Clinical trials: Laryngeal Obstruction
Exercise-Induced Laryngeal Obstruction
Headgear Accessory for Exercise-Induced Laryngeal Obstruction Studies
Exercise-induced laryngeal obstruction (EILO) is a condition in which the larynx, or voice box, narrows during high-intensity exercise, and is often mis-diagnosed.
- Trial name
- HALOS (NCT05314478)
- Testing
- Continuous laryngoscopy during exercise test using the HALOS headgear
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Sleep Apnea, Obstructive, Respiration Disorders
Treatment of Children With Obstructive Sleep Apnea and Laryngomalacia: the Role of Laser Supraglottoplasty
This is a research study of the effect of treating laryngomalacia (floppiness of tissue on top of the voice box that can possibly block breathing) found in association with obstructive sleep apnea (blockage of breathing while…
- Trial name
- NCT00394550
- Testing
- supraglottoplasty with laser
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
Respiratory Failure
Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients
The COSMIC trial will be a multicentred, national, parallel-group, pragmatic vanguard pilot trial.
- Trial name
- COSMIC (NCT05456542)
- Testing
- Cuff Leak Test, Dexamethasone 4mg
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Exercise Induced Asthma, Exercise Induced Pharyngeal Collapse
Diagnostics and Quality of Life With EIA and EILO
The purpose of this study is to investigate the quality of life of subjects suffering from dyspnoea while exercising and quantify the number of diagnoses of Exercise induced Asthma (EIA) and Exercise induced laryngeal obstruction…
- Trial name
- NCT03550456
- Testing
- ECC, ECC with CLE, Speech therapy
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Superior Laryngeal Nerve Block, Sedation
Nerve Block Vs Sedation Infusion for Awake Fiberoptic Intubation.
This study compares the efficacy and safety of dexmedetomidine infusion versus superior laryngeal nerve block during awake fiberoptic intubation in hemimandibulectomy patients.
- Conditions
- Superior Laryngeal Nerve Block, Sedation, Dexmedetomidine, Awake Fiberoptic Intubation
- Trial name
- NCT06651905
- Testing
- Dexmedetomidine, Superior laryngeal nerve block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Larynx, Obstruction
CLE During Exercise Testing in Asthma
The purpose is to assess visualize the level of laryngeal obstruction and vocal cord dysfunction and to obtain more information on causes for dyspnea in asthma and severe asthma and to assess safety of CLE in patients with asthma…
- Conditions
- Larynx, Obstruction, Vocal Cord Dysfunction
- Trial name
- CLEtesting (NCT04168671)
- Testing
- Continuous laryngoscopy during exercise test
- Where
- Finland
- Sponsor
- Helsinki University Central Hospital
Pain, Postoperative, Cancer of Larynx
Efficacy of Adding Dexmedetomidine in Ultrasound-guided Intermediate Cervical Plexus Block for Thyroidectomy Surgery
The cervical plexus block (CPB) is one such block used to provide effective anesthesia and analgesia for surgery in the head and neck region.
- Trial name
- NCT05814744
- Testing
- dexmedetomidine, bupivacaine 0.25%, Thyroidectomy Surgery
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Pain, Anxiety
Active vs. Passive VR During Office-based ENT Procedures
The purpose of this research is to evaluate whether active virtual reality reduces pain and anxiety more effectively than passive virtual reality during office-based ENT procedures.
- Conditions
- Pain, Anxiety, Chronic Rhinosinusitis (CRS), Nasal Obstruction
- Trial name
- NCT07599826
- Testing
- Passive virtual reality headset or goggles, Active virtual reality headset or goggles
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Cedars-Sinai Medical Center
Endoscopic Laryngeal Surgery
Dex vs SLNB in Spontaneous Breathing Via THRIVE for Laryngeal Surgery
This prospective, randomized controlled trial evaluated the efficacy and safety of two anesthetic strategies-dexmedetomidine infusion and ultrasound-guided superior laryngeal nerve block (SLNB)-in patients undergoing…
- Trial name
- NCT05581485
- Testing
- Dexmetedomedine infusion, Ultrasound-Guided Superior Laryngeal Nerve Block (SLNB)
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Muscle Tension Dysphonia, Vocal Fold Palsy
Evaluating the Feasibility of Acapella® Choice as a Dysphonia Treatment
A feasibility study to identify the immediate effect on the voices of patients with voice disorders (muscle tension dysphonia, vocal fold palsy or presbylaryngis) produced by exercising with Acapella Choice as a form of…
- Conditions
- Muscle Tension Dysphonia, Vocal Fold Palsy, Vocal Cord Paralysis, Presbylarynx
- Trial name
- NCT04764604
- Testing
- Acapella Choice, Tube-in-water
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Breathing, Mouth, Lung Function Decreased
Evaluating the Use of a Device Called Impulse Oscillometry in Participants With Vocal Cord Disorders or Asthma
This study will determine if airway resistance to airflow and pressure, measured by Impulse Oscillometry, is impacted in subjects with vocal cord disorders and whether these measurements are different when compared to subjects…
- Conditions
- Breathing, Mouth, Lung Function Decreased, Vocal Cord Dysfunction, Laryngeal Obstruction
- Trial name
- NCT05246930
- Testing
- Impulse Oscillometer
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Rochester
Vocal Cord Paralysis, Bilateral, Airway Obstruction, Postoperative
Peri-operative BiPAP to Prevent Tracheostomy in High-Risk Bilateral Vocal-Cord Paralysis (BVCP)
Why: After thyroid or neck surgery, some patients can lose movement of both vocal cords (bilateral vocal-cord paralysis, BVCP). This can make breathing difficult and often leads to an emergency or preventive tracheostomy…
- Conditions
- Vocal Cord Paralysis, Bilateral, Airway Obstruction, Postoperative, Thyroid Neoplasms, Sleep Apnea, Obstructive
- Trial name
- BVCP-BiPAP (NCT07042971)
- Testing
- Pre-operative BiPAP Training, Post-extubation BiPAP Support, Standard Peri-operative Care
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Fujian Medical University
Bilateral Vocal Cord Paralysis
Selective Laryngeal Reinnervation for Bilateral Vocal Fold Paralysis
This is a prospective observational study examining the treatment outcomes of selective laryngeal reinnervation procedures for patients with bilateral vocal fold paralysis.
- Trial name
- NCT03980275
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Weill Medical College of Cornell University
Airway Obstruction
Comparison of High Dose and Low Dose Dexamethasone in Preventing Post-Extubation Airway Obstruction in Adults
The specific objectives were to determine whether high dose dexamethasone are more effective than low dose dexamethasone in the reduction or prevention of post-extubation airway obstruction among patients with a cuff leak volume…
- Trial name
- NCT00548483
- Testing
- dexamethasone (Oradexon, Nederland)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Mackay Memorial Hospital
Voice Disorders
Voice Therapy With a Semi-occluded Vocal Tract
1. The first objective of this research is to investigate the immediate effects of three semi-occluded vocal tract (SOVT) exercises (straw phonation in air, straw phonation in 2cm water, and straw phonation in 5cm water) on…
- Trial name
- NCT06137131
- Testing
- Straw phonation in air, straw phonation in water, /u/ phonation
- Where
- Belgium
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University Ghent
Vocal Cord Polyp
The Study of Bilateral Upper Laryngeal Nerve Block for Supporting the Removal of Vocal Cord Polyps Under Laryngoscopy
With the continuous development of microsurgery, supporting laryngoscopy acoustic polyp removal has become a very mature clinical operation.
- Trial name
- NCT05309174
- Testing
- USG-guided iSLN block
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Guizhou Provincial People's Hospital
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Airway Obstruction, Difficult Intubation
Evaluation of the Use of Tracheal Intubation Through a Laryngeal Tube to Intubate Anesthetized Patients
Failed intubation is currently one of the most important factors leading to morbidity and mortality in anesthesia. The development of supraglottic airway devices (SGDs), such as the intubating laryngeal tube, has revolutionized…
- Trial name
- IKING (NCT03165461)
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Formacion Internacional para la Docencia e Investigación de la Vía Aérea
General Anesthesia, Breast Disease
Neuromuscular Block in Laryngeal Mask Airway(LMA) Insertion
The aim of this study is to evaluate the success rate, insertion time and complication depending on the use of neuromuscular blocking agent when inserting the laryngeal mask airway (LMA).
- Trial name
- NCT01035021
- Testing
- use of rocuronium when the LMA is inserted
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Bundang Hospital
Vocal Cord Disease, Vocal Cord Polyp
Effect of Superior Laryngeal Nerve Blocks on Patient Outcomes in Laryngeal Surgery
Patients undergoing surgery on their vocal cord will either receive a numbing injection to their throat or a saline injection during surgery.
- Conditions
- Vocal Cord Disease, Vocal Cord Polyp, Vocal Cord Cyst
- Trial name
- NCT06734975
- Testing
- Superior laryngeal nerve block - Intervention (Bupivacaine and triamcinolone acetonide suspension)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Rutgers, The State University of New Jersey