Clinical trials: Labour
Virtual Reality, Labor Pain
Investigating the Effect of Virtual Reality on Labour Analgesia Use
Childbirth is associated with labour pain and can be regarded as one of the most serious kinds of pain. Labour pain management methods include pharmacological and non-pharmacological methods.
- Conditions
- Virtual Reality, Labor Pain, Labor Analgesia
- Trial name
- DELIVR (NCT04992663)
- Testing
- PICO glasses and controller with BirthVR
- Where
- Netherlands
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Premature Labour
Vaginal Progesterone Versus Cervical Cerclage for Pregnant Women With Short Cervix and History of PTL and/or MTM
The aim of this study to compare vaginal progesterone supplementation to cervical cerclage for prevention of preterm labor in women with short cervical length and history of previous midtrimester miscarriage and/or preterm labor.
- Trial name
- NCT02673359
- Testing
- Progesterone, Cervical cerclage
- Where
- 3 sites in Egypt
- Volunteers
- 220 people
- Sponsor
- Mohamed Sayed Abdelhafez
Labor Complication
Study of the Fluid Intake Effect During Labour
Ingestion during labor is an issue that has attracted the attention of the scientific community in recent decades, with different practices occurring in different countries.
- Trial name
- NCT06371742
- Testing
- Liquid ingestion during labour
- Where
- Portugal
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Gestational Diabetes, Pre-Eclampsia
Body Fat Index for Obstetric Risk Stratification
Primary Outcome:- GDM Diagnosis Secondary Outcomes:- Pre-eclampsia diagnosis. Cesarean section delivery due to labor dystocia defined as protracted or arrested progress of labor using labor partogram.
- Conditions
- Gestational Diabetes, Pre-Eclampsia, Labour Dystocia
- Trial name
- BFIors (NCT05533996)
- Testing
- ultrasound
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Assiut University
Preterm Labour
N-Acetyl Cysteine for Prevention of Preterm Birth
The antioxidant effect of N-Acetyl cysteine can abort the inflammatory cascade responsible for initiation of preterm labour especially among patients with reccurent preterm birth and patients having bacterial vaginosis
- Trial name
- NAC (NCT00568113)
- Testing
- acetylcysteine in arm 1
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pregnancy, Labour Onset and Length Abnormalities
Role of Maternal Physical Exercise on Spontaneous Labor Onset
Evaluate the effects of the practice of maternal physical exercise on the term of pregnancy as a method to enhance spontaneous labor.
- Trial name
- NCT02460185
- Testing
- Study group: Maternal Physical Exercise
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Lisboa Norte
Obstetric Pain, Labor Pain
Dural Puncture Epidural VS Standard Epidural on Physician Top-ups During Labour Analgesia
The purpose of this prospective randomized controlled study is to compare the number of physician top-up interventions during the first stage of labour between two different neuraxial analgesia techniques : the dural puncture…
- Conditions
- Obstetric Pain, Labor Pain, Anesthesia
- Trial name
- DPE (NCT04728048)
- Testing
- Dural puncture epidural, Standard epidural
- Where
- Canada
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Induction of Labor, Previous Cesarean Section
Labor Induction After Cesarean Section: Outcome, Hormonal Trends
Objectives- To compare changes in labour-associated maternal and fetal hormone levels during breast stimulation, balloon induction and spontaneous labour.
- Conditions
- Induction of Labor, Previous Cesarean Section, Hormonal Changes
- Trial name
- NCT04244747
- Testing
- induction of labor by breast stimulation, induction of labor by catheter balloon
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Induced; Birth
The REDUCED-I Pilot Trial: REDucing the Utilization of CEsarean Sections With Induction
This pilot project is a randomized controlled trial where induced patients receive an intervention of oxytocin discontinuation once in the active stage of labor (≥6 cm dilation).
- Trial name
- (REDUCED-I) (NCT05037617)
- Testing
- Continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation).
- Where
- Canada
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Labour Analgesia, Epidural Anaesthesia
An Observational Study Investigating the Positioning of Epidural Catheters and Their Function During Labour Analgesia
This is a small observational study investigating the physical changes that occur to epidural catheters after insertion for obstetric anaesthesia.
- Trial name
- NCT02924779
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rotkreuzklinikum München gGmbH
Obstetric Labor Complications
The Effect of Perineal Massage in Childbirth
Objective To examine the effects of perineal massage applied during the action of birth on the frequency of episiotomy procedures, perineal tearing and the duration of the second stage of birth.
