Clinical trials: Knee Osteoarthrosis
Osteoarthritis
Effect of Genicular Nerve Block on Proprioception in Knee Osteoarthritis
The study was conducted to investigate the effect of genicular nerve block on pain, quality of life, and proprioception, which are already diminished due to the impact of osteoarthritis in individuals with knee osteoarthritis.
- Trial name
- NCT06744842
- Testing
- genicular nerve block, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara City Hospital Bilkent
Knee Osteoarthritis
Investigation of the Effect of Superimposed Neuromuscular Electrical Stimulation in Patients With Knee Osteoarthritis.
The aim of the study is to investigate the effects of superimposed neuromuscular electrical stimulation with active contraction on physical function, muscle and joint structure, functionality, and quality of life in patients with…
- Trial name
- NCT06277570
- Testing
- conventional physiotherapy, NMES, Superimposed NMES
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Gulhane School of Medicine
Osteoarthritis
Use of Synvisc® in Knee Osteoarthritis - Medico-economical Study
The USAGE study aims at assessing on a long-term period (two years in average) the outcome in clinical or economical term of patients with knee osteoarthritis (OA) treated or not with Synvisc®, in the 1139.4 clinical trial.
- Trial name
- NCT02195505
- Volunteers
- 374 people
- Sponsor
- Boehringer Ingelheim
Osteoarthritis
The HIHO Study: Hospital Inpatient vs Home Rehabilitation After Total Knee Replacement
Total knee replacement (TKR) surgery is a common and highly effective treatment option for alleviating the pain and disability caused by chronic arthritis.
- Trial name
- HIHO (NCT01583153)
- Testing
- Hospital Inpatient Rehabilitation, Hybrid Home Programme (HO)
- Where
- 3 sites in Australia
- Volunteers
- 165 people
- Sponsor
- Mark Buhagiar
Knee Osteoarthritis
Autologous Adipose Tissue Derived Mesenchymal Stem Cells Therapy for Patients With Knee Osteoarthritis
Two injections in total and 3 ml autologous adipose-tissue-derived stem cells(haMSCs) for each injection; time-points for intervention: 1) initial injection; 2) 3 weeks following initial injection.
- Trial name
- NCT01809769
- Testing
- Mesenchymal stem cells low-dose group, Mesenchymal stem cells mid-dose group, Mesenchymal stem cells high-dose group
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai AbelZeta Ltd.
Osteoarthritis, Post-traumatic Arthritis
Foundation Knee Study - Retrospective
The purpose of this study is to evaluate the use and efficacy of the Encore Foundation Knee System in a group of 200 patients for whom data has already been collected.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Inflammatory Tissue Disorders, Arthritis Secondary to Other Diseases
- Trial name
- NCT00764894
- Testing
- Foundation Knee
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Encore Medical, L.P.
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Cold and Compression Post TKA
The purpose of this study is to compare pain score (Patient-Reported Outcomes Measurement Information System: PROMIS NRS Pain Subscale) between the control and cold/compression groups pre-surgically, daily after surgery for 14…
- Trial name
- NCT07023185
- Testing
- Cold and Compression, SOC (Standard of care)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ochsner Health System
Osteoarthritis, Osteo Arthritis Knee
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Use of Biocellular and cellular approaches to treatment of Osteoarthritis (OA), musculoskeletal aging processes, pain, and degenerative changes are to be studied with minimally invasive protocols, and non-pharmaceutical means to…
- Conditions
- Osteoarthritis, Osteo Arthritis Knee, Osteo Arthritis Shoulders, Osteoarthritis of Multiple Joints
- Trial name
- GARM-MSK-ALD (NCT04238143)
- Testing
- Tissue Stromal Vascular Fraction (tSVF) Arm 1, PRP Concentrate Arm 1, Tissue Stromal Vascular Fraction (tSVF) Arm 2
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Healeon Medical Inc
Knee Osteoarthritis
Exercise and Pain Sensitivity in Knee Osteoarthritis
A commonly administered conservative non-pharmacological treatment for OA is exercise, with beneficial effects in terms of reduced pain and disability. While the link between exercise and reduced disability is mediated by e.g.
- Trial name
- NCT01545258
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Frederiksberg University Hospital
Degenerative Joint Disease
Comparison of A Mobile-Bearing Total Knee System With A Fixed-Bearing Total Knee System In Cemented Total Knee Arthroplasty
Pain, weakness, instability, and progressive dysfunction are the hallmarks of arthritis of the knee. Total knee replacement may frequently be the only therapeutic intervention to provide adequate improvement in pain and function.
- Trial name
- NCT00589108
- Testing
- Sigma Knee System, Sigma Pressfit Condylar Posterior Cruciate Substituting System with a metal back tibial tray, Sigma Pressfit Condylar Posterior Cruciate Substituting System all polyethylene tray
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Mayo Clinic
Osteoarthritis of Knee
Total Knee Replacement Component Alignment Using Manual Versus Custom Instrumentation
1. To determine whether the low-dose, biplanar x-ray imaging (EOS) has the same accuracy as computed axial tomography (CT) 2. To validate low-dose, biplanar x-ray imaging (EOS) as a tool to evaluate 3-dimensional alignment of…
- Trial name
- NCT02579174
- Testing
- Medacta GMK Sphere
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Northwestern University
Knee Osteoarthritis
Exercise and Physical Fitness for Persons With Knee Osteoarthritis
The purpose of this project is to establish evidence to support specific, targeted exercise and rehabilitation recommendations for people over 50 with osteoarthritis of the knee.
- Trial name
- NCT00265447
- Testing
- Strength training, Aerobic conditioning, Delayed exercise
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Kinematics in Posterior Cruciate Retaining and Bi-Cruciate Retaining Total Knee Replacements
The purpose of the study is to acquire kinematic in vivo fluoroscopy data from subjects who were implanted with the Smith \& Nephew Journey II posterior cruciate retaining (PCR) total knee arthroplasty (TKA) or Journey II…
- Trial name
- NCT03088748
- Testing
- Journey II posterior cruciate retaining total knee arthroplasty, Journey II posterior bi-cruciate retaining total knee arthroplasty
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- The University of Tennessee, Knoxville
Osteoarthritis, Arthritis
Efficacy And Safety Study Of Tanezumab Subcutaneous Administration In Osteoarthritis - A Subcutaneous/Intravenous Bridging Study
This is an efficacy and safety study of 3 doses (2.5 mg, 5 mg and 10mg) of tanezumab administered subcutaneously versus placebo.
- Conditions
- Osteoarthritis, Arthritis, Pain
- Trial name
- NCT01089725
- Testing
- Tanezumab SC, Tanezumab IV
- Where
- 91 sites in United States
- Volunteers
- 385 people
- Sponsor
- Pfizer
Cartilage Diseases, Osteoarthritis
Human Umbilical Cord Mesenchymal Stem Cell Transplantation in Articular Cartilage Defect
The purpose of this study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC) for articular cartilage defect of knee.
- Trial name
- NCT02291926
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Cardiovascular Disease Risk, Rheumatoid Arthritis (RA)
Cardiovascular Disease Awareness in Rheumatoid Arthritis and Knee Osteoarthritis
Cardiovascular diseases (CVD) are still the most common cause of death. For these reasons, individuals, especially those with chronic diseases, need to be aware of CVD.
- Conditions
- Cardiovascular Disease Risk, Rheumatoid Arthritis (RA), Knee Osteoarthritis
- Trial name
- NCT07056608
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Osteoarthritis (OA) of the Knee
Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty
Participants are being invited to take part in a research study about pain control after total knee replacement surgery (also called total knee arthroplasty or TKA).
- Trial name
- NCT07775248
- Testing
- Periarticular Injection, Adductor Canal Block, Bupivacaine-Meloxicam
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Henry Ford Health System
Knee Osteoarthritis
A Multi-centre Study of Shoe-worn Insoles and Knee Osteoarthritis
Shoe-worn insoles (also known as orthotics) can provide symptomatic relief for people with knee osteoarthritis. However, given they act at the feet, and given that many people with knee osteoarthritis also report foot pain, it is…
- Trial name
- MULTIWEDGE (NCT06251167)
- Testing
- Lateral wedge insoles (LWIs), Lateral wedge plus custom arch support (LWAS)
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- University of British Columbia
Knee Osteoarthritis
A Clinical Trial of YH23537 in Patients With Knee Osteoarthritis
The purpose of this study is to evaluate efficacy and safety of YH23537 versus celebrex in patients with knee osteoarthritis.
- Trial name
- NCT02759198
- Testing
- YH23537, Celecoxib
- Where
- South Korea
- Volunteers
- 456 people
- Sponsor
- Yuhan Corporation
Knee Osteoarthritis
Therapeutic Effect of Oral Hyaluronic Acid on Knee Osteoarthritis
The goal of this clinical trial is to investigate the effect of oral hyaluronate in patients with knee osteoarthritis. The main question it aims to answer is: the therapeutic effect in the combined treatment of oral nutritional…
- Trial name
- NCT07033312
- Testing
- oral hyaluronate and injection, hyaluronate injection
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Taichung Veterans General Hospital
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