Clinical trials: Knee Osteoarthrosis
Knee Osteoarthritis, Cartilage Degeneration
Effectiveness of Autologous Adipose-derived Stem Cells in the Treatment of Knee Cartilage Injury
This study was aimed to evaluate the efficacy and safety of Autologous Adipose-derived Mesenchymal Stem Cell Gel combine with High tibial osteotomy therapy in the treatment of cartilage damage in the knee.
- Trial name
- NCT03955497
- Testing
- Autologous Adipose-derived Mesenchymal Stem Cell Gel, Sodium Hyaluronate, Extraction of abdominal fat
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Qilu Hospital of Shandong University
Knee Osteoarthritis
Cartilage Recovery in Adults With Knee Osteorthritis by Mesenchymal Cell Therapy: Randomized Trial of Radiologic and Clinical Outcomes
The treatment of osteoarthritis (OA) of the knee remains still controversial. Despite that fact advanced stages with symptomatic and functional improvement are obtained with total knee replacement, however, there is no treatment…
- Trial name
- INMUNOCEM-OA (NCT05936060)
- Testing
- INMUNOCEM
- Volunteers
- 32 people
- Sponsor
- GUSTAVO SALGUERO
Knee Osteoarthritis
Live and Interactive Fitness Training Program (Vivo Knee OA)
Potential participants will be screened at clinic. Patients who meet eligibility criteria will be considered for study. After written informed consent is obtained, participants will complete baseline testing and participants who…
- Trial name
- LIFT-OA (NCT06462560)
- Testing
- Vivo Online Exercise Program, Medbridge Home program
- Where
- United States
- Volunteers
- 334 people
- Sponsor
- Intermountain Health Care, Inc.
Anterior Knee Pain Syndrome
Does Arthroscopic Patellar Denervation With High Tibial Osteotomy Improve Anterior Knee Pain
Arthroscopy will be done in all cases before osteotomy to assess lat. Comp and grade of patellofemoral O.A Arthroscopic patellar denervation with vaper or diathermy will be done plus open wedge high tibial osteotomy in one group…
- Trial name
- NCT03615976
- Testing
- high tibial osteotomy with or without arthroscopic circumpatellar denervation with or without arthroscopic circumpatellar denervation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Osteoarthritis
Weighted Dangling Exercises vs Vastus Medialis Oblique Muscle Neuromuscular Stimulation for Knee Osteoarthritis
This randomized controlled trial aims to compare the effectiveness Weighted dangling exercises versus vastus medialis oblique muscle neuromuscular electrical stimulation(VMO+NMES) in patients with knee osteoarthritis.
- Trial name
- NCT07701174
- Testing
- Interventional group A, interventional group B
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- University of Lahore
Knee Osteoarthritis
Mulligan and Maitland Techniques in Post PRP Knee Osteoarthritis
Knee osteoarthritis (OA) is a major cause of disability nowadays. Osteoarthritis (OA), also known as degenerative joint disease, is typically the result of wear and tear and progressive loss of articular cartilage.
- Trial name
- NCT06460168
- Testing
- Mulligan(MWM) MobilizationTechnique, Maitland Mobilization technique
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Osteo Arthritis Knee, Knee Arthroplasty
Effects of Motor Imagery Intervention on Functional Recovery Following Total Knee Arthroplasty
The knee osteoarthritis becoming a leading cause of disability among older adults' population. When conventional treatments fail, a total knee arthroplasty (TKA) is suggested.
- Trial name
- KSV2017 (NCT03684148)
- Testing
- Motor imagery practice
- Where
- Slovenia
- Volunteers
- 34 people
- Sponsor
- Science and Research Centre Koper
Osteoarthritis
ActaVisc and ActaVisc Mx Intra-articular Injection for Pain Associated With Osteoarthritis in the Knee
To evaluate the safety and performance of ActaVisc™ intra-articular injection (ActaVisc) and ActaVisc Mx, for management of pain associated with osteoarthritis in the knee in patients who have failed to respond adequately to…
- Trial name
- NCT00665574
- Testing
- ActaVisc and ActaVisc Mx Intra-articular Injection
- Where
- 2 sites in Latvia
- Volunteers
- 23 people
- Sponsor
- Carbylan Therapeutics, Inc.
Osteoarthritis, Knee
Double-Blind, Double Dummy, Randomized Comparison Study to Evaluate the Efficacy and Safety of Valdecoxib 10 mg Once Daily and Naproxen 500 mg Twice Daily in Treating the Signs and Symptoms of Osteoarthritis of the Knee
This study was performed to demonstrate that treatment with valdecoxib 10 mg daily (QD) was at least as effective as with naproxen 500 mg twice daily (BID), a standard non-steroidal anti-inflammatory drug (NSAID), when taken for…
- Trial name
- NCT00652808
- Testing
- valdecoxib, naproxen
- Where
- 8 sites in South Korea
- Volunteers
- 265 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
HTO and Tranexamic Acid Study
The purpose of the study is to assess the effect of Tranexamic acid (TXa), a commonly used medication to prevent bleeding, in reducing blood loss during High Tibial Osteotomy (HTO).
