Clinical trials: Language Disorder
Autism Spectrum Disorder, Social Communication Disorder
Virtual Group Social ABCs - Multi-site Randomized Controlled Trial
The goal of this randomized control trial is to test the efficacy of the Social ABCs 6 week, group-based model using a virtual delivery platform.
- Conditions
- Autism Spectrum Disorder, Social Communication Disorder, Autism or Autistic Traits, Autism Spectrum Disorder With Impaired Functional Language
- Trial name
- NCT05663970
- Testing
- VG Social ABCs
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Apraxia of Speech
Searching of Apraxia of Speech in Children With Specific Language Impairment
Searching of Apraxia of Speech in Children with Specific Language Impairment
- Trial name
- NCT05584033
- Testing
- Mansora Arabic test battery for childhood apraxia of speech
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Developmental Language Disorder
Syntactic Intervention for Cantonese-speaking Children With DLD
The goal of this clinical trial is to compare the efficacy of explicit vs. implicit intervention on subject relative clause production in Cantonese-speaking children with Developmental Language Disorder (DLD).
- Trial name
- NCT06954194
- Testing
- Explicit intervention (Shape Coding+syntactic priming), Implicit intervention (syntactic priming only)
- Where
- Hong Kong
- Volunteers
- 32 people
- Sponsor
- The Hong Kong Polytechnic University
Aphasia, Apraxia of Speech
Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia
Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works.
- Trial name
- NCT05248295
- Testing
- Unison speech (vs. solo), Metrical timing (vs. conversational)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Autism Spectrum Disorder, Language Disorders
Treatment of Social and Language Deficits With Leucovorin for Young Children With Autism
The primary objective of this study is to evaluate the cognitive and behavioral effects of liquid leucovorin calcium on young children with autism spectrum disorder (ASD) and determine whether it improves social communication as…
- Trial name
- NCT04060030
- Testing
- Levoleucovorin Calcium
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Southwest Autism Research & Resource Center
Stroke, Aphasia
Enhance of Language Learning With Neurostimulation
The purpose of this study is to test the effect of transcranial direct current stimulation over the motor cortex of the language dominant hemisphere on language learning in healthy subjects and stroke patients with aphasia.
- Conditions
- Stroke, Aphasia, Aging
- Trial name
- NCT00854893
- Testing
- transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Prostate Cancer
NLP-Based Feedback to Improve Risk Comms and Informed Shared Decision Making
In this pilot study, the investigators will show feasibility of the NLP-based feedback system in 20 consultations of men with newly diagnosed prostate cancer.
- Trial name
- NCT05923684
- Testing
- NLP-based Feedback
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Cedars-Sinai Medical Center
Autism Spectrum Disorder, Complication of Prematurity
Correlation of CXCR4 Expression in Premature Infants With a Diagnosis of Autism at 24 Months
Preterm children are at increased risk for autism spectrum disorders, with an estimated rate of 10%. In the US, about 1 in 8 pregnancies ends with a premature birth.
- Trial name
- ASD-CXCR4 (NCT01686685)
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Urinary Stones, Prostate Cancer
Development of an AI-Agent for Urological Disease Diagnosis and Treatment
Urological diseases such as urinary stones, prostate cancer, and bladder cancer are very common and often require highly specialized diagnosis and treatment.
- Conditions
- Urinary Stones, Prostate Cancer, Bladder Cancer
- Trial name
- NCT07721935
- Where
- 3 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Dysarthria, Intelligibility, Speech
Perceptual Training to Improve Listeners' Ability to Understand Speech Produced by Individuals With Dysarthria
There exist very few effective treatments that ease the intelligibility burden of dysarthria. Perceptual training offers a promising avenue for improving intelligibility of dysarthric speech by offsetting the communicative burden…
- Trial name
- NCT04897711
- Testing
- Perceptual Training
- Where
- 2 sites in United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Utah State University
Stroke, Aphasia
Exploration of Repeated High-frequency Transcranial Magnetic Stimulation for the Treatment of Acute Phase Aphasia in Post-stroke Patients
Stroke is currently an important cause of death and disability among adults worldwide, with acute ischemic stroke being the most common type of stroke, accounting for 69.6% -72.8% of new strokes in China.
- Conditions
- Stroke, Aphasia, Control Patients
- Trial name
- NCT06787508
- Testing
- TMS
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Stroke, Aphasia
Adjustment With Aphasia After Stroke: SUPERB
Aims: This exploratory trial will: 1. Explore the feasibility of a definitive/phase III RCT on clinical and cost-effectiveness of peer-befriending for people with aphasia post-stroke. 2.
- Trial name
- SUPERB (NCT02947776)
- Testing
- PEER, USUAL
- Where
- 5 sites in United Kingdom
- Volunteers
- 62 people
- Sponsor
- City, University of London
Subcortical Aphasia, Ischemic Stroke
Language Functional Reorganization in Subcortical Infarction Patients
Post stroke aphasia (PSA) is one of the most frequently happened deficiency of stoke, affecting speaking,comprehension, writing and reading of language.
- Trial name
- NCT03668132
- Testing
- ischemic brain damage
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Diabetes (Insulin-requiring, Type 1 or Type 2), Insomnia Type; Sleep Disorder
Indonesian-Language Application-Based Guided Imagery Therapy for Insomnia and Glycemic Control in Diabetic Patients
The goal of this clinical trial is to learn if guided imagery therapy using mobile application in Indonesian language can improve sleep quality and lower fasting blood glucose levels in diabetics patients who have problems with…
- Conditions
- Diabetes (Insulin-requiring, Type 1 or Type 2), Insomnia Type; Sleep Disorder, Fasting Plasma Glucose
- Trial name
- NCT07141940
- Testing
- Indonesian-language application-based auditory guided imagery therapy, Psychoeducation
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Neurodegenerative Disease, Behavioral Variant Frontotemporal Dementia (bvFTD)
Tracking and Predicting How Brain Damage Spreads in Neurodegenerative Diseases
Neurodegenerative diseases, including frontotemporal lobar degeneration (FTLD) spectrum syndromes, are characterized by the accumulation of insoluble protein aggregates in the central nervous system.
- Conditions
- Neurodegenerative Disease, Behavioral Variant Frontotemporal Dementia (bvFTD), Primary Progressive Aphasia(PPA), Progressive Supranuclear Palsy(PSP)
- Trial name
- NCT07567664
- Testing
- 3 Tesla MRI without contrast medium, Blood sample for genetic analysis, Cerebrospinal fluid sampling (CSF)
- Where
- Italy
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Marijuana Use
Computer-Mediated Versus Face-to-Face Motivational-Type Interviews
This study looks at whether in-person and computer-based motivational type interviews lead to the same kind of language and behavior change in young adults when they talk about their marijuana use.
- Trial name
- NCT06945471
- Testing
- 1) Face-to-face, and 2) Computer-mediated motivational type interviews
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Hematologic Neoplasms, Oncologic Disorders
LLM-Generated Plain-Language Patient Synopses to Improve Comprehension in Hematology and Oncology (oncOPAL)
This study tests whether patients with blood cancer or other cancers better understand their medical information when it is rewritten in plain language by an artificial intelligence (AI) system.
- Trial name
- oncOPAL (NCT07519811)
- Testing
- LLM-Generated Plain-Language Patient Synopsis
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Technical University of Munich
Stroke
Stimulating Language in Subacute StrokE
The investigators will study the effects of transcranial direct current (tDCS) stimulation during language therapy for naming in individuals with aphasia in the acute and subacute post stroke period.
- Trial name
- SLISSE (NCT02674490)
- Testing
- A-tDCS (1 mA), SALT
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Johns Hopkins University
Language Disorder
Parent Child Interaction Therapy vs Conventional Parent Led Therapy in Down Syndrome
To determine the effect of Parent child interaction therapy vs Conventional Parent Led Therapy in the management of language disorders in Children with Down Syndrome
- Trial name
- NCT07128810
- Testing
- Parent Child Interaction Therapy, Conventional Parent Led Therapy
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
Language Development Disorders, Learning Disorders
Building Complex Language
This study is designed to examine how much therapy is needed in order to make significant gains in knowledge and use of complex sentences.
- Trial name
- NCT01337232
- Testing
- Complex sentence treatment protocol
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Governors State University
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