Clinical trials: Knee Degenerative Disease
Osteoarthritis of the Knee
Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis
This study will test the efficacy and safety of topical diclofenac sodium gel in the treatment of knee osteoarthritis.
- Trial name
- NCT00426621
- Testing
- Diclofenac Sodium Gel
- Where
- 64 sites in United States
- Volunteers
- 420 people
- Sponsor
- Novartis
Osteoarthritis, Knee Pain Arthritis
Long-Term Study of CartiPRO for Knee Pain Due to Osteoarthritis or Cartilage Damage
This clinical trial aims to evaluate and compare the efficacy and safety of CartiPRO, an approved intra-articular atelocollagen injection, versus Synovian injection for the relief of knee pain in patients with knee…
- Conditions
- Osteoarthritis, Knee Pain Arthritis, Cartilage Defects of the Knee, Knee Osteoarthritis
- Trial name
- NCT07267793
- Testing
- CartiPRO, Synovian®
- Where
- 5 sites in South Korea
- Volunteers
- 194 people
- Sponsor
- DALIM TISSEN Co., Ltd.
Non-inflammatory Degenerative Joint Disease
Safety and Efficacy of the ANTHEM™ CR Total Knee System
This clinical study will evaluate the short-term (1- and 2-year) and medium term (5-year) safety and performance of the ANTHEM™ CR Total Knee System in patients with non-inflammatory degenerative joint disease of the knee…
- Trial name
- Anthem CR (NCT03885622)
- Testing
- ANTHEM™ CR Total Knee System
- Where
- 8 sites in India, Italy and 2 more
- Volunteers
- 153 people
- Sponsor
- Smith & Nephew Pte Ltd
Knee Osteoarthritis
Stimulate Brain and Reduce Knee Pain Due to Degeneration
Osteoarthritis (OA) knee is chronic, slowly progressive, degenerative disease of joint which affects articular cartilage and accompanied by pain, swelling and loss of function .
- Trial name
- NCT04320875
- Testing
- Transcranial direct current stimulation, Conventional Physiotherapy
- Volunteers
- 80 people
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Elastic Band Resistance Exercise With Comorbid Type 2 Diabetes Mellitus and Knee Osteoarthritis
Elastic Band Resistance Exercise on Glycated Haemoglobin and Muscle Strength, Balance, and Physical Function in Patients With Comorbid Type 2 Diabetes Mellitus and Knee Osteoarthritis
Whether elastic band resistance exercise (EBRE) as a home-based rehabilitation routine can control the glycated heamoglobin (HbA1c) level and improve the muscle strength, dynamic balance, and physical function in older patients…
- Trial name
- NCT04026139
- Testing
- Elastic Band Resistance Exercise, active joint range-of-motion exercises and isometric contraction exercises
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Shu-Mei Chen
Knee Osteoarthritis, Cartilage Degeneration
Knee Osteoarthritis Treatment With Percutaneous Injections of Autologous Bone Marrow Concentrate
Recently there has been a growing interest in the role of subchondral bone in knee arthritis, both in its etiology and evolution and in its clinical significance.
- Trial name
- Bone-Gun (NCT04310852)
- Testing
- BioCue Concentration Kit
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Clinico Humanitas
Osteoarthritis, Osteo Arthritis Knee
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Use of Biocellular and cellular approaches to treatment of Osteoarthritis (OA), musculoskeletal aging processes, pain, and degenerative changes are to be studied with minimally invasive protocols, and non-pharmaceutical means to…
- Conditions
- Osteoarthritis, Osteo Arthritis Knee, Osteo Arthritis Shoulders, Osteoarthritis of Multiple Joints
- Trial name
- GARM-MSK-ALD (NCT04238143)
- Testing
- Tissue Stromal Vascular Fraction (tSVF) Arm 1, PRP Concentrate Arm 1, Tissue Stromal Vascular Fraction (tSVF) Arm 2
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Healeon Medical Inc
Osteo Arthritis Knee, Degenerative Joint Disease of Knee
Intra-articular Transplantation of Autologous Adipose Derived Stromal Vascular Faction (SVF) for Treatment of Osteoarthritis of the Knee
Researchers are trying to determine the safety and feasibility of autologous, adipose derived stromal vascular fraction injections in the treatment of knee osteoarthritis
- Trial name
- NCT03940950
- Testing
- Autologous Adipose-Derived SVF (Stromal Vascular Fraction)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Osteoarthritis, Knee
The Effectiveness of Resistance Training for Patients With Degenerative Arthritis After Surgery
Osteoarthritis is a common degenerative disease that significantly impacts mobility and disability in older adults. This pilot randomized controlled study aimed to examine the effects of a three-month resistance training program…
- Trial name
- Arthritis (NCT07696195)
- Testing
- Progressive Lower Extremity Resistance Exercise, Routine Postoperative Rehabilitation Care
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Tzu Chi University
Degenerative Meniscal Tears, Knee Osteoarthritis
DEMAND - DEgenerative Meniscal Tears - Arthroscopy vs. Dedicated Exercise
Patients with wear and tear in their knees (osteoarthritis) are often referred to orthopaedic surgeons following a sudden worsening of pain and mechanical symptoms (grinding, locking, giving way) in their knee due to tears of…
- Trial name
- DEMAND (NCT02113280)
- Testing
- Arthroscopy, Physiotherapy
- Where
