Clinical trials: Knee Osteoarthritis
Knee Osteoarthritis
Effects of Mindfulness-Based Stress Reduction on Knee Osteoarthritis
The purpose of this study is to see if stress reduction can lead to less pain due to knee osteoarthritis. To do this the investigators will compare two types of stress reduction modalities, Mindfulness-Based Stressed Reduction…
- Trial name
- MBSR on KOA (NCT03527849)
- Testing
- Mindfulness-Based Stress Reduction, Health Enhancement Program
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of California, Davis
Knee Osteoarthritis
Sinew Acupuncture for Knee Osteoarthritis
The study aims to exam whether sinew acupuncture can relieve pain and symptoms of KOA and improve functional movement by Visual Analog Scale (VAS), Western Ontario and McMasters University Osteoarthritis Index (WOMAC), Timed up…
- Trial name
- NCT03099317
- Testing
- Sinew acupuncture
- Where
- Hong Kong
- Volunteers
- 86 people
- Sponsor
- The University of Hong Kong
Osteoarthritis, Knee
Study of SI000413 in Knee Osteoarthritis Patients
The purpose of this study is to evaluate efficacy and safety of SI000413 in patients with knee osteoarthritis by orally administration and to determine optimal dose.
- Trial name
- NCT01525758
- Testing
- SI000413, microcrystalline cellulose
- Where
- 3 sites in South Korea
- Volunteers
- 152 people
- Sponsor
- Dong-A Pharmaceutical Co., Ltd.
Total Knee Replacement, Osteoarthritis
Knee Replacement Outcome Predicted by Physiotherapists
The aim is to assess if physiotherapists attending inpatients at elective orthopaedic wards can predict the future course (post hospitalisation) of recovery of patients undergoing KA.
- Trial name
- NCT02982785
- Testing
- Standard post-operative rehabilitation
- Where
- 2 sites in Denmark
- Volunteers
- 364 people
- Sponsor
- Marius Henriksen
Laparascopic Sleeve Gastrectomy, Obesity & Overweight
Impact Of Laparoscopic Sleeve Gastrectomy On Obesity-Related Comorbidities In Patients Over 65 Years
This study compares laparoscopic sleeve gastrectomy (a type of weight-loss surgery) with non-surgical care in adults aged 65 or older who have severe obesity and related health problems like type 2 diabetes, high blood pressure…
- Conditions
- Laparascopic Sleeve Gastrectomy, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus, Obstructive Sleep Apnea (OSA)
- Trial name
- NCT07437716
- Testing
- Laparoscopic Sleeve Gastrectomy (LSG), Structured Dietary Counseling
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Knee Osteoarthritis
Clinical Trials of Prosthesis and Surgery Guide System
1. The subject continues the research of Professor JiaKuo Yu's research group on the personalized design, processing and manufacturing of personalized total knee replacement artificial joint prostheses and the verification of…
- Trial name
- NCT04950348
- Testing
- Personalized TKA prosthesis, Zimmer NexGen prostheses
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Knee Osteoarthritis
Clinical Investigation to Compare the Safety and Efficacy of Cellular Matrix to Those of Ostenil® Plus and to Those of PRP Only
Platelet-rich plasma (PRP) is an autologous product prepared from the patient's own blood, representing a powerful source of platelet-derived growth factors, particularly useful in the field of regenerative medicine.
- Trial name
- NCT02964143
- Testing
- Cellular Matrix / A-CP HA, Ostenil® Plus, RegenKit-BCT-1
- Volunteers
- 306 people
- Sponsor
- Regen Lab SA
Osteoarthritis, Knee
Efficacy and Safety of G001 in Patients With Osteoarthritis (OA) of the Knee
Phase 2 multicenter, double-blind, randomized, parallel-group, vehicle-controlled study to evaluate the efficacy, safety, and local tolerability of G001 topical gel compared to matching Vehicle topical gel in patients with…
- Trial name
- NCT05007808
- Testing
- G001 Topical Gel, Vehicle
- Where
- 10 sites in Canada
- Volunteers
- 210 people
- Sponsor
- BUZZZ Pharmaceuticals Limited
Arthroplasty, Replacement, Knee, Rehabilitation
Patient Reported Outcome Measures (PROMs) in Rehabilitation With or Without the Possible Use of a Mobile Application After Primary Knee or Hip Arthroplasty
Rehabilitation after primary knee or hip arthroplasty may include performing exercises with a physiotherapist. For patients who can work well with a computer, tablet or smartphone, it is now possible to use a mobile application…
- Conditions
- Arthroplasty, Replacement, Knee, Rehabilitation, Hip Arthrosis
- Trial name
- NCT04628468
- Testing
- moveUp, Predefined number of traditional physiotherapy sessions
- Where
- 11 sites in Belgium
- Volunteers
- 416 people
- Sponsor
- University Hospital, Ghent
Osteoarthritis, Osteoarthritis, Knee
Intraoperative Liposomal Bupivacaine Injection in Primary Total Knee Arthroplasty
The purpose of the study is to evaluate the efficacy of local infiltration of liposomal bupivacaine versus use of an indwelling femoral peripheral nerve block in controlling early postoperative pain in primary total knee…
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Arthritis, Degenerative, Osteoarthrosis
- Trial name
- NCT02341079
- Testing
- Bupivacaine Liposome Injection, Indwelling femoral nerve block
- Where
- United States
- Sponsor
- United States Naval Medical Center, San Diego
Meniscus; Degeneration, Knee Osteoarthritis
NUsurface Implant Registry
The purpose of this active post-market surveillance clinical registry study is to further characterize the therapeutic effect, the long-term safety and effectiveness of the NUsurface® meniscus implant in the real-world…
- Conditions
- Meniscus; Degeneration, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NIR (NCT03953846)
- Where
- 6 sites in Belgium, Germany and 2 more
- Volunteers
- 36 people
- Sponsor
- Phoenix Kinetics
Knee Joint Osteoarthritis
Effectiveness and Safety of Autologous ADRC for Treatment of Degenerative Damage of Knee Articular Cartilage
Autologous adipose-derived regenerative cells (ADRC) extracted using Celution 800/CRS System (Cytori Therapeutics Inc) from a portion of the fat harvested from the patient's front abdominal wall.
- Trial name
- NCT02219113
- Testing
- Arthroscopic surgery, Liposuction, ADRC isolation
- Where
- Russia
- Volunteers
- 12 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Pain, Inflammation
Efficacy and Safety of Postoperative Intravenous Parecoxib Sodium Followed by Oral Celecoxib in Osteoarthritis Patients
In mainland China, knee Osteoarthritis (OA) is the leading cause of disability in older persons. Total knee arthroplasty (TKA) is now generally regarded by orthopaedic surgeons and patients as an effective treatment for end-stage…
- Trial name
- NCT02198924
- Testing
- Parecoxib and Celecoxib
- Where
- China
- Volunteers
- 246 people
- Sponsor
- Peking Union Medical College Hospital
Knee Osteoarthritis
A Comparison of the Persona Total Knee Arthroplasty System Using CR or MC Polyethylene
Knee replacement is an established treatment for late stage osteoarthritis (OA) of the knee (Charnley et al. 1961). Recently, Zimmer-Biomet have introduced Persona Total Knee system with design changes that include asymmetric…
- Trial name
- NCT03568123
- Testing
- MC polyethylene bearing, CR polyethylene bearing
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Anders Troelsen
Moderate Pain in Knee Osteoarthritis, Severe Pain in Knee Osteoarthritis
A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis
Primary Objective: To explore the effectiveness of different doses of HRS-2129 in the treatment of patients with moderate to severe pain in knee osteoarthritis.
- Trial name
- NCT07351968
- Testing
- HRS-2129 Tablet, Celecoxib capsule
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Arthritis, Osteoarthritis
A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, in Patients With Rheumatoid Arthritis or Osteoarthritis
The purpose of this study is to assess the degree of pain control achieved by treatment with fentanyl, administered via adhesive patches applied to the skin ('transdermal system") in patients with rheumatoid arthritis or…
- Conditions
- Arthritis, Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT00524160
- Testing
- Fentanyl transdermal patch
- Volunteers
- 264 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
OA Knee, OA Knee Pain
Comparison of Medial Knee Pain Between Patients With and Without Preoperative Tibia Vara Underging Mobile-bearing Unicompartmental Knee Arthroplasty
to compared VAS for medial knee pain between oa knee with or without tibia vara following mobile bearing UKA
- Conditions
- OA Knee, OA Knee Pain, Osteoarthritis
- Trial name
- bow leg (NCT07720024)
- Testing
- mobile bearing UKA
- Where
- Thailand
- Volunteers
- 150 people
- Sponsor
- Thammasat University
Knee Osteoarthritis, Knee Injuries
The Relationship Between Disease Severity and Various Lower Extremity Parameters in Individuals With Knee Osteoarthritis
This study perform to investigate the relationship between quadriceps femoris (QF) strength, QF thickness, femoral cartilage thickness, knee function, balance, kinesiophobia and gait of the patients with knee osteoarthritis.
- Trial name
- NCT05294224
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dilara Özen Oruk
Knee Osteoarthritis
Habitual Physical Activity and Sedentary Behavior Following Total Knee Arthroplasty
The purpose of this study is to determine whether habitual physical activity and sedentary behaviour improve six weeks and between three to six months after total knee replacement surgery in people with osteoarthritis.
- Trial name
- NCT02675062
- Where
- South Africa
- Volunteers
- 80 people
- Sponsor
- University of Witwatersrand, South Africa
Osteoarthritis, Knee
Custom Cutting Block Instrument vs Regular Instrumentation Total Knee Replacement (TKR)
To determine if the use of patient-specific custom cutting blocks for implantation of total knee components results in improved limb alignment and component positioning compared to regular instrumentation.
- Trial name
- NCT03416946
- Testing
- Visionaire, Traditional
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Innovation Centre
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