- Trial name
- NCT07825350
- Testing
- Tranexamic Acid, Routine medial opening wedge high tibial osteotomy
- Volunteers
- 200 people
- Sponsor
- Western University, Canada
Hyaluronic Acid
ArtiAid® Plus for Knee Osteoarthritis: A Post-market Study
The goal of this open-label, post-market clinical follow-up study is to demonstrate the safety and performance of ArtiAid® Plus Intra-articular Injection in patients with knee osteoarthritis(OA).
- Trial name
- NCT05881317
- Testing
- ArtiAid® Plus Intra-articular Injection
- Where
- Taiwan
- Volunteers
- 59 people
- Sponsor
- Maxigen Biotech Inc.
Osteoarthritis, Knee
Role of Bone in Knee Osteoarthritis (OA)
The purpose of the study is to investigate protein and gene expression among damaged knee tissues. We will perform MRI's on subjects prior to total knee replacement to identify the location of bone marrow lesions.
- Trial name
- NCT00850538
- Testing
- MRI, Primary Total Knee Replacement
- Where
- Australia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The New England Baptist Hospital
Osteo Arthritis Knee
Effects of Anti-gravity Treadmill Training on Knee Osteoarthritis in Geriatric Population.
Knee osteoarthritis is a very common disorder affecting majority of elderly population. There is considerable functional disability associated with this disorder. The financial burden associated with this disease is quite high.
- Trial name
- NCT04299568
- Testing
- Anti gravity treadmill training, Physical Therapy
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Foundation University Islamabad
Obesity, Knee Osteoarthritis
Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA)
This is a trial of tirzepatide in people with obesity and knee osteoarthritis. The main purpose of this study is to see if tirzepatide can reduce number of these participants who require a knee replacement.
- Conditions
- Obesity, Knee Osteoarthritis, Osteoarthritis, Knee
- Trial name
- STOP KNEE-OA (NCT06191848)
- Testing
- Tirzepatide
- Where
- 4 sites in Australia
- Volunteers
- 352 people
- Sponsor
- University of Melbourne
Total Knee Arthroplasty, Knee Replacement
Investigating Patient Satisfaction With Smart Knee Implants
The main goal of this study is to see if there is a connection between the social and economic resources available in a patient's neighborhood (measured by the Area Deprivation Index, ADI) and their recovery after knee…
- Conditions
- Total Knee Arthroplasty, Knee Replacement, Knee Replacement Arthroplasty, Knee Osteoarthritis
- Trial name
- NCT06968143
- Testing
- Smart Knee Implant
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Osteoarthritis (OA) of the Knee
Investigation of Biopsychosocial Characteristics of Individuals with Knee Osteoarthritis
Since pain and depression are observed together in rheumatic diseases, the concept of limitation caused by the disease and health-related quality of life becomes more determinant than radiological joint damage.
- Trial name
- NCT06591715
- Testing
- Home exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Aysima Barlak
Osteoarthritis
Study of FLEXISEQ® for Treatment of Osteoarthritis of the Knee in NSAID-compromised Patients
Primary Objective To substantiate the efficacy of 2.2 g FLEXISEQ® for the treatment of pain related to osteoarthritis (OA) of the knee in patients contraindicated for or with clinical intolerance to NSAIDs.
- Trial name
- OANIT (NCT02594176)
- Testing
- FLEXISEQ®
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Pro Bono Bio
Osteoarthritis, Knee
Comparative Outcomes Between Imageless Robotic-assisted and Conventional Total Knee Arthroplasty
The purpose of this study is to compare post-operative mechanical alignment (Hip-Knee-Ankle angle; HKA) between imageless robotic-assisted (Navio™ Robotics-assisted Surgical System) and Conventional Total Knee Arthroplasty
- Trial name
- NCT04307251
- Testing
- Navio™ Robotics-assisted Surgical System, LEGION Total Knee System, Conventional, LEGION Total Knee System
- Where
- Thailand
- Volunteers
- 168 people
- Sponsor
- Navamindradhiraj University
Knee Osteoarthritis
Kinematics of Contemporary Knee Arthroplasty
Total joint replacement is an efficacious treatment for osteoarthritis of hips and knees. Both total knee replacement (TKR) and total hip replacements (THR) have excellent implant survivorship.
- Trial name
- NCT02965690
- Testing
- Zimmer Biomet NexGen CR, Medacta International GMK Sphere
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Osteoarthritis
A Trial of a Single Delivery of SB-061 in Osteoarthritis of the Knee
This study evaluates a novel agent, SB-061, for the treatment of osteoarthritis of the knee. Half of the patients will receive the agent via intra-articular injection and half will receive a placebo injection.
- Trial name
- MODIFY2 (NCT03231280)
- Testing
- SB-061
- Where
- 2 sites in Estonia
- Volunteers
- 60 people
- Sponsor
- Symic OA Co.
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