Clinical trials: Levothyroxine
Brain Death
Thyroxine Replacement in Organ Donors
To compare oral versus intravenous administration of thyroid hormone: 1) for reversibility of hemodynamic instability in organ donors, and, 2) the pharmacokinetics of oral vs iv thyroid administration
- Trial name
- NCT00238030
- Testing
- L-thryoxine, iv thryoxine
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Healthy Volunteers
Thyroid and Fat Tissue Metabolism
This study will use a technique called microperfusion to examine how thyroid hormones are involved in fat metabolism. The thyroid gland produces two kinds of hormones: T3 and T4.
- Trial name
- NCT00312715
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
The Clinical Incidence of Low Triiodothyronine Syndrome
An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation Enteritis
Radiation enteritis (RE) is by simple definition an inflammatory process occurring at the level of the intestines as a response to abdominal or pelvic radiation energy exposure.
- Trial name
- NCT02452073
- Testing
- Thyroid function tests
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shengxian Fan
Drug Interactions
Sorafenib Drug Drug Interaction Study in Healthy Male Subjects
To evaluate the effect of levothyroxine on the absorption, distribution, metabolization and elimination of sorafenib and safety in healthy male subjects
- Trial name
- NCT02332031
- Testing
- Sorafenib (Nexavar, BAY43-9006), Levothyroxine
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bayer
Subclinical Hypothyroidism, Hypothyroxinemia
Thyroid Therapy for Mild Thyroid Deficiency in Pregnancy
The purpose of this study is to determine whether treating women, who are diagnosed with a mild imbalance of thyroid hormones during pregnancy, with thyroid hormone replacement affects their children's intellectual development at…
- Conditions
- Subclinical Hypothyroidism, Hypothyroxinemia, Pregnancy
- Trial name
- TSH (NCT00388297)
- Testing
- Levothyroxine
- Where
- 14 sites in United States
- Volunteers
- 1,203 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Healthy
A Comparative Study of New Formulation and Approved Formulation for Levothyroxine in Healthy Volunteers
The study investigated the bioequivalence between the new and the approved formulation for levothyroxine.
- Trial name
- NCT03979274
- Testing
- Reference Eutirox®, Test Eutirox®
- Where
- Mexico
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Pregnancy Related, Thyroid
Safety and Efficacy of Empiric Levothyroxine (LT4) Dose Increase Versus Individualized LT4 Dose Increase in Hypothyroid Women During Pregnancy
In women who require thyroid hormone replacement medication, the investigators will compare 2 ways to adjust thyroid medication during pregnancy to determine superiority in maintaining optimal blood levels of thyroid hormone.
- Trial name
- NCT03115515
- Testing
- levothyroxine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Healthy
A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028)
Levothyroxine (T4) is a man-made thyroid hormone used to treat certain thyroid conditions. After taking levothyroxine, a person's body changes it to triiodothyronine (T3).
- Trial name
- NCT06625814
- Testing
- Levothyroxine, Enlicitide Decanoate
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Hashimoto Disease
Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease
Oxidative stress leads to or accompanies with numerous disease. Oxidative balance in subclinical hypothyroid or euthyroid state in Hashimoto disease are not known.
- Trial name
- NCT01102205
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Vakif Gureba Training and Research Hospital
Dyslipidemia
Thyroxin Treatment in Sub Clinical Hypothyroidism, on the Apnea Hypopnea Index Score, Lipids and Highly Sensitive CRP
Obstructive sleep apnea (OSA) and hypothyroidism are both commonly found in clinical practice, and share a number of symptoms and clinical features.
- Trial name
- NCT01486667
- Testing
- levothyroxine, sugar pill
- Where
- Saudi Arabia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- King Saud University
Healthy
BE of Euthyrox® Tablets (Merck Nantong Versus Merck Darmstadt Sites)
The purpose of this study is to demonstrate bioequivalence (BE) between Euthyrox® tablets manufactured at Merck Nantong (Test Euthyrox) versus the tablets manufactured at Merck Darmstadt (Reference Euthyrox).