- Trial name
- NCT02201615
- Testing
- Perineal massage in childbirth
- Where
- Turkey (Türkiye)
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Ductus Arteriosus
The Role of Fetal Ductus Arteriosus in Predicting Spontaneous Labour at Term
The exact mechanism stimulating the parturition in humans is still relatively unknown. Prostaglandins, by mediating cervical ripening and early stimulation of myometrial contractions, are likely to play a major role in the…
- Trial name
- NCT03073460
- Testing
- Ultrasound examination
- Sponsor
- Unity Health Toronto
Anesthesia
Ultrasound Assessment of Clear Liquid Intake During Labour
We designed a two arms prospective, randomised, simple blinded trial to compare the impact of clear liquid intake on gastric content before delivery.
- Trial name
- EGTO (NCT02362815)
- Testing
- Apple juice
- Where
- 3 sites in France
- Volunteers
- 156 people
- Sponsor
- Hopital Foch
Fetal Infection, Fetal Inflammatory Response Syndrome
IL-6 and Lactates in Cord Blood and Neonatal Outcomes
The goal of this observational study or clinical trial is to evaluate interleukin-6 (IL-6) and lactate levels in maternal and cord blood to identify early signs of fetal inflammation or infection.
- Conditions
- Fetal Infection, Fetal Inflammatory Response Syndrome, Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn
- Trial name
- ECCO-IL6 (NCT07211503)
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Uterine Contraction, Pregnancy
Comparative Study of the Propagation of Uterine Electrical Activity (EHG) in Pregnant Women During Pregnancy and During Labour
The original aspect of the methodology proposed for this study concerns the use of as many as 16 electrodes to study the propagation and coordination (or synchronization) of uterine contraction.
- Conditions
- Uterine Contraction, Pregnancy, Delivery, Obstetric
- Trial name
- PropEHG (NCT02814344)
- Testing
- Electrohysterography
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Propranolol, Labour Induction
Effects of Oral Propranolol on Induction-Delivery Interval During Induction of Labour With Oxytocin
Prolonged pregnancy could lead to perinatal and maternal complications. Oxytocin has been wildly used for induction of labour, but prolonged labour continued to occur with its attendant sequelae.
- Trial name
- NCT06960850
- Testing
- Propranolol
- Where
- Nigeria
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Federal Teaching Hospital Abakaliki
Labor Induction, Cervical Ripening
Safety and Efficacy Study of Misoprostol Vaginal Insert for Induction of Labour
The primary objective of the study was assessment of the efficacy of four dose reservoirs (25 mcg, 50 mcg, 100 mcg, 200 mcg) of intravaginal controlled release misoprostol administered for up to 24 hours.
- Trial name
- NCT00346840
- Testing
- Misoprostol vaginal insert 25 mcg, Misoprostol vaginal insert 50 mcg, Misoprostol vaginal insert 100 mcg
- Where
- 6 sites in United Kingdom
- Volunteers
- 124 people
- Sponsor
- Ferring Pharmaceuticals
Neonatal Encephalopathy
Uterine Activity in Moderate-Severe Neonatal Encephalopathy: A Case Control Study
Excessive uterine activity may be one of several aetiological factors that contribute to depressed neurological function in the newborn.
- Trial name
- NCT03122808
- Testing
- Uterine Activity Analysis, Partogram Analysis
- Where
- Ireland
- Volunteers
- 264 people
- Sponsor
- The Rotunda Hospital
Pregnant Women, Labour Analgesia
A Research Comparing Efficacy of PIEB Plus PCEA vs CEI Plus PCEA for Labour Analgesia
During labour process, one of the most effective ways to manage pain is via epidural analgesia. It is commonly and widely use for all pregnant women underwent labour process.
- Trial name
- NCT07592364
- Testing
- Programmed intermittent epidural bolus 10 ml, continuous epidural infusion
- Where
- Malaysia
- Volunteers
- 88 people
- Sponsor
- Aiman Bin Ab Adzim
Pregnant Women Who Requested Epidural Analgesia in the Early Stage of Labor
Onset of Labour Epidural Analgesia With Different Concentration Bupivacaine and Different Doses of Sufentanyl
This study aimed to compare the effects of three commonly used combination doses on the onset time and adverse reactions.
- Trial name
- NCT03395600
- Testing
- B1S5, B125S5, B1S10
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Fudan University