Clinical trials: Knee Arthritis Disease
Central Sensitization, Knee Osteoarthristis
Aquatic Exercise in Patients With Knee Osteoarthritis
The effect of aquatic exercise on central sensitization in patients with knee osteoarthritis are not fully known in the studies conducted to date.
- Conditions
- Central Sensitization, Knee Osteoarthristis, Aquatic
- Trial name
- NCT07883824
- Testing
- Standard physical therapy, Hydrotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Knee Osteoarthritis (OA)
Altered Joint Mechanics and Biological Response in Osteoarthritic Knees.
Osteoarthritis (OA) stands out as the most prevalent joint disease. It manifests as a progressive degradation of articular cartilage, new bone growth and often synovial tissue proliferation, resulting in pain and compromised…
- Trial name
- AMB-OK (NCT07481461)
- Testing
- Photon counting CT scanning (PCCT scanning), Magnetic resonance imaging (MRI scanning), Gait analysis
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Knee Osteoarthritis
Genicular Artery Embolization to Reduce Pain Associated With Unilateral Mild to Moderate Osteoarthritis
The goal of this study is to perform a feasibility study to show the effectiveness of the genicular artery embolization procedure in reducing bilateral or unilateral osteoarthritic knee pain at 12 months as measured by WOMAC…
- Trial name
- GAE (NCT04592562)
- Testing
- the Terumo Hydropearl® microspheres device
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Chicago
Osteoarthritis, Knee, Dementia
Effect of Tai Chi on Osteoarthritic Knee Pain in Elders With Mild Dementia
This is the first study to test the effect of Tai Chi on pain from knee osteoarthritis in community-dwelling elders with mild cognitive impairment.
- Trial name
- NCT01528566
- Testing
- Tai Chi, Attention control
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Arkansas
ACL Injury, Meniscus Tear
MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)
This is a multicenter randomized, placebo-controlled trial to assess whether a 6-month course of oral montelukast after ACL reconstruction reduces systemic markers of inflammation and biochemical and imaging biomarkers of…
- Conditions
- ACL Injury, Meniscus Tear, Post-traumatic Osteoarthritis
- Trial name
- MOCHA (NCT04572256)
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Austin V Stone
Knee Osteoarthritis
Unicompartmental Knee Arthroplasty vs. High Tibial Osteotomy for Medial Knee Osteoarthritis (UNIKORN): a Study Protocol of a Randomized Controlled Trial
Unicompartmental knee arthroplasty (UKA) and High Tibial Osteotomy are both valid treatment options for isolated medial knee osteoarthritis.
- Trial name
- UNIKORN (NCT05442242)
- Testing
- Unicompartmental knee arthroplasty, High tibial osteotomy
- Volunteers
- 100 people
- Sponsor
- Töölö Hospital
Osteoarthritis, Knee
Safety and Tolerability of PG110 in Patients With Knee Osteoarthritis Pain
The purpose of this study is to evaluate the safety and tolerability of a single intravenous dose of PG110, a monoclonal antibody that inhibits the effects of the naturally occurring substance, nerve growth factor (NGF).
- Trial name
- NCT00941746
- Testing
- PG110
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- Abbott
Osteoarthritis, Knee, Cartilage Degeneration
Analysis of the Pathophysiological and Functional State of the Knee Joint
Osteoarthritis is the most common degenerative condition affecting the knee joint globally, with an incidence of about 7% of the population.
- Trial name
- Gait-MRI-Knee (NCT06490770)
- Testing
- Gait analysis, Magnetic Resonance Imaging
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis
Effectiveness of Oral Hyaluronic Acid in Knee Osteoarthritis
This study was a randomized, double-blind, placebo-controlled study evaluating the efficacy of an oral liquid HA supplement (A+HA) in symptoms relief and improvement of quality of life in knee osteoarthritis patients with mild…
- Trial name
- NCT04352322
- Testing
- A+HA(tm)
- Where
- Taiwan
- Volunteers
- 47 people
- Sponsor
- China Medical University Hospital
Osteoarthritis
A Study to Evaluate the Performance of the DePuy Low Contact Stress (LCS®) Complete Anterior-Posterior Glide (APG) Mobile Bearing Knee
The primary objective of this investigation is to determine the survivorship of the LCS Complete AP Glide mobile bearing knee prosthesis at 5 years.
- Trial name
- NCT00733486
- Testing
- L.C.S. APG Knee Anterior Posterior Glide knee
- Where
- 3 sites in South Korea
- Volunteers
- 233 people
- Sponsor
- DePuy International
Knee Osteoarthritis
Comparative Effects of Strain Counter Strain and Myofascial Release in Patients With Knee Osteoarthritris
Osteoarthritis is a degenerative disease, the cartilage present in the joint gets damaged and the bones become hypertrophied. In US, the most commonly occuring arthritis is osteoarthritis. Myofascial release focuses on fascia.
- Trial name
- NCT07403383
- Testing
- Strain Counter Strain, Myofascial Release
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Knee Osteoarthritis, Hip Osteoarthritis
An Analysis of the Outcomes From Protocolized Perioperative Care for Patients Receiving Total Hip or Knee Arthroplasty
The care for patients receiving total hip and knee arthroplasty at the University of Arkansas for Medical Sciences has followed a structured care pathway since July 2015.
- Conditions
- Knee Osteoarthritis, Hip Osteoarthritis, Knee Arthritis, Hip Arthritis
- Trial name
- NCT03071250
- Testing
- Total knee or Hip Arthroplasty
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Arkansas
Knee Osteoarthritis
Kinematics of Contemporary Knee Arthroplasty
Total joint replacement is an efficacious treatment for osteoarthritis of hips and knees. Both total knee replacement (TKR) and total hip replacements (THR) have excellent implant survivorship.
- Trial name
- NCT02965690
- Testing
- Zimmer Biomet NexGen CR, Medacta International GMK Sphere
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Osteoarthritis, Knee, Obesity
Long-term Intervention With Weight Loss in Patients With Concomitant Obesity and Knee Osteoarthritis. The LIGHT Study
Obesity and osteoarthritis (OA) co-exist in an increasing part of the population. The two diseases intertwine in several ways. The evolution in the population shows a tendency towards deterioration of both by increasing general…
- Trial name
- LIGH T (NCT00938808)
- Testing
- day formula diet
- Where
- Denmark
- Volunteers
- 154 people
- Sponsor
- Henning Bliddal
Osteoarthritis, Knee
Single-Dose Hybrid Hyaluronic Acid and Sodium Chondroitin with Rehabilitation for Sports Adults with Knee Osteoarthritis
: This observational case-control study aims to evaluate the efficacy of a single-dose intra-articular injection of a hybrid purified hyaluronic acid with high molecular weight and sodium chondroitin of biotechnological origin…
- Trial name
- NCT06890247
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Palermo
Knee Osteoarthritis
Manual Therapy Versus Exercise on Knee Osteoarthritis
Earlier research has shown that exercising while receiving manual therapy improves function and reduces pain in people with knee osteoarthritis.
- Trial name
- NCT00988468
- Testing
- Manual Therapy, Therapeutic Exercise, Video Observation
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Knee Osteoarthritis
Clinical Importance of Occult Suprapatellar Effusion in Knee Osteoarthritis
Small amounts of fluid in the knee joint may not always be visible during a standard ultrasound examination performed while the leg is relaxed.
- Trial name
- NCT07876752
- Testing
- Static and Dynamic Suprapatellar Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Mardin Artuklu University
Hemi Knee Arthroplasty, Patello-femoral Osteoarthritis
Evaluation of Orthopedic Knee Measurement Using Lunar iDXA
This study is to compare scans of the knee performed using new software designed specifically to look at the knee joint with those performed using approved software designed for scans of the hip.
- Trial name
- NCT01348958
- Testing
- iDXA knee software
- Where
- New Zealand
- Volunteers
- 36 people
- Sponsor
- GE Healthcare
Osteoarthritis, Knee, Osteoarthritis
Phase 4 Study of Laybon Tab. in Knee Osteoarthritis
This Phase 4, multicenter, randomized, double-blind, active-controlled, parallel study aims to evaluate the non-inferiority of Laybon Tab. compared to Layla Tab. (PMG Pharm Co., Ltd.) in patients with knee osteoarthritis.
- Trial name
- NCT07203547
- Testing
- Layla Tab., Laybon Tab.
- Volunteers
- 172 people
- Sponsor
- Mather's Pharm. Co., Ltd.
Osteoarthritis
Efficacy of Lower Tourniquet Pressure During Total Knee Arthroplasty
This study aims to determine whether the lower tourniquet pressure, which is set by adding 120mmHg (millimeter of mercury) on the systolic blood pressure just before tourniquet inflation, are efficient and safe during total knee…
- Trial name
- NCT01993758
- Testing
- Low tourniquet pressure, Conventional tourniquet pressure
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
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