Clinical trials: Lesion of Brain
Brain Tumor, Brain Cancer
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors
The neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (M1) includes performing a craniotomy with intraoperative direct electrical stimulation (DES) mapping and to resect as much…
- Conditions
- Brain Tumor, Brain Cancer, Motor Cortex; Lesion
- Trial name
- NCT05023434
- Testing
- Intraoperative Brain Simulation - Alternate Stimulation Parameters
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Brain Lesion (General), Mrs
Role of MRS in Brain Lesions
Aim of the study is evaluation of accuracy of magnetic resonance spectroscopy in differentiation between neoplastic and non neoplastic lesions and determination the type of neoplasm
- Trial name
- NCT05565690
- Testing
- MRS
- Volunteers
- 64 people
- Sponsor
- Assiut University
Multiple Sclerosis
Augmenting Cerebral Blood Flow to Treat Established Multiple Sclerosis
This study will evaluate how improved cerebral blood flow affects the way in which newly formed MS lesions evolve and whether tissue repair is improved.
- Trial name
- perfuseMS (NCT02466074)
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center, Houston
Brain Lesion
Radiologic Pathologic Correlation of Advanced MR Imaging to Guide the Biopsy of Cerebral Malignancies
The goal of this clinical research study is to learn if using advanced magnetic resonance imaging (AMRI) will improve the targeting of brain tumor needle biopsies compared to the standard targeting techniques.
- Trial name
- NCT03458676
- Testing
- Advanced Magnetic Resonance Imaging Scan, Standard of Care Brain Biopsy and Tumor Removal
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- M.D. Anderson Cancer Center
Brain Lesions, Brain Metastasis
FLT PET/MR for Evaluation of Pseudoprogression in Patients With Brain Lesions
This is a single arm, single center study of 15 patients with brain lesions being treated at UNC Hospitals. Subjects will undergo one (1) FLT-PET-MRI scan before their scheduled surgical biopsy of their brain lesion(s).
- Conditions
- Brain Lesions, Brain Metastasis, Brain Metastases
- Trial name
- NCT02328300
- Testing
- FLT PET/MR
- Where
- United States
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Parkinson's Disease, Mild Cognitive Impairment
Mild Cognitive Impairment in Parkinson's Disease
Mild cognitive impairment, including difficulty with solving problems, planning, attention, or recalling information, can be a significant problem for individuals with Parkinson's disease.
- Trial name
- NCT01519271
- Testing
- Exelon Patch (rivastigmine transdermal system)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Pennsylvania
Premature Infants, Intracranial Hemorrhages
Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome
Preterm and very preterm infants are at risk of developing encephalopathy of prematurity and long-term neurodevelopmental delay.
- Conditions
- Premature Infants, Intracranial Hemorrhages, Periventricular Leukomalacia, Cerebral Palsy
- Trial name
- NCT03110341
- Testing
- Erythropoietin, Normal saline
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Alzheimer's Disease
Clinical Effectiveness of 10 cm^2 Rivastigmine Patch in Patients With Alzheimer's Disease
This study evaluated the safety and efficacy of 10 cm^2 rivastigmine patch in patients with Alzheimer Disease (MMSE 10-26). The primary objective was the percentage of patients who stayed on the target size of 10 cm^2 for at…
- Trial name
- ADEPT (NCT00561392)
- Testing
- Rivastigmine 5 and 10 cm^2 patch
- Where
- Germany
- Volunteers
- 208 people
- Sponsor
- Novartis
Cerebrovascular Disorders, Brain Lesions
Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage
Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative disorders and selective cognitive…
- Conditions
- Cerebrovascular Disorders, Brain Lesions, Degenerative Diseases, Developmental Pathology
- Trial name
- CORAC (NCT01849549)
- Testing
- Neuropsychological testing, MRI
- Where
- France
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Alzheimer's Disease
Efficacy and Safety of Rivastigmine Transdermal Patch in Patients With Mild to Moderate Alzheimer's Disease
The purpose of this study was to investigate the 5cm^2 and 10cm^2 doses of rivastigmine transdermal patch in terms of efficacy and safety in patients with probable Alzheimer's Disease (MMSE [Mini Mental State Examination] 10-20).
- Trial name
- NCT00423085
- Testing
- Rivastigmine transdermal patch
- Where
- Japan
- Volunteers
- 859 people
- Sponsor
- Novartis Pharmaceuticals
Pituitary Neoplasms, Craniopharyngiomas
Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions
The purpose of this four-arm randomized controlled study is to determine whether eliminating glucocorticoids (GC) replacement in perioperative period in surgical patients with sellar lesion could result in similar or better…
- Trial name
- NCT02190994
- Testing
- Hydrocortisone, Prednisone
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Stroke
Feasibility of Using Prism Adaptation to Treat Spatial Neglect and Motor Function in Stroke
This research project is a study designed to address both motor and cognitive changes after stroke. Treatment for SN is elusive however there is support for prism adaptation treatment (PAT).
- Trial name
- NCT02419222
- Testing
- Prism Adaptation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Alzheimer's Disease
A Phase IV Study to Evaluate Safety, Tolerability and Effectiveness of Rivastigmine Patch 15cm2 in Patients With Severe Dementia of the Alzheimer's Type.
This was a multicenter, prospective, phase IV study evaluating safety, tolerability and effectiveness of rivastigmine 27 mg -15 cm^2 transdermal patch prescribed in patients with severe dementia of the Alzheimer's type as per…
- Trial name
- NCT02989402
- Testing
- Rivastigmine
- Where
- 9 sites in India
- Volunteers
- 100 people
- Sponsor
- Novartis Pharmaceuticals
Vascular Cognitive Impairment, White Matter Lesions
Mechanism of Gamma Oscillation Synchronization in the Prefrontal-hippocampal Circuit for Memory Dysfunction in Patients With White Matter Lesions of Cerebral Small Vessel Disease
The mechanism underlying memory impairment caused by white matter lesions of cerebral small vessel disease is still unclear. The disrupted synchronization of gamma oscillations in the prefrontal-hippocampal circuit is a potential…
- Conditions
- Vascular Cognitive Impairment, White Matter Lesions, Gamma Oscillation
- Trial name
- NCT07042633
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Cerebellar Disorders, Cerebellar Degeneration
Variable Intense Training for Ataxia and Locomotion
The goal of this study is to evaluate the feasibility and potential preliminary efficiency of high-intensity training focused on stepping in variable contexts as compared to conventional training in individuals with cerebellar…
- Conditions
- Cerebellar Disorders, Cerebellar Degeneration, Cerebellar Atrophy, Cerebellar Lesions
- Trial name
- VITAL (NCT07621978)
- Testing
- High-intensity training in variable contexts, Conventional balance training
- Volunteers
- 20 people
- Sponsor
- Indiana University
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Brain Lesion, Stereotactic Biopsy
General Anesthesia vs. Local Anesthesia in Stereotaxy
Examination of stress level in general anesthesia in comparison to local anesthesia in stereotactic biopsy
- Trial name
- GALAXY (NCT01515852)
- Testing
- general anesthesia in stereotactic biopsy, local anesthesia in stereotactic biopsy
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Brain-injured Patients on Extracorporeal Life Support
Multimodal Assessment of the Neurological Prognosis of Patients With Brain Lesions on ExtraCorporeal Life Support
It seems of the greatest importance to evaluate the neurological prognosis of patients with brain lesions after cardiorespiratory arrest or circulatory failure requiring circulatory assistance.
- Trial name
- NeuroECMO (NCT03633981)
- Testing
- clinical examinations, neurological assessment when a neurological event occurs, mortality assessment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cerebral Lesion
Questionnaire for the Evaluation of Anger, Hostility and Aggression After Acquired Brain Injury.
The incidence of aggression and violent behavior is usually reported to be high after acquired brain injury, around 54%. Behaviors with verbal agression and, less frequently, physical agressions, are described.
- Trial name
- NCT04034875
- Testing
- Questionnaire
- Where
- 3 sites in Belgium, France
- Volunteers
- 50 people
- Sponsor
- Brugmann University Hospital
Silent Stroke, Silent Cerebral Infarct
Incidence of Silent Atrial Fibrillation in Patients With Clinically Silent Brain Ischemic Lesions
Arterial Fibrillation (AF) is well-recognized as a cause for cryptogenic Acute Ischemic Stroke (AIS) and is associated with Silent Brain Infarction (SBI).
- Conditions
- Silent Stroke, Silent Cerebral Infarct, Fibrillation
- Trial name
- SILENT2 (NCT04449523)
- Where
- 8 sites in Austria, Germany and 1 more
- Volunteers
- 150 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern