Clinical trials: Later Life
Late Life Depression (LLD)
The Leuven Longitudinal Late-Life Depression Study
The goal of this observational study is to learn about the long-term effects of late-life depression (LLD) in adults aged 60 and older. LLD is depression that begins for the first time later in life.
- Trial name
- L4D (NCT07768098)
- Where
- Belgium
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mental Health Wellness 1
Lifestyle Matters: An Occupational Approach Towards Health and Well-being in Later Life
Lifestyle Matters is an occupational approach to healthy ageing, which helps older people to get the most out of life. The intervention is based on an American model of health promotion called Lifestyle Redesign.
- Trial name
- NCT03054311
- Testing
- Lifestyle Matters
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Depression, Inflammation
Stress and Inflammation in Late-Life Depression
Over 18% of Americans aged 65 years and older have depression. Recent evidence suggests that there is a link between depression and inflammatory disease.
- Trial name
- S&I (NCT02389465)
- Testing
- Escitalopram + Celecoxib
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Premature Baby 33 to 36 Weeks, Mother-Infant Interaction
A Pilot Randomized Controlled Trial of the Effects of Daily Skin-to-skin Contact (PRCTS2S)
Late preterm infants are at risk of experiencing inadequate glycogen stores with immature glucose metabolism and increased adenosine triphosphate (ATP) degradation, which indicates cellular increased and stress.
- Conditions
- Premature Baby 33 to 36 Weeks, Mother-Infant Interaction, Oxidative Stress
- Trial name
- PRCTS2S (NCT04368767)
- Testing
- Skin-to-skin
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Anxiety Disorders
Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders
This study seeks to develop and test a novel, mechanistic treatment for mitigating cognitive impairment in older adults with anxiety disorders. Anxiety disorders are common, severe, and disabling in older adults.
- Trial name
- Mifepristone (NCT01333098)
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Breast Neoplasms, Quality of Life
Breast Cancer and Resilience in Couple
This is a prospective pilot study examining the couple's dyadic attitudes from diagnosis to 24 months later when one member is affected by illness and the adaptive strategies the couple employs when stressful events occur.
- Trial name
- resilience (NCT06875414)
- Testing
- Nursing care model
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Depression in Old Age, Recurrence
Recurrence Markers, Cognitive Burden and Neurobiological Homeostasis in Late-Life Depression
Late-life depression (LLD) is associated with disability, increased risk for cognitive decline and dementia, elevated suicide risk, and greater all-cause mortality.
- Conditions
- Depression in Old Age, Recurrence, Cognitive Dysfunction
- Trial name
- REMBRANDT (NCT05331599)
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Major Depressive Disorder
Games to Overcome Late Life Depression
This is a pilot study divided into two phases. IN phase 1 (completed) participants will be randomized to receive 8 weeks of Problem Solving Therapy (PST) alone or 8 weeks of a cognitive training game called, Evolution (Evo) plus…
- Trial name
- GOLD (NCT02229188)
- Testing
- Problem Solving Therapy, Evolution, Words
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Washington