Clinical trials: Knee Replacement
Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\)
Suzetrigine in TKA
Total knee replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery.
- Conditions
- Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\), Total Knee Replacement, Total Knee Replacement Surgery
- Trial name
- NCT07864896
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Sleep Patterns After Total Joint Replacement Surgery
The purpose of this study is to determine sleep patterns and sleep quality following total joint arthroplasty, in order to understand when patients should expect to return to baseline or improved sleep following total joint…
- Trial name
- NCT04896892
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Arthroplasty, Replacement, Knee, Total Knee Replacement
Metal Ion Concentrations After Total Knee Arthroplasty
The purpose of this study is to analyze the metal ion concentrations in the patients blood following robotic-assisted total knee arthroplasty (TKA) compared to conventional total knee arthroplasty using cutting guides.
- Conditions
- Arthroplasty, Replacement, Knee, Total Knee Replacement, Blood Metal Ion Concentration
- Trial name
- NCT06447922
- Testing
- Metal ion level testing
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Arthroplasty Replacement, Knee, Anesthesia Conduction
Migration Rate for Continuous Adductor Canal Block Catheters After Primary Total Knee Arthroplasty Surgery: a Comparison Between Two Insertion Techniques
Continuous adductor canal block (CACB) is becoming increasingly popular for providing postoperative analgesia following knee arthroplasties.
- Trial name
- ISAFExOOPS (NCT07681622)
- Testing
- ISAFE technique for adductor canal catheter insertion, OOPS technique
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Arthroplasty, Replacement
sACB vs cACB in TKA
This study compares the analgesic efficacy of single-dose adductor canal block (sACB) versus continuous-dose adductor canal block (cACB) for postoperative pain management in total knee replacement patients.
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- NCT07581886
- Testing
- Continuous ACB, Single-shot ACB
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Arthroplasty Replacement, Knee
Three Dimensional Gait Analysis After Total Knee Arthroplasty - Comparison of Objective and Patient-reported Outcomes Between Rotational and Fixed Tibial Platforms.
We prospectively enrolled patients with knee osteoarthritis indicated for total knee arthroplasty and randomized for either mobile rotational tibial platform arthroplasty or fixed-stabilised tibial platform arthroplasty.
- Trial name
- NCT07515378
- Testing
- total knee arthroplasty
- Where
- Czechia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Osteoarthritis, Total Knee Replacement
Adductor Canal Block
The investigators aim to investigate whether the addition of a surgeon-administered adductor canal blockade to a multimodal periarticular injection cocktail provides additional pain relief for patients undergoing total knee…
- Trial name
- NCT04513145
- Testing
- Ropivacaine injection, Saline Injection, Total Knee Arthroplasty
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- OrthoCarolina Research Institute, Inc.
Pain After Total Knee Arthroplasty, Pain, Postoperative
Comparison of BiFeS + ACB and IPACK + ACB Block Combinations for Postoperative Pain After Total Knee Arthroplasty
This prospective observational study will compare the postoperative analgesic efficacy of two multimodal regional anesthesia combinations routinely used after total knee arthroplasty (TKA) performed under spinal anesthesia.
- Conditions
- Pain After Total Knee Arthroplasty, Pain, Postoperative, Arthroplasty, Replacement, Knee
- Trial name
- NCT07231692
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Total Knee Replacement
Comparative Effect of Instrument Assisted Soft Tissue Mobilization and Cross Fiber Massage in Patients With Total Knee Replacement.
Comparative effect of Instrument Assisted Soft Tissue Mobilization and Cross Fiber Massage in patients with Total Knee Replacement
- Trial name
- NCT07361770
- Testing
- Instrument-assisted soft tissue mobilization, Cross Fibre Massage
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rashid Latif Medical College
Total Knee Replacement
Analgesic Efficacy of Pre-Operative Dose of Palmitoylethanolamide in Patients Undergoing Total Knee Arthroplasty
Analgesic Efficacy of Pre-Operative Dose of palmitoylethanolamide in Patients Undergoing total Knee Arthroplasty, A Randomized Double-Blinded Controlled Trial.
- Trial name
- Total knee (NCT07330765)
- Testing
- Effect of two different drugs on post operative pain after TKA
- Where
- Egypt
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Abdelrahman Gaber Sayed Elkhateeb
Arthroplasties, Knee Replacement, Nerve Block
Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine
Revision total knee arthroplasty (rTKA) is a frequently performed procedure. Adequate pain management is an important feature, especially for fast-track and Enhanced Recovery After Surgery (ERAS) programs.
- Conditions
- Arthroplasties, Knee Replacement, Nerve Block, Urinary Retention Postoperative, Anesthesia, Spinal
- Trial name
- POURRKA (NCT07050277)
- Testing
- Intrathecal Morphine, No Intrathecal Morphine
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Total Knee Arthroplasty, Knee Replacement
Investigating Patient Satisfaction With Smart Knee Implants
The main goal of this study is to see if there is a connection between the social and economic resources available in a patient's neighborhood (measured by the Area Deprivation Index, ADI) and their recovery after knee…
- Conditions
- Total Knee Arthroplasty, Knee Replacement, Knee Replacement Arthroplasty, Knee Osteoarthritis
- Trial name
- NCT06968143
- Testing
- Smart Knee Implant
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Pain Measurement, Knee Replacement Arthroplasty
Anterior Cutaneus Nerve and Distal Adductor Canal Block With USG for Total Knee Replacement Analgesia
This prospective clinical study was approved by the institutional ethics committee on September 27, 2023, and patient enrollment started in October 2023.
- Conditions
- Pain Measurement, Knee Replacement Arthroplasty, Nerve Block
- Trial name
- NCT06201195
- Testing
- Adductor canal blockade, Distal adductor canala blockade and anterior cutaneus nerve blockade
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Pain, Postoperative, Surgery
The Effect of Baduanjin on Patients Undergoing Knee Replacement Surgery
This randomized controlled trial aims to evaluate the effects of Baduanjin, a traditional Chinese mind-body exercise, on pain, comfort, and quality of recovery in patients undergoing total knee arthroplasty (TKA).
- Conditions
- Pain, Postoperative, Surgery, Knee Replacement, Nurse's Role
- Trial name
- NCT07109557
- Testing
- Baduanjin
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Niran Çoban
Unicompartmental Knee Replacement, Osteo Arthritis Knee
RCT: Mako Medial Unicondylar Knee Arthroplasty vs Oxford Unicondylar Knee Arthroplasty
The overall aim of this prospective, randomised, single-blinded, controlled trial is to compare clinical outcomes and accuracy of implant positioning in Mako robotic UKA versus jig-based Oxford UKA with navigation control.
- Conditions
- Unicompartmental Knee Replacement, Osteo Arthritis Knee, Surgery
- Trial name
- NCT04095637
- Testing
- Medial knee arthroplasty
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University College, London
Knee Replacement, Knee Replacement Revision
Prevalence and Incidence of Multiple Revisions Following Knee Arthroplasty in Denmark 1998-2021: A Nationwide Population-based Study
The purpose of this study is to investigate the incidence and prevalence rates of multiply revised knee arthroplasty patients in Denmark from 1998-2021.
- Trial name
- EMKAR ONE (NCT06064318)
- Testing
- Revision
- Where
- Denmark
- Volunteers
- 161,384 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Total Knee Replacement
Robotic Assisted TKA
As an intraoperative tool, a modern robotic total knee arthroplasty (TKA) system should be able to identify a patient's native femoral and tibial anatomy, as well as, assess ligament tension and gap balance.
- Trial name
- NCT06062615
- Testing
- Total knee replacement using Omnibot Knee System, Conventional Total knee replacement, Omnibot Robotic Knee System
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Knee Osteoarthritis, Total Knee Replacement
Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement
This research aims to explore differences in walking and functional movement mechanics, exercise response, and physical activity between people with osteoarthritis (OA), those who have undergone total joint replacement, and…
- Trial name
- MDOA&TKR (NCT06829433)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Total Knee Replacement
The Efficacy of Low-load Blood Flow Restricted Resistance Before TKR
The primary aim of this study is to investigate the efficacy of 8 weeks of Low-load blood flow restricted exercise (BFRE) compared to receiving standard care only (no preoperative training) before total knee replacement (TKR) on…
- Trial name
- NCT04081493
- Testing
- Low-load blood flow restricted exercise
- Where
- 3 sites in Denmark
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Aarhus