Clinical trials: Knee Osteoarthritis
Knee Osteoarthritis
Characteristics of Patients Declining INKA Trial Participation
The objective of this study is to compare baseline characteristics of overweight knee OA patients accepting vs. declining enrolment in the INKA trial (NCT05172843) to explore if enrolled patients differ systematically from the…
- Trial name
- n-INKA (NCT05215678)
- Testing
- Acceptance of invitation to trial participation, Declining invitation to trial participation
- Where
- Denmark
- Volunteers
- 129 people
- Sponsor
- Marius Henriksen
Osteoarthritis, Varus Malalignment
Ellipse Intramedullary High Tibial Osteotomy Nail Study
The purpose of this study is to collect outcomes data in patients implanted with the Ellipse IM HTO Nail System.
- Trial name
- NCT02519218
- Testing
- Ellipse Technologies Intramedullary High Tibial Osteotomy Nail System
- Volunteers
- 6 people
- Sponsor
- Ellipse Technologies, Inc.
Knee Replacement, Hip Replacement
Perioperative Hyperglycaemia in Primary Total Hip and Knee Replacement
The purpose of this study is to analyze how common stress hyperglycaemia (abnormally high blood glucose) is in primary hip and knee replacement surgeries and which factors predispose to hyperglycaemia.
- Conditions
- Knee Replacement, Hip Replacement, Hyperglycemia
- Trial name
- HyTe-1 (NCT01021826)
- Where
- Finland
- Volunteers
- 193 people
- Sponsor
- Coxa, Hospital for Joint Replacement
Knee Osteoarthritis
Efficacy of Micro-fragmented Adipose Tissue Injection for Knee Osteoarthritis.
Knee osteoarthritis (OA) causes patients considerable joint pain and leads to instability, reduced range of motion, and functional limitations.
- Trial name
- NCT03379168
- Testing
- Microfragmented Adipose Tissue (Lipogems), Corticosteroid injection, Saline
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dustin L. Richter, MD
Osteoarthritis of Knee, Osteoarthritis Hip
Cannabinoids for Osteoarthritis Pain Effectiveness Trial
This study aims to investigate whether oral cannabis extracts can effectively manage pain caused by osteoarthritis (OA), a common joint condition affecting one in seven Canadians.
- Trial name
- COPE (NCT06878417)
- Testing
- CBD, THC
- Where
- 3 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Osteoarthritis, Rheumatoid Arthritis
PS150 Total Knee Arthroplasty Outcomes Registry
This registry is intended to evaluate the clinical outcomes of the DePuy P.F.C. Sigma PS150 RP Total Knee System. 200 participants will be enrolled prospectively or retrospectively and the follow up period will be 5 years.
- Trial name
- NCT02319291
- Testing
- P.F.C. Sigma PS150 RP Total Knee System
- Where
- 4 sites in Australia, South Korea
- Volunteers
- 175 people
- Sponsor
- DePuy Orthopaedics
Knee Osteoarthritis
Assessment of Protective Effect of JOINS on Cartilage in Knee Osteoarthritis
A Pilot study Randomized and Double-blinded Placebo controlled In 2 parallel group (JOINS 200mg:Placebo = 1:1) Overall 24 months treatment (JOINS:Placebo comparison up to 12 months, Additional follow-up assessment up to 24…
- Trial name
- Joins_Carp_Ⅳ (NCT01293955)
- Testing
- JOINS 200mg
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- SK Chemicals Co., Ltd.
Knee Osteoarthritis
Impact of Physical Activity and Vitamin D on Osteoarthritic Knee Pain
Knee Osteoarthritis (KOA) is a major cause of pain and disability, particularly in those of increasing age and body fat. As there are no very effective therapies for KOA, disease often progresses until knee replacement surgery is…
- Trial name
- NCT02293889
- Testing
- Vitamin D3 2000IU/daily 3 months, PA intervention People with Osteoarthritis Walking Programme
- Where
- 2 sites in United Kingdom
- Volunteers
- 45 people
- Sponsor
- Newcastle University
Osteoarthritis, Knee
Protocol for the Clinical Evaluation of Lyophilized Amniotic Fluid in the Treatment of Knee Osteoarthritis
To evaluate the efficacy of Lyophilized amniotic fluid as compared to the Saline Injection, placebo control in the treatment of moderate osteoarthritis of the knee.
- Trial name
- NCT03074526
- Testing
- Amniotic Fluid
- Where
- 4 sites in United States
- Volunteers
- 156 people
- Sponsor
- MiMedx Group, Inc.
Knee Osteoarthritis
Home Based Hip Strengthening for Knee OA Patients
In knee osteoarthritis patients, weakness of hip abductor muscles is considered an important contributing factor leading to the progression of the disease.
- Trial name
- NCT05131048
- Testing
- conventional group, experimental group
- Volunteers
- 90 people
- Sponsor
- University of Lahore
Total Knee Arthroplasty, Osteoarthritis
Kinematic and Mechanical Alignment Randomized Trial
Knee replacement surgery is the second most common surgery in Canada. People who have very painful knee arthritis usually receive a knee replacement where the surgeon aims to make everyone's knee as straight as possible (called…
- Trial name
- KMART (NCT06787417)
- Testing
- Restricted Kinematically-aligned Arthroplasty, Mechanically-Aligned Arthroplasty
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- McMaster University
Osteoarthritis (OA)
Comparison of the Pain and Functional Improvement of Combined Extracorporeal Shockwave Therapy With or Without Intra-articular Hyaluronic Acid and Platelet-rich Plasma Injection on Advanced Osteoarthritis of the Knees.
This was a single group, double-blind, randomized clinical trial that enrolled 48 patients with Kellgren-Lawrence grade II to IV osteoarthritis of the knee.
- Trial name
- NCT07819955
- Testing
- Extracorporeal Shock Wave Therapy, Normal Saline, Hyaluronic Acid (HA)
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Chang Gung Memorial Hospital
Postoperative Anemia, Osteoarthritis, Knee
Comparing Intravenous and Oral Iron in Postoperative Anemia
Postoperative anaemia are common in patients undergoing major orthopaedic surgery. The main consequence of perioperative anaemia is an increased risk of red blood cell (RBC) transfusions.
- Trial name
- NCT01913808
- Testing
- Ferric carboxymaltose, ferrous glycine sulphate
- Where
- Spain
- Volunteers
- 122 people
- Sponsor
- Parc de Salut Mar
ACL Injury
Multimodal Assessment of Knee Conditions in Rehabilitation
The purpose of this study is to assess ACL injury and other pathological knee conditions from the combination of signals that are known to provide information on the knee joint.
- Trial name
- NCT03608189
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- University of Oulu
Osteoarthritis, Knee
MR Imaging of Knee Osteoarthritis and Acute Knee Injuries
The purpose of this study is to use better magnetic resonance imaging (MRI) techniques to examine the knee and the bony and soft tissue changes so as to better predict the progression of osteoarthritis and acute knee injuries.
- Trial name
- NCT00504114
- Testing
- ACL Reconstruction Surgery, Cartilage Resurfacing Surgery, Total Knee Replacement
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee
Sleep and Pain in Osteoarthritis
People with osteoarthritis and painful joints often report poor sleep, but poor sleep can also increase pain. There have been very few studies of sleep in osteoarthritis using physical measuring devices, but in other painful…
- Trial name
- NCT07821047
- Volunteers
- 73 people
- Sponsor
- University of Reading
Total Knee Arthroplasty, Osteoarthritis
Computer Assisted Total Knee Replacement
The purpose of this study is to determine whether intraoperative computer-assisted navigation improves prosthetic implant positioning as compared to conventional intraoperatve instrumentation in Total Knee Arthroplasty (TKA).
- Trial name
- NCT00279838
- Testing
- Computer Assisted Navigation Knee Replacement
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis
Comparative Effectiveness of Otago and Neuromuscular Exercise Programs in Knee Osteoarthritis
This randomized controlled trial aims to compare the effects of the Otago Exercise Program (OEP) and neuromuscular exercises on pain, functional status, postural control, and balance in patients with knee osteoarthritis (KOA).
- Trial name
- NCT07078526
- Testing
- Otago Exercise Program, Neuromuscular Exercise
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Riphah International University
Osteoarthritis, Knee
How Does Platelet Dose Impact Clinical Outcomes After PRP Treatment?
The purpose of this study is to determine which platelet rich plasma (PRP) injection dosage provides the most improvement in a patient's knee pain level at 26 weeks post-injection.
- Trial name
- NCT05330689
- Testing
- PRP injection dose (<5 billion platelets), PRP injection dose (between 5 and <10 billion platelets), PRP injection dose (between 10 and <20 billion platelets)
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Primary Osteoarthritis of Knee Nos
A Prospective Study to Evaluate Robot Assisted Total Knee Replacement Outcomes
This study aims to see if outcomes for patients that receive the traditional total knee replacement surgical technique are different than the outcomes for patients that receive robot-assisted total knee replacement.
- Trial name
- NCT03523897
- Testing
- Robot Assisted Total Knee Replacement, Traditional Total Knee Replacement
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
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