Clinical trials: Labor Epidural Analgesia
Postpartum Depression (PPD)
Intranasal Dexmedetomidine for Postpartum Depression Prevention
Brief Title: Intranasal Dexmedetomidine for Postpartum Depression Prevention: A Randomized Trial This study aims to evaluate the effect of intranasal dexmedetomidine (Dex) administered before combined spinal-epidural labor…
- Trial name
- NCT07501728
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Chengdu Jinjiang Maternity and Child Health Hospital
Labor Long, Labor Pain
Comparison of Combined Spinal-epidural Analgesia Versus Epidural Analgesia for Pain Management During Labor
The investigators want to compare the safety and efficacy between the combined spinal-epidural analgesia and epidural analgesia during labor.
- Conditions
- Labor Long, Labor Pain, Labor Fetal Anoxia
- Trial name
- NCT03600272
- Testing
- Combined spinal-epidural analgesia, Epidural analgesia
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Deng Dongrui
Labor Pain
Epidural Analgesia in Different Cervix Diameter and the Rate of Cesarean Delivery
Epidural analgesia in the early stage of labor at cervix < 4.0cm was considered as a risk period for increasing the rate of cesarean delivery.
- Trial name
- EACDRCD (NCT00677274)
- Testing
- Epidural labor analgesia
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Nanjing Medical University
Labor Pain
Analgesic Efficacy of a Multiport Versus Uniport Flexible Catheter for Labor Epidural Analgesia
The purpose of this study is to determine whether multiple ports improve the analgesic efficacy of flexible catheters used for the provision of epidural analgesia during the entire continuum of labor and delivery
- Trial name
- NCT01861821
- Testing
- Multiport flexible catheter, Uniport flexible catheter
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- Baylor Research Institute
Labor Pain
3 Simple Questions to Predict Labor Pain and Epidural Analgesia Use in Parturients
Labor pain is complex to understand and challenging to define because of the interaction of multiple maternal and fetal factors.
- Trial name
- NCT02824302
- Testing
- Survey
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Labor Pain
Intermittent Automated Devices for Labor Analgesia in Emilia Romagna
The study aims to determine whether the use of automated intermittent devices for labor analgesia could prevent the increase of instrumental deliveries, with same analgesia.
- Trial name
- PA-RER (NCT02710877)
- Testing
- Programmed Intermittent bolus, Manual epidural bolus, Levobupivacaine
- Where
- 3 sites in Italy
- Volunteers
- 671 people
- Sponsor
- University of Modena and Reggio Emilia
Labor Onset and Length Abnormalities
Goal-directed Labor Epidural Analgesia Maintenance
The GLEAM trial is a multicenter, pragmatic, cluster-randomized trial to assess the effects of programmed intermittent epidural bolus versus continuous epidural infusion on the rate of spontaneous vaginal delivery and several…
- Trial name
- GLEAM (NCT05255263)
- Testing
- PIEB, CEI
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Labor Pain, Pain
The Effects of Intermittent Epidural Bolus on Fever During Labor Analgesia
Epidural analgesia is associated with maternal intra-partum fever during labor. Intermittent epidural injections appear to reduce the incidence of maternal intra-partum fever compared to continuous epidural infusion during labor…
- Conditions
- Labor Pain, Pain, Neurologic Manifestations, Signs and Symptoms
- Trial name
- EIEBFLA (NCT01708668)
- Testing
- Epidural analgesia, Combined spinal-epidural analgesia, Continuous epidural infusion
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- ShanWu Feng, M.D.
Gestational Diabetes Mellitus in Pregnancy, Diet- Controlled
Maternal Glucose, Cortisol, and Neonatal Outcomes With and Without GDM
This study will compare maternal blood glucose and cortisol responses and neonatal outcomes between women with gestational diabetes mellitus and women without gestational diabetes mellitus who receive epidural analgesia during…
- Trial name
- NCT07870629
- Where
- 3 sites in Vietnam
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Hanoi Medical University
Labor Pain
Usefulness of the Tsui Test in Combined Spinal-Epidural Analgesia in Labour
Combined spinal epidural anesthesia (CSE) is a very effective technique to provide labor analgesia. One of the disadvantages of this technique is the delay in recognizing an error in the position of the epidural catheter because…
- Trial name
- NCT00464841
- Testing
- Combined spinal epidural, Tsui Test for intrathecal catheter
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Labor Pain
Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor: Comparing 125 mL/h Versus 250 mL/h Bolus Delivery Flow
At Mount Sinai Hospital, epidural analgesia for labor pain is delivered by programmed intermittent epidural bolus (PIEB), in combination with pushes of medication activated by the patient, a technique called patient controlled…
- Trial name
- NCT03236298
- Testing
- CADD-Solis Ambulatory Infusion System
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Depression, Postpartum, Pregnancy
Labor Pain and Postpartum Behavioral Health Outcomes Study
In this pilot prospective longitudinal observational study, women who are pregnant and who will be experiencing childbirth for the first time will be recruited at the third trimester and observed longitudinally for psychiatric…
- Conditions
- Depression, Postpartum, Pregnancy, Child Development, Pain
- Trial name
- LPPD (NCT02692404)
- Where
- 2 sites in United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Labor Pain
Initiation Ropivacaine Dose for Labor Analgesia Via Double Dural Puncture Epidural Technique
This study aims to determine the 90% effective dose (ED₉₀) of an initial regimen of 0.1% ropivacaine combined with 0.3 μg/mL sufentanil, administered via the double dural puncture epidural technique for epidural labor analgesia.
- Trial name
- NCT07882004
- Testing
- 0.1% Ropivacaine
- Volunteers
- 30 people
- Sponsor
- General Hospital of Ningxia Medical University
Labor Pain
Determination of the Optimal "Next Bolus" Interval for Programmed Intermittent Bolus Epidural Analgesia
The current standard of practice for the maintenance of epidural analgesia is through use of a continuous infusion pump. Enhanced technology now supports the use of programmed intermittent bolus (PIEB) administration.
- Trial name
- NCT03044392
- Testing
- Next Bolus Interval
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Labor Pain
Comparison of Epidural Fentanyl and Clonidine for Breakthrough Pain
Epidural analgesia has proven to be an effective method for severe pain relief associated with labor and delivery. During labor, a low dose continuous infusion of local anesthetic and narcotic will be administered through an…
- Trial name
- NCT01846221
- Testing
- Clonidine, Fentanyl
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Columbia University
Labor Pain
CSE for Labour Analgesia: A Comparison of Two Intrathecal Regimens
Analgesia in labour is not readily available in many parts of Sub-Saharan Africa. The overall cost of Epidural services in terms of human personnel and financial implication makes this inaccessible to many women in labour.
- Trial name
- SSS (NCT03117595)
- Testing
- Bupivacaine-fentanyl, Bupivacaine-fentanyl morphine
- Where
- Nigeria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sarah Beckley
Anesthesia
Magnesium for Shivering in Epidural Lidocaine Deliveries
Magnesium has been shown to decrease the shivering experienced from neuraxial anesthesia. This study aims to investigate whether magnesium decreases the shivering experienced in parturients undergoing labor epidural anesthesia…
- Trial name
- Mag-SHIELD (NCT03439358)
- Testing
- Magnesium Sulfate, Normal Saline
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Maternal Hypotension, Labor Epidural Analgesia
Maternal and Fetal Clinical Significance of Hypotension Following Labor Epidural Analgesia
The goal of this study is to learn how often blood pressure drops after an epidural for labor and how these drops may affect the parent and the baby.
- Conditions
- Maternal Hypotension, Labor Epidural Analgesia, Fetal Heart Rate Abnormalities
- Trial name
- NCT07272018
- Testing
- Epidural Analgesia (Standard Clinical Care)
- Volunteers
- 480 people
- Sponsor
- The Chaim Sheba Medical Center
Anesthesia Complications
Effect of Sufentanil and Ropivacaine
The investigators study the efficacy of epidural sufentanil/ropivacaine for analgesia labor in primiparas so as to decrease perinatal complications of analgesia labor.
- Trial name
- NCT02488291
- Testing
- 0.25 sufentanil, 0.5µg/ml sufentanil, 0.1% ropivacaine
- Volunteers
- 120 people
- Sponsor
- Fudan University
Labor Pain
The Effect of Metrics Based Performance Based Progression in Provision of Labor Epidural Analgesia
Procedural skills are an important determinant of clinical outcomes for certain patient groups. Training for procedural skills in the medical profession is still largely based on an apprenticeship model.
- Trial name
- NCT02185079
- Testing
- Training to proficiency, Conventional training
- Where
- Ireland
- Volunteers
- 16 people
- Sponsor
- Cork University Hospital