Clinical trials: Labour
Epidural Analgesia for Labour and Delivery
M-mode Ultrasonography for Epidural Catheter Identification and Confirmation of Correct Catheter Position
In France, 80% of women choose epidural analgesia for delivery and birth. The localization of the epidural space is classically achieved by loss of resistance to saline.
- Trial name
- ETEMERC (NCT05897814)
- Testing
- Location of the epidural analgesia catheter
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Pain
Minimum Local Anesthetic Volume of Bupivacaine in Labour Epidurals
Different medications can be used as analgesics in labor epidurals. Bupivacaine is one of the most commonly used drugs for that purpose. The efficacy of a certain medication injected epidurally depends on the dose that is given.
- Trial name
- NCT00450099
- Testing
- bupivacaine
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Arrested Labor
Bicarbonate Given During Dystocic Labor
Dystocic deliveries and the use of bicarbonate
- Trial name
- NCT02805387
- Testing
- Treatment
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Preterm Labor
Impact of Suspected Preterm Labour on Cardiometabolic Profile and Neurodevelopment
Suspected preterm labour (SPL), define as the presence of regular and painful uterine contractions and cervical shortening, constitute a prenatal insult with potential long-term consequences.
- Trial name
- SKs (NCT05211297)
- Where
- Spain
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Labor Onset and Length Abnormalities, 37 or More Completed Weeks of Gestation
Comparative Study Between Using WHO Labour Care Guide & Modified WHO Partograph
This randomized clinical trial is based on comparing the efficiency of modified WHO partographs vs. the new WHO labour care guide in monitoring and assessing the outcome of labour.
- Conditions
- Labor Onset and Length Abnormalities, 37 or More Completed Weeks of Gestation, First Birth
- Trial name
- NCT06537089
- Testing
- Supportive care measures, LCG guided labour interference
- Where
- Egypt
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Hend Mahmoud Abdelghany
Induction of Labor
A Randomized Trial of Oral Misoprostol Alone Versus Oral Misoprostol Followed by Oxytocin for Labour Induction
The primary objective of the trial is to assess the following: In women who have undergone cervical preparation with oral misoprostol as part of labour induction for hypertensive disease in India, is augmentation using oral…
- Trial name
- MOLI (NCT03749902)
- Testing
- Oral misoprostol, Oxytocin
- Where
- 3 sites in India
- Volunteers
- 520 people
- Sponsor
- University of Liverpool
Labour Pain
Combined Spinal-Epidural Versus Traditional Labor Epidural
The purpose of this study to compare the use of spinal-epidural versus traditional labor epidural on maternal and fetal effects.
- Trial name
- NCT00151346
- Testing
- Bupivacaine and Fentanyl (for CSE), Bupivacaine and Fentanyl (for traditional epidural)
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Labour
Role of Simulators in Improving Obstetric Vaginal Examination Skills
A prospective study will be performed at the Department of Obstetrics and Gynecology at (VESSALKA unit),at El kasr Al_Ainy hospital, cairo university.
- Trial name
- NCT05190692
- Testing
- Use simulators in Obstetrics vaginal examination
- Where
- 3 sites in Egypt
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pregnancy Overdue - Week 41+6
Can Acupuncture be Used as Preparation for Induction of Labour
The purpose of the study is to evaluate whether acupuncture can be used to ripen cervix before medicinal induction of labor or even be used as method for induction, and thereby eliminating other and more potentially harmful…
- Trial name
- NCT00245752
- Testing
- acupuncture
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital Skejby
Effects of Movement
Upright Position During First Stage of Labour
There are several physiological advantages for being upright during labour. These include the effect of gravity on the fetus within the uterus; reduced risk of aorto-caval compression this maximizes uterine blood flow to the…
- Trial name
- NCT05392660
- Testing
- assumed upright position during first stage of labor
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Pain, Prolonged Labour
Diazepam at the Active Phase of Labor
Prolonged labour can lead to increased maternal and neonatal mortality and morbidity due to increased risks of maternal exhaustion, postpartum haemorrhage and sepsis, fetal distress and asphyxia and requires early detection and…
- Trial name
- NCT02232035
- Testing
- normal saline/diazepam at the active phase of labor
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Navy General Hospital, Beijing
Ultrasonography, Pelvic Floor
Intrapartum Ultrasonography in Labour Arrest
Determination of fetal head position during labour is highly subjective and depends on clinician's experience in vaginal digital examination.
- Conditions
- Ultrasonography, Pelvic Floor, Delivery Complication, Maternal-Fetal Relations
- Trial name
- IPUSGLA (NCT04796155)
- Testing
- Intrapartum ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Hydration
Bioimpedance In Pregnancy and Labour: A Fluid Balance Concept Study.
The purpose of our study is to find out if using a simple bed side test can tell us information about changes that occur in women's body water content.
- Trial name
- BiPAL (NCT03823820)
- Testing
- Bioimpedance Analyser
- Where
- United Kingdom
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Cardiac Arrest, Heart Arrest
Rehabilitation for Survivors of Out-of-hospital Cardiac Arrest
This study is a parallel group multicentre investigator-initiated clinical randomised controlled superiority trial that will include a total of 214 survivors of OHCA.
- Conditions
- Cardiac Arrest, Heart Arrest, Cardiopulmonary Resuscitation, Return to Work
- Trial name
- NCT05173740
- Testing
- Individually tailored rehabilitation intervention, Usual care
- Where
- Denmark
- Volunteers
- 214 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obstetric Labour, Premature, Premature Labor
Absorption, Distribution, Metabolism And Excretion Study For GSK221149A
This is a phase one study investigating the absorption, distribution, metabolism and excretion of GSK221149A in six healthy women of non-child bearing potential.
- Trial name
- NCT00457925
- Testing
- GSK221149A
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Perineal Tear
Effectiveness of Warm Packs, Perineal Massage and Hands Off During Labour in the Perineal Outcomes.
This study evaluates the effectiveness of warm packs, perineal massage and hands off, during labour, in the perineal outcomes. The perineal outcomes are perineal tears, grade of perineal tears, need of suture, perineal edema…
- Trial name
- NCT02588508
- Testing
- Warm packs, Perineal massage
- Where
- Brazil
- Volunteers
- 201 people
- Sponsor
- Universidade Federal de Pernambuco
Labor Pain
The Response Patterns to the Electrical Stimulation of Epidural Catheters With Varying Pulse Widths in Term Pregnant Women
Epidural analgesia is commonly used for labor pain relief due to its safety and effectiveness. Despite a very high success rate, the epidural technique remains a somewhat blind technique and failures continue to occur.
- Trial name
- NCT02762149
- Testing
- Nerve stimulator
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Metabolic Acidosis
Value of Fetal Scalp Lactate Sampling During Labour in Cases of Abnormal Fetal Heart Rate
ST-analysis of the foetal ECG (STAN®) is another second line technique for intrapartum foetal monitoring. Combining ST-analysis with standard CTG interpretation aims to identify hypoxic foetuses more accurately than CTG alone.
- Trial name
- NCT05259202
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Labor Pain
A Case Series of VPIA Using Remifentanil for Labour and Delivery
This study is a prospective case series aiming to evaluate a new VPIA remifentanil algorithm which would benefit labouring mothers who are unable or unwilling to receive epidural analgesia.
- Trial name
- VPIA (NCT02122705)
- Testing
- VPIA remifentanil
- Where
- Singapore
- Volunteers
- 29 people
- Sponsor
- KK Women's and Children's Hospital
Obese, Primiparous Women
Effect of Increased Oxytocin Doses on the Mode of Delivery in Obese Primiparous Women With Spontaneous or Induced Labour
The rate of caesarean section is higher among obese pregnant women, leading to increased morbidity in this already vulnerable population.
- Conditions
- Obese, Primiparous Women, Oxytocin
- Trial name
- PROXYMA (NCT04760496)
- Testing
- Oxytocin 4 mIU/mL, Oxytocin 2 mIU/mL
- Where
- 12 sites in France
- Volunteers
- 443 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris