Clinical trials: Knee Osteoarthritis
Knee Osteoarthritis
Efficacy of Bone-marrow-derived and Placenta-derived Multipotent Mesenchymal Stem / Stromal Cells for Osteoarthritis
To define the clinical effects of intra-articular transplantation of bone-marrow-derived (BM-MMSCs) and placenta-derived multipotent mesenchymal stem / stromal cells (P-MMSCs) for knee osteoarthritis.
- Trial name
- NCT04453111
- Testing
- Placenta-derived MMSCs, Bone marrow-derived MMSCs, Hyalgan 20 mg in 2 ML Prefilled Syringe
- Where
- Ukraine
- Volunteers
- 45 people
- Sponsor
- Institute of Cell Therapy
Osteoarthritis, Knee
Effects of Low Intensity Blood Flow Restriction on Clinical Outcomes in Women With Knee Osteoarthritis
Objective is to compare the effects of routine physical therapy with and without low intensity blood flow restriction on pain and quadriceps muscle strength in women with knee osteoarthritis.
- Trial name
- BFR (NCT04865692)
- Testing
- BFRT, Routine Physical Therapy
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Osteoarthritis, Varus Malalignment
Ellipse Intramedullary Nail High Tibial Osteotomy Study
This study further evaluates the safety profile and efficacy of the Ellipse IM HTO Nail system in subjects with osteoarthritis and varus malalignment of the knee.
- Trial name
- IM HTO (NCT02412163)
- Testing
- Ellipse IM HTO Nail
- Where
- 11 sites in Germany, Netherlands and 2 more
- Volunteers
- 41 people
- Sponsor
- Ellipse Technologies, Inc.
Osteoarthritis, Knee
An Open-Label Long-term Safety Study of Tramadol HCl OAD (Once A Day) 300 mg in the Treatment of Pain Due to Osteoarthritis of the Knee
The purpose of this study is to collect information regarding the long-term (6 and 12 months) safety of Tramadol HCl Once-A-Day(OAD) 300 mg.
- Trial name
- NCT00833911
- Testing
- Tramadol Once A Day
- Volunteers
- 392 people
- Sponsor
- Labopharm Inc.
Knee Osteoarthritis
Effect of Different Injection Regimens of Autologous Conditioned Plasma for Knee Osteoarthritis
The clinical efficacy of hyaluronic acid or corticosteroid injections has been reported, but effects are short lived. This has led to the development of additional injection options such as autologous derived blood products which…
- Trial name
- NCT03889925
- Testing
- Hyaluronan, Autologous conditioned plasma
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Andrews Research & Education Foundation
Knee Osteoarthritis
A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA)
The study was established to show safety and efficacy of canakinumab and LNA043 in patients with knee osteoarthritis (OA).
- Trial name
- NCT04814368
- Testing
- canakinumab, LNA043
- Where
- 11 sites in United States, Czechia and 4 more
- Volunteers
- 23 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee
Extended Post-operative Oral TXA in Primary THA
The goal of this clinical trial is to learn if extended post-operative oral tranexamic acid (TXA) - a medication that reduces bleeding by slowing the breakdown of blood clots - can improve functional recovery following surgery in…
- Trial name
- NCT07685743
- Testing
- Extended oral tranexamic acid regimen
- Volunteers
- 170 people
- Sponsor
- Oregon Health and Science University
Osteoarthritis of the Knee
Efficacy of Celecoxib 200mg in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee
The purpose of this study is to compare the efficacy of celecoxib versus placebo in delaying the onset of pain and improving walking function in subjects with knee Osteoarthritis
- Trial name
- NCT00597415
- Testing
- celecoxib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Degenerative Joint Disease
Comparison of A Mobile-Bearing Total Knee System With A Fixed-Bearing Total Knee System In Cemented Total Knee Arthroplasty
Pain, weakness, instability, and progressive dysfunction are the hallmarks of arthritis of the knee. Total knee replacement may frequently be the only therapeutic intervention to provide adequate improvement in pain and function.
- Trial name
- NCT00589108
- Testing
- Sigma Knee System, Sigma Pressfit Condylar Posterior Cruciate Substituting System with a metal back tibial tray, Sigma Pressfit Condylar Posterior Cruciate Substituting System all polyethylene tray
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Rheumatoid Arthritis
Comparison of Rotating vs. Fixed Platform of the COLUMBUS Knee Prosthesis
A population of 100 patients randomised to rotating and fixed PE inlays in the Columbus knee prosthesis received a navigated TKR.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic; Arthrosis
- Trial name
- NCT00822640
- Testing
- Total Knee Arthroplasty
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Aesculap AG
Knee Osteoarthritis
A Study Evaluating the Safety and Efficacy of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis
This phase 2 study is a placebo-controlled, double-blind, parallel group study of four concentrations of SM04690 (0.03, 0.07, 0.15, and 0.23 mg per 2 mL injection) injected intraarticularly (IA) into the target knee joint of…
- Trial name
- NCT03122860
- Testing
- SM04690
- Where
- 74 sites in United States
- Volunteers
- 700 people
- Sponsor
- Biosplice Therapeutics, Inc.
Allergic Contact Dermatitis, Osteoarthritis, Hip
Rate of Allergic Contact Dermatitis and Cosmetic Outcomes
The patients from the Department of Orthopaedics Center for Joint Replacement will be asked to participate in the study. These patients will be randomized to one of three wound closure products, Sylke adhesive dressing, Exofin…
- Conditions
- Allergic Contact Dermatitis, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT06957444
- Testing
- Sylke Adhesive Dressing, Exofin Skin Glue, Suture Strip Plus
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- West Virginia University
Primary Osteoarthritis
Effect of Zoledronic Acid in Primary Knee Osteoarthritis
We try to find out the effect of zoledronic acid over pain of primary knee osteoarthritis and also functional status in a period of 6 months.
- Trial name
- NCT06051344
- Testing
- Zoledronic acid
- Where
- Bangladesh
- Volunteers
- 92 people
- Sponsor
- Toufiqe-E-Ealahi
Osteoarthritis Knee Pain
A Study in the Treatment of Osteoarthritis Knee Pain
To gather data on whether a new drug for osteoarthritis knee pain will be safe and have an effect on pain levels.
- Trial name
- NCT00790790
- Testing
- LY545694 49 mg, LY545694 105 mg
- Where
- 10 sites in United States, Puerto Rico and 1 more
- Volunteers
- 147 people
- Sponsor
- Eli Lilly and Company
Pain, Stiffness
Telerehabilitation for Knee Osteoarthritis: Study Protocol
Patient Recruitment and Enrolment All patients diagnosed with knee OA who present at Artros Medical Center for an orthopaedic specialist consultation will undergo a radiological examination.
- Conditions
- Pain, Stiffness, Physical Function
- Trial name
- NCT07137897
- Testing
- Telerehabilitation, Control group
- Where
- Slovenia
- Volunteers
- 118 people
- Sponsor
- University of Novo Mesto
Knee Osteoarthritis
To Evaluate the Performance and Safety of the Medical Device IRADYN in Subjects With Osteoarthritis of the Knee
The benefits of single or repetitive administration (1 to 6) can have similar result in terms of muscular strength and patients' quality of life improvement, benefiting of the advantages of polymerized polynucleotides (IRADYN)…
- Trial name
- IRADYN (NCT05206474)
- Testing
- IRADYN
- Where
- 2 sites in Romania
- Volunteers
- 50 people
- Sponsor
- I.R.A. Istituto Ricerche Applicate S.p.A.
Metabolic Syndrome, Osteoarthritis, Hip
Effects of a Clinical Dietary Intervention During Inpatient Treatment
The purpose of the study is a scientific and prospective documentation of the clinical effects of an inpatient treatment at the Immanuel Hospital of Berlin, in the department for complementary and integrative medicine, with the…
- Conditions
- Metabolic Syndrome, Osteoarthritis, Hip, Osteoarthritis, Knee, Rheumatoid Arthritis
- Trial name
- FASTA (NCT03785197)
- Testing
- Prolonged modified fasting
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Charite University, Berlin, Germany
Osteoarthritis
Safety of Diclofenac Sodium Gel in Knee Osteoarthritis
This study will test the efficacy and safety of topical Voltaren in the treatment of knee osteoarthritis.
- Trial name
- NCT00171691
- Testing
- Diclofenac Topical Sodium Gel 1%
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Novartis
Medial Collateral Ligament Lesions, Knee Osteoarthritis
Comparison of the Efficacy of Ultrasound-Guided Injections of Saline, High-Concentration Dextrose, and Ligament Repair Agents for the Treatment of Medial Collateral Ligament Pathology in Degenerative Knee Osteoarthritis: A Randomized Double-Blind Trial.
The goal of this clinical trial is to evaluate the effectiveness of STABHA, high-concentration glucose water, and saline injections in treating knee osteoarthritis with medial collateral ligament lesions.
- Trial name
- NCT06620874
- Testing
- STABHA Injection, High-Concentration Glucose Water Injection, Saline Injection
- Volunteers
- 51 people
- Sponsor
- Chen Ting-an
Osteoarthritis, Knee, Pain
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis
Osteoarthritis (OA) in the knee is characterized by chronic inflammatory pain that is not necessarily related to the amount of joint damage.
- Conditions
- Osteoarthritis, Knee, Pain, Physical Activity, Mitochondrial Pathology
- Trial name
- NCT03344913
- Testing
- Walking
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
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