Clinical trials: Lichen Planus, Oral
Oral Leukoplakia, Autofluorescence
Identification of Oral Lesions Through an Autofluorescence System
The aim of the study will be to evaluate the efficacy of a tissue autofluorescence detection system as an aid to clinical screening in identifying lesions of the oral mucosa.
- Conditions
- Oral Leukoplakia, Autofluorescence, Secondary Prevention, Keratosis
- Trial name
- NCT05942794
- Testing
- Screening examination
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Federico II University
Oral Lichen Planus, Tumor Necrosis Factor-alpha
Efficacy of Aloe Vera Compared to Corticosteroid in Topical Treatment of Oral Lichen Planus and on Salivary Levels of Tumor Necrosis Factor Alpha
Aloe Vera Herbal treatment has been widely used as an anti-inflammatory and antioxidant the objective of this study was to evaluate the clinical efficacy of Aloevera gel compared to corticosteroid gel o for symptomatic oral…
- Trial name
- NCT07792512
- Testing
- aloevera gel, Topical Corticosteroid Creams (Triamcinolone acetonide 0.1% and Hydrocortisone 2.5%)
- Where
- 5 sites in Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Oral Lichen Planus
Impact of Topical Clobetasol on Gingival Crevicular Fluid miRNAs in Subjects Affected by Oral Lichen Planus
According to recent research, microRNAs (miRNAs) may function as early disease indicators and contribute to the severity of a number of precancerous and malignant oral disorders.
- Trial name
- NCT05818618
- Testing
- Clobetasol Topical Gel
- Where
- Italy
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Catania
Oral Lichen Planus, Periodontitis
Periodontal Status in Patients With Oral Lichen Planus
This case-control study will enroll 176 patients age- and sex- matched at the Oral Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome.
- Trial name
- NCT07597616
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Saliva, Oral Lichen Planus
Unveiling the Protein Expression Patterns in Oral Lichen Planus and Leukoplakia Through Comparative Salivary Proteomics
The goal of this observational study is to compare salivary proteome profiles in patients with Oral Lichen Planus (OLP), Oral Leukoplakia (OL), and healthy individuals without oral mucosal disease.
- Conditions
- Saliva, Oral Lichen Planus, Oral Leukoplakia, Proteomics
- Trial name
- NCT07416318
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Oral Lichen Planus
Relationship Between Oral Lichen Planus and Autoimmune Thyroid Diseases
On the basis of previous studies, a validation cohort will be established to explore the relationship between oral lichen planus and autoimmune thyroid diseases, and a disease efficacy prediction strategy can be formed.
- Trial name
- NCT05403216
- Testing
- no intervention
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Oral Lichen Planus
Metagenomic Analysis of the Oral Microbiome in Patients With Oral Lichen Planus: A Pilot Study in the Turkish Population
Lichen planus is a common chronic mucocutaneous inflammatory disease that affects the skin, nails, eyes, urogenital system, and oral mucosa. Oral lichen planus (OLP) specifically occurs in the oral cavity.
- Trial name
- NCT07137156
- Testing
- cytobrush, next-generation sequencing
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Oral Cancer, Oral Lichen Planus
Artificial Intelligence Based Program to Classify Oral Cavity Findings Based on Clinical Image Analysis
This study aims to develop an AI program that can classify oral findings into Normal/variation of normal or an oral disease by clinical photos analysis, aiding in lowering the percentages of false positive and false negative…
- Conditions
- Oral Cancer, Oral Lichen Planus, Fordyce Granule, Leukoplakia
- Trial name
- NCT06325514
- Testing
- Artificial intelligence based program
- Where
- Egypt
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus, Oral Lichenoid Reaction
Systemic Absorption of Dexamethasone Oral Rinse in Patients With Oral Lichen Planus
The objective of this study is to see the amount of systemic absorption of a standard dose of dexamethasone oral rinse for patients with symptomatic oral lichen planus (OLP) or oral lichenoid reactions (OLR) and healthy subjects…
- Trial name
- NCT06428630
- Testing
- dexamethasone oral rinse
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tufts University
Oral Lichen Planus, Leptin Levels
Salivary and Serum Leptin Levels in Oral Lichen Planus Patients: A Case-control Study.
