Clinical trials: LPS
Pit and Fissure Sealant
Retention of Flowable Resin With Sprg and of a Flowable Resin in First Permanent Molars
Objective: Determine which of the two sealants has better retention during the periods of 6, 9 and 12 months, one based on flowable resin with sprg or the other only based on flowable resin and we have the following hypothesis…
- Trial name
- NCT04701294
- Testing
- Giomer Beautifil flow plusF03 Shofu-Japan, Tetric N flow ivoclar vivadent-Germany
- Where
- Peru
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Catherine Christie Ruiz Yasuda
Endotoxemia
The Effects of Acetylsalicylic Acid on Immunoparalysis Following Human Endotoxemia
Rationale: The last years, research focus has moved to immunostimulatory agents in order to restore or increase the functionality of the immune system during sepsis-induced immunoparalysis.
- Trial name
- SALYCENDO (NCT02922673)
- Testing
- Aspirin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Arthritis, Rheumatoid
Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy Subjects
This exploratory study aims to assess exposure of healthy subjects to systemic challenge with either LPS or GM-CSF. This will be done by measuring inflammatory mediators and cellular activation markers both in circulation and in…
- Trial name
- NCT03306589
- Testing
- Cantharidin, Lipopolysaccharide, Granulocyte-Macrophage Colony-Stimulating Factor
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Imparied Retinal Vascular Reactivity, Healthy Subjects
Effect of Retaron® on Oxygen Induced Retinal Vasoconstriction in LPS Induced Inflammatory Model in Humans
Oxidative stress has been implicated to play a pathogenic role in many disease processes, especially in age-related disorders such as age-related macular degeneration.
- Trial name
- NCT02221089
- Testing
- Escherichia coli Endotoxin, Retaron®
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Chronic Respiratory Diseases
Intestinal Microbiota in COPD and Asthma
The composition of the intestinal microbiota, the level of lipopolysaccharides, TMAO in the blood, and other parameters of patients with COPD (n=50), asthma (n=50) and the control (n=40) will be assessed as factors associated…
- Trial name
- MicrObAs (NCT04802317)
- Testing
- Identification of the composition of the intestinal microbiota
- Where
- Russia
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Pit and Fissure Sealant
Clinical Efficiency of Bioactive Pit and Fissure Sealant
This study will compare the performance of newly introduced bioactive resin based pits and fissure sealant versus fluoride releasing filled resin based pits and fissure sealant in posterior molars prone to carious lesions of…
- Trial name
- NCT06493942
- Testing
- BioCoat® by Premier®, UltraSeal XT™ plus by Ultradent
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endotoxemia
Ticagrelor in Human Endotoxemia Response to Human Endotoxemia
Rationale: In patients suffering a myocardial infarction the P2Y12 receptor antagonists prasugrel and ticagrelor improve outcome and prognosis compared to clopidogrel.
- Trial name
- NCT02612480
- Testing
- ticagrelor, Clopidogrel, Acetylsalicylic acid lysinate
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cardiovascular Disease, Inflammation
Dose Response Effects of Marine Omega-3 Fatty Acids on Inflammation
The purpose of this study is to determine the lowest effective dose of EPA + DHA (300, 600, 900 and 1,800 mg/day delivered as fish oil supplements) that significantly attenuates the inflammatory response to in vivo and ex vivo…
- Trial name
- NCT01078909
- Testing
- Eicosapentaenoic Acid and Docosahexaenoic Acid (EPA + DHA)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Penn State University
Healthy
Nitric Oxide, LPS and the Pathogenesis of Asthma Phase II
The purpose of the study is to determine the role of nitric oxide (NO) in asthma and to characterize the symptoms associated with inhaled endotoxin (lipopolysaccharide [LPS]) in normal subjects.
- Trial name
- NCT00643058
- Testing
- LPS endotoxin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- John Sundy
Healthy Volunteers
Adrecizumab-LPS Study
In this randomized, double-blind, placebo-controlled study, either a single dose of Adrecizumab (0.5, 2.0 or 8.0 mg/kg) or placebo will be administrated to 24 healthy male volunteers during experimental endotoxemia.
