Clinical trials: Knee Osteoarthritis
Osteoarthritis, Knee
A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain
This is a phase 3, randomized, double-blind, placebo-controlled, single injection, 52-week study to evaluate the analgesic efficacy and safety of a single intra-articular (IA) CNTX-4975-05 (capsaicin), compared to IA placebo, in…
- Trial name
- NCT03429049
- Testing
- CNTX-4975-05
- Where
- 33 sites in United States
- Volunteers
- 332 people
- Sponsor
- Centrexion Therapeutics
Total Knee Arthroplasty Recovery, Knee Osteoarthritis
Wearable Knee-Assisted Rehabilitation for Range of Motion and Muscle Strength After Total Knee Arthroplasty
This randomized controlled trial evaluates a wearable electrogoniometry-based telerehabilitation system designed to support recovery after total knee arthroplasty.
- Trial name
- NCT07875725
- Testing
- ReBK Wearable Telerehabilitation System, Standard Home-Based Rehabilitation
- Where
- 3 sites in Chile
- Volunteers
- 80 people
- Sponsor
- University of Chile
Osteoarthritis, Knee, Microfragmented Adipose Tissue
Microfragmented Adipose Tissue Versus Platelet-rich Plasma for Knee Osteoarthritis: a Randomized Comparative Trial
The study aims to conduct a randomized trial comparing the clinical outcomes of PRP (standard intervention) versus Microfragmented adipose tissue (investigational) for the treatment of knee osteoarthritis.
- Conditions
- Osteoarthritis, Knee, Microfragmented Adipose Tissue, Platelet-Rich Plasma
- Trial name
- NCT04351087
- Testing
- Platelet Rich Plasma
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Ohio State University
Chronic Pain, Osteoarthritis
Effects of Transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound on Osteoarthritis Pain of the Knee
The purpose of this study is to see the effects of transcranial direct current stimulation (tDCS) on the pain associated with osteoarthritis of the knee.
- Trial name
- NCT01404052
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Spaulding Rehabilitation Hospital
Knee Osteoarthritis
Effectiveness of Resistive Capacitive Diathermy in Patients Affected by Knee Osteoarthritis
It is a double-blind randomized sham-controlled clinical trial to evaluate the effectiveness of resistive capacitive diathermy in subjects affected by knee osteoarthritis in comparison with a "sham" diathermy treatment.
- Trial name
- NCT01800955
- Testing
- resistive capacitive diathermy treatment (resistive capacitive diathermy, Hcr 902, Unibell)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Catholic University of the Sacred Heart
Observational Study, Geniculate Artery
Prospective Observational Study Of Geniculate Artery Embolization For Symptomatic Knee Osteoarthritis In A Cancer Population
To explore associations with demographics/clinical factors; assess trajectories via annual follow-up; evaluate healthcare utilization and barriers; oversample >10-year survivors.
- Conditions
- Observational Study, Geniculate Artery, Embolization, Symptomatic Knee Osteoarthritis
- Trial name
- NCT07807943
- Testing
- SOC (Standard of care)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Osteoarthritis
The PLE²NO Self-management and Exercise Program for Knee Osteoarthritis
The PLE²NO (in Portuguese Education and Exercise Free Program for osteoarthritis) is a self-management and exercise program specific for elderly with knee osteoarthritis (OA), with the goals of managing OA symptoms, improving…
- Trial name
- NCT02562833
- Testing
- Self-Management and exercise, Educational
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Technical University of Lisbon
Osteoarthritis
Survivorship and Outcomes of Robotic-Arm Assisted Medial Unicompartmental Knee Arthroplasty
The purpose of the study is to determine the survivorship of robotic-arm assisted MCK medial onlay Unicompartmental knee arthroplasty implants at two, five and tem year follow up.
- Trial name
- NCT03668717
- Testing
- Robotic-arm assisted medical MCK implant
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- St. Helena Hospital Coon Joint Replacement Institute
Obesity, Knee Osteoarthritis
Wearable Bioimpedance Analyzer for Tracking Body Composition Changes
Obesity, namely at body mass index (BMI) levels exceeding 40kg/m2 (class III obesity), is a risk factor for many diseases including osteoarthritis (OA).
- Trial name
- NCT05986617
- Testing
- InBody Band 2
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Iowa
Osteoarthritis
Saline-Controlled Study of nSTRIDE APS for Knee Osteoarthritis
A double-blind, multicenter, randomized, controlled trial (RCT) that will evaluate the efficacy of a single dose of Autologous Protein Solution (APS) in patients with Osteoarthritis (OA) of the knee.
- Trial name
- PROGRESS IV (NCT02905240)
- Testing
- nSTRIDE APS, Saline
- Where
- 27 sites in United States
- Volunteers
- 332 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
KAATSU Training to Enhance Physical Function of Older Adults With Osteoarthritis
As the U.S. population ages and the prevalence of osteoarthritis (OA) among older adults rises, the prevention of OA-associated disability is an important public health priority.
- Trial name
- KAATSU-OA (NCT02132715)
- Testing
- Resistance Exercise, KAATSU exercise
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Florida
Osteoarthritis
Comparison of Quadriceps-sparing Minimally Invasive and Medial Parapatellar Total Knee Arthroplasty
Quadriceps-sparing minimally invasive total knee arthroplasty (TKA) with side-cutting instruments has been proposed to limit surgical dissection without compromising the surgical outcome.
- Trial name
- NCT01160835
- Testing
- total knee arthroplastyinstruments
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Osteo Arthritis of the Knee
Lubricin-inspired Osteoarthritis Treatment: a Unique Solution
This goal of this open label study is to evaluate the safety and tolerability of a single intra-articular administration of ABR1 in adults with knee osteoarthritis with a KL grade from 2 to 4.
- Trial name
- LOTUS (NCT07611708)
- Testing
- ABR1
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- Pleryon Therapeutics (Hangzhou) Limited
Osteoarthritis, Knee
Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain
The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with subcutaneous injections of placebo in participants with knee osteoarthritis…
- Trial name
- NCT04809376
- Testing
- Pentosan Polysulfate Sodium twice weekly, Pentosan Polysulfate Sodium Fixed Dose, Pentosan Polysulfate Sodium once weekly
- Where
- 33 sites in United States, Australia
- Volunteers
- 602 people
- Sponsor
- Paradigm Biopharmaceuticals USA (INC)
Knee Osteoarthritis
A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA)
The study was established to show safety and efficacy of canakinumab and LNA043 in patients with knee osteoarthritis (OA).
- Trial name
- NCT04814368
- Testing
- canakinumab, LNA043
- Where
- 11 sites in United States, Czechia and 4 more
- Volunteers
- 23 people
- Sponsor
- Novartis Pharmaceuticals
Osteo Arthritis Knee, Pain, Chronic
Dry Cupping Therapy in Knee Osteoarthritis
Introduction: Knee osteoarthritis (KOA) is the biggest cause of pain and disability worldwide. As a non-pharmacological approach, ventosatherapia has been used to control pain, improve function and quality of life.
- Conditions
- Osteo Arthritis Knee, Pain, Chronic, Pain
- Trial name
- VentosaOA (NCT04331158)
- Testing
- Dry cupping therapy
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Osteoarthritis, Knee, Osteoarthritis, Hip
Radiofrequency Ablation and Steroid Versus Steroid Alone for Relief of Pain in Patients With Advanced Knee and Hip Osteoarthritis
The purpose of this trial is to determine if radiofrequency ablation plus steroid perineural injections at the knee or hip provide longer pain relief and better function to patients than the current standard of care, perineural…
- Trial name
- NCT05490355
- Testing
- Radiofrequency Ablation (RFA), Perineural Steroid Injection
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Texas Southwestern Medical Center
Osteoarthritis, Rheumatoid Arthritis
Randomized Controlled Clinical Outcomes of the Vanguard XP Bicruciate Knee System
Randomized Controlled Study to determine if preservation of ligaments provides increased functional ability post-operatively in comparison to traditional TKA which sacrifices soft tissue.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Lower Limb Deformity
- Trial name
- GK9B (NCT02175576)
- Testing
- Vanguard XP Bicruciate Knee System, Vanguard CR Knee System
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain
Knee osteoarthritis (KOA) is a common joint disease that causes chronic pain and limits daily activities. Current treatments, such as painkillers or surgery, have limitations like side effects or high costs.
- Trial name
- NCT07698418
- Testing
- Inspiratory muscle training
- Volunteers
- 80 people
- Sponsor
- The Hong Kong Polytechnic University
Osteoarthritis
Low Power Laser and Exercise in Osteoarthritis of the Knee: a Randomized Clinical Trial
Indroduction: Knee osteoarthritis (OA) is a painful condition causing disability, weakness and poor quality of live. The results are very consistent about the benefits of laser and exercises to improve pain and function in…
- Trial name
- NCT01306435
- Testing
- Laser
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
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