Clinical trials: Knee Injuries
ACL Tear
Comparison of Methods in Post Operative Knee Arthroscopy Rehabilitation
The aim of this study is to investigate the efficacy of blood flow restriction (BFR) therapy in post-operative rehabilitation following knee arthroscopy for primary ACL reconstruction.
- Trial name
- ACL BFR (NCT05735236)
- Testing
- BFR Cuff
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Colorado, Denver
Anterior Cruciate Ligament Injuries
Blood Flow Restriction Training in ACL Surgery
This will be a randomized pilot study to determine the effectiveness of Personalized Blood Flow Restriction (PBFR) technique in conjunction with prescribed physical therapy (PT) in a cohort of anterior cruciate ligament (ACL)…
- Trial name
- NCT05245864
- Testing
- blood flow restriction, physical therapy standard of care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Arkansas
Anterior Cruciate Ligament Injuries, Knee Injuries
The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial
While there are a number studies that have reported on the use of blood flow restriction training (BFRT) in the adult population, there is limited information about the use of BFRT in the adolescent population.
- Conditions
- Anterior Cruciate Ligament Injuries, Knee Injuries, Quadriceps Muscle Atrophy
- Trial name
- NCT05754632
- Testing
- Blood Flow Restriction using Delfi Personalized Tourniquet System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Connecticut Children's Medical Center
Anterior Cruciate Ligament Tear, Meniscal Tear
Prospective Registry of Anterior Cruciate Ligament Reconstructions
The purpose of the study is to investigate factors that are associated with outcomes of injury to the anterior cruciate ligament (ACL) in the knee among patients who are undergoing surgical reconstruction.
- Conditions
- Anterior Cruciate Ligament Tear, Meniscal Tear, Cartilage Injury, Bone Bruising
- Trial name
- NCT04135950
- Where
- United States
- Volunteers
- 1,646 people
- Sponsor
- State University of New York at Buffalo
Anterior Cruciate Ligament Injuries
Anatomic Anterior Cruciate Ligament With Short Hamstring Graft Compare With a Standard Hamstring Graft Technique
this study was to evaluate the functional outcome of quadruple hamstring graft in femoral tunnel less than 15 mm and morethan or equal 15 mm of ACL reconstruction.
- Trial name
- NCT03954925
- Testing
- Anatomic anterior cruciate ligament with short hamstring graft technique, Anatomic anterior cruciate ligament with a standard hamstring graft technique
- Volunteers
- 29 people
- Sponsor
- Ramathibodi Hospital
ACL Injury, ACL Augmentation
Augmentation of Partial Anterior Cruciate Ligament Tear: Early Results
Clinical evaluation for the patients with partial ACL tear who had ACL augmentation
- Trial name
- Augmentation (NCT05391672)
- Testing
- we will do ACL augmentation surgery to the patients who have partial ACL tear
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Anterior Cruciate Ligament Injury
Psychological Readiness and Return to Sport After ACL Reconstruction
The goal of this observational study is to evaluate psychological readiness, kinesiophobia, subjective knee function, sport activity level, and return-to-sport status in athletes who have undergone primary anterior cruciate…
- Trial name
- NCT07733895
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Biruni University
Anterior Cruciate Ligament Injury, Quadriceps Dysfunction
Exercise Loading Biology Post-Traumatic OsteoArthritis Study - a Pilot and Feasibility Study
FROM RISK FACTORS TO THE PREVENTION OF LONG-TERM CONSEQUENCES AFTER CRUCIATE LIGAMENT INJURY (ACL injury) - This is a research project where we seek new knowledge about why some people have a high risk and others a low risk of…
- Conditions
- Anterior Cruciate Ligament Injury, Quadriceps Dysfunction, Knee Joint Loading, Anterior Cruciate Ligament Reconstruction
- Trial name
- ExeLoadBioPTOA (NCT06892899)
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- May Arna Risberg
Ischemia
The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery
Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx.
- Trial name
- NCT02756715
- Testing
- propofol group, Desflurane group
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Konkuk University Medical Center
Tibial Fractures, Fibula Fracture
Effect of Palmitoylethanolamide on Reducing Opioid Consumption for Below Knee Fracture Fixation
Palmitoylethanolamide (PEA), a non-psychoactive cannabis compound derived from peanuts, egg yolks, and soybeans, is an Endogenous FA Amide produced in the body as a biological response and a repair mechanism in chronic…
- Conditions
- Tibial Fractures, Fibula Fracture, Knee Fracture
- Trial name
- NCT05317676
- Testing
- Palmitoylethanolamide
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Knee Injuries, Anterior Cruciate Ligament Injuries
Effects of Blood Flow Restriction (BFR) Therapy on ACL Graft Maturation
This is a study comparing the effects of blood flow restriction (BFR) therapy on the maturation of the Anterior Cruciate Ligament (ACL) graft after reconstruction surgery compared to physical therapy without the use of BFR.