- Trial name
- NCT03083171
- Testing
- Endotoxin, Adrecizumab
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Adrenomed AG
Influenza, Human
Effects of p38 MAPK Inhibitor POLB 001 on in Vivo LPS Challenge Responses
A single center trial to evaluate the effect of POLB 001 on inflammatory responses following an intradermal LPS challenge in healthy volunteers.
- Trial name
- NCT05765955
- Testing
- POLB 001
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Poolbeg Pharma plc
Parkinson's Disease
Evaluation of a Biomarker Related to the GI Tract for the Diagnosis of Parkinson's Disease
The cause of Parkinson's disease (PD) is currently unknown. Both environmental and genetic factors have been found to contribute to PD pathogenesis.
- Trial name
- NCT01904240
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Endotoxemia
The Role of Dietary Fat on Postprandial Endotoxemia in Healthy Adults
The purpose of this study was to determine the effect of different dietary fats (saturated or unsaturated) on postprandial endotoxemia and systemic low grade acute inflammation.
- Trial name
- NCT02521779
- Testing
- Low-fat Treatment Meal, Saturated-fat Treatment Meal, N-3 fat Treatment Meal
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Skin Infection
Skin Inflammation and PK of Azithromycin
This study will investigate the tissue distribution of azithromycin in healthy, artificially inflamed and actually infected tissue of humans.
- Trial name
- AZI_IMQ_LPS (NCT06170983)
- Testing
- Azithromycin, Biopsy, Skin inflammation model
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Insomnia, Sleeplessness
Evaluation of Vestibular Stimulation to Help Occasional Sleeplessness
The purpose of this study is to determine whether a small electrical current to the vestibular nerve (balance organ) will decrease the time it take for participants to fall asleep.
- Conditions
- Insomnia, Sleeplessness, Transient Insomnia
- Trial name
- VSOM (NCT00594022)
- Testing
- Electric stimulation of the Vestibular Nerve - "VirtuSom"
- Where
- 6 sites in United States
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Philips Respironics
Lupus Nephritis
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear
To determine the mechanisms and significances of synergistic effects of mycophenolic acid and LPS on IL-1β secretion by mononuclear
- Trial name
- NCT02435368
- Testing
- mycophenolic acid
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated Hospital of Southern Medical University
Inflammation Biomarkers, Inflammation
Individual Differences in Acute Response to Experimental Inflammation: Microcirculatory Changes and Psychological Predictors
The physiological and behavioral responses to inflammatory vary greatly between individuals. The knowlegde about what causes these differences is sparse but plausible explanations are variations in sensitivity to peripheral…
- Trial name
- NCT06618716
- Testing
- endotoxin escherichia coli (E. coli) lipopolysaccharide (LPS), Placcebo
- Where
- Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Immobilization, Tonic, Fasting
A New Model of Acute Febrile Disease
The investigators want to establish a new model of acute febrile disease by mimicking the conditions seen in hospitalized patients in regards to inflammation, immobilisation and fasting.
- Conditions
- Immobilization, Tonic, Fasting, Endotoxemia, Metabolism
- Trial name
- NCT03158363
- Testing
- LPS, 36 hour immobilization and fast
- Where
- Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypersensitive, Molar Incisor Hypomineralization
Effect of Glass-Ionomer Sealing Technique on Hypersensitive Teeth With Molar Incisor Hypomineralisation
This single armed cohort study is aimed to assess the acceptance, durability and efficiency of glass-Ionomer sealing technique on hypersensitive MIH molars (TNI-3 \& 4a/b/c) clinically shortly (15 minutes) after the application…
- Conditions
- Hypersensitive, Molar Incisor Hypomineralization, Pit and Fissure Sealants
- Trial name
- MIH_GIC (NCT05945381)
- Testing
- GIC on MIH
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Healthy
PH-797804 LPS Study in Healthy Volunteers
The study was performed to assess the effect of PH-797804 on neutrophils (white cells) in the sputum after a challenge with an endotoxin (inhaled LPS).
- Trial name
- NCT02084485
- Testing
- PH-797804
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer