Clinical trials: Leukoderma
Non-segmental Vitiligo
Topical Ruxolitinib Evaluation in Vitiligo Study 1 (TRuE-V1)
The purpose of this study is to evaluate the efficacy and safety of ruxolitinib cream in adolescent and adult participants with non-segmental vitiligo for whom total body involved vitiligo area (facial and nonfacial) does not…
- Trial name
- NCT04052425
- Testing
- Ruxolitinib cream, Vehicle
- Where
- 57 sites in United States, Bulgaria and 6 more
- Volunteers
- 330 people
- Sponsor
- Incyte Corporation
Vitiligo
A Study to Compare the Efficacy and Safety of SCENESSE and Narrow-Band Ultraviolet (NB-UVB) Light Versus NB-UVB Light Alone in Patients With Vitiligo
The CUV105 study will assess the efficacy and safety of afamelanotide and NB-UVB light in patients with vitiligo on the body and face versus NB-UVB light alone.
- Trial name
- NCT06109649
- Testing
- Afamelanotide and NB-UVB Light, NB-UVB Light
- Where
- 30 sites in United States, France and 2 more
- Volunteers
- 200 people
- Sponsor
- Clinuvel, Inc.
Vitiligo
Long-term Follow-up in Patients Affected With Acrofacial Vitiligo
Acrofacial vitiligo is a clinical form of vitiligo characterized by macules in distal digits, periorificial-facial and ano-genital areas.
- Trial name
- NCT01459055
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Irmandade da Santa Casa de Misericordia de Curitiba
Vitiligo
Molecular Mechanisms of Helium-Neon Laser on Melanocyte Regeneration in Skin Equivalent Vitiligo Model
This current three-year proposal aims to clarify the mechanisms of melanocyte destruction and regeneration in vitiligo lesions using both traditional cell culture and skin equivalent model (organotypic culture).
- Trial name
- NCT00172939
- Testing
- foreskin from healthy adults
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Vitiligo
Histochemical Study of Vitiligo in Sohag University Hospital Patients
Vitiligo is a common acquired idiopathic disorder characterized by depigmentation of the skin, hair, and mucous membranes in the form of macules and patches due to selective melanocyte destruction .
- Trial name
- NCT05869942
- Testing
- Light microscopic studies, Immunohistochemical studies
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Upper Cross Syndrome
Effectiveness of Exercise in the Treatment of Upper Cross Syndrome
Upper cross syndrome (UCS) is a common postural deformity characterized by a change in neck, torso and shoulder muscle activity and shoulder movement.
- Trial name
- NCT06185322
- Testing
- Physical therapy program with upper cross syndrome specific exercises, Physical therapy program with conventional neck strengthening exercises
- Volunteers
- 30 people
- Sponsor
- Baskent University
Vitiligo
Narrowband UVB Treatment in Patients With Vitiligo
The study offers narrowband UVB light therapy to patients who have 5% of their body involved with vitiligo. The hypothesis is that Narrowband UVB promotes melanocyte proliferation in vitiligo lesions.
- Trial name
- NCT00398723
- Testing
- Narrowband UVB
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mary Sullivan-Whalen
Psoriasis, Alopecia Areata
Development and EValuation of an Online Intervention to Reduce Self-Stigma in People With Visible Chronic Skin disEases
This project aims to develop and evaluate an online intervention to prevent and/or reduce self-stigma in German patients with visible chronic skin diseases.
- Conditions
- Psoriasis, Alopecia Areata, Hidradenitis Suppurativa, Vitiligo
- Trial name
- DEVISE (NCT06324695)
- Testing
- HautKompass
- Where
- 12 sites in Germany
- Volunteers
- 298 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Gingival Pigmentation
Efficacy of Microneedling With Vitamin C in Performing Gingival Depigmentation
The present study will be carried to clinically evaluate the efficacy of microneedling with vitamin C in performing gingival depigmentation in comparison with conventional scalpel and diode laser.
- Trial name
- NCT07070024
- Testing
- Vitamin C, Microneedling, Diode laser
- Volunteers
- 30 people
- Sponsor
- Fayoum University
Vitiligo
Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients
Comparing the Efficacy of Three Different Surgical Methods on Resistant Sites in Stable Vitiligo.
- Trial name
- NCT03717025
- Testing
- SUCTION BLISTER EPIDERMAL GRAFTING, MINI PUNCH GRAFTING, NON CULTURED EPIDERMAL CELL SUSPENSION
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Albinism, Inborn Errors of Metabolism
Oral Pirfenidone for the Pulmonary Fibrosis of Hermansky-Pudlak Syndrome
Hermansky-Pudlak Syndrome (HPS) is an inherited disease that results in decreased pigmentation (oculocutaneous albinism), bleeding problems due to a platelet abnormality (platelet storage pool defect), and storage of an abnormal…
- Conditions
- Albinism, Inborn Errors of Metabolism, Oculocutaneous Albinism, Platelet Storage Pool Deficiency
- Trial name
- NCT00001596
- Testing
- Pirfenidone
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- William Gahl, M.D.
Gingival Hyperpigmentation
Clinical Effectiveness Of Polishing Brush Compared To Ceramic Soft Tissue Trimming Bur In Gingival Depigmentation
Gingival hyperpigmentation, particularly of melanin origin, can pose significant aesthetic concerns, especially among patients with a high smile line.
- Trial name
- NCT07402720
- Testing
- Gingival Depigmentation using polishing brush, Depigmentation using ceramic soft tissue trimming bur
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Upper Cross Syndrome
The Effect of Instrument- Assisted Soft Tissue Mobilization on Upper Crossed Syndrome
This study will be a randomized controlled trial conducted to investigate the effect of myofascial release with IASTM on pain intensity level, cervical ROM, chest expansion, craniovertebral angle and kyphotic angle in upper…
- Trial name
- NCT06104761
- Testing
- Release group, strength exercises and stretching for upper crossed syndrome
- Volunteers
- 52 people
- Sponsor
- Cairo University
Upper Cross Syndrome
Effectiveness of Rib Mobilization Combined With Postural Correction Exercises in Individuals With Upper Crossed Syndrome
This randomized controlled trial aims to evaluate the effectiveness of rib mobilization combined with postural correction exercises in reducing pain, improving cervical posture, and enhancing rib and thoracic mobility among…
- Trial name
- NCT07573553
- Testing
- Rib Mobilization and Postural Correction Exercises, Postural Correction Exercises Only
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Riphah International University
Administrative Staff, Upper Cross Syndrome
Comparative Effects of Stabilization Exercises and Corrective Exercises in Administrative Staff With Upper Cross Syndrome
This study compares two types of rehabilitation strategies' - the stabilization exercises and the corrective exercises - to improve pain, respiratory function, and postural alignment in administrative staff with upper cross…
- Conditions
- Administrative Staff, Upper Cross Syndrome, Forward Head Posture, Computer Workers
- Trial name
- SE vs CE (NCT07766070)
- Testing
- Stabilization Exercises, Corrective Exercises
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Faisalabad
Vitiligo, Excimer Laser
Effect Of Topical Prostaglandin F2α Analogs,Fractional CO2 Laser, Excimer Laser Or Their Combination In Treatment Of Vitiligo
Vitiligo is a chronic disease with an unpredictable clinical course, characterized by the appearance of white macules and patches on the skin and mucous membranes due to the disappearance of melanocytes in the affected area.
- Conditions
- Vitiligo, Excimer Laser, Fractional CO2 Laser
- Trial name
- NCT04577027
- Testing
- Topical travoprost 0.004% solution, Fractional CO2 laser, Excimer laser
- Volunteers
- 30 people
- Sponsor
- Assiut University
Alopecia Areata, Alopecia Totalis
The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic
The study series consists of three studies with the aim to assess the incidence, prevalence, risk factors, comorbidities and management of patients with alopecia areata in Czech Republic based on the patients and registry of a…
- Conditions
- Alopecia Areata, Alopecia Totalis, Alopecia Universalis, Alopecia Areata (& Ophiasis)
- Trial name
- NCT05098600
- Testing
- Exposure of interest
- Where
- Czechia
- Volunteers
- 123 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Upper Cross Syndrome
Effects of Klapp Method in Upper Cross Syndrome Patients
This study was conducted to determine the effects of Klapp Method on posture, craniovertebral angle and disability in upper cross syndrome patients.
- Trial name
- NCT07435519
- Testing
- Klapp Method, Conventional treatment
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Upper Crossed Syndrome
Scapular Stabilization Exercises Versus Eccentric Muscle Energy Techniques in Patients With Upper Crossed Syndrome
This study will be a Randomized Clinical Trial in which Scapular Stabilization Exercises and Eccentric Muscle Energy technique will be applied on the individuals with upper crossed syndrome and changes will be recorded using…
- Trial name
- NCT06509594
- Testing
- Protocol of Scapular Stabilization Exercises;, Protocol of Muscle Energy technique;
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Vitiligo
Deciphering the Vitiligo Transcriptomic Signature Between Repigmented and Non Repigmented Lesions
The purpose of this study is to perform an in-depth analysis of the molecular pathways involved in lesions responding to current treatment and lesions not responding to current treatment
- Trial name
- STRAVI (NCT05927272)
- Testing
- SKIN SAMPLES, BLOOD SAMPLES, narrowband UVB
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bordeaux