Clinical trials: Lens Disease
Cataract, Corneal Astigmatism
ClarVista HARMONI Toric Trial With Intraoperative Exchange
The purpose of this study was to demonstrate the safety and effectiveness of the HARMONI® Modular Intraocular Lens System with a toric optic in subjects with pre-existing corneal astigmatism in need of cataract surgery.
- Conditions
- Cataract, Corneal Astigmatism, Aphakia
- Trial name
- NCT03054649
- Testing
- HARMONI® Modular Intraocular Lens System, Intraoperative optic exchange
- Where
- 2 sites in Mexico, Philippines
- Volunteers
- 44 people
- Sponsor
- ClarVista Medical
Myopia
A Prospective Study of Two Daily Disposable Contact Lenses
The purpose of this study was to evaluate the performance of a novel silicone hydrogel contact lens, DAILIES TOTAL1® (DT1) compared to the standard hydrogel material in 1-DAY ACUVUE® MOIST® (1DAVM) contact lens in contact lens…
- Trial name
- NCT01636986
- Testing
- Delefilcon A contact lenses, Etafilcon A contact lenses
- Volunteers
- 62 people
- Sponsor
- Alcon Research
Cataract
Quality Assurance Via Telephone Interviews After Cataract Surgery
To analyse quality assurance after cataract surgery by assessing discomfort and other symptoms via telephone interviews either in the evening of the day of the surgery or 1 day after surgery versus no additional call after…
- Trial name
- NCT05215002
- Testing
- Telephone Call, No telephone call
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Cataract
Recommendations for Monitoring Clinical Experience Following Implantation of the AcrySof® Toric
To allow surgeons to obtain clinical experience on the postoperative uncorrected and best distance corrected visual acuities (UCVA and BDCVA) and corneal and refractive cylinder of the AcrySof Toric IOL.
- Trial name
- NCT00761488
- Testing
- AcrySof® Toric IOL
- Where
- United States
- Sponsor
- Alcon Research
Cataract
Calhoun Vision Light Adjustable Lens (LAL) in Subjects With Pre-Existing Corneal Astigmatism
The purpose is to evaluate the Calhoun Vision Light Adjustable Lens (LAL) and Light Delivery Device (LDD) for reducing astigmatism and improving uncorrected vision after implantation.
- Trial name
- NCT01496066
- Testing
- LAL (Light Adjustable Lens) and Light Deliver Device (LDD), Monofocal control IOL
- Where
- 17 sites in United States
- Volunteers
- 600 people
- Sponsor
- Calhoun Vision, Inc.
Glaucoma Open-Angle Primary, Cataract
Comparing the Effectiveness of Phacoemulsification + ECP Laser and Phacoemulsification Alone for Glaucoma Patients
Laser endoscopic cyclophotocoagulation (ECP) has been in use for the treatment of glaucoma for over 20 years and is usually used in conjunction with cataract surgery.
- Trial name
- CONCEPT (NCT04295122)
- Testing
- Phacoemulsification+ Endoscopic cyclophotocoagulation (ECP) laser
- Volunteers
- 160 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cataract
Confirmatory Study Nepafenac 0.3%
The purpose of this study was to assess the safety and efficacy of an investigational eye drop intended for the prevention and treatment of inflammation (swelling and redness) and pain in the eye after cataract extraction.
- Trial name
- NCT01109173
- Testing
- Nepafenac Ophthalmic Suspension, 0.3%, Nepafenac Ophthalmic Suspension, 0.1%, Nepafenac Ophthalmic Suspension 0.3% Vehicle
- Where
- United States
- Volunteers
- 2,120 people
- Sponsor
- Alcon Research
Cataract
A Comparison of Two Devices for Taking Measurements of the Eye to Assist in Lens Selection for Cataract Surgery
The purpose of this study is to compare the Ziemer Ophthalmic Systems AG GALILEI G6 Lens Professional to the Oculus Pentacam® AXL for taking images and measurements of the anterior segment of the eye, including the cornea, pupil…
- Trial name
- NCT03396003
- Testing
- GALILEI G6 Lens Professional, Oculus Pentacam AXL
- Where
- Switzerland
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Ziemer Ophthalmic Systems AG
Age Related Cataracts
A Multicenter, Randomized, Double-Masked, Placebo-Controlled Pilot Study to Evaluate the Efficacy and Safety of ZOC2017217 in Subjects With Age-Related Cataract
This is a multicenter, randomized, double-masked, placebo-controlled pilot study conducted in the United States (US) in subjects with age-related cataract in one or both eyes.
- Trial name
- NCT07395986
- Testing
- 0.4% ZOC2017217, Control
- Where
- 21 sites in United States
- Volunteers
- 8 people
- Sponsor
- Ocusun Ophthalmic Pharmaceutical (Guangzhou) Co., Ltd.
Cataract
AI-Driven IOL Prediction Using SS-OCT Biometry
This prospective, multicenter, non-interventional observational study aims to evaluate the agreement between a novel swept-source optical coherence tomography (SS-OCT) biometer and the IOLMaster 700 for ocular biometric…
- Trial name
- NCT07733154
- Testing
- IOLMaster 700, Novel SS-OCT Biometer
- Where
- 3 sites in Australia, China and 1 more
- Volunteers
- 2,500 people
- Sponsor
- The Hong Kong Polytechnic University
Eye Disorders, Cataract Extraction
Effectiveness of a Large Language Model-Based Educational Tool on Intraocular Lens Options
Patients with cataracts disease need to choose what type of artificial lens will go into their eye prior to surgery date. Some lenses are standard and are usually covered by insurance.
- Conditions
- Eye Disorders, Cataract Extraction, Cataract and IOL Surgery, Cataract Surgery Experience
- Trial name
- NCT07317661
- Testing
- LLM-based Education
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Stanford University
Myopia
Clinical Assessment of a Daily Wear Monthly Replacement Soft Silicone Hydrogel Contact Lens
The purpose of this study is to assess the clinical performance of an investigational contact lens over 30 days of daily wear.
- Trial name
- NCT04476784
- Testing
- Lehfilcon A contact lenses, Comfilcon A contact lenses, CLEAR CARE
- Where
- 5 sites in United States
- Volunteers
- 66 people
- Sponsor
- Alcon Research
Cataracts
Clinical Investigation of AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric Intraocular Lens (IOL)
The purpose of this study is to evaluate the safety and effectiveness of an investigational multifocal toric intraocular lens (IOL) compared to an FDA-approved multifocal IOL.
- Trial name
- NCT01424189
- Testing
- AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL, AcrySof® ReSTOR® Multifocal IOL Model SA60D3
- Volunteers
- 677 people
- Sponsor
- Alcon Research
Cataract, Lens Opacities
PMCF Study on Comparison of EDOF Lenses (Switzerland)
Single center, prospective, randomised, controlled, double-blind post-market clinical follow-up (PMCF) study to compare the clinical outcomes of a premium monofocal intraocular lens (PhysIOL ISOPURE 1.2.3.) with clinical data…
- Trial name
- PHY2130 (NCT05235139)
- Testing
- IOL implantation experimental (ISOPURE 1.2.3.), IOL implantation active comparator (Acrysof Vivity)
- Where
- Switzerland
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Beaver-Visitec International, Inc.
Cataract and IOL Surgery, Epi-retinal Membrane
Outcomes of Combined Cataract Surgery With Retinal Surgery for Visually Significant Epiretinal Membrane With Vivity Versus Monofocal Intraocular Lens
To investigate the patient Quality of Life and satisfaction outcomes of combined cataract surgery with retinal surgery for visually significant epiretinal membrane in patients receiving Vivity IOL versus standard monofocal…
- Trial name
- NCT07070492
- Testing
- cataract surgery, retinal surgery
- Volunteers
- 36 people
- Sponsor
- Debbie Kuo, MD
Cataract, Ocular Inflammation
Safety and Effectiveness of Drop-free Small Incision Cataract Surgery
This is a randomized control trial comparing the effects of subconjunctival triamcinolone administration during surgery to topical prednisolone drops on the development of post-operative inflammation and macular edema in manual…
- Conditions
- Cataract, Ocular Inflammation, Ocular Hypertension, Post-Op Complication
- Trial name
- NCT05248139
- Testing
- Intraoperative delivery of medication, Kenalog (Triamcinolone), Topical post-operative eyedrops, Prednisolone acetate
- Volunteers
- 100 people
- Sponsor
- Visualiza
Epiretinal Membrane, Macular Hole
UNITY VCS Vitreoretinal Surgery
This purpose of this study is to compare the safety and effectiveness of two eye surgery systems-UNITY VCS and CONSTELLATION-in treating adults with vitreoretinal diseases or disorders.
- Conditions
- Epiretinal Membrane, Macular Hole, Visually Significant Vitreous Floater, Vitreomacular Traction
- Trial name
- NCT07054281
- Testing
- UNITY Vitreoretinal Cataract System (VCS), CONSTELLATION Vision System, Vitreoretinal ophthalmic surgery
- Where
- 8 sites in United States
- Sponsor
- Alcon Research
Presbyopia Correction, Astigmatism
A Planned Study at Multiple Sites is Being Done to Compare the Results of Two Types of Trifocal Toric Intraocular Lenses Used in Cataract Surgery
To evaluate the clinical outcomes and patient satisfaction of two commercially available trifocal toric intraocular lenses Primary Objective: To compare the distance-corrected intermediate visual acuity between the two trifocal…
- Conditions
- Presbyopia Correction, Astigmatism, Cataract
- Trial name
- NCT07232615
- Testing
- Optiflex TRIO Intraocular Lens, AcrySof® IQ PanOptix®
- Where
- 6 sites in Germany, India and 1 more
- Volunteers
- 138 people
- Sponsor
- Biotech Healthcare Holding Gmbh
Vitreous Disorder, Cataract
Outcome of Zeiss AT LARA EDOF Lens Implantation in Vitrectomized Eyes
To determine the surgical outcome and patient satisfaction in patients who underwent AT LARA lens implantation during or after vitrectomy at a relatively young age (around 55 years of age), mostly to treat (urgent) retinal…
- Trial name
- LARA (NCT05427526)
- Testing
- intraocular lens implantation
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cataract
Victus Versus Conventional
Cataract surgery is among the world's most frequently performed operations. It involves removal of an opaque lens from the human eye and implantation of an artificial lens.
- Trial name
- NCT01991717
- Testing
- Victus, Conventional Phaco
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Matthias Bolz
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