Clinical trials: Knee Osteoarthritis
Osteoarthritis of the Knee
Apitox, Honeybee Venom Treatment for Osteoarthritis Pain and Inflammation
The study will evaluate Apitox, pure honeybee venom as a treatment for pain and inflammation of osteoarthritis of the knee.
- Trial name
- HBV (NCT00949754)
- Testing
- honeybee venom (Apitoxin (Korea) Apitox (USA))
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Apimeds, Inc.
Gonarthrosis
Dexmedetomidine Infusion and Iscemia and Reperfusion Injury
The effect of deksmedetomidine infusion on ischemia-reperfusion injury related to tourniquet application during total knee replacement will be evaluated by malondialdehyde and total antioksidant status.
- Trial name
- NCT07875231
- Testing
- Dexmedetomidine, saline
- Volunteers
- 60 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Osteoarthritis
Influence of Whole Body Vibration Compared to Conventional Physiotherapy in Patients With Gonarthrosis
40 patients with osteoarthritis of the knee will be randomly assigned to conventional physiotherapy on the one and whole body vibration exercises on the other hand.
- Trial name
- NCT01037972
- Testing
- Conventional physiotherapy, Whole body vibration
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Cologne
Total Knee Anthroplasty, Knee Osteoarthritis
IPACK vs Adductor Magnus Plane Block Added to Adductor Canal Block for Total Knee Arthroplasty
Total knee arthroplasty (TKA) is among the most frequently performed surgical procedures for degenerative joint diseases, including advanced knee osteoarthritis, rheumatoid arthritis, and post-traumatic arthritis.
- Conditions
- Total Knee Anthroplasty, Knee Osteoarthritis, Postoperative Pain Management
- Trial name
- NCT07643883
- Testing
- ACB+IPACK, ACB+AMM
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Osteoarthritis, Knee, Mobility Limitation
Effects of Improved Calf Muscle Function on Gait, Balance and Joint Loading in Older Adults
This study investigates the role of calf muscle function in gait performance, balance and knee joint loading. Previous studies have linked age-related loss of calf muscle function with impairments in gait performance and balance…
- Conditions
- Osteoarthritis, Knee, Mobility Limitation, Accidental Fall
- Trial name
- NCT03921801
- Testing
- Gait retraining, Gait retraining + strength training
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Osteoarthritis, Knee, Exercise Training
Investigation of the Effects of Progressive Resistance Exercises in Individuals With Knee Osteoarthritis
It is known that the global socioeconomic burden of individuals with knee osteoarthritis (OA) is on a constantly rising curve. In addition, it is predicted that this burden will increase with the increase in the aging rate of…
- Conditions
- Osteoarthritis, Knee, Exercise Training, Biomarkers
- Trial name
- OA (NCT05997966)
- Testing
- Progresive Resistance Exercises, No intervation
- Volunteers
- 40 people
- Sponsor
- Meltem Meran Çağlar
Osteoarthritis
Osteoarthritis Bedside Testing Kit
Develop and test a bedside testing kit for evaluating pain and symptoms of osteoarthritis
- Trial name
- NCT00794651
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Analgesic Solutions
Osteoarthritis, Knee
Performance of CCoat Intra-Articular Injections in Mild to Moderate Knee Osteoarthritis: A Prospective, Randomized, Double-Blind, Multi-center Trial
Performance of CCoat Intra-Articular Injections in Mild to Moderate Knee Osteoarthritis: A Prospective, Randomized, Double-Blind, Multi-center Trial
- Trial name
- NCT07052851
- Testing
- CCoat, Liposphere Ltd, Synvisc-One® (hylan G-F 20)
- Volunteers
- 200 people
- Sponsor
- Lipo-Sphere
Joint Diseases, Osteoarthritis
Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With Cruciate Sacrificing Insert
MicroPort Orthopedics Inc. (MPO) plans to market the EVOLUTION® NitrX™ Non-Porous Keeled Tibia and EVOLUTION® NitrX™ CS/CR Non-Porous Femur with the EVOLUTION® Cruciate Sacrificing (CS) Tibial Insert globally, including in the…
- Conditions
- Joint Diseases, Osteoarthritis, Arthritis Knee, Avascular Necrosis
- Trial name
- NCT04816773
- Testing
- EVOLUTION® NitrX™
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 150 people
- Sponsor
- MicroPort Orthopedics Inc.
