Clinical trials: Leukocytes
Ewing, Soft Tissue Sarcoma
Hematopoietic Stem Cell Transplantation From Human Leukocyte Antigen (HLA) Compatible Donor in Ewing Sarcomas and Soft Tissues Sarcomas
This is a perspective multicentric study for the treatment of patients aged equal or less than 60 years and submitted to an allogeneic hematopoietic stem cell transplantation from an HLA compatible related or unrelated donor…
- Trial name
- NCT00998361
- Testing
- Allogeneic hemopoietic stem cell transplant
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Eosinophilic Esophagitis
A Trial to Evaluate EP-104GI in Adults With Eosinophilic Esophagitis (EoE).
A Phase 1b/2 study to explore the safety, efficacy and pharmacokinetics of EP-104GI in adults with eosinophilic esophagitis (EoE).
- Trial name
- RESOLVE (NCT05608681)
- Testing
- EP-104GI, Matching vehicle control
- Where
- 23 sites in Australia, Canada and 4 more
- Volunteers
- 117 people
- Sponsor
- Eupraxia Pharmaceuticals Inc.
Eosinophilic Esophagitis
Budesonide Effervescent Tablets vs. Viscous Budesonide Suspension vs. Placebo in Eosinophilic Esophagitis
The purpose of this study is to assess the efficacy of a low and high dose of a budesonide effervescent tablet and oral viscous budesonide suspension vs. placebo for the induction treatment of active eosinophilic esophagitis.
- Trial name
- NCT02280616
- Testing
- low dose budesonide tablet, high dose budesonide tablet, high dose budesonide suspension
- Where
- Germany
- Volunteers
- 76 people
- Sponsor
- Dr. Falk Pharma GmbH
Neutropenia
A Pharmacokinetics/Dynamics Ib Study of F-627 in Women With Breast Cancer Receiving Myelotoxic Chemotherapy
This study was a phase Ib study of the safety and pharmacokinetics/pharmacodynamics of F-627 once per cycle as prophylaxis therapy to chemotherapy in women with breast cancer.
- Trial name
- NCT02522234
- Testing
- F-627 240 μg/kg, F-627 320 μg/kg
- Where
- China
- Volunteers
- 15 people
- Sponsor
- EVIVE Biotechnology
Eosinophilic Esophagitis
Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis
The investigators seek to assess esophageal inflammation or lack of it in response to treatment with a novel non-invasive method that would measure eosinophil-associated inflammatory mediators in the blood and urine to determine…
- Trial name
- NCT03822325
- Where
- 2 sites in United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Acute Myeloid Leukemia, Relapsed, Adult, Acute Myeloid Leukemia Refractory
Intensity Modulated Total Marrow Irradiation in Fully Human Leukocyte Antigen (HLA)-Matched and Partially-HLA Mismatched Allogeneic Transplantation Patients With High-Risk Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), and Myelodysplastic Syndrome (MDS)
The study is a Phase II clinical trial. Patients will receive intensity-modulated total marrow irradiation (TMI) at a dose of 9 Gray (Gy) with standard myeloablative fludarabine intravenous (IV) and targeted busulfan (FluBu4)…
- Conditions
- Acute Myeloid Leukemia, Relapsed, Adult, Acute Myeloid Leukemia Refractory, Chronic Myeloid Leukemia - Accelerated Phase, Myelodysplastic Syndromes
- Trial name
- BMT-13 (NCT06802315)
- Testing
- Intensity modulated total marrow irradiation, Cyclophosphamide (CTX), Fludarabine (Fludara)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Illinois Chicago
Eosinophilic Asthma
Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment
This study evaluates the efficacy and safety of benralizumab as an add-on therapy in uncontrolled eosinophilic asthma participants treated with medium-dose ICS-LABA compared to the conventional treatment step of escalation of…
- Trial name
- BRISOTE (NCT06750289)
- Testing
- ICS-LABA, benralizumab
- Where
- 86 sites in United States, Bulgaria and 11 more
- Volunteers
- 130 people
- Sponsor
- AstraZeneca
Eosinophilic Esophagitis
Efficacy and Safety of Three Doses of Florence Oral Suspension in Adults With Eosinophilic Esophagitis
The purpose of this study is to evaluate the efficacy of three doses of Florence oral suspension on changes of eosinophilic infiltration in esophageal biopsies.
- Trial name
- NCT02873468
- Testing
- Florence 30 μg/mL, Florence 60 μg/mL, Florence 90 μg/mL
- Where
- Brazil
- Volunteers
- 116 people
- Sponsor
- EMS
IGA Nephropathy, Proteinuria
Safety Study of of Intravenous CCL2-LPM in Patients With IgA Nephropathy
The purpose of this study is to evaluate the safety of several dose levels of CCL2-LPM in patients with IgA Nephropathy who have high levels of protein in the urine.
- Trial name
- NCT00856674
- Testing
- OPL-CCL2-LPM
- Where
- 3 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Osprey Pharmaceuticals USA, Inc.
Underdose (Unintentional), Cancer
Safety and Efficacy Studies of rHSA/GCSF Fusion Protein For Injection to Treat Neutropenia
Safety and efficacy studies of rHSA/GCSF fusion protein for injection in treatment of neutropenia induced by chemotherapy of cancer patients.