- Trial name
- NCT05174000
- Testing
- Test Euthyrox®, Reference Euthyrox®
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Hypothyroidism
Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers
GSK markets a drug called levothyroxine or T4 that is used to treat patients with hypothyroidism. Till date, the active drug substance or active pharmaceutical ingredient (API) for levothyroxine tablets marketed in India has been…
- Trial name
- NCT01536678
- Testing
- Levothyroxine
- Where
- India
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
L-thyroxine
Impact of Increasing Levothyroxine Dose in Ramadan for UAE Patients With Hypothyroidism
The study aims to compare the mean change in Thyroid Stimulating Hormone (TSH) levels among patients with hypothyroidism treated with an increased dose of L-thyroxine (treatment group) versus standard/regular dose of L-thyroxine…
- Trial name
- NCT06135948
- Testing
- Extra dose of L-thyroxine, 25 mcg during Ramadan
- Where
- United Arab Emirates
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Emirates Health Services (EHS)
Postpartum Depression
Postpartum Thyroid Measures and Mood
Women with abnormal serum thyroid antibody levels or abnormal TSH and/or T4 values are more likely than their normal counterparts to have higher scores on a common postpartum depression screening test.
- Trial name
- NCT00565032
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Healthy
Fasting Study of Levothyroxine Sodium Tablets 300 μg to Synthroid® Tablets 300 μg
The objective of this study was to investigate the bioequivalence of Mylan's levothyroxine sodium 300 μg tablets to Abbott's Synthroid® 300 μg tablets following a single 600 μg (2 x 300 μg) dose administered in healthy volunteers…
- Trial name
- NCT00647855
- Testing
- Levothyroxine Sodium Tablets 300 μg, Synthroid® Tablets 300 μg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Healthy
Fasting Study of Levothyroxine Sodium Tablets 200 mg to Synthroid Tablets 200 mg
The objective of this study was to investigate the bioequivalence of Mylan's levothyroxine sodium 200 μg tablets to Abbott's Synthroid® 200 μg tablets following a single 600 μg (3 x 200 μg) dose administration in healthy…
- Trial name
- NCT00648557
- Testing
- Levothyroxine Sodium Tablets 200 mg, Synthroid Tablets 200 mg
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Healthy
Fasting Study of Levothyroxine Sodium Tablets 300 mcg to Synthroid® Tablets 300 mcg
The objective of this study was to investigate the bioequivalence of Mylan's levothyroxine sodium 300 mcg tablets to Abbott's Synthroid® 300 mcg tablets following a single, oral 600 mcg dose (2 × 300 mcg) administered under…
- Trial name
- NCT00648882
- Testing
- LEVOTHYROXINE SODIUM TABLETS,, SYNTHROID® 300 mcg Tablets
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Aging, Primary Hypothyroidism
Evaluation of Evening Versus Morning Levothyroxine Intake in Elderly
A study designed to compare evening versus morning levothyroxine intake in the elderly.
- Conditions
- Aging, Primary Hypothyroidism, Interaction Drug Food
- Trial name
- MONIALE (NCT03614988)
- Testing
- Evening Levothyroxine Administration, Morning Levothyroxine Administration
- Where
- Brazil
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Epilepsy
Study to Evaluate Serum Free Thyroxine (FT4) and Free Triiodothyronine (FT3) Measurements for Subjects Treated With Eslicarbazeine Acetate (ESL)
The purpose of this research study is to determine if the blood tests used to measure free thyroid hormone levels are affected by a drug called eslicarbazepine acetate.
- Trial name
- NCT02491073
- Testing
- blood draw
- Where
- 7 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Sumitomo Pharma America, Inc.
Pharmacokinetics
Bioavailability Investigations of Thyronajod Mite Tablets of Dosage Strengths 50 μg Levothyrox-ine/75 μg Iodine, and 100 μg Levothyroxine/75 μg Iodine vs. a Levothyroxine Drinking-Solution: A Randomised Cross Over Study in Healthy Male Individuals. Currently: 100 μg/ 75 μg Tablets
The purpose of this study is to measure the area under the curve (AUC0-48h; extent of systemic availability) and the maxi-mum concentrations (Cmax) of total serum levothyroxine (TT4, bound and free fraction) after a single…
- Trial name
- NCT01465646
- Testing
- levothyroxine
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Heidelberg University