Clinical trials: Labor and Delivery Complication
Postpartum Hemorrhage
Retrospective Evaluation of the Impact of Epidural on the Risk of Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is a major complication of childbirth. Epidurals are often implicated in the onset of postpartum hemorrhages.
- Trial name
- NCT06816654
- Testing
- Data extraction from medical records
- Where
- Belgium
- Volunteers
- 5,753 people
- Sponsor
- Tatiana Besse-Hammer
Puerperal Sepsis, Postpartum Hemorrhage
Assessing Childbirth-related Complications at the Community Level in Kenya
Kenya is one of the countries in sub-Saharan Africa that still experience high maternal mortality. For instance, in 2008/09 maternal mortality ratio was estimated to be 488/100,000 live births.
- Conditions
- Puerperal Sepsis, Postpartum Hemorrhage, Preeclampsia and Eclampsia, Retained Placenta, Without Hemorrhage
- Trial name
- NCT01665456
- Where
- Kenya
- Volunteers
- 585 people, healthy volunteers welcome
- Sponsor
- Wilson Liambila
Doula Support, Postpartum
The Goal is to Examine the Impact of Doula-delivered, Nurse-coordinated Postpartum Care Among Individuals With Preterm Births <34 Weeks' Gestation Requiring NICU Admission.
The primary objective of this research is to conduct a randomized clinical trial to examine the impact of nurse-coordinated, doula-delivered postpartum support (intervention arm) on postpartum health care utilization, health…
- Conditions
- Doula Support, Postpartum, Postpartum Depression (PPD), Postpartum Anemia
- Trial name
- NEST (NCT07787845)
- Testing
- Doula-delivered, Nurse-coordinated postpartum support
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of South Carolina
Prematurity, Extreme Prematurity
Early Intervention Based on Neonatal Crawling in Very Premature Infants at Risk For Neurodevelopmental Disorder
Extreme prematurity is constantly increasing according to the World Health Organization. However, methods to train premature infants at risk of disability is sorely lacking. The goal of this project is to overcome this problem.
- Conditions
- Prematurity, Extreme Prematurity, Infant Development, Brain Damage
- Trial name
- Premalocom2 (NCT06027645)
- Testing
- Crawling stimulation with a mini-skateboard (i.e. the crawliskate)
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Marianne Barbu-Roth
Preeclampsia, Gestational Hypertension
Serum Vasohibin, Cardiotrophin, Endocan & Perinatal Outcomes
Investigation of the relationship between maternal serum vasohibin-1, vasohibin-2, cardiotrophin -1 and endocan concentrations at the 11th and 14th weeks of gestation and adverse perinatal outcomes.
- Conditions
- Preeclampsia, Gestational Hypertension, Gestational Diabetes, Preterm Birth
- Trial name
- NCT06416995
- Testing
- first trimester serum diagnostic test
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Umraniye Education and Research Hospital
Feeding Intolerance
Preterm Neonatal Feeding Protocol Comparing Feed Administration Time
Doctors have tried many different methods of feeding to try to decrease feeding intolerance in preterm babies so that they spend less time receiving liquid nutrition and have fewer problems with feeding intolerance.
- Trial name
- NCT00997854
- Testing
- Length of time for feed administration
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Prematurity, Very Low Birth Weight
Impact of Sex and Own Mother's Milk Pasteurization on Morbidity and Mortality of Very Low Birth Weight Infants
In very low birth weight (<1500g) preterm infants, nutrition with mother's own milk, as opposed to formula, is associated with reduced morbidity and mortality.
- Trial name
- G-PAMINEO (NCT07411872)
- Where
- Germany
- Volunteers
- 900 people
- Sponsor
- Charite University, Berlin, Germany
Prematurity; Extreme
Assessment of Renal Function in Adults Born Preterm: The HAPI-Kidney Study
Every year in Canada, 1500 babies are born ≤29 weeks' gestational age (GA) and the majority survive to adulthood. Preterm birth occurs during a critical period of nephrogenesis.
- Trial name
- NCT04735315
- Testing
- Preterm birth
- Where
- Canada
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Prolonged Labor, Labor Dystocia
Efficacy of Bicarbonate on the Risk of Assisted Delivery in Nulliparous Women With Prolonged Labour
The goal of this clinical trial is to learn if oral bicarbonate can treat prolonged labour in nulliparous women with prolonged labour.
- Trial name
- ProLabour (NCT07321379)
- Testing
- Sodium bicarbonate
- Where
- 3 sites in Denmark
- Volunteers
- 1,520 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Preterm Birth, Premature
Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns
Infants in the neonatal intensive care unit (NICU) may be lost due to risks such as being sensitive, frequent exposure to birth complications and being prone to infection.
- Conditions
- Preterm Birth, Premature, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- therapy (NCT05036603)
- Testing
- chest physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sanko University
Prematurity, Anemia
Transfusions and Nitric Oxide Level in Preterm Infants
The purpose of this study is to better understand S-nitrosohemeglobin (SNO-Hb) in transfused blood of extremely preterm infants.
- Conditions
- Prematurity, Anemia, Necrotizing Enterocolitis
- Trial name
- NCT00787124
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Duke University
Premature Birth
Using Nasal High Flow From Birth in Premature Infants - a Pilot Study
Recent large studies have shown that not all premature babies need to be intubated (have a breathing tube inserted) and ventilated, nor do they all need to be given lung surfactant routinely.
- Trial name
- NCT01991886
- Testing
- Vapotherm Precision Flow
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Ashford and St. Peter's Hospitals NHS Trust
Mental Health Wellness 1, Premature Birth
Fathers and Partners in Family Integrated Care Study
AIMS: The primary aim is to investigate the impact of enhancing father/partner engagement in FICare of preterm infants on their mental health (MH) up to 6 weeks post discharge.
- Trial name
- TARGET (NCT06022991)
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Homerton University Hospital NHS Foundation Trust
Placenta Previa, Post Partum Hemorrhage
Glove-loaded Foley's Catheter Tamponade for Cesarean Section for Placenta Previa
Objective: To investigate the effect of A glove-loaded Foley's catheter tamponade versus stepwise uterine devascularization on blood loss during cesarean section (CS) in patients with complete placenta previa.
- Trial name
- NCT03570723
- Testing
- A glove-loaded Foley's catheter tamponade, stepwise uterine devascularization
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Aswan University Hospital
Infant, Premature, Infants, Extremely Premature
The Alberta BLOOM Preterm Neonate Study
This is a prospective, observational clinical cohort study involving 100 mothers and their very preterm infants born at less than 32 weeks gestation.
- Conditions
- Infant, Premature, Infants, Extremely Premature, Microbiota, Gastrointestinal Microbiome
- Trial name
- BLOOM-PTN (NCT03840980)
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- University of Calgary
Preterm Delivery, Neonatal Complications
Progestagens for the Tertiary Prophylaxis of Preterm Delivery
Objective: This trial would evaluate the clinical effectiveness of Progesterone(P) and 17-hydroxy Progesterone (17P) in reducing PTD, in symptomatic women at risk because of cervical shortening, in the present pregnancy.
- Trial name
- PROTECT (NCT01178788)
- Testing
- 17 alpha-hydroxy progesterone caproate, micronized Progesterone, Control
- Where
- Italy
- Volunteers
- 254 people
- Sponsor
- University of Modena and Reggio Emilia
BPD - Bronchopulmonary Dysplasia
Safety and Efficacy of Umbilical Cord-derived Mesenchymal Stem Cell(MSC) Transplantation in the Treatment of Bronchopulmonary Dysplasia(BPD) in Premature Infants
Bronchopulmonary dysplasia (BPD) is a chronic lung disease, which is a major complication of very low and ultra-low preterm infants.
- Trial name
- MSC，BPD (NCT06788470)
- Testing
- MSC
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Enteral Feeding
Effect of Feed Warming Method on Feeding Tolerance in the Preterm Infant Born at Less Than 30 Weeks Gestation
The temperature of milk fed to infants in the Neonatal Intensive Care Unit (NICU) has been shown to vary greatly, and is influenced by individual provider practice.
- Trial name
- NCT02034903
- Testing
- Feedings warmed with commercial warmer
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Advocate Center for Pediatric Research
Premature Birth, Obstetric Labor, Premature
Family Nurture Intervention in the NICU
The purpose of this study is to compare neurodevelopment and activity in infants born very preterm (26 to 33 6/7 weeks gestational age (GA)) receiving Standard Care (SC) or Family Nurture Intervention (FNI) in the neonatal…
- Trial name
- NCT02710474
- Testing
- Family Nurture Intervention, Standard Care
- Where
- 2 sites in United States
- Volunteers
- 461 people
- Sponsor
- Columbia University
Prematurity, Feeding Intolerance
Feeding Tolerance in Preterm Infants
Premature infants, especially those less than 1250 gm at birth are extremely difficult to feed. For unknown physiologic reasons oral feeding also called enteral feeding is not well tolerated in these immature babies.
- Trial name
- NCT00450697
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Weill Medical College of Cornell University