This study aims to evaluate the levels of leptin in both saliva and serum samples of patients diagnosed with oral lichen.
- Trial name
- NCT06078579
- Testing
- Leptin
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
Efficacy of Topical Treatment With Clobetasol in Symptomatic Oral Lichen Planus.
The investigators want to study the effect of clobetasol in symptomatic oral lichen planus. The investigators will include 90 patients and randomly allocate them in three groups.
- Trial name
- NCT04364555
- Testing
- Clobetasol Propionate
- Where
- 2 sites in Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Malmö University
Oral Lichen Planus, Vitamin D Deficiency
Vitamin D Deficiency As a Risk Factor for the Development and Malignant Transformation of Oral Lichen Planus
To examine how a lack of vitamin D may increase the risk of developing oral lichen planus and its malignant progression while accounting for sex, food habits, sunlight, socioeconomic level, and psychological variables.
- Trial name
- NCT06033105
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Lichen Planus, Oral
Evaluation of Desmoglein-3 Autoantibodies in the Tissues of Oral Lichen Planus and Correlation with Disease Severity
1. evaluate the level of Dsg3 autoantibodies in tissue biopsy of Atrophic/Bullous Erosive (A/BE) OLP (Primary Objective). 2. correlate the severity of the disease with the level of tissue Dsg3 autoantibodies (Secondary Objective).
- Trial name
- NCT06652477
- Testing
- ELISA
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Oral Lichen Planus
Impact of Fluocinonide 0,05% in Oral Lichen Planus
A double-blind placebo-controlled trial is conducted in order to evaluate the efficacy of Fluocinonide 0,05% and determinate the statistical significance of the outcome variables.
- Trial name
- NCT06135805
- Testing
- Fluocinonide 0,05% oral gel
- Where
- Italy
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Catania
Oral Lichen Planus, Thyroid Disease
Association Between Oral Lichen Planus and Thyroid Disease
The goal of this observational study is to determine the prevalence of thyroid disease in adults with oral lichen planus (OLP) treated at the Dental Hospital of the University of Barcelona (HOUB), and to evaluate the association…
- Trial name
- NCT06550154
- Testing
- Data collection
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Oral Lichen Planus
Oral Lichen Planus and Systemical Oncological Comorbidities
Lichen planus (LP) is a chronic mucocutaneous inflammatory disease of unknown etiology. In its oral variant, oral lichen planus (OLP) has a reported prevalence ranging from 0.5% to 2.2% in the general population.
- Trial name
- NCT06449248
- Testing
- Checking of appropriateness of OLP diagnosis
- Where
- Italy
- Volunteers
- 1,517 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Oral Lichen Planus, Mucous Membrane Pemphigoid
Dexamethasone Solution and Dexamethasone in Mucolox™
Topical steroid therapy is considered the first line of treatment for Oral Inflammatory Ulcerative Diseases with current treatment regimens requiring multiple application or rinses daily.
- Conditions
- Oral Lichen Planus, Mucous Membrane Pemphigoid, Pemphigus Vulgaris, Chronic Graft-versus-host-disease
- Trial name
- NCT04540133
- Testing
- dexamethasone 0.5mg/5ml solution, dexamethasone 0.5mg/5ml solution in Mucolox™
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Oral Premalignant Lesions as Leukoplakia and Lichen Planus, Oral Cancer
Dipeptidyl Peptidase-4 Link With Oral Cancer and Premalignant Lesions
Aim: The current study targets linking serum and salivary dipeptidyl peptidase-4 with oral squamous cell carcinoma and comparing it with potentially malignant lesions and control to validate dipeptidyl peptidase-4 as a diagnostic…
- Trial name
- NCT06087042
- Testing
- serum and unstimulated salivary samples
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Oral Lichen Planus, Oral Cancer
the Oncogenic Potential of Salivary miRNA-93 and miRNA-412-3P in Oral Lichen Planus Patients
Assessment The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus
- Trial name
- NCT05400057
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Moataz Mahmoud
Potentially Malignant Lesions, Oral Lichen Planus
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
- Conditions
- Potentially Malignant Lesions, Oral Lichen Planus, Leukoplakia, Oral
- Trial name
- NCT05730855
- Testing
- Real-time Polymerase Chain Reaction technique
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University