Clinical trials: Labour
Labor Pain, Analgesia
Sacral Spread of Sensory Block After Dural Puncture Epidural Technique Compared With Epidural for Labour Analgesia
Neuraxial labor analgesia is a very widely used technique for labor pain relief with a high efficacy and safety. EA (Epidural analgesia) can guarantee a proper control of pain in 95-100% of cases in the first stage of labor, but…
- Trial name
- NCT05217134
- Testing
- DPEA
- Where
- 2 sites in Italy
- Volunteers
- 108 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Labor, Premature, Premature Birth
A Proof of Concept Study Assessing the Effect of Four Different Single Bolus Intravenous Doses of FE200440 and Placebo on Stopping Preterm Labor
To determine the effects of four different single bolus doses of FE200440 administered intravenously on stopping preterm labour compared to placebo in pregnant women with advanced gestational age
- Trial name
- NCT00209326
- Testing
- FE200440
- Where
- 17 sites in Belgium, Czechia and 4 more
- Volunteers
- 163 people
- Sponsor
- Ferring Pharmaceuticals
Labour Pain
Testing the Efficiency of a Device Meant to Relieve Labour Pain
The suggested research is aimed to test the effectiveness of an external mechanical device to be applied and used by the parturient herself in pain relieving during labour .
- Trial name
- NCT00426725
- Testing
- EasyLabour
- Where
- Israel
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- ACU Medical Technologies Ltd
Labour Analgesia
Effect of Epidural Needle Injection on Catheter Placement Success During Painless Labour
Epidural analgesia is the gold standard for painless labour, but successful catheter placement can be technically challenging due to anatomical and physiological changes in pregnancy.
- Trial name
- NCT07327918
- Testing
- Injection Group, Control group
- Where
- Egypt
- Volunteers
- 216 people
- Sponsor
- Al-Azhar University
Labour Pain
Spoken Animation for Labour Epidural
The purpose of this study is to evaluate a new animated information film as a tool for introducing the concept of epidural as a method of labour pain relief to expectant women.
- Trial name
- SALE (NCT07202221)
- Testing
- Participant views Epidural animation before reading gold standard written information, Participant receives current gold standard written information alone
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Pregnant Women Who Requested Epidural Analgesia in the Early Stage of Labor
Onset of Labour Epidural Analgesia With Different Concentration Bupivacaine and Different Doses of Sufentanyl
This study aimed to compare the effects of three commonly used combination doses on the onset time and adverse reactions.
- Trial name
- NCT03395600
- Testing
- B1S5, B125S5, B1S10
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Fudan University
Fetal Distress, Birth Asphyxia
Effect of Intrapartum Oxygen Administration on Fetal and Early Neonatal Outcomes
Introduction Birth asphyxia is one of leading causes of neonatal mortality in Uganda. It is associated with long term neuro-developmental complications among the babies that survive.
- Trial name
- Intra-O (NCT04043299)
- Testing
- 100% Oxygen, 21% oxygen
- Where
- Uganda
- Volunteers
- 1,108 people
- Sponsor
- Makerere University
Labour Dystocia
Implementation of AFL Monitoring in Clinical Use
The overall objective of this randomized controlled trial is to develop a clinical standard procedure for measuring lactate in amniotic fluid (amniotic fluid lactate = = AFL) during childbirth before oxytocin stimulation is…
- Trial name
- NCT03650972
- Testing
- Samarin
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Total Dose of Bupivacaine Administered During Labor
Dexmedetomidine as an Adjuvant During Dural Puncture Epidural
The study aimed to determine the effects of using varied doses of DEX on the concentration of bupivacaine injected for epidural labor analgesia, and to assess the benefits of the dural puncture epidural.
- Trial name
- NCT07506044
- Testing
- Epidural Catheter with bupivacaine, Epidural with dural puncture, Dexmedetomidine 0.4 added
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Menoufia University
Pregnancy Related, Fever
Assessment of Labour Progress by Intrapartum Ultrasound
Assessment of labor progress via digital exams is considered the standard of care in most delivery rooms. However, this method can be stressful, painful and imprecise and multiple exams increase the risk for chorioamnionitis.
- Conditions
- Pregnancy Related, Fever, Chorioamnionitis, Labor Complication
- Trial name
- NCT04651309
- Testing
- Transperineal Ultrasound
- Where
- Israel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Preterm Labor, Preterm Birth
Aspiration Technique-based Device for Preterm Labor
Premature birth (PTB, birth before 37 weeks of pregnancy) is a global, yet unsolved, problem. With a global amount of approximately 15 M babies born prematurely, PTB is the leading cause of perinatal morbidity and mortality in…
- Trial name
- PREGNOLIA (NCT05355649)
- Testing
- PREGNOLIA SYSTEM
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Lactate Values During Labour in Women Receiving Neuraxial Anaesthesia
Lactate Values During Labour and Their Correlation With Maternal and Foetal Outcome
Postpartum haemorrhage (PPH) represents a significant cause of morbidity in the obstetric population, with a mortality rate of 140,000 women per year, and the predominant cause of PPH (70%) is uterine atony.
- Trial name
- NCT06807255
- Testing
- Lactate levels were assessed via a venous blood gas test utilising an IV cannula already placed in the woman's limb upon admission
- Where
- Italy
- Volunteers
- 303 people
- Sponsor
- Papa Giovanni XXIII Hospital
Labour
Effect of World Health Organization Labour Care Guide On Reducing Cesarean Section Rates
After taking informed consent for participation in the study, all selected cases will be divided into two groups by lottery method.
- Trial name
- NCT07550439
- Testing
- WHO Labour Care Guide, Partogram
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Pak Emirates Military Hospital
Gestational Diabetes Mellitus (GDM)
The Feasibility Of Expectant Management Versus Induction At 38 Weeks Among Individuals With Gestational Diabetes Mellitus: A Randomized Controlled Pilot Trial (EAGER Pilot Trial)
The EAGER pilot trial is designed to assess the feasibility of a Canadian, multicentre prospective randomized open-label blinded end-point (PROBE) clinical trial addressing whether induction of labour (IOL) at 38 weeks' gestation…
- Trial name
- EAGER Pilot (NCT06641141)
- Testing
- Induction of Labour
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Ottawa Hospital Research Institute
Pain During Labour, Fear of Childbirth
The Effects of the Use of Virgin Mary Herb in Childbirth
This is a study to see if the use of virgin mary herb during birth has an effect on fear, pain and duration during birth. Virgin mary herb is a dry plant and it is believed that when added to water during birth, it makes birth…
- Trial name
- EVMHUBDPFC (NCT06824558)
- Testing
- primiparous pregnant woman following virgin mary, primiparous pregnant
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Obstetric Pain, Other Complications of Obstetric Anesthesia - Delivered
Epidural Dexamethasone for Labor Analgesia: the Effects on Ropivacaine Consumption and Labour Outcome
To assess the efficacy of epidural dexamethasone administration, compared to placebo, in reducing local anesthetics consumption during labor epidural analgesia in parturient women
- Trial name
- DEXAPER (NCT02857465)
- Testing
- Dexamethasone, Ropivacaine, Sufentanil
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Delivery Complication, Labor Long
Effect of Oral Carbohydrate Intake > 44kCal Per Hour During Labour on the Rate of Instrumental Vaginal Delivery
Carbohydrate intake during physical exercise improves muscle performance and decreases fatigue. We hypothesized that carbohydrate intake during labor which is a period of significant physical activity can decrease the…
- Conditions
- Delivery Complication, Labor Long, Pregnancy Related
- Trial name
- soliso-2 (NCT05080309)
- Testing
- carbohydrate oral intake, free water only
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Parturients in Labour
Alteration in Hearing Following Accidental Dural Puncture. A Study in Parturients
Headache following accidental dural punction as during epidural analgesia can be severe and sometimes very disabling. The incidence of PDPH is 10-40%, most starting within 48 h of dural puncture.
- Trial name
- AHEAD (NCT01682967)
- Where
- 2 sites in Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Labor Pain
Parturient Satisfaction With Epidural Analgesia by PCEA or Manual Boluses
Those prospective parturients that express that they may want an epidural labour analgesia for their delivery will be informed about the possibility to choose between a pump driven epidural or midwife administered intermittent…
- Trial name
- NCT06094946
- Testing
- Ropivacaine Hydrocloride, Fentanyl Citrate
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Women's Hospital HUS
Labour Induction
Vaginally Administered Versus Per Oral Misoprostol in Induction of Labour
The purpose of this study is to investigate the effectiveness and safety of vaginally administered misoprostol (Misodel) versus per orally administered misoprostol (Cytotec) in induction of labour in nulliparous women.
- Trial name
- NCT02539199
- Testing
- Misoprostol, modified-release pessary, Misoprostol, per-oral tablets
- Where
- 5 sites in Finland
- Volunteers
- 270 people
- Sponsor
- Tampere University Hospital