Clinical trials: Knee Osteoarthrosis
Osteoarthritis of Knee
Clinical Trial to Evaluate Safety and Efficacy of MesoCellA-Ortho Tissue-Engineered Advanced Therapy Product in Patients With Osteoarthrosis and Civilisation Diseases
The aim of the study is to evaluate safety, tolerability and clinical efficacy of a newly developed MesoCellA-Ortho tissue-engineered advanced therapy medicinal product in adult patients suffering with osteoarthritis and…
- Trial name
- BioMiStem-CT (NCT05081921)
- Testing
- MesoCellA-Ortho administration, HA administration
- Where
- Poland
- Volunteers
- 192 people
- Sponsor
- Jagiellonian University
Knee Osteoarthritis
"Effectiveness of Mulligan Mobilization Technique and Proprioceptive Exercises Among Patients With Knee Osteoarthritis"
This research analyzes the effectiveness of Mulligan mobilization in comparison to proprioceptive exercises for treating patients with mild to moderate Knee osteoarthritis whose condition falls under Kellgren and Lawrence grading…
- Trial name
- MWMPETKOA (NCT06971016)
- Testing
- Mulligan Mobilization technique, Proprioceptive Exercises, Traditional Physical therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- National Healthcare Center
Osteo Arthritis Knee
Efficacy of Mesotherapy Added to Intra-articular Platelet-rich Plasma (PRP) in Patients With Knee Osteoarthritis
In this study, the investigators aimed to determine whether platelet rich plasma (PRP) and mesotherapy combined treatment is effective on pain and function compared to PRP alone in patients with knee osteoarthritis (OA).
- Trial name
- NCT05329116
- Testing
- Lidocaine 2% Injectable Solution, Platelet-rich plasma
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Necmettin Yildiz
Osteoarthritis, Knee
Cell-free Stem Cell-derived Extract Formulation for Knee Osteoarthritis
The purpose of this study is to determine the safety and efficacy of intraarticular injection of Cell-free Stem Cell-derived Extract Formulation for treatment of knee osteoarthritis symptoms.
- Trial name
- NCT04971798
- Testing
- Cell-free Stem Cell-derived Extract Formulation (CCM)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- General Therapeutics
Knee Osteoarthritis
Using ROSA for Challenging The TKA Standard of Care
This is a prospective, randomized controlled trial using the cruciate retaining, MC Persona to comparing the conventional TKA to ROSA assisted TKA. Patients will be randomized to one of three study trial arms. 1.
- Trial name
- NCT06267482
- Testing
- ROSA PSA Parapatellar Approach, ROSA PSA Subvastus Approach
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
HIP AND KNEE OSTEOARTHRITIS
Prepare II - Predictive Model Training and External Validation
The general aim of the project is training and testing a predictive model of inpatient rehabilitation stay after hip and knee replacement for osteoarthritis.
- Trial name
- NCT07304323
- Testing
- Functional rehabilitation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Osteoarthritis, Deep Venous Thrombosis
Exercise and Cycle Ergometry Post TKA - A Randomized Controlled Trial
The purpose of this investigation is to examine the effect of, and improve patient compliance and motivation following total knee arthroplasty; to determine the efficacy of two post-surgical exercise programs on knee pain…
- Trial name
- NCT02265523
- Testing
- Cycle ergometer
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Lakehead University
Knee Osteoarthritis
Platelet Rich Plasma (PRP) Injections For Knee Osteoarthritis
It was conducted a prospective study with a series of 153 patients treated with PRP injections in patient affected by knee osteoarthritis.
- Trial name
- NCT04852380
- Testing
- PRP injections
- Where
- Italy
- Volunteers
- 153 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Degenerative Osteoarthritis, Defect of Articular Cartilage
Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect
This is a long term follow-up study to investigate the safety and efficacy of CARTISTEM®, human umbilical cord blood-derived mesenchymal stem cells, in repair of cartilage injury or defects, compared with microfracture.
- Trial name
- NCT01626677
- Testing
- CARTISTEM, Microfracture
- Where
- 10 sites in South Korea
- Volunteers
- 103 people
- Sponsor
- Medipost Co Ltd.
Arthroplasty, Replacement Material
Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when…
- Conditions
- Arthroplasty, Replacement Material, Knee Arthritis Osteoarthritis, Knee Arthroplasty, Total
- Trial name
- CRYO-TKA (NCT07425457)
- Testing
- CT-guided Cryoneurolysis of the Genicular Nerves
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Knee Osteoarthritis
Staged Versus Simultaneous Bilateral Knee Arthroplasty
The purpose of this study is to assist surgeons and patients in answering the question "Should I have both knees replaced at the same time, or should I just do one and wait to do the second one?"
- Trial name
- NCT03564730
- Testing
- Simultaneous Knee Arthroplasty (UKA), Staged Knee Arthroplasty (UKA)
- Where
- 8 sites in Canada
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Innovation Centre
Knee Osteoarthritis, Meniscus Disorder
Evaluation of Meniscal Extrusion by Dynamic Ultrasonography in Patients With Ostearthritis
This is a diagnostic, open-label, single-center interventional study. The aim of the study is to evaluate the relationship between medial and lateral meniscus extrusion determined by dynamic ultrasound study and bone edema…
- Trial name
- NCT06113536
- Testing
- Ultrasonographic evaluation
- Where
- Italy
- Volunteers
- 202 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis (Knee OA), Osteoarthritis
Retro-walking Versus Forward-walking Training Using Underwater Treadmill in Patients With Knee Osteoarthritis
The purpose of this study Will investigate and compare the effects of retro-walking and forward-walking underwater treadmill training on pain, function and ROM in subjects with chronic knee OA
- Trial name
- NCT06896032
- Testing
- physical therapy intervention
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nourhan Atwa Said
Knee Osteoarthritis, Hip Osteoarthritis
Comparison of Knotless Barbed Suture and Standard Suture in Knee Replacement Patients
Barbed suture use has been gaining increased acceptance and has been reported to offer potential advantages in wound closure of hip and knee replacement surgeries.
- Trial name
- NCT03031314
- Testing
- barbed suture, standard suture
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Washington Hospital Healthcare System
Osteoarthritis, Knee
Gait Modifications and Cutaneous Stimulation
The purpose of this study is to quantify differences in joint mechanics between different types of walking in healthy individuals and individuals with knee pathology.
- Trial name
- NCT02884414
- Testing
- Cutaneous stimulation
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Stanford University
Osteoarthritis
ARVIS TKA vs Conventional TKA
This study is a pilot analysis of a novel augmented reality guidance platform, the augmented reality visualization and information system (ARVIS, Insight Medical), with aims to demonstrate accuracy of bone resection and implant…
- Trial name
- ARVIS (NCT06663384)
- Testing
- Evaluation of Augmented Reality technology in TKA compared to standard TKA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Foundation for Orthopaedic Research and Education
Osteoarthritis
Tourniquet vs. no Tourniquet During Total Knee Arthroplasty
The purpose of this study is to correlate functional outcomes and perioperative complications with tourniquet use during total knee arthroplasty.
- Trial name
- NCT02907047
- Testing
- tourniquet inflated, tourniquet not inflated
- Where
- United States
- Sponsor
- Rothman Institute Orthopaedics
Knee Osteoarthritis
The Effect of Reflexology and Knee Massage With Black Cumin Oil on Pain and Fatigue
In this study, black cumin extract oil was used in elderly individuals with Knee Osteoarthritis (OA). The effects of foot reflexology and knee massage on pain and fatigue symptoms.
- Trial name
- NCT06298760
- Testing
- Knee Massage With Black Cumin Oil Group:, Foot Reflexology Group With Black Cumin Oil
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Erzurum Technical University
Knee Osteoarthritis
Stem Cell Transplantation for the Treatment of Knee Osteoarthritis
The purpose of this study is to find if autologous stem cell transplantation can improve clinical manifestations of knee osteoarthritis.
- Trial name
- NCT00550524
- Testing
- Autologous Stem Cell Transplantation
- Where
- Iran
- Volunteers
- 5 people
- Sponsor
- Tehran University of Medical Sciences
Osteoarthritis, Knee
The Instant Effect of Kinesiology Taping in Patients With Knee OA
The aim of this study is to determine instant effect of kinesiology taping applied to the rectus femoris on muscle activation, physical performance and proprioception in patients with knee osteoarthritis.
- Trial name
- NCT05160246
- Testing
- kinesiology tape
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kırıkkale University
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