- Trial name
- NCT04528992
- Testing
- Blood Flow Restriction Therapy, Standard Postoperative Physical Therapy
- Where
- United States
- Sponsor
- Stanford University
Tibial Fractures
Use of a Reinforced Injectable Calcium Phosphate Bone Cement in the Treatment of Tibial Plateau Fractures
Case series of tibial plateau fractures using Norian Drillable.
- Trial name
- NCT01132508
- Testing
- Norian Drillable Bone Void Filler
- Where
- 6 sites in Australia, China and 2 more
- Volunteers
- 33 people
- Sponsor
- Synthes GmbH
Cartilage Injury
Second Line Treatment of Knee Osteochondral Lesion With Treated Osteochondral Graft
Patient with IKDC score < 65, pretreated with mosaicplasty or ACI ( with matrix or not) within > 18 months, with one or two osteochondral lesions are recruited to have treated osteochondral allografts in mosaicplasty.
- Trial name
- ODPHOENIX2 (NCT02430558)
- Testing
- OD-PHOENIX
- Volunteers
- 10 people
- Sponsor
- TBF Genie Tissulaire
ACL Injury, Graft Failure
Differences in Outcomes and Failure Rates Between Allografts and Autografts in Revision Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament (ACL) rupture is one of the most common knee injuries, particularly in young and physically active individuals.
- Trial name
- ACLREV_GRAFT (NCT07671235)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Stefano Zaffagnini
Orthopedic Disorders, Foot Diseases
Efficacy of Ultrasound-Guided Local Anesthetic Injection Into or Around the Sciatic Nerve for Lower Limb Anesthesia
This study was designed to assess whether the injection of local anesthetic into the nerve (intraneural), as opposed to around it (perineural), requires a shorter time to develop surgical anesthesia of the lower leg.
- Conditions
- Orthopedic Disorders, Foot Diseases, Injuries, Leg, Injuries, Foot
- Trial name
- NCT01999647
- Testing
- Intraneural Injection for Subgluteal Sciatic Nerve Block, Perineural Injection for Subgluteal Sciatic Nerve Block, Femoral Nerve Block
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- University of Parma
Anterior Cruciate Ligament Injuries, Atrophy
Effect of Blood Flow Restriction Training on Patient With Anterior Cruciate Ligament Reconstruction
This study investigates the effects of plyometric training with blood flow restriction on muscular strength, quadriceps thickness and knee joint function in patients with muscle weakness and atrophy (quadriceps muscle and…
- Conditions
- Anterior Cruciate Ligament Injuries, Atrophy, Muscle Weakness
- Trial name
- NCT04284748
- Testing
- Plyometric exercise with blood flow restriction, Plyometric exercise, Routine physiotherapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Rupture of Anterior Cruciate Ligament
Multicenter Orthopaedics Outcomes Network for ACL Reconstructions
The purpose of this study is to determine the effect of modifiable risk factors on knee function, osteoarthritis, and re-rupture of the anterior cruciate ligament (ACL) following ACL reconstruction.
- Trial name
- NCT00463099
- Where
- 8 sites in United States
- Volunteers
- 3,294 people
- Sponsor
- Vanderbilt University Medical Center
Anterior Cruciate Ligament Tear
Anterior Cruciate Ligament (ACL) Reconstruction: Single Bundle Versus Double Bundle
ACL tear is a common injury among athletes. The recommended treatment includes reconstruction of the ligament. The common reconstruction technique is single bundle reconstruction.
- Trial name
- NCT01025895
- Testing
- acl reconstruction - double bundle technique, acle reconstruction - single bundle technique
- Volunteers
- 60 people
- Sponsor
- Assaf-Harofeh Medical Center
Total Knee Anthroplasty, Postoperative Pain
Proximal Spread in Adductor Canal Block(ACB)
This prospective, randomized clinical study is designed to evaluate the effects of two different injection levels of adductor canal block (ACB) on the proximal spread of local anesthetic and clinical outcomes in patients…
- Trial name
- ACB (NCT07595471)
- Testing
- Comparison of Proximal Adductor Canal Block, Comparison True Distal Adductor Canal Block.
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Ankara Etlik City Hospital
Osteoarthritis, Injury of Anterior Cruciate Ligament
Multimodal Assessment of Knee Conditions
The purpose of this study is to assess both osteoarthritis and other pathological knee conditions from the combination of signals that are known to provide information on the knee joint.
- Conditions
- Osteoarthritis, Injury of Anterior Cruciate Ligament, Knee Injuries and Disorders
- Trial name
- MAKnee (NCT02937064)
- Where
- Finland
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Oulu