Clinical trials: Latent Autoimmune Diabetes in Adult (LADA)
Diabetes
Treatment of Latent Autoimmune Diabetes of the Adult
The purpose of the study is to clarify whether patients classified as Latent autoimmune diabetes of the adult (LADA) benefit from early treatment with insulin added to per oral treatment and lifestyle measures.
- Trial name
- LADA (NCT01140438)
- Testing
- metformin+ NPH insulin, metformin + sitagliptin +/- repaglinide
- Where
- Norway
- Volunteers
- 64 people
- Sponsor
- Norwegian University of Science and Technology
Type 1 Diabetes, Liver Steatoses
Prevalence and Risk Factors of Metabolic-Associated Hepatic Steatosis in Individuals Living With Type 1 Diabetes
The goal of this observational cross-sectional study is to assess the prevalence and stage of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), specifically liver steatosis and fibrosis in adults aged 18 and older…
- Conditions
- Type 1 Diabetes, Liver Steatoses, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Liver Fibrosis
- Trial name
- STEA-DT1 (NCT07475962)
- Testing
- Adiposity and BMI Classification
- Volunteers
- 100 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes, Autoimmune
Safety, Tolerability, Immunological and Clinical Efficacy of Multiple Subcutaneous Doses of DiaPep277 in Latent Autoimmune Diabetes in Adults (LADA)
Randomized, double-blind, parallel-group study to evaluate safety and efficacy of multiple subcutaneous doses of DiaPep277 in patients with Latent Autoimmune Diabetes in Adults (LADA).
- Trial name
- NCT00058981
- Testing
- DiaPep277
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- DeveloGen Israel, Ltd.
Latent Autoimmune Diabetes in Adults LADA
Randomized Controlled Trial of Insulin Versus Tablets for Latent Autoimmune Diabetes in Adults (LADA)
Background: Latent autoimmune diabetes in adults [LADA] is a type 1 diabetes that is slowly developing. This means many people are treated as having type 2 diabetes at diagnosis as they are adults who are not immediately insulin…
- Trial name
- LIT (NCT00776607)
- Testing
- NovoMix 30, Tablet treatment
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Abertawe Bro Morgannwg University NHS Trust
Diabetes, Autoimmune, Diabetes Mellitus, Adult-Onset
Early Insulin Treatment in Patients With Latent Autoimmune Diabetes
Among adult patients diagnosed with type 2 diabetes, about 6% have autoantibodies directed against the insulin producing beta cells in the pancreas.
- Trial name
- NCT01109927
- Testing
- Insulin
- Volunteers
- 42 people
- Sponsor
- Lund University Hospital
Latent Autoimmune Diabetes in Adults (LADA)
Effects of Cofrogliptin on Beta-Cell Function in LADA Patients
This single-center, randomized, open-label, controlled study aims to evaluate the effect of cofrogliptin on pancreatic β-cell function in adults with latent autoimmune diabetes in adults (LADA).
- Trial name
- NCT07460336
- Testing
- Cofrogliptin, Vitamin D3, Metformin
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Second Xiangya Hospital of Central South University
Latent Autoimmune Diabetes in Adult (LADA)
Safety of Diamyd® in Patients With LADA (Latent Autoimmune Diabetes in Adult)
This is a study to investigate the safety of 20ug Diamyd® (rhGAD65 formulated in Alhydrogel®), administered subcutaneously four weeks apart in patients with Latent Autoimmune Diabetes in Adult (LADA).
- Trial name
- NCT00456027
- Testing
- rhGAD65 formulated in Alhydrogel® (Diamyd®)
- Where
- 17 sites in Sweden
- Volunteers
- 160 people
- Sponsor
- Diamyd Therapeutics AB
Diabetes Mellitus, Type 1
Protective Effects of Saxagliptin (And Vitamin D3) on β Cell Function in Adult-onset Latent Autoimmune Diabetes
The main purpose of this study is to evaluate whether saxagliptin or (and vitamin D3) with metformin (and insulin) therapy can better protect islet β cell function than metformin(and insulin) .
- Trial name
- NCT02407899
- Testing
- Saxagliptin, Vitamin D3, Insulin
- Where
- 39 sites in China
- Volunteers
- 300 people
- Sponsor
- Second Xiangya Hospital of Central South University
Type 1 Diabetes (T1D), Latent Autoimmune Diabetes in Adult (LADA)
Building and Sustaining Exercise Habits for Adults With Type 1 Diabetes
The challenges of living with type 1 diabetes often stand in the way of getting enough exercise. Continuous blood sugar monitoring has revolutionized type 1 diabetes care but remains underutilized to sustainably support exercise…
- Conditions
- Type 1 Diabetes (T1D), Latent Autoimmune Diabetes in Adult (LADA), Pancreatitis
- Trial name
- NCT06967701
- Testing
- Exercise program, Self-monitoring
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Latent Autoimmune Diabetes
Detection of LADA in a Hospital in the Mexican Southeast
Patients with Latent Autoimmune Diabetes in Adults (LADA) show autoantibodies that indicate an autoimmune pathogenesis. Glutamic acid decarboxylase autoantibodies (GADA) are most prevalent islet autoantibodies in European…
- Trial name
- LADA patients (NCT05235672)
- Where
- Mexico
- Volunteers
- 110 people
- Sponsor
- Universidad Juárez Autónoma de Tabasco
Type 1 Diabetes
Protective Effects of Sitagliptin on β Cell Function in Patients With Adult-onset Latent Autoimmune Diabetes (LADA)
The aim of this study is to investigate the protective effects of sitagliptin on β cell function in patients with adult-onset latent autoimmune diabetes (LADA) and its mechanisms.
- Trial name
- DPP-ⅣLADA (NCT01159847)
- Testing
- sitagliptin, Insulin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- European Foundation for the Study of Diabetes
Autoimmune Diabetes
Autoimmune Diabetes: Markers of the Disease and Treatment of Latent Autoimmune Diabetes in Adults (LADA)
Autoimmunity is the main cause of diabetes type 1 and an important factor as cause of Latent Autoimmune Diabetes in Adults (LADA).
- Trial name
- NCT01148238
- Volunteers
- healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Latent Autoimmune Diabetes in Adults
Injections of Glutamic Acid Decarboxylase (GAD) for LADA Type of Diabetes
This study will evaluate the effects of 3 intra-nodal injections of GAD-alum (Diamyd), together with oral vitamin D supplementation.
- Trial name
- GADinLADA (NCT04262479)
- Testing
- recombinant human glutamic acid dehydrogenase (rhGAD65), formulated in aluminium hydrogel, Vitamin D
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 14 people
- Sponsor
- Norwegian University of Science and Technology
Latent Autoimmune Diabetes in Adults (LADA)
Hybrid Closed-Loop System in LADA Patients: A Randomized Trial
Based on the difficulties in blood glucose control among the Latent Autoimmune Diabetes in Adults (LADA) population and the deficiencies of previous studies, this research aims to conduct a clinical comparative study.
- Trial name
- NCT06941675
- Testing
- Hybrid Closed-Loop Artificial Pancreas System
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanxi Bethune Hospital
Latent Autoimmune Diabetes in Adult
Genetics of Latent Autoimmune Diabetes in Adults
This is a prospective study that will study adults and has the objective of examining 'Latent Autoimmune Diabetes in Adults' (LADA) to understand how this trait is influenced by genetic factors.
- Trial name
- LADA (NCT01793974)
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 205 people
- Sponsor
- Children's Hospital of Philadelphia
Latent Autoimmune Diabetes in Adults, Type 2 Diabetes
Infections and Latent Autoimmune Diabetes in Adults
Infections are proposed risk factors for type 1 diabetes in children. The investigators will examine whether a diagnosis of infectious disease also confers an increased risk of latent autoimmune diabetes in adults.
- Trial name
- LADA (NCT06167616)
- Where
- Sweden
- Volunteers
- 5,048 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Type 1 Diabetes Mellitus, Latent Autoimmune Diabetes in Adult (LADA)
Evaluation of Oxidative Stress: Comparison Between Type 1 Diabetes Mellitus and Latent Autoimmune Diabetes in Adults
After obtaining informed consent, the investigators will recruit 75 patients with T1DM and 75 with LADA with an age ≥ 18 years and ≤ 75 years, of both sexes.
- Trial name
- NCT07434154
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Type 1 Diabetes Mellitus, Autoimmune Diabetes
Effects Of Berberine Plus Inulin On Diabetes Care in Patients With LADA
The primary purpose of this study is to evaluate the effects of oral berberine (BBR) and inulin combined with insulin therapy on diabetes care in patients with LADA.
- Trial name
- NCT04698330
- Testing
- Berberine, Inulin
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Second Xiangya Hospital of Central South University