Clinical trials: Leukoderma
Non-segmental Vitiligo, Vitiligo
ReNovaCell in Non-segmental Vitiligo
Rationale: Autologous epidermal cell suspension grafting is an effective method of surgical treatment in vitiligo, which is suitable for treating large areas with good cosmetic results.
- Trial name
- NCT03022019
- Testing
- ReNovaCell
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Netherlands Institute for Pigment Disorders
Vitiligo
Evaluation of Human Melanocytes After the Use of PRP Versus Fractional CO2 Laser in Vitiligo
Vitiligo is considered the most common chronic depigmentation disorder that affects around 0.5 -2% of the world population . In Africa , its prevelance is around 0.4% and 1.22 % in Assiut .
- Trial name
- PRP (NCT04320160)
- Testing
- Platelet rich plasma, Fractional CO2 laser
- Volunteers
- 30 people
- Sponsor
- Assiut University
Dermatologic Disease, Vitiligo
Vitiligo Registry for Adults and Children in the UK
Vitiligo is the most common depigmentation disorder affecting around 1% of the population worldwide. Fifty two percent of patients develop vitiligo before the age of 20 and around 80% develop vitiligo before the age of 30 years…
- Trial name
- VIRTUAL-UK (NCT06218082)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Vitiligo
Treatment of Vitiligo With Low-energy Visible Light Laser
The purpose of this study is the evaluate the efficacy of using a low-energy 635 nm visible light laser in the treatment of various recalcitrant forms of vitiligo.
- Trial name
- NCT01259986
- Testing
- Laser treatment
- Volunteers
- 3 people
- Sponsor
- Henry Ford Health System
Upper Cross Syndrome
Upper Cross Syndrome and Neck Proprioception
Correlation Between Upper Cross Syndrome and Neck Proprioception Hypothesis: No statistically significant relationship exists between upper cross syndrome and neck proprioception.
- Trial name
- NCT06801613
- Testing
- Intervention Group
- Volunteers
- 80 people
- Sponsor
- Cairo University
Vitiligo
Comparative Efficacy of hUCMSC-Secretome Delivered Via Microneedling and Intradermal Microinjection as Adjuvant Therapy to NB-UVB in Nonsegmental Vitiligo: A Quasi-Experimental Study
The goal of this clinical trial is to analyze the effectiveness of SM-hUCMSC secretome administered via microneedling and intradermal microinjection as adjuvant therapy to NB-UVB, compared with NB-UVB alone, in terms of…
- Trial name
- Vitiligo (NCT07509242)
- Testing
- NB-UVB combined with microneedling and topical 10% secretome, receives NB-UVB combined with intradermal secretome injection, NB-UVB alone
- Where
- Indonesia
- Volunteers
- 150 people
- Sponsor
- Yohanes Firmansyah, dr, MH, MM
Vitiligo
Comparison of Efficacy and Safety of 0.1% Tacrolimus and 0.1% Mometasone Furoate for Adult Vitiligo
Vitiligo has remained a difficult disease to treat. Previous available therapies are often ineffective. It usually takes several months or years for complete repigmentation and some areas of the body get at best only partial…
- Trial name
- NCT01333410
- Testing
- tacrolimus ointment, Mometasone furoate
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Vitiligo, Dermatology/Skin - Other
Early Molecular Changes in Vitiligo After Narrowband Ultraviolet Therapy
Vitiligo is a chronic acquired cutaneous disease of pigmentation that affects patients' quality of life across all degrees of involvement and severity.
- Trial name
- NCT03270241
- Testing
- Phototherapy (NB-UVB) via the 3 Series PC & SP phototherapy cabinet
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Gingival Pigmentation
The Adjunctive Role of Vitamin C on Pigment Recurrence (Randomized Clinical and Histological Trial)
The goal of this clinical trial is to determine the role of vitamin C on recurrence of gingival pigment after patients who are healthy and esthetically concerned with it received surgical removal of this pigment.
- Trial name
- NCT06312605
- Testing
- Injectable applied vitamin C, Topical applied Vitamin C, Surgical depigmentation only
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Post Coronary Artery Bypass Grafting, Post-Cardiac Surgery Patients
Effect of Respiratory Trainer on Cardiopulmonary Functions in Patients with Upper Cross Syndrome Post-Cardiac Surgery
The purpose of this study is to investigate if there is any effect of the respiratory training on cardiopulmonary functions in patients with upper cross syndrome post-cardiac surgery.
- Conditions
- Post Coronary Artery Bypass Grafting, Post-Cardiac Surgery Patients, Upper Cross Syndrome, Respiratory Muscle Weakness
- Trial name
- NCT06673953
- Testing
- Respiratory Muscle Training by (The Breather), Traditional physical therapy program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Vitiligo Vulgaris
The Effect of Fractional Co2 Laser Either With Tacrolimus, Calcipotriol or NB-UVB in Stable Generalized Vitiligo
Vitiligo is an acquired disorder of the skin and mucous membranes characterized by well circumscribed depigmented macules and patches that occur secondary to selective destruction of melanocytes (Zhang et al., 2009).
- Trial name
- NCT03234673
- Testing
- Tacrolimus ointment, calcipotriol ointment, NB-UVB
- Volunteers
- 30 people
- Sponsor
- Assiut University
Cross Syndrome
Effects of ELAVl and CDOA vs Upper Thoracic Mobilization on Forward Head Posture in Upper Cross Syndrome
This randomized controlled study will examine the patient of forward head posture who suffering with upper cross syndrome. There will be comparison of two treatment methods 1st one is elongation longitudinaux articular vertebral…
- Trial name
- NCT06739889
- Testing
- Elongation longitudinaux articular vertebral and columnar decoaption osteo-articulaire also known as ELDOA, upper thoracic mobilization
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Superior University
Vitiligo
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients
This study investigates the relationship between Transient Receptor Potential Melastatin 2 (TRPM2) gene polymorphism and Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome expression in…
- Trial name
- NCT07232238
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aswan University
Acne, Actinic Keratosis
Potential Research Study Participant Registry
The purpose of the potential research study participant registry is to keep potential research subjects informed about any future research studies in which they may meet the criteria for enrollment.
- Conditions
- Acne, Actinic Keratosis, Dysplastic Nevi, Eczema
- Trial name
- NCT00710489
- Where
- United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Blood Coagulation Disorders
Study of Megakaryocytes From Patients With Abnormal Platelet Vesicles
Congenital bleeding disorders characterized by abnormal platelet granules include Gray Platelet syndrome (GPS; defective alpha-granules), Hermansky-Pudlak syndrome (HPS; defective delta-granules), and combined alpha delta-storage…
- Trial name
- NCT00086476
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Oculocutaneous Albinism (OCA)
Safety and Efficacy of a Single Suprachoroidal Injection of JWK010 Gene Therapy in Subjects With Oculocutaneous Albinism Type 1 (OCA1)
Oculocutaneous albinism (OCA) is the most common type of albinism. People with OCA have little or no pigment (melanin) in their eyes, skin, and hair.
- Trial name
- NCT07313618
- Testing
- JWK010 gene therapy
- Where
- China
- Volunteers
- 18 people
- Sponsor
- West China Hospital
Vitiligo
Effect of Combination Non Steroidal Antiinflammatory Drugs and Narrowband UVB Treatment in Non-Photoadapters
Narrow band UVB phototherapy is the mainstay of therapy for vitiligo. However, about 1/3 of patients cannot respond to phototherapy.
- Trial name
- NCT05256147
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Vitiligo
The Value of Adding Mini-oral Pulse Steroid Therapy in Preventing Peri-lesional Halo Post Non-cultured Epidermal Cell Suspension (NCES) in Cases With Stable Segmental and Non-acral Vitiligo.
The goal of this clinical trial is to learn if adding mini-oral pulse steroid therapy improves the results of non-cultured epidermal cell suspension (NCES) surgery in patients with stable vitiligo.
- Trial name
- NCT07472816
- Testing
- Non-cultured epidermal cell suspension (NCES) surgery, Oral mini pulse, Excimer Sessions
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Vitiligo
A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream With Phototherapy in Participants With Vitiligo
The purpose of this study is to evaluate the efficacy and safety of Ruxolitinib cream with or without phototherapy in adolescent and adult participants with non-segmental vitiligo for whom vitiligo area (facial and nonfacial)…
- Trial name
- NCT05247489
- Testing
- Ruxolitinib 1.5% cream, NB-UVB phototherapy
- Where
- 13 sites in United States, Canada
- Volunteers
- 55 people
- Sponsor
- Incyte Corporation