Osteoarthritis
Effects of Tele- or In-person Prehabilitation in Candidates Awaiting Total Hip or Knee Arthroplasty
This pilot single blind randomized controlled trial aims therefore to evaluate the feasibility and the impact on pain and disabilities of a telerehabilitation prehabilitation program for patients awaiting a total joint (hip or…
- Trial name
- NCT02636751
- Testing
- 12-week prehabilitation program, Walking aid adjustment, Information about pain control
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Université de Montréal
Osteoarthritis, Overweight or Obesity
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have…
- Trial name
- ENLIGHTEN-4 (NCT07353931)
- Testing
- Eloralintide
- Where
- 147 sites in United States, Argentina and 11 more
- Volunteers
- 900 people
- Sponsor
- Eli Lilly and Company
Knee Osteoarthritis, Knee Injuries
Clinical Study of Novel Diagnostic Techniques for Knee Osteoarthritis
The purpose of this study is to clarify the potential of intra-articular ultrasound imaging, non-invasive ultrasound imaging, quantitative MRI imaging, contrast-enhanced CT imaging and arthroscopy for diagnostics of knee…
- Trial name
- NCT01359553
- Testing
- Intra-articular ultrasound imaging of knee joint during arthroscopy, Non-invasive ultrasound imaging of knee, Quantitative MRI imaging of knee
- Where
- Finland
- Volunteers
- 12 people
- Sponsor
- University of Oulu
Osteoarthritis, Knee
Clinical Trial of YYC301 P3 for Treatment of Osteoarthritis of the Knee
A Multi-center, Double-blinded, Randomized, Active-controlled, Parallel Design, phase 3 Clinical Trial to Evaluate the Efficacy and Safety of YYC301 in Patients with Osteoarthritis of the Knee Joint
- Trial name
- NCT05362851
- Testing
- YYC301-1 & YYC301-2 & YYC301-3
- Where
- South Korea
- Volunteers
- 692 people
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Knee Osteoarthritis
Observation of the Clinical Efficacy of Two Surgical Procedures for Varus Knee Osteoarthritis
The purpose of this study is to conduct a prospective randomized controlled trial to compare the effects between two surgical procedures in the treatment of varus knee osteoarthritis.The hypothesis was that there would be no…
- Trial name
- NCT05382429
- Testing
- OWHTO, CWHTO
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Knee Osteoarthritis
Evaluation of the Effect of SURGICEL® Powder in TKA
The study subjects are patients in our hospital's orthopedics department undergoing unilateral primary total knee arthroplasty (TKA) due to primary osteoarthritis.
- Trial name
- NCT06608992
- Testing
- SURGICEL® Powder
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Peking University Third Hospital
Osteoarthritis, Osteoarthritis, Knee
Reliability of Measuring Walking-related Performance Fatigability Using Six Minute Walk Test in Persons With Knee Osteoarthritis
Evidence has shown that knee osteoarthritis causes an increase in base of support and a decrease in stride length and gait velocity which results in an increase in energy expenditure during walking.
- Trial name
- NCT04530266
- Testing
- Six minute walk test
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Knee Osteoarthritis
Effects of Muscle Energy Technique in Knee Osteoarthritis Patients
To determine the effectiveness of muscle energy technique along conventional physical therapy after mesenchymal stem cell transplantation in knee Osteoarthritis patients regarding Pain, range of motion, functional disability and…
- Trial name
- NCT05349565
- Testing
- CONVENTIONAL PHYSICAL THERAPY, MUSCLE ENERGY TECHNIQUE
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Knee Osteoarthritis
Safety and Efficacy of a Lipiodol Emulsion for the Embolization of Hypervascularizations in Patients With Knee Pain (LipioJoint1)
Knee osteoarthritis is a common cause of disability in patients who are often young and active. Surgery being an option only for the most severe cases, there is little alternative in case of failure of recommended medication.
- Trial name
- LipioJoint1 (NCT04733092)
- Testing
- Lipiodol
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarthritis, Knee, Traumatic Arthritis
Physica System Total Knee Replacement Registry Study
The primary objective of this study is to obtain long-term implant survivorship (out to 10 years) and to assess clinical, patient-reported outcome measures, and radiographic data for the commercially available Physica system.
- Conditions
- Osteoarthritis, Knee, Traumatic Arthritis, Avascular Necrosis, Degenerative Joint Disease of Knee
- Trial name
- NCT03048201
- Testing
- Physica Kinematic Retaining Knee System, Physica Cruciate Retaining Knee System, Physica Posterior Stabilized Knee System
- Where
- 5 sites in United States
- Volunteers
- 800 people
- Sponsor
- Limacorporate S.p.a
Knee Osteoarthritis
Comparing Efficacy of PRP Combined With Different Hyaluronan for the Treatment of Knee Osteoarthritis
Either PRP or HA is each effective for treating knee OA. However, the efficacy of combined PRP and HA injections remains unknown clinically.
- Trial name
- NCT04931719
- Testing
- PRP+Artz group, PRP+ HYAJOINT Plus group
- Where
- Taiwan
- Volunteers
- 95 people
- Sponsor
- Kaohsiung Veterans General Hospital.