- United Kingdom
- Sponsor
- Northumbria Healthcare NHS Foundation Trust
Osteoarthritis, Joint Disease
Autologous Adipose-Derived Stromal Vascular Fraction Cells for Osteoarthritis Treatment
Adipose-derived stromal vascular fraction cells (SVFs) include regenerative cell populations (hematopoietic cells, pericytes, endothelial cells and progenitors, stromal/stem cells) and thus are potentially important as new…
- Conditions
- Osteoarthritis, Joint Disease, Osteoarthritis,Knee, Arthritis, Degenerative
- Trial name
- NCT02967874
- Testing
- Intra-articular auto-SVFs injection, Hyaluronic Acid
- Where
- Russia
- Volunteers
- 27 people
- Sponsor
- Russian Academy of Medical Sciences
Degenerative Arthritis
Combined Administration of Intravenous and Topical Tranexamic Acid in Total Knee Arthroplasty
This prospective randomized controlled trial was conducted To compare the efficacy of TNA in terms of total blood loss and the allogenic transfusion rate among the three study groups; intravenous alone, combined intravenous and…
- Trial name
- NCT02286973
- Testing
- Tranexamic Acid
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Degenerative Osteoarthritis
A Study to Determine the Safety and Efficacy of TG-C in Subjects With Kellgren and Lawrence Grade 2 or 3 OA of the Knee
A randomized, double-blind, placebo-controlled, multi-center, phase 3 study to determine the safety and efficacy of TG-C in subjects with Kellgren and Lawrence Grade 2 or 3 Osteoarthritis of the Knee, Osteoarthritis Research…
- Trial name
- NCT03203330
- Testing
- TG-C
- Where
- 44 sites in United States
- Volunteers
- 535 people
- Sponsor
- Kolon TissueGene, Inc.
Osteoarthritis
Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee
To study of efficacy and safety of Naproxcinod vs. Naproxen and Placebo in the indication of signs and symptoms of osteoarthritis
- Trial name
- NCT00504127
- Testing
- Naproxcinod 375 mg bid, Naproxcinod 750 mg bid, Naproxen 500 mg bid
- Where
- 73 sites in United States
- Volunteers
- 1,020 people
- Sponsor
- NicOx
Inflammatory Arthritis, Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis)
A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)
The purpose of this study is to assess the long-term safety and performance of the LEGION Medial Stabilized insert and to generate clinical evidence to support and maintain product registration in global markets.
- Conditions
- Inflammatory Arthritis, Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis), Post-traumatic Arthritis
- Trial name
- NCT07199738
- Testing
- Cemented CoCr, Cemented Oxinium, Cementless
- Where
- 4 sites in United States
- Volunteers
- 144 people
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthritis, Cartilage Damage
Clinical Study of Pain Reduction by Peri-arthroscopic PRP Application in Knee Degeneration
The purpose of this study is to investigate reduction of pain, gain of function and improvement of life quality by intraoperative applied platelet- rich- plasma ( PRP ) during knee arthroscopy for degeneration and osteoarthritis…
- Conditions
- Knee Osteoarthritis, Cartilage Damage, Meniscal Tear
- Trial name
- PRP-Bochum (NCT02189408)
- Testing
- Platelet rich plasma
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Ruhr University of Bochum
Knee Osteoarthritis, Degenerative Joint Disease of Knee
Genicular Artery Embolization Vs Observation for Symptomatic Knee Osteoarthritis
The purpose of this clinical trial is to determine whether genicular artery embolization (GAE) is an effective way to treat knee pain from osteoarthritis. Pain from arthritis is often due to underlying inflammation in the joint.
- Trial name
- GRAVITY (NCT04682652)
- Testing
- Embozene MicroSpheres
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Osteoarthritis (OA), Knee Injury
Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis
This Phase I/II randomized clinical trial investigates the safety, feasibility, and early regenerative potential of intra-articular administration of mesenchymal stem cell (MSC)-derived secretome combined with Plasma Rich in…
- Conditions
- Osteoarthritis (OA), Knee Injury, Cartilage Degeneration
- Trial name
- PRGFSECKOA (NCT07157891)
- Testing
- MSC-Derived Secretome, MSC-Derived Secretome + Autologous PRGF
- Volunteers
- 25 people
- Sponsor
- University of the Punjab
Degenerative Knee Disease
LLM-Guided Rehabilitation in Degenerative Knee Disease
This randomized, four-arm clinical trial will investigate the effects of large language model (LLM)-assisted exercise prescriptions integrated with conventional physiotherapy on pain, function and quality of life in adults with…
- Trial name
- LLM-RehabKnee (NCT07267962)
- Testing
- Supervised conventional physiotherapy, ChatGPT-5-assisted exercise planning, DeepSeek V3.1-assisted exercise planning
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Knee
Structured Rehabilitation Program for Patients With Total Knee Replacement
This study will be a randomized controlled trial. This study will be conducted in Horizon Hospital Lahore. A sample size of 26 patients will be taken. Patients will be divided into two groups by lottery method.
- Trial name
- NCT04694625
- Testing
- Structured Rehabilitation Program, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University