Clinical trials: Lacrimal Stenosis
Punctal Stenosis
AS OCT Evaluation for Perforated Punctual Plugs
Evaluation of the perforated punctal plugs after implantation in cases of punctal stenosis regarding position and patency in the early postoperative period (during the first operative weak)
- Trial name
- NCT04624022
- Testing
- Anterior segment optical coherent tomography
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Minia University
Epiphora, Conjunctivitis
Perforated Punctal Plugs for Treatment of Papillary Conjunctivitis in Otherwise Healthy Patients
Assessing efficacy of punctal dilatation with insertion of perforated punctal plugs for the management of acquired punctal stenosis due to allergic conjunctivitis in otherwise healthy patients.
- Trial name
- NCT02503956
- Testing
- Perforated Punctal plugs, Crawford tube insertion, Crawford lacrimal tube
- Where
- Israel
- Volunteers
- 14 people
- Sponsor
- Rabin Medical Center
Punctal Stenosis
Diagnosis of Acquired Punctal Stenosis Using Anterior Segment Optical Coherence Tomography
Purpose of the study To evaluate the lower puntum dimensions in cases of acquired punctal stenosis(APS), using anterior segment optical coherence tomography (AS-OCT).
- Trial name
- NCT03498144
- Testing
- Anterior segment OCT
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Ophthalmopathy , Lacrimal System
Evaluation of Lacrimal Punctal Changes by Anterior Segment Optical Coherence Tomography AS-OCT After Topical Combined Antibiotics and Steroids Treatment in Cases of Inflammatory Punctual Stenosis
Punctal stenosis is an important etiological factor that should be considered when assessing patients with epiphora. Anatomically, acquired punctal stenosis is a condition in which the external opening of the lacrimal canaliculus…
- Trial name
- NCT05028907
- Testing
- 5 mg chloramphenicol, 1 mg dexamethasone sodium phosphate, 0.25 mg tetryzoline hydrochloride, 2 mg Hydroxypropyl Methyl Cellulose, 10 mg α-tocopherol acetate and 8 mg macrogol 400)., sodium hyaluronate, polyethylene and propylene glycol based) three times daily for three months
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Sohag University
Epiphora
Topical Cyclosporine vs. Placebo for Epiphora Associated With Docetaxel
Objective: To evaluate the safety and efficacy of topical cyclosporine eye drops (Restasis®) for the treatment of epiphora caused by canalicular stenosis secondary to Docetaxel (Taxotere®) treatment for various cancers.
- Trial name
- NCT00824811
- Testing
- Cyclosporine Eye Drops (Restasis), Lubricant Eye Drops (Refresh Endura™), Fluorometholone Eye Drops (FML Forte®)
- Sponsor
- M.D. Anderson Cancer Center
Lacrimal Duct Obstruction, Lacrimal Stenosis
A Feasibility Study to Develop a Protocol for Functional Lacrimal Magnetic Resonance Imaging
Watering eyes (epiphora) is a very common ophthalmic condition. It is frequently caused by dysfunction of the lacrimal (tear) drainage system which is the 'pipework' that takes tears from the eye to the nasal cavity.
- Trial name
- NCT03411889
- Testing
- MRI scanning
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Epiphora
Management of Lower Punctal Stenosis.
a prospective non-randomized study conducted upon 24 patients with severe lower punctual stenosis (grade 0 according to Kashkouli scale) attending at Menoufia University hospitals. The upper punctum and canaliculus were patent.
- Trial name
- NCT03731143
- Testing
- insertion of self retaining bicanalicular stent
- Volunteers
- 24 people
- Sponsor
- Menoufia University
Epiphora, Punctal Stenosis
A Comparative Analysis of the Effectiveness of Nepafenac Combined With a Lubricant Versus a Lubricant Alone in the Treatment of Epiphora Associated With Lacrimal Punctum Stenosis
Establish the efficacy of combined treatment with nepafenac and lubricant versus lubricant alone in improving epiphora and resolving punctal stenosis in Mexican adults.
- Trial name
- CAENLVLTELPMA (NCT07372014)
- Testing
- Nepafenac and lubricant
- Where
- Mexico
- Volunteers
- 68 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Epiphora
Topical Cyclosporine-A for Management of Epiphora
to investigate the clinical outcomes and tolerances of Cyclosporine A (CsA) in treating epiphora in eyes with acquired punctum stenosis
- Trial name
- CSA-epiphora (NCT04637633)
- Testing
- topical 0.05% CsA (Restasis®, Allergan Inc, Irvine, California)twice daily dose,
- Where
- Kuwait
- Volunteers
- 12 people
- Sponsor
- Farwaniya Hospital
Epiphora
Placement of Three Interrupted Sutures After Triangular Three-snip Punctoplasty
a prospective randomized study conducted upon 40 eyes of 24 patients with lower punctual stenosis (grade 1 or 2 according to Kashkouli scale) attending at Menoufia University hospitals and Kafr Elsheikh ophthalmic eye center.
- Trial name
- NCT04680078
- Testing
- Placement of three interrupted sutures after Triangular Three-snip Punctoplasty of the lower punctum, Conventional Triangular Three-snip Punctoplasty of the lower punctum
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Epiphora, Nasolacrimal Duct Obstruction
Lacrimal Drainage Resistance Study
Epiphora, or uncontrolled tearing of the eyes, represents a common presenting complaint of patients seen by ophthalmologists. Epiphora may be due to non-obstructive causes, such as tear hypersecretion or functional tear pump…
- Conditions
- Epiphora, Nasolacrimal Duct Obstruction, Canalicular Stenosis, Functional Tear Pump Failure
- Trial name
- LDRS (NCT01766232)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Cleveland Clinic
Lacrimal Stenosis of Both Eyes
Lacrimal Deroofing for Epiphora
Puncto-canalicular abnormalities, such as obstruction and canaliculitis, are a significant cause of epiphora. They involve proximal lacrimal drainage system.
- Trial name
- NCT06983717
- Testing
- lacrimal deroofing
- Where
- United Arab Emirates
- Volunteers
- 39 people
- Sponsor
- Benha University
Congenital Lacrimal Stenosis
Microbiological Examination of Children Operated for Congenital Lacrimal Stenosis
Children with congenital lacrimal stenosis are treated by probing and intubation of the lacrimal drainage system. Hypothesis: Microbiological findings at the time of insertion and removal of the silicon intubation have an…
- Trial name
- NCT00312689
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University Hospital Muenster
Lacrimal Duct Obstruction, Lacrimal Apparatus Diseases
Closed Dacryointubation vs Bicanalicular Intubation for Proximal Tear Duct Obstruction
In Mexico, upper lacrimal duct obstruction (ULDO) is a common pathology, and the standard surgical treatment is closed dracryointubation.
- Conditions
- Lacrimal Duct Obstruction, Lacrimal Apparatus Diseases, Lacrimal Stenosis, Lacrimal Elimination
- Trial name
- DICvsBIcanal (NCT06428266)
- Testing
- Bicanalicular intubation, Closed dacryointubation
- Where
- Mexico
- Volunteers
- 31 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana