Clinical trials: Language Disorders
Cleft Lip and/or Palate, Speech Disorder
Neural Changes After Speech Therapy in Patients With Cleft Palate: A Brain Imaging Study
Cleft palate is one of the most common maxillofacial congenital malformations, which results in severe speech disorders. Compensatory articulation disorder, also known as non-oral articulation disorder (NOA), is considered as the…
- Conditions
- Cleft Lip and/or Palate, Speech Disorder, Speech Therapy, Brain
- Trial name
- fMRI-Speech-CP (NCT07330687)
- Testing
- Structured Speech Training for Decompensation
- Where
- China
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Shufan Zhao
Developmental Dyslexia
V5/MT Stimulation on Reading and Reading-related Measures in Developmental Dyslexia
The present study grounds on the absence of evidence-based treatment in individuals with developmental dyslexia (DD). At this topic, the present study will explore the potential effect of transcranial direct current stimulation…
- Trial name
- NCT05972200
- Testing
- Active HD-tDCS over V5/MT, Active HD-tDCS over V1
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bambino Gesù Hospital and Research Institute
MCI, Dementia
Tailored Brain Health Insights Through Nurturing Knowledge-based Change - Stakeholder-driven, Human-centered, AI-powered Refinement for Prevention
The goal of this clinical trial is to evaluate whether an AI-powered digital brain health coaching intervention can improve modifiable brain health risk factors in community-dwelling adults aged 40 and above in Singapore.
- Trial name
- THINK-SHARP (NCT07612800)
- Testing
- BLAZE (Brain health Lifestyle Action with personaliZed Engagement)
- Where
- Singapore
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Alexandra Hospital
Stuttering
Large Language Models for Stuttering Assessment and Therapy
This observational study aims to compare the quality of responses generated by four large language models (ChatGPT, Claude, Google Gemini, and Grok-4.20) to questions about stuttering.
- Trial name
- NCT07835347
- Testing
- ChatGPT-Generated Responses, Claude-Generated Responses, Google Gemini-Generated Responses
- Where
- Turkey (Türkiye)
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Language Development Disorders, Down Syndrome
Strategies for Teaching Verbs
This study is designed to evaluate whether children with Down syndrome and children with typical development exhibit different levels of accuracy demonstrating novel verbs taught under three conditions: semantic cues (perform…
- Conditions
- Language Development Disorders, Down Syndrome, Child Language
- Trial name
- NCT03441685
- Testing
- Semantic cues (perform action), syntactic cues (sentence frame), or combined semantic and syntactic cues
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Social Phobia
Treatment of Childhood Social Phobia
This 4-year study will compare the long-term effectiveness of behavioral treatment, fluoxetine (Prozac®), and placebo for treatment of social phobia in children and adolescents.
- Trial name
- NCT00043537
- Testing
- Social Effectiveness Therapy for Children (SET-C), Fluoxetine
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Stuttering, Adult
Effects of Al-Lisaan Urdu Digital Software for Self-Assessment and Treatment of Adult Stutters
The study plans to find the efficacy of a digital application/software, Al-lisan that adult stutters can be used for assessment and management of their stuttering.
- Trial name
- Al-Lisaan (NCT06059729)
- Testing
- Al-Lisaan
- Where
- 2 sites in Pakistan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Aphasia
Sentence Production Training in Aphasia
This project focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming.
- Trial name
- NCT05415501
- Testing
- Sentence training
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Purdue University
Selective Mutism
Evaluating Intensive Group Behavioral Treatment for Children With Selective Mutism
This goal of this study is to evaluate an intensive group behavioral treatment (IGBT) program for children with selective mutism, a low base-rate childhood anxiety disorder.
- Trial name
- NCT03612102
- Testing
- Intensive Group Behavioral Treatment (IGBT)
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Florida International University
Thyroid Cancer, Large Language Models
Evaluation of an Artificial Intelligence-enabled Clinical Assistant to Support Thyroid Cancer Management
This study aims to evaluate the clinical feasibility of adopting artificial intelligence (AI)-based models to improve clinical management of thyroid cancer.
- Trial name
- NCT07234539
- Testing
- AI-enabled clinical assistant
- Where
- 2 sites in Hong Kong
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Schizophrenia, Schizophreniform Disorders
Functional Brain Activation Patterns in Schizophrenia, Measured Before and After Treatment
In this study we, the investigators at UMC Utrecht, intend to investigate changes in brain activation patterns using functional magnetic resonance imaging (MRI), in patients suffering from schizophrenia who are medication naive…
- Trial name
- NCT00161057
- Where
- Netherlands
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
High School 11th Grade Students, Absence of Any Language, Hearing, Mental or Psychological Disability
The Effect of Motivational Support Program Applied to Adolescents on Sleep Quality and Academic Achievement
It was planned as a randomized controlled experimental study with a single-blind technique, pretest-posttest control group and repetitive measurements, in order to determine the effect of motivational support program applied to…
- Conditions
- High School 11th Grade Students, Absence of Any Language, Hearing, Mental or Psychological Disability, Turkish Speaking and Understanding, Having a PUKI Index Above 5ı
- Trial name
- NCT06004778
- Testing
- Motivational Support Program, Educational support
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Autism Spectrum Disorder
Tool for Evaluating the Effectiveness of the DENVER Protocol
Early remediation of the communicative and social difficulties of children with autism spectrum disorders (ASD) is central. However, from the age of 6-8 months, children with ASD show a lack of attention to social stimuli such as…
- Trial name
- FACECOM (NCT06253793)
- Where
- 3 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Stuttering, Adult
Dopamine and Sensorimotor Function in Stuttering
This study is being done to understand the effect of aripiprazole on adults who stutter. Stuttering is a disorder that affects speech fluency.
- Trial name
- NCT07215884
- Testing
- Aripiprazole 10 MG
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Aphasia, Acquired, Language Disorders
Enhancing Language Function in Aphasia
Aphasia is an acquired impairment of language, that commonly results from damage to language areas in the brain (typically the left side of the brain).
- Conditions
- Aphasia, Acquired, Language Disorders, Primary Progressive Aphasia, Stroke, Cerebrovascular
- Trial name
- NCT05443633
- Testing
- individualized speech-language training, standard language intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Stroke, Stroke (CVA) or TIA
The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
Stroke is a major cause of death and disability worldwide, frequently resulting in persistent cognitive deficits among survivors.
- Conditions
- Stroke, Stroke (CVA) or TIA, Dementia, Vascular, Cerebrovascular Disorders
- Trial name
- IC3 (NCT05885295)
- Testing
- MRI brain, Blood tests, cognitive assessments
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Dyslexia, Developmental
Poly-unsaturated Fatty Acids and Developmental Dyslexia
Poly-unsaturated fatty acids (PUFAs) represent a component of lipids that covers a relevant role in human diet and biological functions such as provision of energy, functionality of cell membranes and tissue metabolism.
- Trial name
- NCT04287530
- Testing
- Poly-unsaturated fatty acids supplementation, Neuropsychological intervention
- Where
- 2 sites in Italy
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Primary Progressive Aphasia, Frontotemporal Dementia
Better Living With Non-memory-led Dementia
This is a feasibility study on the effects of an online-based training and education programme for carers of people with posterior cortical atrophy (PCA), primary progressive aphasia (PPA) and behavioural-variant frontotemporal…
- Conditions
- Primary Progressive Aphasia, Frontotemporal Dementia, Alzheimer Disease
- Trial name
- NCT05525377
- Testing
- Better living with non-memory led dementia course
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University College, London
Cancer Screening
Increasing Access to Breast Cancer Screening Among Immigrants
The investigators aim to test whether inviting immigrants to breast cancer screening with a letter in their mother tongue in addition to the standard letter in Norwegian changes screening uptake in these immigrant groups…
- Trial name
- NCT04672265
- Testing
- Mother tongue and Norwegian
- Where
- Norway
- Volunteers
- 11,355 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Aphasia Primary Progressive
Characterisation of Primary Progressives Aphasias
Primary progressive aphasias (PPA) represent a challenging group of degenerative language diseases that has led to growing interest in the scientific and medical community.
- Trial name
- CAPP (NCT02297035)
- Testing
- Behavioural testing, Brain imaging, Genetic screening
- Where
- France
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris