Clinical trials: Lacrimal Duct Obstruction
Dry Eye
Evaluating a Device for Blocking the Tear Duct
Participants will receive a tear duct plug to see if their eye comfort improves.
- Trial name
- NCT05748951
- Testing
- Canalicular occlusion device
- Where
- Mexico
- Volunteers
- 33 people
- Sponsor
- AesculaTech, Inc.
Nasolacrimal Duct Obstruction
A Comparison of Endonasal Dacryocystorhinostomy With and Without Silicone Tubes
Aim of study is to investigate whether the use of silicone tubes in endonasal DCR surgery increases the success rate and / or complication rate compared to surgery without tubes.
- Trial name
- NCT00784992
- Testing
- Endonasal dacryocystorhinostomy
- Where
- 2 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Epiphora, Dacryostenosis
Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain?
Purpose: It is unknown whether instillation of a drop of anesthetic ophthalmic solution into the eye such as proparacaine hydrochloride 0.5% prior to probing and irrigation of the tear duct (lacrimal drainage) system improves…
- Conditions
- Epiphora, Dacryostenosis, Dacryocystitis
- Trial name
- NCT04229771
- Testing
- Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Corewell Health East
Primary Acquired Nasolacrimal Duct Obstruction
External Versus Powered Endoscopic Dacryocystorhinostomy With Mitomycin C for Primary Acquired Nasolacrimal Duct Obstruction
Primary acquired nasolacrimal duct obstruction causes persistent tearing because tears cannot drain normally from the eye into the nose.
- Trial name
- NCT07754058
- Testing
- External Dacryocystorhinostomy, Powered Endoscopic Dacryocystorhinostomy, Mitomycin C 0.02%
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Military Institute od Medicine National Research Institute
Lacrimal Duct Obstruction
A Comparative Study of Two Endoscopic Operations for Lacrimal Duct Obstruction
To compare the clinical effects between the silicone nasolacrimal intubation under nasoendoscopy and dacryocystorhinostomy on patients with lacrimal duct obstruction.
- Trial name
- ACSOTEOFLDO (NCT02636257)
- Testing
- Recessive Spherical Headed Silicone Intubation, Dacryocystorhinostomy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Lacrimal Apparatus Diseases, Lacrimal Duct Obstruction
Analysis of 86 Dacryoliths at the University Hospital Ostrava
Background Because dacryoliths occur at low frequency, few studies have focused on their composition. The investigators aimed to present findings from morphological, chemical, and mineralogic analysis of 86 dacryoliths.
- Trial name
- NCT01826734
- Where
- Czechia
- Volunteers
- 86 people
- Sponsor
- University Hospital Ostrava
Nasolacrimal Duct Obstruction
Study of Surgical Procedures for Treatment of Persistent Nasolacrimal Duct Obstruction in Children < 4 Years Old
The purpose of this study is: To report the success proportions for the treatment of persistent nasolacrimal duct obstruction for three surgical procedures: balloon catheter dilation, nasolacrimal intubation, and simple probing.
- Trial name
- NLD2 (NCT00315315)
- Testing
- Nasolacrimal balloon catheter dilation, Nasolacrimal intubation, Nasolacrimal duct probing
- Where
- 2 sites in United States
- Volunteers
- 194 people
- Sponsor
- Jaeb Center for Health Research
Lacrimal Apparatus Disease
Lacrimal Drainage System Obstruction Associated to Radioactive Iodine Therapy for Thyroid Carcinoma
The radioactive radioiodine therapy (Na131I) for the treatment of differentiated thyroid carcinoma is a procedure used for ablation of remaining thyroid tissue after thyroidectomy and metastases.
- Trial name
- NCT01579344
- Testing
- Radioiodine therapy
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Fabricio Lopes da Fonseca
Lacrimal Duct Obstruction
Long Term Effectiveness of Dacryocystorinostomy With and Without Bicanalicular Intubation
Dacryocystorinostomy (DCR) is an operation that is indicated for lacrimal duct obstruction. As a result of the lacrimal duct obstruction, tears are retained over the obstacle and repeated lacrimal infections occur.
- Trial name
- NCT03960996
- Testing
- dacryocystorinostomy
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Lacrimal Duct Obstruction
Low Temperature Plasma Ablation Combined Lacrimal Duct Catheterization in the Treatment of Lacrimal Duct Obstructive
To compare the clinical effects of low temperature plasma ablation combined with lacrimal duct catheterization and YAG lacrimal duct laser combined with lacrimal duct catheterization in the treatment of lacrimal duct obstruction
- Trial name
- NCT04943055
- Testing
- Low temperature plasma lacrimal duct obstruction ablation combined with lacrimal duct catheterization, YAG lacrimal duct laser combined with lacrimal duct catheter
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Eye Diseases, Lacrimal Duct Obstruction
Nasolacrimal Duct Obstruction
1.1 Background Obstructions of the lacrimal drainage system can be differentiated based on anatomical location or severity. But also, differentiating between congenital and acquired nasolacrimal duct obstruction (NLDO) is…
- Trial name
- NCT04931186
- Testing
- retrospective analyis
- Where
- Austria
- Volunteers
- 625 people
- Sponsor
- Medical University of Vienna
Nasolacrimal Duct Obstruction
Effect of Standardized Lacrimal Sac Massage Compared With Probing for Congenital Lacrimal Duct Obstruction
Congenital nasolacrimal duct obstruction (CNLDO) is a common ophthalmic condition in children, presenting with tearing and pus overflow, with a prevalence of 5%-20% within 1 year of age.
- Trial name
- NCT06924723
- Testing
- tear duct probing, Lacrimal sac massage
- Volunteers
- 160 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Dacryocystitis, Dacryocystitis; Chronic
Examination of Lacrimal Sac and Nasal Mucosa Preparations Taken in Dacryocystorhinostomy Surgery of Patients With Nasolacrimal Duct Obstruction and Comparison of Clinical Groups With Each Other
The goal of this observational study is to investigate etiology and pathogenesis of nasolacrimal duct obstruction and dacryocystitis in different adult clinic groups.
- Conditions
- Dacryocystitis, Dacryocystitis; Chronic, Dacryocystorhinostomy, Epiphora
- Trial name
- NCT06810089
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Uludag University
Nasolacrimal Duct Obstruction, Dacryocystorhinostomy
Amniotic Membrane for Dacryocystorhinostomy
This study aims to compare the success rate of external dacryocystorhinostomy with and without amniotic membranes in patients with nasolacrimal duct obstruction.
- Trial name
- AMDCRex (NCT06226181)
- Testing
- Dacryocystorhinostomy and amniotic membrane, Conventional dacryocystorhinostomy
- Where
- Mexico
- Volunteers
- 22 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Epiphora, Dacryostenosis
Does Topical Ophthalmic Proparacaine 0.5% Prior to Probing and Irrigation Decrease Pain?
Purpose: It is unknown whether instillation of a drop of anesthetic ophthalmic solution into the eye such as proparacaine hydrochloride 0.5% prior to probing and irrigation of the tear duct (lacrimal drainage) system improves…
- Conditions
- Epiphora, Dacryostenosis, Dacryocystitis
- Trial name
- NCT05663684
- Testing
- Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Primary Acquired Nasolacrimal Duct Obstruction
Efficacy Evaluation of 5-Fluorouracil as an Adjuvant to Endoscopic Dacryocystorhinostomy in Managing Primary Acquired Nasolacrimal Duct Obstruction With Small Lacrimal Sac: A Randomized Controlled Study
Primary acquired nasolacrimal duct obstruction (PANDO) is a lacrimal duct obstruction disease characterized by inflammatory fibrosis of the nasolacrimal duct, with primary symptoms including epiphora and increased secretions…
- Trial name
- NCT07154121
- Testing
- 5-fluorouracil group, saline group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Lacrimal Duct Obstruction
Endoscopic Dacryocystorhinostomy Prospective Research
Endoscopic dacryocystorhinostomy (EN-DCR) is an effective procedure when treating saccal and postsaccal obstructions of the nasolacrimal pathway. The benefit of silicone tubing after DCR is still controversial.
- Trial name
- NCT00571129
- Testing
- DCR with no tubes or mitomycin
- Where
- Finland
- Volunteers
- 80 people
- Sponsor
- Kuopio University Hospital
Nasolacrimal Duct Obstruction
The Efficacy of Dexmedetomidine Versus Labetalol In Providing Controlled Hypotension In Dacryocystorhinostomy SurgeryA Comparative Randomized Prospective Study
The most important symptoms of nasolacrimal duct obstruction are excessive tearing and mucoid discharge. The proposed treatment in this regard is dacryocystorhinostomy (DCR) surgery.
- Trial name
- NCT06346561
- Testing
- Dexmedetomidine, Labetalol
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Canalicular Obstruction
Self-retaining Bicanalicular Intubation Stent Versus Bicanalicular Silicone Tube for Management of Canalicular Obstruction
The aim of the study is to evaluate outcomes of the use of self_retaining intubation set versus bicanalicular silicone tube in management of canalicular obstruction
- Trial name
- NCT04706117
- Testing
- Self-retaining bicanalicular intubation stent
- Volunteers
- 40 people
- Sponsor
- Minia University
Neonatal Dacryocystitis, Congenital Nasolacrimal Duct Obstruction
Efficacy and Safety of Piclosept in the Complex Treatment of Neonatal Dacryocystitis
This single-center, prospective, randomized, controlled, assessor-blinded study will evaluate the efficacy and safety of Piclosept® ophthalmic solution as an adjunct to standardized lacrimal sac massage in children aged 1 to 12…
- Trial name
- NCT07875517
- Testing
- Picloxidine, Levofloxacin, Standardized lacrimal sac massage
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- Kazakh Eye Research Institute