Clinical trials: Knee Pain
Knee Osteoarthritis
Transcutaneous Vagus Nerve Stimulation As a Pain Modulator in Knee Osteoarthritis
a single-blinded, randomized clinical trial, 68 patients divided into 2 groups: active and sham treatment. Afferents of the Auricular branch of vagus nerve are stimulated using a transcutaneous Vagus Nerve Stimulation device…
- Trial name
- NCT05387135
- Testing
- Transcutaneous Vagus Nerve Stimulation
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Suez Canal University
Knee Osteoarthritis
The Effect of Acupressure in Patients With Knee Osteoarthritis
Abstract Pain is the most common symptom of osteoarthritis and affects people's functional status with quality of life. This study was conducted to determine the effect of acupressure on pain, functional status, and quality of…
- Trial name
- NCT05238350
- Testing
- Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Acute Knee Pain
Efficacy of Microcurrent Therapy for Treatment of Knee Pain
The purpose of this study is to evaluate the effect of microcurrent therapy at the knee pain.
- Trial name
- NCT03511014
- Testing
- Microcurrent
- Where
- Japan
- Volunteers
- 70 people
- Sponsor
- Omron Healthcare Co., Ltd.
Osteoarthritis of Knee
Genicular Radiofrequency Ablation Versus Pulsed Radiofrequency
This study investigates the effectiveness of two treatments-genicular nerve radiofrequency ablation and pulsed radiofrequency-in reducing pain and improving function in osteoarthritis patients.
- Trial name
- GRFT-PRF (NCT06894147)
- Testing
- Genicular nerve pulse radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis, Knee / Osteoarthritis, Hip
Efficacy and Safety of MT-5547 in Patients With Osteoarthritis Accompanied by Moderate to Severe Pain
The objective of this study is to verify the superiority of 16 weeks of MT-5547 treatment to placebo, as evidenced by the WOMAC pain score (the efficacy outcome measure), in patients with osteoarthritis of the knee or hip.
- Trial name
- NCT03245008
- Testing
- MT-5547
- Where
- 27 sites in Japan
- Volunteers
- 626 people
- Sponsor
- Tanabe Pharma Corporation
Anesthesia, Pain
A Comparison of US and Evoked Motor Response-guided Placement of Continuous Femoral Nerve Block Following TKA
The purpose of this study is to determine which technique for catheter placement in continuous femoral nerve block (FNB) is most successful - guidance with (1) ultrasound or (2) nerve stimulation and ultrasound.
- Conditions
- Anesthesia, Pain, Nerve Pain, Knee Arthroplasty
- Trial name
- NCT03121976
- Testing
- Ultrasound, Ultrasound + Nerve Stimulation
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Sunnybrook Health Sciences Centre
Knee Osteoarthritis
Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)
Knee replacement surgery for osteoarthritis is a commonly performed procedure in Canada with 75,000 of these surgeries performed each year.
- Trial name
- RELIFE (NCT06423716)
- Testing
- Duloxetine
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- Sunnybrook Health Sciences Centre
Osteoarthritis
A Study Comparing 4 Dose Regimens of PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee
Objectives: Primary:To assess the efficacy and safety of PLA-695 in subjects with active osteoarthritis (OA) of the knee. Secondary:To determine the pharmacokinetics (PK) and pharmacodynamics (PD) of PLA-695 among dose levels.
- Trial name
- NCT00396955
- Testing
- PLA-695
- Where
- 83 sites in United States, Argentina and 8 more
- Volunteers
- 560 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Knee Osteoarthritis
Improvements in Function and Pain in the Rehabilitation of Patients With Knee Osteoarthritis Using an Exercise Program Telemonitored Compared to Conventional Treatment
Osteoarthritis is a very prevalent pathology after the fifth decade of life. It usually appears in the hip and hand, although its presence in the knee is even greater, with a prevalence in subjects over 45 years of age of 19%…
- Trial name
- KNEE_Telemon (NCT06647446)
- Testing
- Exercise supported by the digital physiotherapy and telerehabilitation software TRAK, Standard home-based exercise
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Valencia
Knee Osteoarthritis
Effects of Egoscue Exercises in Patients With Knee Osteoarthritis
Knee osteoarthritis (KOA) is a chronic, debilitating illness with multiple etiologies that affects the entire knee joint. It is a leading cause of disability among the elderly population and necessitates effective interventions…
- Trial name
- NCT07063953
- Testing
- Standard Physical Therapy, Egoscue Exercises
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Total Knee Arthroplasty, Pain Management
Peri-articular Injection Utilizing a Pain Cocktail With and Without Exparel
A prospective, randomized control study will be conducted to compare postoperative pain control in a series of patients treated with either: 1. a local cocktail. 2. a local cocktail plus Exparel. 3.
- Trial name
- NCT02571283
- Testing
- Cocktail, Exparel, Marcaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville
Osteoarthritis, Knee, Pain
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis
Osteoarthritis (OA) in the knee is characterized by chronic inflammatory pain that is not necessarily related to the amount of joint damage.
- Conditions
- Osteoarthritis, Knee, Pain, Physical Activity, Mitochondrial Pathology
- Trial name
- NCT03344913
- Testing
- Walking
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Osteoarthritis, Knee, Osteoarthritis
A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis
The goal of this clinical study is to evaluate the effectiveness of the properties that support the functional state of the joints and the safety of the dietary supplement for food ARTNEO®, oral capsules, in patients with stage…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Knee Osteoarthritis, Knee Arthritis
- Trial name
- NCT05975879
- Testing
- undenaturated collagen type II, methylsulfonylmethane, boswellia serrata, vitamin D3 (cholecalciferol), vitamin C (ARTNEO)
- Where
- 12 sites in Russia
- Volunteers
- 212 people
- Sponsor
- NPO Petrovax
Pain, Postoperative
Defining the Best Approach to Block the Pain After Knee Surgery
The study aims to compare standard techniques used to control pain after knee surgery. The investigators hypothesize that the fascia iliaca block is faster, safer and as good as or better than the femoral block, with or without a…
- Trial name
- NCT00294073
- Testing
- Fascia Iliaca Block, Femoral Block (with stimulating catheter), Femoral Block (without stimulating catheter)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Osteoarthritis, Knee
Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial
The primary aim of this study is to investigate whether low-dose radiotherapy is an effective treatment to reduce the pain of knee osteoarthritis.
- Trial name
- RADIO-KO (NCT06887829)
- Testing
- Low dose radiotherapy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Mayo Clinic
Pain, Postoperative Complications
Acupuncture for Pain Management After Hip or Knee Arthroplasty
The purpose of this study is to determine whether patients treated with acupuncture post-operatively following knee or hip arthroplasty achieve better pain control as measured by the Visual Analog Scale and pain medication use.
- Trial name
- NCT00455182
- Testing
- Acupuncture, Standard medical care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- HealthEast Care System
Osteoarthritis, Pain
fMRI and Central Sensitization in Chronic Knee Osteoarthritis. A Pre and Post TKR Study
Painful osteoarthritis (OA) is the 4th largest cause of disability in the UK. Preoperative temporal summation, a measure of central pain facilitation, has been shown to predict postoperative pain after total knee replacement…
- Conditions
- Osteoarthritis, Pain, Postoperative Pain, Surgery
- Trial name
- NCT03126279
- Testing
- Total Knee Replacement Surgery
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Inflammation, Osteoarthritis
Photobiomodulation Therapy in Patients Receiving Total Knee Arthroplasty
Photobiomdoulation is the use of near-infrared light to relieve pain, stimulate healing and reduce inflammation. Swelling and inflammation is a common condition after orthopedics surgeries over extremity and spine.
- Conditions
- Inflammation, Osteoarthritis, Post Operative Pain
- Trial name
- NCT06426251
- Testing
- Photobiomodulation
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Knee Osteoarthritis
TENS Effectiveness and Knee Osteoarthritis in Humans
TENS is a non pharmacological intervention to control pain. Both high (>50 Hz) and low (<10 Hz) frequency TENS are used in the clinic and it is thought that each type works through different mechanisms (see for review Sluka and…
- Trial name
- TOPS (NCT01354054)
- Testing
- High Frequency TENS, Low frequency TENS
- Where
- 3 sites in United States, Brazil and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Osteoarthritis, Pain
Patellar Resurfacing in Total Knee Arthroplasty
Background: The best treatment of the patella during total knee arthroplasty (TKA) is controversial. The implantation of a patellar component adds to the operation time and the costs of the operation.There is a huge variation as…
- Trial name
- NCT00553982
- Testing
- Patellar component, No patellar component
- Where
- Norway
- Volunteers
- 130 people
- Sponsor
- Sykehuset Innlandet HF