Clinical trials: Late-life Depression
Late Life Depression, Cognitive Decline
Dopaminergic Dysfunction in Late-Life Depression
Late-Life Depression (LLD), or depression in older adults, often presents with motivational deficits, deficits in performance in cognitive domains including processing speed and executive dysfunction, and mobility impairments.
- Conditions
- Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa
- Trial name
- D3 (NCT04469959)
- Testing
- L-Dopa
- Where
- 2 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Major Depression
Conventional Bilateral rTMS vs. Bilateral Theta Burst Stimulation for Late-Life Depression
This trial will compare conventional sequential bilateral rTMS to a bilateral theta burst stimulation protocol. The right and left dorsolateral prefrontal cortices will be the site of stimulation in both treatment conditions.
- Trial name
- NCT02998580
- Testing
- LFR followed by HFL, cTBS followed by iTBS
- Where
- Canada
- Volunteers
- 163 people
- Sponsor
- Centre for Addiction and Mental Health
Learning; Lack of (Specific), Depression
Nano-Learning for Improving Compliance Among Older Adults With Sarcopenia
Empirical evidence suggests that the use of short videos is associated with decreased feelings of loneliness and social isolation, thereby reducing depression among older adults .
- Conditions
- Learning; Lack of (Specific), Depression, Older Adults, Sarcopenia
- Trial name
- NCT07185763
- Testing
- Nano-Learning interventional program
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Depression
Assessing Anterior Cingulate Brain Activity in People With Late-Life Depression
This study will examine differences in activity of the anterior cingulate cortex, a brain area involved in emotion and cognitive regulation, between older adults with and without depression.
- Trial name
- NCT00926653
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Mild Cognitive Impairment
Retaining Cognition While Avoiding Late-Life Depression
This study will adapt Problem Solving Therapy (PST) for individuals with mild cognitive impairment (MCI) as an intervention for preventing major depression (DEP).
- Trial name
- RECALL (NCT01886586)
- Testing
- Problem Solving Therapy, Problem Solving Therapy + Exercise, Enhanced Usual Care
- Where
- 2 sites in United States
- Volunteers
- 94 people
- Sponsor
- University of Pittsburgh
Depression
Brain Imaging Biomarkers of Pathological Brain Aging in Late-life Depression
This study investigates the relationships and differences in PET-MRI brain imaging biomarkers of abnormal aging and behavioral measures in late life depression compared to healthy controls, and evaluates relationships and…
- Trial name
- NCT03849417
- Testing
- ECT
- Where
- Belgium
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Female, Late Life Depression
Central Glutathione Levels in Women With Late Life Depression: a Cross Sectional Pilot Feasibility Study
Female participants with an episode of late-life depression (LLD) and age-matched control participants with no history of mental disorder will attend a one hour Magnetic Resonance Imaging (MRI).
- Trial name
- NCT02757833
- Testing
- A 3 Tesla MRI scanner (Siemens, Erlangen Germany), will be used to measure levels of GSH in the brain.
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression
Buprenorphine for Late-Life Treatment Resistant Depression
The goals of this pilot study are to gather data about the safety and clinical effect of low-dose buprenorphine in older adults with treatment resistant depression.
- Trial name
- BUILD (NCT01071538)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Automatic Self Transcending Meditation Versus Treatment as Usual
Depression is a leading contributor to global burden of disease. Antidepressants do not provide adequate response for many patients.
- Trial name
- NCT02149810
- Testing
- Automatic Self Transcending Meditation
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Major Depressive Disorder
Neural Mechanisms of Monoaminergic Engagement in Late-life Depression Treatment Response (NEMO)
The Department of Psychiatry at the University of Pittsburgh is conducting a research study to learn about the changes that occur in the brain when individuals suffer from and then are treated for depression.
- Trial name
- NEMO (NCT03128021)
- Testing
- Escitalopram Pill, Levomilnacipran Pill
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Howard Aizenstein
Depression, Anxiety Disorder
Preventing Depression in Late Life: A Model for Low and Middle Income Countries
This study is being conducted in GOA India. The study addresses specific issues of depression prevention in older adults living in low- and middle income countries (LMICs), by developing risk-reduction strategies through the use…
- Trial name
- NCT02145429
- Testing
- Problem Solving therapy and Brief Behavioral Treatment of Insomnia
- Where
- India
- Volunteers
- 181 people
- Sponsor
- University of Pittsburgh
Depression
Short-term Cognitive Training in Late-life Depression
The purpose of this study is to examine the effects of the alternative uses training (AUT) and word association training (WAT) on cognitive functions and mood symptoms in late-life depression (LLD). The hypotheses are: 1.
- Trial name
- NCT01748032
- Testing
- Cognitive training
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Rotman Research Institute at Baycrest
Major Depression, Late Life Depression (LLD)
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD).
- Trial name
- ADNI-D (NCT02434393)
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Southern California
Treatment Resistant Depressive Disorder
Ketamine for Treatment Resistant Late-Life Depression
The purpose of this study is to examine the effectiveness of a single infusion of ketamine (KET), to determine which dose is optimal 7 days after infusion using Bayesian Adaptive Randomization, and to learn about how ketamine…
- Trial name
- NCT02556606
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder, Depression
Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED)
The objective of this clinical trial is to evaluate whether an anti-inflammatory medication, pentoxifylline, reduces depressive symptoms and improves artery function.
- Conditions
- Major Depressive Disorder, Depression, Depressive Symptoms, Cardiovascular Disease (CVD)
- Trial name
- INFLAMED (NCT01625845)
- Testing
- Pentoxifylline, Standard Treatment
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Indiana University
Major Depression
Comparing Engage to PST for Late Life Depression
This is a non-inferiority trial of Engage, a new intervention for late-life depression, and problem solving therapy (PST). Patient participants will be randomized to either Engage or PST and receive 9 weeks of either…
- Trial name
- Engage (NCT02086201)
- Testing
- Problem Solving Therapy, Engage
- Where
- 2 sites in United States
- Volunteers
- 262 people
- Sponsor
- University of Washington
Depressive Symptoms, Metabolic Syndrome X
Reducing Disparities in Late Life Depression and Metabolic Syndrome
Linkages between depression and cardiovascular disease have been well documented. These appear to be more than associations, and may reflect causal relationships through a number of proposed pathways, including decreased physical…
- Conditions
- Depressive Symptoms, Metabolic Syndrome X, Overweight, Obesity
- Trial name
- BRIGHTEN-Heart (NCT01428791)
- Testing
- Generations older adult membership program, BRIGHTEN Heart Virtual Team intervention
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Depression, Suicidal Ideation
Social Connections and Late Life Suicide
With the long-term goal of improving interventions for late-life suicide, the purpose of this study is to examine whether a mechanism by which behavioral interventions reduce risk for late-life suicide is by increasing social…
- Trial name
- NCT02188485
- Testing
- ENGAGE
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Rochester
Major Depressive Disorder
Individualized Targeting and Neuromodulation of Late-Life Depression
An open-label, single-arm, clinical research study about how to make transcranial magnetic stimulation (TMS), an FDA-approved treatment, more effective for patients with late-life depression using fMRI.
- Trial name
- TMS-LLD (NCT04543773)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of New Mexico
Depression, Dementia
RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)
The purpose of this study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD), and to test whether treatment-resistant late life depression is associated with declines in…
- Conditions
- Depression, Dementia, Mild Cognitive Impairment, Treatment Resistant Depression
- Trial name
- ONR (NCT05531591)
- Testing
- Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion
- Where
- 4 sites in United States, Canada
- Volunteers
- 87 people
- Sponsor
- Centre for Addiction and Mental Health