
- Conditions
- Osteoarthritis, Knee, Obesity, Arthropathy of Knee
- Trial name
- NCT03865524
- Testing
- Total knee arthroplasty implanted with GPS navigation system, Total knee arthroplasty implanted with standard guides.
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- Pedro-José Torrijos-Garrido
Osteoarthritis
Osteopuncture for Osteoarthritis-Associated Knee Pain & Disability
The purpose of this study is to investigate the feasibility, effectiveness, and duration of treatment response of periosteal electro-acupuncture (osteopuncture) for osteoarthritis (OA)-associated chronic knee pain.
- Trial name
- NCT00417313
- Testing
- periosteal electro-acupuncture (osteopuncture).
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- National Institute on Aging (NIA)
Osteo Arthritis Knee, Joint Diseases
SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization
An open label, prospective, two-arm, multicenter, randomized controlled trial comparing SakuraBead genicular artery embolization (GAE) with a control (corticosteroid injection).
- Conditions
- Osteo Arthritis Knee, Joint Diseases, Musculoskeletal Diseases, Rheumatic Diseases
- Trial name
- SURE (NCT06550024)
- Testing
- SakuraBead Resorbable Microspheres, Corticosteroid Injection
- Where
- 8 sites in United States, Georgia and 2 more
- Volunteers
- 89 people
- Sponsor
- CrannMed
Osteoarthritis, Knee
Effect of Hydrotherapy After Unilateral UKA
Osteoarthritis (OA) is a progressive disease of the synovial joints that causes joint pain and limitation of function resulting in considerable morbidity and impairment of quality of life.
- Trial name
- NCT06459960
- Testing
- Hydrotherapy, Convention
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthritis, Osteo Arthritis Knee
Microfragmented Adipose Tissue Compared to Saline Injection for the Treatment of Knee Osteoarthritis
The goal of this clinical trial is to examine the effect of a single autologous, intra-articular injection of MFat versus saline injection for the treatment of pain and function associated with K/L grade 2/3 knee Osteoarthritis.
- Trial name
- ARISE2 (NCT06121882)
- Testing
- Microfragmented Adipose Tissue derived using the Lipogems® System, Saline Injection
- Where
- 16 sites in United States
- Volunteers
- 173 people
- Sponsor
- Lipogems International spa
Osteoarthritis, Knee
Reaching Exercise Goals: Comparison of Exercise Means in Patients With Knee Osteoarthritis
The primary objective is to evaluate water based treadmill exercise, land based treadmill exercise, and upright cycling in meeting American College of Sports Medicine exercise goals for moderate exercise.
- Trial name
- NCT01359124
- Testing
- Exercise Cycle, Land-based Treadmill, Water-based Treadmill
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Milton S. Hershey Medical Center
Osteoarthritis, Knee
Effects of Multicomponent Exercise on Subchondral Bone and Cartilage in Postmenopausal Women With Knee Osteoarthritis
Today, osteoarthritis (OA) is considered a whole-organ disease that is amenable to prevention and treatment in the early stages.
- Trial name
- LuRu2 (NCT06173193)
- Testing
- Multicomponent exercise regimen, Standard rehabilitative management
- Where
- Finland
- Volunteers
- 103 people
- Sponsor
- University of Jyvaskyla
Pain, Physical Function
Osteoarthritis Outcomes in Different Ages
We aim to study if there are differences in outcomes between different age groups for persons with knee or hip osteoarthritis during treatment in digitally delivered exercise and education treatment.
- Conditions
- Pain, Physical Function, Age
- Trial name
- NCT05208463
- Testing
- Joint Academy
- Where
- Sweden
- Volunteers
- 14,610 people
- Sponsor
- Joint Academy
Knee Osteoarthritis (Knee OA)
Effects of Core Stabilization Exercises in Female Patients With Gonarthrosis
Osteoarthritis (OA) is a non-inflammatory degenerative disease characterized by progressive deterioration of cartilage tissue, synovial membrane, and joint capsule, primarily affecting weight-bearing joints.
- Trial name
- NCT07482332
- Testing
- 10 days of conventional physiotherapy (Hot Pack, TENS, Ultrasound) and 6 weeks of routine knee exercises, Six weeks of core stabilization exercises.
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cumhuriyet University
Bilateral Knee Osteoarthritis
Study to Compare Exposure of TA Following Administration of Either FX006 or TAcs in Patients With Bilateral Knee OA
This is a randomized, open-label, parallel group study to compare systemic exposure of triamcinolone acetonide following administration into both knees of either FX006 or TAcs.
- Trial name
- NCT03378076
- Testing
- FX006 32 mg, TAcs 40 mg
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Amputation, Osteo Arthritis Knee
Femoral Cartilage Thickness In Patients With Lower Limb Amputation
The aim of the study to investigate any relation with functional parameters and femoral cartilage thickness evaluation by ultrasonography in lower extremity amputate individuals.
- Trial name
- NCT04422717
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Osteoarthritis, Mindfulness
A Mindfulness Program (MBSR) in the Management of Symptomatic Hip and Knee Osteoarthritis
Symptomatic osteoarthritis (OA) is the most common joint disease and the leading cause of disability in industrialized countries.
- Conditions
- Osteoarthritis, Mindfulness, MBSR
- Trial name
- MINDFULNESS_OA (NCT03644615)
- Testing
- Mindfluness and usual care, Usual care
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Osteoarthritis, Knee
Prospective Post-Market Data Collection on Patients With Knee OA and Treated With nSTRIDE APS
This study will document treatment effects, changes in quality of life, procedure complications, adverse events, healthcare resource utilization, and further needed intervention(s) following treatment with nSTRIDE autologous…
- Trial name
- PROGRESS III (NCT02580643)
- Testing
- APS
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- Zimmer Biomet
Osteoarthritis (OA) of the Knee
Kinesio Taping After Platelet-Rich Plasma Treatment in Individuals With Knee Osteoarthritis
This randomized controlled study evaluated whether kinesio taping provided additional benefits compared with sham taping in women with knee osteoarthritis who had received platelet-rich plasma (PRP) treatment as part of routine…
- Trial name
- NCT07773324
- Testing
- Kinesio Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Agri Ibrahim Cecen University
Osteoarthritis
Total Knee Arthroplasty Comparing Cementless to Cemented Fixation
The purpose of this study is to determine if there are any clinical or radiographic differences in cemented and cementless fixation in total knee replacement.
- Trial name
- NCT01335438
- Testing
- Cementless (Nexgen), Cemented (Nexgen)
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Young Hoo Kim
Knee Osteoarthritis, Task Performance and Analysis
Knee Osteoarthritis, Motor Control, Risk of Falls and Virtual Reality
The goal of this clinical trial is to learn about knee osteoarthritis, functionality, and risk of falls in community-dwelling adults aged 60 years and older.
- Conditions
- Knee Osteoarthritis, Task Performance and Analysis, Accidental Falls, Virtual Reality
- Trial name
- NCT06362785
- Testing
- Virtual Reality, Therapeutic exercise
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
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