- Conditions
- Underdose (Unintentional), Cancer, Tumor
- Trial name
- NCT01919710
- Testing
- rHSA/GCSF
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Tianjin SinoBiotech Ltd.
Third Molars Extraction
The Use of Advanced Platelet-rich Fibrin in Mandibular Third Molar Surgery
The purpose of the study is to quantify the levels of platelets and inflammatory markers in A-PRF from a standard venous whole blood sample, and to evaluate the effect of A-PRF on postoperative discomfort and complications…
- Trial name
- NCT07761338
- Testing
- Third molar
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Sepsis With Acute Organ Dysfunction
Prognostic Interest of Leucocyte Immunophenotyping During the Acute Phase of Sepsis
Septic shock is still a major cause of death in ICU. Sepsis diagnosis is linked with many clinical, hemodynamic and biological criteria which have a low sensitivity and specificity if they are considered separately.
- Trial name
- SEPTIFLUX2 (NCT01995448)
- Testing
- Blood test
- Where
- 9 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Limoges
Male Infertility, Leukopenia
Male Infertility Related With Post Infection Inflammatory Syndrome
BACKGROUND: One couple out of 6 consults for infertility during their sexual life. In 60% of cases a male factor is associated or is the main infertility factor.
- Conditions
- Male Infertility, Leukopenia, Postinfection Inflammation, Oxidative Stress
- Trial name
- SIGMA (NCT01407484)
- Testing
- Prednisone
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer, Transcriptomes
Transcriptomes Breast, Ovarian and Leukocyte Hereditary Genes Predisposing to Breast and / or Ovarian Cancer
This is a case-control study of molecular diagnostics. This study requires two steps: The first part of the study will be conducted on a population of 20 women without breast cancer and, or ovarian family (Healthy Volunteers…
- Conditions
- Breast Cancer, Transcriptomes, Molecular Diagnostic, Ovarian Cancer
- Trial name
- CASOHAR (NCT02560818)
- Testing
- collection of a blood sample and breast and ovarian tissue, use of a previous blood collection for patients
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Francois Baclesse
Cytomegalovirus Disease, Cytomegalovirus Infections
Letermovir Use in Heart Transplant Recipients
This is an open label trial in which letermovir will be given as prophylaxis for the prevention of cytomegalovirus (CMV) infection and disease to all heart transplants who are at risk for cytomegalovirus.
- Conditions
- Cytomegalovirus Disease, Cytomegalovirus Infections, Heart Transplant Infection, Antiviral Toxicity
- Trial name
- NCT04904614
- Testing
- Letermovir
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Tufts Medical Center
Carotid Atherosclerosis, Cerebrovascular Accident
Potential Risk Factors for Stroke
Early studies have shown that the immune system may play a role in the development of strokes. Conditions such as high blood pressure, high cholesterol, diabetes, and old age can activate the immune system and increase the risk…
- Conditions
- Carotid Atherosclerosis, Cerebrovascular Accident, Diabetes Mellitus, Hypercholesterolemia
- Trial name
- NCT00001368
- Testing
- cytokine and leukocyte activation profile
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hypereosinophilia, Hypereosinophilic Syndrome
Intravenous Mepolizumab In Subjects With Hypereosinophilic Syndromes (HES)
Hypereosinophilic syndrome (HES) is a rare disease with broad clinical signs and symptoms which is diagnosed based on a persistent blood eosinophil count of greater than 1500 cells, various end-organ damages (including skin…
- Trial name
- NCT00086658
- Testing
- mepolizumab
- Where
- 29 sites in United States, Australia and 6 more
- Volunteers
- 86 people
- Sponsor
- GlaxoSmithKline
CCUS Clonal Cytopenia of Undetermined Significance, Anemia
Luspatercept for Clonal Cytopenias of Uncertain Significance
The purpose of this clinical trial is to test how well the drug luspatercept works in improving low blood cell counts in people with clonal cytopenias of uncertain significance (CCUS).
- Conditions
- CCUS Clonal Cytopenia of Undetermined Significance, Anemia, Leukopenia, Thrombocytopenia
- Trial name
- NCT06788691
- Testing
- Luspatercept
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Eosinophilic Esophagitis, Food Allergies
Prevalence of Food Allergies in a Cohort of Adult Patients With Eosinophilic Esophagitis
Eosinophilic esophagitis is characterized by an eosinophilic infiltration of the esophagus. It presents clinically with a variety of symptoms including dysphagia, emesis, and food impaction.
- Trial name
- EE (NCT01631591)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of South Florida
Pulmonary Disease, Chronic Obstructive
Prevalence of Chronic Obstructive Pulmonary Disease (COPD) and Eosinophilia Among Primary Care Patients
Early diagnosis and appropriate treatment for COPD subjects are both critical to minimize the progression of COPD and improve outcomes.
- Trial name
- NCT03018808
- Testing
- Minimal questionnaire, Medical interview, CAT
- Where
- 4 sites in Brazil
- Volunteers
- 800 people
- Sponsor
- GlaxoSmithKline
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