Clinical trials: Knee Chondral Lesion
Knee Injuries, Cartilage Injury
Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee
Multi-center, prospective, concurrently controlled, non-randomized, double-blind (patient and assessor). Treatment of large chondral lesions in the knee with microfracture plus the Chondro-Gide® ACC is non-inferior to treatment…
- Conditions
- Knee Injuries, Cartilage Injury, Cartilage Disease, Knee Discomfort
- Trial name
- SECURE (NCT04537013)
- Testing
- Microfracture, Microfracture plus placement of Chondro-Gide® ACC
- Where
- 15 sites in United States, Canada and 1 more
- Volunteers
- 82 people
- Sponsor
- Geistlich Pharma AG
Knee Chondral Lesion
PRP vs AD-SVF in Addition to Marrow Stimulation for Knee Chondral Lesion
The goal of this clinical trial is to learn if PRP and adipose-derived stem cells (AD-SVF) enhance healing after knee microfracture for chondral lesions. It will also learn about the safety of the procedure.
- Trial name
- NCT07255547
- Testing
- Bone Marrow Stimulation, stromal vascular fraction (SVF), PRP injection
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Università degli Studi dell'Aquila
Cartilage Injury, Defect of Articular Cartilage
BioPoly RS Knee Registry Study for Cartilage Defect Replacement
Information will be collected on the pre-op and post-op clinical status of patients with focal cartilage defects of the femoral condyles treated with the BioPoly RS Partial Resurfacing Knee Implant, a permanent orthopaedic…
- Conditions
- Cartilage Injury, Defect of Articular Cartilage, Cartilage Damage
- Trial name
- NCT01473199
- Testing
- BioPoly RS Partial Resurfacing Knee Implant
- Where
- 5 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- BioPoly LLC
Chondral Lesion of the Knee, Patellofemoral Disorder
Mid- and Long-term Evaluation of the Results of Patients Undergoing Spinal Cord Stimulation With Microfractures + BST CarGel in the Treatment of Patellofemoral Chondral Lesions of the Knee
The study consists of 3 phases (Identification of eligible patients, follow-up by telephone or telemedicine platform and the collection of study-specific clinical data of enrolled patients): Identification by trained medical…
- Trial name
- CARGEL-LT (NCT06477315)
- Testing
- survey
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Chondral Lesion, Knee Osteochondral Lesion
Study for the Treatment of Knee Chondral and Osteochondral Lesions
INTRODUCTION Marrow stimulation techniques as subchondral drilling or microfractures represent ones of the most frequently used methods for chondral and osteochodral defects repair and considered as standard techniques.
- Trial name
- NCT01282034
- Testing
- Marrow stimulation - Drilling or Microfractures, MaioRegen Surgery
- Where
- 10 sites in Austria, Belgium and 7 more
- Volunteers
- 145 people
- Sponsor
- Fin-Ceramica Faenza Spa
Traumatic; Lesion, Degenerative Lesion of Articular Cartilage of Knee
Randomized Evaluation of BST-CarGel Versus Microfracture Alone On Recovery From Distal Femoral Cartilage Lesions
This multi-centre randomized, controlled trial will assess the impact of BST-CarGel scaffold with microfracture versus microfracture alone on short and long term clinical benefit in patients with cartilage lesions of the femoral…
- Trial name
- RECORD (NCT02981355)
- Testing
- Microfracture treatment, BST-CarGel
- Where
- 15 sites in Australia, Canada and 5 more
- Volunteers
- 5 people
- Sponsor
- Piramal Healthcare Canada Ltd
Tear; Knee, Cartilage, Articular
Autologous Chondrocyte Transplantation For Articular Cartilage Regeneration
The purpose of this study is to assess safety and efficacy of autologous chondrocyte implantation delivered arthroscopically into chondral lesions of the knee using clinical, biochemical, and MRI outcomes.
- Trial name
- NCT01503970
- Testing
- Arthroscopic matrix encapsulated chondrocyte implantation
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Knee Osteoarthritis
Comparison Between MR Arthrography ,ct Arthrography and Conventional MR in Osteoachondral Lesions of Knee Osteo Arthritis
The aim of this study is to compare the diagnostic efficacy of conventional MRI, MR arthrography and MDCT arthrography in the detection and grading of chondral lesions of the osteoarthritic knee with arthroscopic correlation
- Trial name
- NCT05764603
- Testing
- MRI
- Volunteers
- 50 people
- Sponsor
- Assiut University
Tear; Knee, Cartilage, Articular
Clinical Trial for the Regeneration of Cartilage Lesions in the Knee
The purpose of this study is to investigate the efficacy of an engineered cartilage transplant (N-TEC) in comparison to a cell-activated matrix (N-CAM) for the treatment of articular cartilage lesions in the knee.
- Trial name
- NosetoKnee2 (NCT02673905)
- Testing
- Tissue Engineered Product
- Where
- 5 sites in Croatia, Germany and 2 more
- Volunteers
- 108 people
- Sponsor
- University Hospital, Basel, Switzerland
Chondral Defect, Articular Cartilage Defect
A Comparison of JointRep® and Microfracture in Repair of Cartilage Lesions on the Femoral Condyle or Trochlea,
The aim of the study is to compare whether JointRep® plus microfracture is more effective than microfracture alone when treating symptomatic focal articular cartilage lesions in the knee (femoral condyles or trochlea).
- Conditions
- Chondral Defect, Articular Cartilage Defect, Articular Cartilage Disorder of Knee
- Trial name
- JMAC (NCT04840147)
- Testing
- JointRep®, Microfracture
- Where
- 8 sites in Australia, Canada
- Volunteers
- 185 people
- Sponsor
- Oligo Medic Pty Ltd
Meniscectomy, Meniscal Tears
Needle Arthroscopy vs Conventional Arthroscopy in Knees
This is a pilot randomized controlled trial will have 54 participants. The purpose of this study is to compare two surgical techniques to determine the differences in postoperative pain and early recovery in patients between…
- Conditions
- Meniscectomy, Meniscal Tears, Meniscal Repair, Chondral Lesion of the Knee
- Trial name
- Nano (NCT07823504)
- Testing
- Needle Arthroscopy
- Volunteers
- 54 people
- Sponsor
- Panam Clinic
Osteochondral Defect
Study Protocol to Evaluate Clinical and Imaging Results of Knee Fresh Osteochondral Allografts
The main objective of this study is to assess the clinical and radiological results after carrying out a transplant of fresh osteochondral allograft in the knee.
- Trial name
- NCT04236492
- Testing
- Fresh osteochondral allografting
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Knee Chondral, Osteochondral Defect
Comparison of Microfracture Treatment and CARTIPATCH® Chondrocyte Graft Treatment in Femoral Condyle Lesions
CARTIPATCH® is an Autologous Chondrocyte Implantation product including functional cells in a matrix, indicated for the treatment of isolated osteocartilaginous lesions.
- Trial name
- NCT00945399
- Testing
- CARTIPATCH® procedure, Microfracture
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- TBF Genie Tissulaire
Symptomatic Knee Osteoarthritis
Micro-fragmented Adipose Tissue Injection Associated With Arthroscopic Procedures in Patients With Knee Osteoarthritis
The study aims to evaluate the effects of a single intra-articular injection of micro-fragmented adipose tissue obtained with the Lipogems® system in patients affected by knee chondropathy.
- Trial name
- LOOK (NCT03527693)
- Testing
- Lipogems injection
- Volunteers
- 38 people
- Sponsor
- Spotorno Foundation
Articular Cartilage Lesion of the Femoral Condyle
Autologous Mesenchymal Stem Cells vs. Chondrocytes for the Repair of Chondral Knee Defects
The objective of our study is to compare the safety and effectiveness of the use of autologous cultured adipose tissue-derived stem cells versus cultured autologous chondrocytes for the treatment of chondral knee lesions.
- Trial name
- ASCROD (NCT01399749)
- Testing
- Implantation of autologous cells
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
Articular Cartilage Lesion of the Knee
Study to Assess the Efficacy and Safety of Treatment of Articular Cartilage Lesions With CartiLife®
The purpose of this study is to assess the safety and efficacy of implanting bead-type autologous chondrocyte (CartiLife®) obtained by culturing expanded costal chondrocytes of the patient with a chondral defect in the knee.
- Trial name
- NCT03545269
- Testing
- CartiLife®, Microfracture
- Volunteers
- 30 people
- Sponsor
- Biosolution Co., Ltd.
Cartilage or Osteochondral Defects in the Knee
COPLA® Cartilage Implant Pilot Clinical Trial
This is a first-in-human clinical, open label, non-randomized, prospective investigation to assess the initial safety and performance of the COPLA® cartilage implant.
- Trial name
- NCT05685316
- Testing
- COPLA® cartilage implant
- Where
- 6 sites in Estonia, Finland and 1 more
- Volunteers
- 20 people
- Sponsor
- Askel Healthcare Ltd
Chondral Lesion Plus Partial Medial Meniscectomy
Mechanical vs. Radiofrequency-Based Debridement in the Treatment of Articular Cartilage Lesions
The purpose of this study is to evaluate changes in clinical and imaging outcomes following arthroscopic treatment of a single medial femoral chondral lesion plus partial medial meniscectomy by Radiofrequency-Based debridement or…
- Trial name
- ACT (NCT01803880)
- Testing
- Mechanical Debridement, RF-Based Debridement
- Where
- 7 sites in United States
- Volunteers
- 148 people
- Sponsor
- Smith & Nephew, Inc.
Traumatic Cartilage Injury
Treating Patients With Traumatic Chondral Lesions With Autologous Bone Marrow Cells Derived Engineered Tissues - Engineered Osteochondral Tissue
The objective of the study is to establish the safety profile of the autologous engineered osteochondral tissues (eOCT) in treating traumatic chondral lesions in patients.
- Trial name
- TCL-aMSC-eOCT (NCT06400862)
- Testing
- eOCT implantation
- Where
- 2 sites in Hong Kong
- Volunteers
- 4 people
- Sponsor
- Chinese University of Hong Kong
Articular Cartilage Lesion of Knee
Study to Assess the Safety of Treatment of Articular Cartilage Lesions With CartiLife®
The purpose of this study is to assess the safety and efficacy of implanting bead-type autologous chondrocytes (CartiLife®) obtained by culturing expanded costal chondrocytes of the patient with a chondral defect in the knee.
- Trial name
- NCT03517046
- Testing
- CartiLife
- Volunteers
- 6 people
- Sponsor
- Biosolution Co., Ltd.