Clinical trials: Labor, Obstetric
Very Preterm Maturity of Infant
Prematurity at the Limit of Viability
Advancements in perinatal care have significantly improved the survival of extremely premature infants, establishing a viability threshold below 25 weeks' gestational age (GA).
- Trial name
- PRELIVIA (NCT06391476)
- Testing
- Study of the evolution of a cohort of children born between 22 and 25 weeks gestational age
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Motor Disorders, Neurodevelopmental Disorders
Neuromotor Development and Motor Related Health Care in Children with a High Risk Neonatal Period
The overall aim of the study is to evaluate the prevalence of motor- and neurological disorders (cerebral pares and other less severe motor disorders) in Swedish infants with a high-risk neonatal period and to elucidate whether…
- Conditions
- Motor Disorders, Neurodevelopmental Disorders, Premature Birth, Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT06645717
- Volunteers
- 2,900 people
- Sponsor
- Karolinska Institutet
Prematurity, Vaccination
Babies Born Early Antibody Response to Men B Vaccination: BEAR Men B
In the UK, babies receive their vaccinations according to a standard schedule, irrespective of their gestation at birth. This policy is designed so that all babies are protected as early as possible from vaccine preventable…
- Conditions
- Prematurity, Vaccination, Meningococcal Disease
- Trial name
- BEAR Men B (NCT03125616)
- Testing
- 4CMenB Vaccine
- Where
- United Kingdom
- Volunteers
- 136 people
- Sponsor
- St George's, University of London
Preterm Pregnancy, Premature Birth
Optimizing Family Counseling for Anticipated Extremely Preterm Delivery
Antenatal family counseling for anticipated extremely preterm deliveries remains ethically and practically challenging for maternal-fetal medicine specialists and neonatologists alike.
- Trial name
- NCT03819933
- Testing
- Educational intervention
- Where
- 3 sites in United States
- Volunteers
- 460 people
- Sponsor
- Boston Children's Hospital
Prematurity
Automatic Oxygen Control for Reducing Extremes of Oxygen Saturation (AreOS): A Randomised Control Trial
Oxygen treatment is common in babies born early (preterm) and requiring intensive care. Having too much or too little oxygen can increase the risk of damage to the eyes and lungs, and contribute to death or disability.
- Trial name
- AreOS (NCT04223258)
- Testing
- Automatic Oxygen control, Manual Oxygen Control
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Postpartum Hemorrhage
Efficacy of Oxytocin vs. Carbetocin in Prevention of Postpartum Hemorrhage After Cesarean Section
Postpartum hemorrhage (PPH) is a common complication of childbirth and a leading cause of maternal morbidity and mortality. The prompt and effective treatment of subjects with PPH would reduce operation risks.
- Trial name
- NCT02079558
- Testing
- Carbetocin, Oxytocin
- Where
- Iran
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Preterm Birth, Short Cervix
Cerclage With Progesterone Versus Progesterone Only in Singleton Pregnancies
This study compares the effectiveness of cervical cerclage with vaginal progesterone to vaginal progesterone only for the prevention of preterm birth in women with a singleton pregnancy and a short cervical length.
- Trial name
- RESILIENT (NCT06463652)
- Testing
- Cervical cerclage, Vaginal progesterone
- Where
- Vietnam
- Volunteers
- 328 people
- Sponsor
- Mỹ Đức Hospital
Preeclampsia, Severe Preeclampsia
First-trimester Prediction of Preeclampsia
Preeclampsia is a complication of pregnancy related to adverse maternal and neonatal outcomes, including fetal growth restriction and perinatal death.
- Conditions
- Preeclampsia, Severe Preeclampsia, Fetal Growth Restriction, Preterm Birth
- Trial name
- PREDICTION (NCT02189148)
- Where
- 4 sites in Canada
- Volunteers
- 7,554 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Pregnancy, Premature Birth
Prevention of Recurrent Preterm Delivery by a Natural Progesterone Agent
To examine the preterm delivery rate of a preterm delivery high risk group of pregnant women, using once daily natural progesterone agent.
- Trial name
- NCT00329316
- Testing
- Crinone Gel 8%
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Neurologic Manifestations, Premature Birth
The Neu-Prem Trial: Neuromonitoring of Preterm Newborn Brain During Birth Resuscitation
The purpose of this study is to characterize the normal brain function of premature infants (23 to 31+6 weeks GA) during birth transition and through the first 72 hours of life.
- Conditions
- Neurologic Manifestations, Premature Birth, Hypoxia-Ischemia, Brain
- Trial name
- Neu-Prem (NCT02605733)
- Testing
- EEG, NIRS
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Sharp HealthCare
Lung Diseases, Bronchopulmonary Dysplasia
Prolonged Outcomes After Nitric Oxide (PrONOx)
The purpose of this study is to look at the long term consequences of prematurity in infants treated with inhaled nitric oxide (iNO) while in the neonatal intensive care unit.
- Conditions
- Lung Diseases, Bronchopulmonary Dysplasia, Premature Birth, Developmental Disabilities
- Trial name
- NCT00234247
- Testing
- Long Term Follow-Up
- Volunteers
- 652 people
- Sponsor
- University of Pittsburgh
Pregnancy, Respiratory Distress Syndrome
Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial
This is a randomized placebo controlled trial to evaluate whether antenatal corticosteroids can decrease the rate of neonatal respiratory support, thus decreasing the rate of NICU admissions and improving short-term outcomes in…
- Conditions
- Pregnancy, Respiratory Distress Syndrome, Pregnancy Outcomes, Preterm Birth
- Trial name
- ALPS (NCT01222247)
- Testing
- Betamethasone
- Where
- 17 sites in United States
- Volunteers
- 2,831 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Extreme Prematurity
Stockholm Preterm Interaction-Based Intervention
Extreme premature Children will at discharge from Karolinska Hospital and Södersjukhuset in Stockholm be asked to participate in a study, examining the effects of a home-visit based post-discharge program aiming at facilitating…
- Trial name
- SPIBI (NCT03714633)
- Testing
- Stockholm Preterm Interaction-Based Intervention (SPIBI)
- Where
- 5 sites in Sweden
- Volunteers
- 130 people
- Sponsor
- Stockholm University
Preterm Infant, Mothers
GP_Posit Intervention for Mothers of Preterm Infants for Maternal Sensitivity : Randomized Pilot Trial
The aim of this study is to evaluate the acceptability, feasibility and preliminary effects a GP_Posit intervention. GP_Posit is an intervention where mothers will learn how to participated in their preterm infant's care and…
- Conditions
- Preterm Infant, Mothers, Parent-Child Relations, Child Development
- Trial name
- GP_Posit (NCT03677752)
- Testing
- GP_Posit
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC) is supported by National Key Research and Development Program of China - Reproductive Health and Women's and Children's Health Protection…
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition, Pre-Term, Pre-Eclampsia
- Trial name
- ChiTwiMC (NCT06414655)
- Where
- 11 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Preterm Birth
Vaginal Progesterone for Prevention of Preterm Birth After an Episode of Preterm Labor
The investigators study objective is to investigate the effectiveness of vaginal micronized progesterone in prolonging pregnancy after an episode of preterm labor which responded to tocolytic treatment.
- Trial name
- NCT01523483
- Testing
- Progesterone
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Prematurity, Neurodevelopmental Disorders
Prevention of Developmental Delay and Xylitol (PDDaX) Study
The goals of this study are to: evaluate and validate the low-cost, transportable, easily-administered Malawi Developmental Assessment Tool (MDAT) for neurodevelopmental assessment of children aged 4-8 years old in Malawi, as…
- Trial name
- NCT05361122
- Testing
- Maternal Use of Xylitol Chewing Gum During Pregnancy, No Maternal Xylitol Chewing Gum Use During Pregnancy
- Where
- Malawi
- Volunteers
- 1,000 people
- Sponsor
- University of Washington
Breech Presentation
Cephalic Version by Acupuncture for Breech Presentation
We want to study the efficiency of acupuncture for cephalic version of breech presentation during pregnancy. Several randomized studies show that acupuncture may be useful in version of breech presentation, but none with a sham.
- Trial name
- NCT00813683
- Testing
- Acupuncture stimulation
- Where
- France
- Volunteers
- 259 people
- Sponsor
- University Hospital, Strasbourg, France
Morbidly Adherent Placenta, Placenta Accreta
Delivery Timing in Morbidly Adherent Placentas: a Randomized, Controlled Trial
This is a randomized controlled trial to investigate the optimal timing of delivery in clinically stable women with a suspected morbidly adherent placenta.
- Trial name
- MAP (NCT02635412)
- Testing
- Scheduled timing of delivery
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Prematurity; Decision Support
Decision Aid - Extreme Prematurity
The purpose of this study is to assess in a pilot randomized controlled trial the following PICOT question: In parents facing extreme premature delivery, does the use of an existing validated visual decision aid as compared to…
- Trial name
- NCT01713894
- Testing
- Decision Aid, Standard
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
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