Clinical trials: Knee Osteoarthritis
Mild to Moderate Knee OA
Effects of Intra-articular Hypertonic Dextrose and Hyaluronic Acid on Primary Knee Osteoarthritis.
The aim of this study is to compare the effectiveness of intra-articular hypertonic dextrose and hyaluronic acid in managing pain and improving function in patients with primary knee osteoarthritis (KOA).
- Trial name
- NCT07102225
- Testing
- prolotherapy solution of 20% dextrose, Hyaluronic Acid (HA)
- Where
- Bangladesh
- Volunteers
- 56 people
- Sponsor
- Bangladesh Medical University
Knee Osteoarthritis, Knee Pain Chronic
iPACK Block for Total Knee Arthroplasty
This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the rehabilitation process of the Interspace between the Popliteal Artery and Capsule of the Posterior Knee (iPACK) block in total knee…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Disease
- Trial name
- NCT06087562
- Testing
- Ropivacaine 0.5% Injectable Solution 20mL, 0,9% normal saline 20mL
- Where
- Poland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Osteoarthritis, Knee
Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN
A previous multicenter trial led by Bioiberica S.A. has confirmed the efficacy and safety of DROGLICAN for the treatment of osteoarthritis (OA) in patients with severe pain.
- Trial name
- DRIP (NCT02821468)
- Testing
- Droglican, Paracetamol or oral NSAIDs excluding COX2 inhibitors
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Bioiberica
Osteoarthritis, Knee, Perfusion
Evaluation of Patients With Knee Osteoarthritis Receiving a Prosthesis
Patients with osteoarthritis of the knee undergo visible joint changes in radiology and Magnetic resonance imaging (MRI) tests, but also clinically and histologically.
- Conditions
- Osteoarthritis, Knee, Perfusion, Bone Marrow, Magnetic Resonance Imaging
- Trial name
- Chondrolike (NCT03644420)
- Testing
- Clinical evaluation, Radiology, Dynamic contrast-enhanced magnetic resonance imaging
- Volunteers
- 22 people
- Sponsor
- Lille Catholic University
Osteoarthritis, Knee Cutaneous Suture, Dermabond, Subcuticular Suture
Comparison of Postoperative Wound Between Dermabond Prineo(2-octyl Cyanoacrylate Adhesive and Polyester Mesh) and Subcuticular Suture in Simultaneous Total Knee Arthroplasty
This study aims to compare the clinical results of postoperative wound between Dermabond PRINEO™(2-octyl Cyanoacrylate adhesive and polyester mesh) and subcuticular suture in simultaneous total knee arthroplasty There is previous…
- Trial name
- NCT04506580
- Testing
- DERMABOND™ PRINEO™(2-octyl Cyanoacrylate Adhesive and Polyester Mesh) vs subcuticular nylon suture
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- The Catholic University of Korea
Osteo Arthritis Knee
A Study to Evaluate the Safety of Human Allogeneic Bone-Marrow-Derived Mesenchymal Stromal Cell Product StromaForte for the Treatment of Knee Osteoarthritis
This open-label, single-arm, phase I/II study in mild-to-moderate stage knee osteoarthritis patients is designed to assess the safety and tolerability of intraarticular human allogeneic bone marrow-derived mesenchymal stromal…
- Trial name
- NCT06084988
- Testing
- Human Allogenic Bone-Marrow-Derived Mesenchymal Stromal Cell Product (StromaForte)
- Where
- United Arab Emirates
- Volunteers
- 12 people
- Sponsor
- Cellcolabs Clinical SPV Limited
Knee Osteoarthritis
Uncemented Tritanium TKR vs Cemented Triathlon TKR
The Study aims to investigate whether there is a clinically important difference in peri-articular bone mineral density (BMD) and trabecular bone score (TBS) between patients undergoing two different types of knee replacement…
- Trial name
- NCT04040764
- Testing
- Tritanium uncemented Total Knee Replacement
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Total Knee Arthroplasty, Manual Lymphatic Drainage
Manual Lymphatic Drainage Before and After Total Knee Replacement, a Single-center Observer-blinded Randomized Controlled Trial
The aim of this observer-blinded randomized controlled trial is the evaluation of the influence of manual lymphatic drainage (MLD) on the outcome of patients receiving total knee replacement (TKA).
- Conditions
- Total Knee Arthroplasty, Manual Lymphatic Drainage, MLD, Rehabilitation
- Trial name
- NCT05119764
- Testing
- Manual Lymphatic Drainage
- Where
- Austria
- Volunteers
- 112 people
- Sponsor
- Moritz Wagner
Primary Knee Osteoarthritis
Safety and Efficacy of Sahasthara ME vs Diclofenac ME for Treating Primary Knee Osteoarthritis
Background: Sahasthara is a traditional Thai herbal remedy used for the anti-inflammatory treatment of the musculoskeletal system, while diclofenac sodium is one of the most topically administered anti-inflammatory drug.
- Trial name
- NCT06184685
- Testing
- Sahasthara Microemulsion, Diclofenac Microemulsion
- Where
- Thailand
- Volunteers
- 87 people
- Sponsor
- Thammasat University
Osteoarthritis, Knee, Osteoarthritis, Hip
A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform
Post-market prospective, multi-center longitudinal study to determine if mobile application-guided education and exercise paired with accurate and sensitive activity monitoring, captured from consumer wearables, can provide a…
- Trial name
- NCT03737149
- Testing
- mymobility with Apple Watch
- Where
- 30 sites in United States, Australia and 2 more
- Volunteers
- 6,559 people
- Sponsor
- Zimmer Biomet
Physical Fittness
Effect of Mulligan'Mobilization With Movement on Pain, Disability and Range of Motion in Patients With Knee Osteoarthritis
we tested the effect of adding the mobilization with movement to the traditional physical therapy program on pain, ROM and functional disability in patients with knee OA.
- Trial name
- NCT01756378
- Testing
- joint mobilization with movement, traditional physical therapy program
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Osteoarthritis, Knee
Study of FX005 for the Treatment of Pain in Patients With Osteoarthritis of the Knee
The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics of FX005 for the treatment of pain in patients with osteoarthritis of the knee.
- Trial name
- NCT01291914
- Testing
- FX005
- Where
- 13 sites in Austria, Canada and 2 more
- Volunteers
- 140 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis
Exploring Massage Benefits for Arthritis of the Knee
The purpose of this study is to verify the efficacy of an 8-week course of manualized Swedish massage for reducing pain and increasing function compared to light-touch bodywork, and usual care, in 222 adults with OA of the knee.
- Trial name
- EMBARK (NCT01537484)
- Testing
- Massage Therapy
- Where
- 3 sites in United States
- Volunteers
- 222 people
- Sponsor
- Duke University
Tricompartmental Gonarthrosis
Sub-Vastus Versus Mid-Vastus Arthrotomy for Total Knee Arthroplasty: a Randomized Clinical Trial
Randomized, single-blind trial in which one group of patients will be operated with a "Mid-Vastus approach" of the knee joint and the other group will undergo knee surgery with a "Sub-Vastus approach".
- Trial name
- NCT00925626
- Testing
- Sub-Vastus arthrotomy, Mid - Vastus arthrotomy
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Knee Osteoarthritis
Intrawound Administration of Vancomycin in TKA
The purpose of this study is to determine the intra-articular and serum levels of vancomycin over the first 24 hours postoperatively after intra-articular administration of a standard dose of vancomycin in primary total knee…
- Trial name
- NCT05338021
- Testing
- Intrawound administration of vancomycin after closure of the arthrotomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Osteoarthritis
Complex Āyurvedic Treatment in Osteoarthritis of the Knee Compared to Standard Care.
The aim of this study is to evaluate the effectiveness of a complex āyurvedic diagnosis and treatment compared to conventional standard care in patients with OA of the knee.
- Trial name
- CARAKA (NCT01225133)
- Testing
- Complex Ayurvedic Treatment, Conventional Care
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Charite University, Berlin, Germany
Osteoarthritis, Knee
An Effectiveness and Safety Study of IDEA-033 in Comparison to Oral Naproxen and Placebo for the Treatment of Osteoarthritis of the Knee
The purpose of this study is to identify the dose(s) of IDEA-033 that will provide a meaningful effect for treating osteoarthritis of the knee.
- Trial name
- NCT00211549
- Testing
- IDEA-033
- Where
- 100 sites in United States
- Volunteers
- 875 people
- Sponsor
- IDEA AG
Osteoarthritis
Comparison of Stability and Outcomes in Single-radius Femoral Component for Total Knee Arthroplasty
This is a comparison of the functional results and Varus-Valgus Stability in Single-radius versus Multi-radius Femoral Component for Total Knee Arthroplasty.
- Trial name
- NCT01379755
- Where
- South Korea
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Chonnam National University Hospital
Primary Total Knee Arthroplasty, Intraosseous Morphine Injection
Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty
Study investigators propose to investigate if a bony injection of pain medication during a knee replacement will help pain levels following primary knee replacement surgery. To investigate this, 86 patients will be enrolled.
- Conditions
- Primary Total Knee Arthroplasty, Intraosseous Morphine Injection, Knee Osteoarthritis
- Trial name
- NCT06716749
- Testing
- Morphine, Vancomycin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Carilion Clinic
Osteoarthritis of the Knees
The Effects of Ambulatory Treatment at the Dead Sea on Osteoarthritis of the Knees
This study will check the efficacy of balneological therapy of bathing in Dead Sea fountain waters over a 6 week period on a twice a week basis (overall 12 treatments) in patients suffering from osteoarthritis of the knees.
- Trial name
- NCT00450606
- Testing
- Balneotherapy and hydrotherapy
- Volunteers
- 50 people
- Sponsor
- Soroka University Medical Center
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