Clinical trials: Knee Rheumatism
Pain, Osteoarthritis, Knee
A Four-Arm Study Comparing the Analgesic Efficacy and Safety of Tramadol Once a Day 100, 200 and 300 mg Versus Placebo for the Treatment of Pain Due to Osteoarthritis of the Knee
The purpose of this study is to compare the analgesic efficacy and safety of Tramadol Once a Day 100, 200, 300 mg and Placebo
- Trial name
- NCT00832416
- Testing
- Tramadol Once A Day
- Volunteers
- 565 people
- Sponsor
- Labopharm Inc.
Osteoarthritis, Knee
Efficacy and Safety of Topical Diclofenac Combined With Oral Diclofenac in the Treatment of Knee Osteoarthritis
Oral non-steroidal anti-inflammatory drugs (NSAIDs) are a recommended treatment for the symptoms of osteoarthritis of the knee. However, NSAIDs may cause a range of negative side effects, including stomach pain, heartburn…
- Trial name
- NCT00108992
- Testing
- Diclofenac, topical
- Where
- 22 sites in United States
- Volunteers
- 750 people
- Sponsor
- Nuvo Research Inc.
Painful Osteoarthritis of the Knee
A Study of the Efficacy and Safety of MEDI7352 in Participants With Painful Osteoarthritis of the Knee
This is a Phase IIb randomised, double-blind, placebo-controlled, dose-response study in participants with painful osteoarthritis (OA) of the knee.
- Trial name
- BESPOKE (NCT04675034)
- Testing
- MEDI7352
- Where
- 41 sites in Denmark, Estonia and 4 more
- Volunteers
- 345 people
- Sponsor
- AstraZeneca
Knee Osteoarthristis
Effect of a Topical Cetylated Fatty Acid Cream on Pain Relief in Patients With Knee Osteoarthritis
This multicenter, randomized, double-blind, placebo-controlled study is designed to evaluate the efficacy and safety of Cetilar® cream in adults with osteoarthritis-related knee pain.
- Trial name
- CETI-KNEE (NCT07745387)
- Testing
- Cetilar® Cream
- Where
- 4 sites in Georgia
- Volunteers
- 156 people
- Sponsor
- Pharmanutra S.p.a.
Osteoarthritis
An Effectiveness and Safety Study of Acetaminophen Extended Release Caplets in the Treatment of Osteoarthritis of the Hip or Knee.
The purpose of this study is to evaluate acetaminophen extended release (3900 mg/day) compared to placebo for safety and effectiveness in the relief of signs and symptoms of osteoarthritis of the hip or knee over 12 weeks
- Trial name
- NCT00240799
- Testing
- acetaminophen extended release
- Volunteers
- 542 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Joint Disease
Post Market Follow-Up Study of the EVOLUTION® Total Knee Arthroplasty System With Cruciate Sacrificing Inserts
MPO is conducting this PMCF study to evaluate the safety and efficacy of its EVOLUTION® Total Knee Arthroplasty (TKA) components marketed in the EU.
- Trial name
- AMETHYST (NCT02351414)
- Testing
- Total Knee Arthroplasty (EVOLUTION®)
- Where
- 5 sites in United States, Belgium and 3 more
- Volunteers
- 150 people
- Sponsor
- MicroPort Orthopedics Inc.
Ankle Sprain, Back Pain
Counterpain PXM Versus Diclofenac Versus Piroxicam
The goal of this clinical trial is to learn if a gel containing Piroxicam plus Counterirritant (warming/cooling ingredients) is as effective and safe as two other common anti-inflammatory gels for treating acute muscle, bone, and…
- Conditions
- Ankle Sprain, Back Pain, Osteoarthritis (OA) of the Knee, Tennis Elbow
- Trial name
- NCT07475663
- Testing
- Piroxicam plus Counterirritant (brand name Counterpain® PXM)., Diclofenac Sodium 10 mg (Brand Name Hotin® DCL), Piroxicam 0.5% (Brand name Pirofel® gel)
- Where
- Indonesia
- Volunteers
- 180 people
- Sponsor
- Taisho Pharmaceutical Indonesia
Osteoarthritis, Knee
A Prospective Study to Evaluate the ConforMIS iTotal® (PS) Knee Replacement System
This is a prospective clinical study designed to observe the long-term clinical outcomes of total knee arthroplasty using a patient-specific, posterior stabilized implant in patients with osteoarthritis.
- Trial name
- NCT03152162
- Testing
- iTotal PS KRS
- Where
- 4 sites in United States
- Volunteers
- 102 people
- Sponsor
- Restor3D
Knee Osteoarthritis
Study on the Use of a Concentrated Growth Factor Preparation Kit for the Treatment of Knee Osteoarthritis
The goal of this clinical trial is to evaluate the effectiveness and safety of an autologous platelet-rich concentrated growth factor (CGF) preparation kit for the treatment of knee osteoarthritis in patients diagnosed with this…
- Trial name
- NCT06869200
- Testing
- Concentrated Growth Factor (CGF) Intra-articular Injection, Platelet-Rich Plasma (PRP) Intra-articular Injection
- Where
- 3 sites in China
- Volunteers
- 104 people
- Sponsor
- Guangdong Hongzhi Health Technology
Osteoarthritis
Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis
This was a multicenter, randomized, double-blind, placebo-controlled Phase IIb study evaluating intra-articular LNA043 in patients with knee osteoarthritis.
- Trial name
- ONWARDS (NCT04864392)
- Testing
- LNA043
- Where
- 75 sites in United States, Argentina and 13 more
- Volunteers
- 576 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis, Knee, Osteoarthritis, Hip
A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform
Post-market prospective, multi-center longitudinal study to determine if mobile application-guided education and exercise paired with accurate and sensitive activity monitoring, captured from consumer wearables, can provide a…
- Trial name
- NCT03737149
- Testing
- mymobility with Apple Watch
- Where
- 30 sites in United States, Australia and 2 more
- Volunteers
- 6,559 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Osteoarthritis, Knee
Post-market Follow up Study of the 'BPK-S Integration' UC as Primary Implant in the Variants CoCr or Ceramic
Prospective Post-Market Clinical Follow up study according to MEDDEV 2.12/2 rev2 of the European Union. Patients receiving the primary knee implant BPK-S UC as primary implant in either variant ceramic or CoCr (metal) are…
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Joint Instability, Arthritis
- Trial name
- NCT03293719
- Testing
- BPK-S Integration UC
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Peter Brehm GmbH
Osteoarthritis, Knee
Evaluation of GW406381 in Treating Adults With Osteoarthritis Of The Knee
This study was designed to evaluate the effectiveness of GW406381 (a COX-2 inhibitor) in treating the signs and symptoms of osteoarthritis of the knee.
- Trial name
- NCT00120900
- Testing
- GW406381
- Where
- 19 sites in Denmark, Netherlands and 4 more
- Volunteers
- 1,340 people
- Sponsor
- GlaxoSmithKline
Osteoarthritis of the Knee
Safety, Tolerability, and Efficacy of IA Verapamil in the Treatment of Joint Pain in Subjects With Osteoarthritis of the Knee
This is a randomized, double-blind, placebo-controlled, multi-center study to evaluate the safety, tolerability, and efficacy of Intra-Articular (IA) verapamil in the treatment of joint pain in patients with knee osteoarthritis…
- Trial name
- NCT01645709
- Testing
- Verapamil
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Calosyn Pharma, Inc.
Pain, Osteoarthritis, Hip
Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee
This clinical trial tests the pain relieving effectiveness of OROS hydromorphone, a once-daily formulation of a strong opioid against placebo in patients, who are suffering from pain due to osteoarthritis of the hip or the knee…
- Conditions
- Pain, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT00980798
- Testing
- OROS hydromorphone HCl
- Where
- 12 sites in Czechia, Romania and 2 more
- Volunteers
- 288 people
- Sponsor
- Janssen-Cilag International NV
Osteoarthritis, Knee
nCap Pain Relief Patch vs. Placebo
The purpose of this study is to determine whether use of the nCap Medical Nano-Capacitive pain relief patch reduces subject pain as measured by subject pain scores, WOMAC scores (pain, stiffness and physical function), global…
- Trial name
- NCT04753567
- Testing
- nCap pain relief patch
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- nCap Medical
Knee Osteoarthritis, Osteoarthritis of the Knee
Postmarketing Multicenter Study of Intra-Articular DIART ONE / EASYGO ONE for Knee Osteoarthritis
This study looked at how safe and effective a hyaluronic acid-based injection (called DIART ONE or EASYGO ONE) is for people with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Osteoarthritis of the Knee, Degenerative Joint Disease
- Trial name
- NCT06927934
- Where
- Ukraine
- Volunteers
- 55 people
- Sponsor
- Yuria-Pharm
Osteoarthritis, Knee
Efficacy of UniRelieverTM Offloading Brace in the Management of Knee Osteoarthritis
The objective of this study is to assess the efficacy and performance of a new semi-rigid offloading brace in the management of knee osteoarthritis.
- Trial name
- UNIBRACE (NCT05905809)
- Testing
- UniRelieverTM offloading brace (THUASNE), Unloader One® X brace (Össur)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Thuasne
Osteoarthritis of the Knee
VISIONAIRE™ Value Study
This is a single center randomized observational study that evaluates the cost benefit ratio between the use of two types of instrumentation in TKA: standard instrumentation vs. VISIONAIRE™ Patient Matched Technology.
- Trial name
- NCT01107769
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Revision Arthroplasty
Pro Osteon Bone Void Filler Study
This study was designed to observe the outcomes of Pro Osteon according to its cleared indications for use.
- Trial name
- PO (NCT00858598)
- Sponsor
- Zimmer Biomet
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