Clinical trials: Knee Osteoarthritis
Defect of Articular Cartilage, Osteoarthritis
Comparison of Efficacy and Safety of Microfracture and Modified Microfracture
This study was designed to evaluate the efficacy and safety of a modified microfracture using collagen, and to compare them with those of a simple microfracture to prove the non-inferiority of the modified microfracture using…
- Conditions
- Defect of Articular Cartilage, Osteoarthritis, Traumatic Arthritis
- Trial name
- NCT02539030
- Testing
- Microfracture, CartiFill
- Where
- 12 sites in South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Knee Osteoarthritis, Muscle Weakness
Knee Pressure Stimuli on Quadriceps Strength in Knee Osteoarthritis
The study aims at investigating the effects of a periarticular knee pressure stimulation on quadriceps strength and neuromuscular activity in subjects with knee ostearthritis.
- Trial name
- NCT05826236
- Testing
- Periarticular compression
- Volunteers
- 50 people
- Sponsor
- Istituto Clinico Humanitas
Gonarthrosis, Knee Osteoarthritis
Efficacy of Craniosacral Therapy in Patients With Gonarthrosis
This randomized controlled trial was designed to investigate the effects of craniosacral therapy on pain, heart rate variability, joint stiffness, physical function, quality of life, body image, kinesiophobia, and dynamic balance…
- Trial name
- NCT07372534
- Testing
- Craniosacral Therapy, Home-Based Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Ankara Yildirim Beyazıt University
Knee Osteoarthritis
Comparison of INIT and Dry Needling on Trigger Points in Knee OA
The purpose of the study is to compare the effects of Integrated Neuromuscular Inhibition Technique and Dry Needling on Functional Disability, Pain and Range of Motion.
- Trial name
- NCT06437730
- Testing
- Integrated Neuromuscular Inhibition Technique:, Dry needling:
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Gonarthrosis; Primary, Genicular Nerve Block
Genicular Nerve Block in Chronic Knee Osteoarthritis
The goal of this clinical trial is to evaluate whether genicular nerve block (GNB) is effective in reducing pain in patients with knee osteoarthritis. It will also assess the comparative efficacy of different injection protocols.
- Conditions
- Gonarthrosis; Primary, Genicular Nerve Block, Gonarthritis
- Trial name
- GNB-KOA-RCT (NCT07174167)
- Testing
- Genicular nerve block with prilocaine, genicular nerve block with prilocaine and triamcinolone
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Knee Osteoarthritis
Effect of Antigravity Treadmill in Knee Osteoarthritis (AGTreadmill)
To date, the anti-gravity treadmill, as a representative method of lower body positive pressure treadmills, has been rarely reported for knee osteoarthritis rehabilitation.
- Trial name
- AGTreadmill (NCT06347692)
- Testing
- antigravity treadmill, physical therapy exercise program
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Prince Sattam Bin Abdulaziz University
Osteoarthritis, Knee Osteoarthritis
Osteoarthritis Initiative (OAI): A Knee Health Study
Knee osteoarthritis (OA) is the most common cause of disability in adults. The "Osteoarthritis Initiative (OAI): A Knee Health Study" is a nationwide research study that will help researchers gather more information about the…
- Trial name
- NCT00080171
- Where
- 5 sites in United States
- Volunteers
- 4,796 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Medial Compartment Osteoarthritis, Genu Varum
TO Plate Fixation vs. External Fixator Comparison (HTO Plate vs. ExFix Study)
This study aims to compare the efficacy, accuracy, and functional outcomes of two different surgical stabilization techniques for medial opening wedge high tibial osteotomy (HTO) in patients with varus deformity and medial…
- Conditions
- Medial Compartment Osteoarthritis, Genu Varum, Varus Deformity, High Tibial Osteotomy
- Trial name
- NCT07220434
- Testing
- Medial HTO Locking Plate, Self-Adjusting HTO External Fixator
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Muhammed Cagatay Engin
Knee Osteoarthritis
Pre-Operative Exercise Therapy and Patient Education Before Total Knee Replacement
The goal of this multi-center randomized controlled trial is to investigate the effect of pre-operative exercise therapy and education for patients awaiting knee replacement surgery on subjective knee function, patient…
- Trial name
- PROTEKT (NCT06290336)
- Testing
- Pre-operative exercise therapy and education, Standardized pre-operative information session
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Linkoeping University
Osteoarthritis, Knee
Comparison of Effectiveness of Two Different Electrotherapy Agents on Central Sensitization
The aim of this study is to compare the efficacy of transcutaneous electrical nerve stimulation (TENS), interferential currents (IFCs) and sham devices in improving central sensitization (CS) findings, including pressure pain…
- Trial name
- NCT04153825
- Testing
- Transcutaneous Electrical Nerve Stimulation, Interferential Current, Hydrocollator hot-pack
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Turkish League Against Rheumatism
Osteoarthritis, Knee, Osteochondral Defect
The Impact of Covid-19 on Patients Waiting for Knee Surgery
The Covid-19 pandemic has led to the postponement and cancellation of elective orthopaedic surgeries worldwide. These delays to elective procedures combined with ongoing demand have led to increasingly longer waiting list times.
- Conditions
- Osteoarthritis, Knee, Osteochondral Defect, Cartilage Injury, Cartilage Damage
- Trial name
- NCT05124613
- Testing
- Survey
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Manchester
Knee Osteoarthritis, Dextrose Prolotherapy Injection
The Effect of Dextrose Prolotherapy on Isokinetic Power in the Treatment of Knee Osteoarthritis
Osteoarthritis is a degenerative joint disease characterized by erosion of the articular cartilage, bone hypertrophy at the margins of the joint, subchondral sclerosis, and some biochemical and morphological changes in the…
- Conditions
- Knee Osteoarthritis, Dextrose Prolotherapy Injection, Physical Therapy
- Trial name
- NCT04958213
- Testing
- Dextrose prolotherapy injection, conventional physical therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Mustafa Kemal University
Osteoarthritis, Knee Arthroplasty
Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty
Patients undergoing primary total knee replacement will receive either motor sparing knee block to be performed by anesthesia or periarticular local anesthetic infiltration at the end of surgery by surgeons to assess pain relief…
- Conditions
- Osteoarthritis, Knee Arthroplasty, Pain Management
- Trial name
- NCT02540070
- Testing
- Periarticular, Motor free, Motor free with dex
- Where
- Canada
- Volunteers
- 135 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Osteoarthritis
New Options for Treating Knee Osteoarthritis Pain
This study will be a single-site, four-arm, randomized, placebo-controlled clinical trial. Knee osteoarthritis patients (N=164) will be randomized to Reiki, Sham Reiki (placebo control), mindfulness meditation (active control)…
- Trial name
- NCT05541718
- Testing
- Reiki, Mindfulness Meditation
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Utah
Knee Osteoarthritis; Insomnia; Cervical Spondylosis; Chronic Low Back Pain; Allergic Rhinitis
Validating Blinding Maintenance of a Sham-Sensitization Control Design for Sensitization Acupuncture Trials
This study is the clinical validation component of a broader research program developing a randomized controlled trial (RCT) comparing sensitization acupuncture (an individualized technique in which treatment points are selected…
- Trial name
- NCT07868224
- Testing
- Sensitization Acupuncture, Traditional Acupuncture
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Knee Osteoarthritis (Knee OA)
Evaluation of a Preoperative Education in Total Knee Arthroplasty
The benefit of preoperative rehabilitation treatment combining physiotherapy and targeted education for patient undergoing Total Knee replacement (TKR) is now well known.
- Trial name
- EPOP (NCT01747759)
- Testing
- Kruskal-Wallis and qualitative parameters
- Where
- France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Clermont-Ferrand
Necrosis of Femoral Head, Knee Osteoarthritis
CSF Cholinergic Biomarkers and Postoperative Cognitive Change
Previous study demonstrated that the condition of central cholinergic nerve is important for the postoperative cognitive dysfunction.
- Conditions
- Necrosis of Femoral Head, Knee Osteoarthritis, Fracture of Lower Limb
- Trial name
- NCT02063542
- Where
- China
- Volunteers
- 102 people
- Sponsor
- RenJi Hospital
Osteoarthritis (OA) of the Knee, Fear of Needles
Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?
This study aims to investigate factors that affect the subjective experience of pain during and after intra-articular knee joint injection of steroids by comparing needle gauge size (22 G vs 25 G needles), as well as the presence…
- Trial name
- NCT06865170
- Testing
- 25 gauge needle, 22 gauge needle, +/- Ethyl Chloride Topical Aerosol Anesthetic
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Osteoarthritis, Knee
Use of Fresh Platelet Rich Plasma With Concentrated Leukocytes or Fresh Platelet Rich Plasma Without Concentrated Leukocytes in the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial
The aim of the study is to compare the triple infiltration of Fresh Platelet Rich Plasma with concentrated Leukocytes against triple infiltration of Fresh Platelet Rich Plasma Without Concentrated Leukocytes in the treatment of…
- Trial name
- PRP019 (NCT04187183)
- Testing
- Fresh Platelet Rich Plasma with leukocyte, Fresh Platelet Rich Plasma without leukocyte
- Where
- Italy
- Volunteers
- 132 people
- Sponsor
- Istituto Ortopedico Rizzoli
Total Knee Replacement
Effects of OEP on Rehabilitation Outcomes on TKR Patients
The aim of this research is to assess the effects of the Otago Exercise Program on Rehabilitation outcomes of balance strength and functional outcomes of post Total Knee Replacement patients.
- Trial name
- NCT06190977
- Testing
- Otago Exercise Program, General TKR pprotocol
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
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