Clinical trials: Labour Induction
Labor Induction, Induced Delivery
Foley Catheter Versus PGE2 for Labor Induction at Term: a Pilot Study
Induction of labor is one of the most common interventions in obstetrics. In the past decade, the rates of labor induction at term have doubled from approximately 9% to 23% in the United States and from 10% to 20.4% in China.
- Trial name
- NCT04780269
- Testing
- Induction of labor with Foley catheter, Induction of labor with PGE2
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Induced; Birth, Labor Onset and Length Abnormalities
Papaverine and Oxytocin vs Oxytocin Alone in Labor Induction
This study aims to evaluate the efficacy and safety of combining papaverine with oxytocin for labor induction compared to oxytocin alone
- Trial name
- NCT06547437
- Testing
- Papaverine, normal saline
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Failed Medical or Unspecified Induction of Labor
Comparing Cervical Foley Catheter, Dinoprostone and a Combination of the Two for Labor Induction
The investigators intend to conduct a randomized clinical trial comparing 3 methods of induction of labor in term primiparous women with singleton.
- Trial name
- Induction (NCT02815865)
- Testing
- Foley catheter and pitocin, Foley catheter and Dinoprostone, Dinoprostone
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Induced Vaginal Delivery
IV PAPAVERINE Prior to Propess for Labor Induction
The investigators aim to evaluate the effect of administering papaverine prior to PGE2 insertion on changes in Bishop-scores and on the induction-to-delivery interval. Researchers will compare drug papaverine to a placebo
- Trial name
- NCT06550232
- Testing
- Papaverine
- Where
- Israel
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Delivery, Obstetric, Cesarean Section
Comparison Between Two Medical Devices for Labor Induction After Previous C-section
The objective of the study ist to compare the Dilapan-S and the Cook Ballon device for the mechanical induction of labour in women with a previous C-section.
- Conditions
- Delivery, Obstetric, Cesarean Section, Obstetric Delivery
- Trial name
- DiBal (NCT06506721)
- Testing
- Double ballon device, Cook, Hygroscopic cervix dilators, Dilapan-S
- Where
- Switzerland
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Intrauterine Fetal Demise, Fetal Death
Mifepristone Induction for Fetal Demise
Methods: Double blinded, randomized controlled trial with 1:1 allocation of mifepristone or placebo at initiation of induction of labor for fetal demise 20 weeks estimated gestational age or greater.
- Trial name
- MIFD (NCT02620904)
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Prolonged Pregnancy, Sleep Disturbance
Sleep and Depression in Induction of Labour
Randomised trial comparing double balloon catheter for induction of labor between inpatient and outpatient groups. The investigators assess how sleep disturbances and depression of the mother affect to the pain during balloon…
- Conditions
- Prolonged Pregnancy, Sleep Disturbance, Depression
- Trial name
- NCT03380897
- Testing
- Intervention for outpatient group was to go home, Intervention for inpatient group was to stay at ward
- Where
- Finland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Cervix; Pregnancy
Comparative Study Between Only Vaginal Misoprostol and Vaginal Misoprostol and Estradiol Cream
To compare the safety and effectiveness of vaginal misoprostol with combined vaginal misoprostol and estradiol for induction of labour in unfavorable cervix
- Trial name
- NCT05306405
- Testing
- Vaginal Tablet
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Induction of Labor Affected Fetus / Newborn
The Impact of a Customized Informative Video Prior to Induction of Labor on Anxiety Relieve.
To determine whether watching a personalized video prior to medically indicated labor induction among term parturients reduces anxiety levels according to the STAI questionnaire, compared to a standard counselling.
- Trial name
- NCT06375746
- Testing
- Personalized video
- Where
- Israel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Premature Rupture of Membranes
I.V Papavrine for Labor Induction in Term PROM
This prospective randomized controlled trial aims to evaluate whether intravenous administration of papaverine 12 hours after term PROM reduces the interval from membrane rupture to delivery and improves maternal and neonatal…
- Trial name
- NCT07517796
- Testing
- Papaverine arm
- Where
- Israel
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Induction of Labor
Using Isosorbide Mononitrate in Reducing Time in Induction of Labor in Post Date Women
We will compare between using isosorbide mononitrate together with misoprostol versus the misoprostol alone in induction of labor in postdate women
- Trial name
- NCT03854383
- Testing
- Isosorbide mononitrate, Misoprostol
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Abdelrahman Ali Fadel Youssef Mohamed
Labor; Forced or Induced, Affecting Fetus or Newborn, Pregnancy
A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor
The purpose of this study is to study if misoprostol administered orally is at least as effective as misoprostol administered vaginally for cervical ripening and the induction of labor.
- Trial name
- NCT02777190
- Testing
- Misoprostol
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Labor Dystocia, Labor Induction
Calcium Carbonate to Augment Labor Contractions
The investigators think that calcium carbonate can act as an assistive medication to improve contractions during labor.
- Conditions
- Labor Dystocia, Labor Induction, Labor Augmentation
- Trial name
- CALC (NCT06580782)
- Testing
- Calcium Carbonate 500 MG, Standard Dose Synthetic Pitocin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Labor Induction
A Randomized Trial of Two Regimens of Misoprostol for Second Trimester Termination for Intrauterine Fetal Death
Misoprostol (Cytotec®) is a synthetic prostaglandin E1 analog that has been marketed in the United States since 1988 as a gastric cytoprotective agent.
- Trial name
- NCT00141895
- Testing
- Misoprostol
- Where
- Lebanon
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Patient Acceptance of Health Care
Patients Acceptance Towards Elective Labor in Induction (PALI)
To assess patients' preference, understanding regarding elective IOL and factors contribute to decision making process towards elective IOL at 39th week of gestation.
- Trial name
- PALI (NCT04736342)
- Testing
- PALI questionaire
- Where
- Vietnam
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hanoi Obstetrics and Gynecology Hospital
Failed Induction (of Labor) by Oxytocin
Continuous Oxytocin Infusion Versus Pulsatile Intravenous Oxytocin for Augmentation of First Stage of Labor
Comparing continuous intravenous oxytocin infusion with pulsatile administration of intravenous oxytocin for augmentation of the first stage of labor.
- Trial name
- NCT02723461
- Testing
- Pulsatile Oxytocin, Continuous Oxytocin
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Labor Onset and Length Abnormalities
Laminaria Tents Versus Vaginal Prostaglandin in Cervical Ripening
Mechanical methods used for induction of labor received a great attention nowadays due to the serious side effects of the pharmacological methods. Hygroscopic dilators are considered important subtype of these mechanical methods.
- Trial name
- NCT06151925
- Testing
- Laminaria, Vaginal prostaglandin
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Diabetes, Gestational
Outpatient Cervical Ripening With Orally Administered Misoprostol in Diabetics
A. Null Hypothesis: In term pregnancies complicated by diabetes, there is no difference in the time interval from start of induction to delivery when outpatient cervical ripening and labor induction is initiated with orally…
- Trial name
- NCT00514618
- Testing
- Misoprostol
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- MemorialCare Health System
Childbirth Problems, Labor Complication
Balloon Catheter Versus Propess for Labour Induction
This study will randomise low-risk women to compare the effectiveness of trans-cervical balloon catheter for pre-induction cervical ripening for out-patient induction of labour with current practice (Propess).
- Trial name
- PROBIT-F (NCT03199820)
- Testing
- Cook cervical balloon, Prostin E2 Vaginal Suppository
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Oligohydramnios
Active Induction of Labor in Pregnancies Complicated With Oligohydramnios at Term
The purpose of this study is to evaluate the risk of cesarean delivery in pregnancies complicated with isolated oligohydramnios managed by induction of labor.
- Trial name
- NCT02581774
- Testing
- normal delivery tracking
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital