Clinical trials: Lichen Planus, Oral
Oral Lichen Planus
Evaluation of Salivary Level of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid
Thirty patients will be recruited from the outpatient clinic of the faculty of dentistry.fifteen systemically healthy individuals with normal mucosa and fifteen atrophic/erosive oral lichen planus patients.
- Trial name
- NCT03871114
- Testing
- Triamcinolone Acetonide in orabase
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
Evaluation of the Effectiveness of Photodynamic Therapy in the Treatment of Lesions of the Lichen Planus Type in the Oral Mucosa and Its Diagnostics With the Use of Autofluorescence, in Various Wavelength Ranges, in Combination With the Use of Texture Analysis and Fractal Dimension
Lesions of the lichen planus type within the oral mucosa are now considered a potentially cancerous condition. One of the minimally invasive methods of treating these lesions is photodynamic therapy, and the gold standard in…
- Trial name
- NCT04991012
- Testing
- PDT Therapy, Triamcinolone (Substance) therapy side
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Oral Lichen Planus
The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus
This study was initiated to evaluate the potential of dietary supplementation of omega-3 for providing an inexpensive, safe and effective therapeutic agent for managing atrophic/erosive lichen planus.
- Trial name
- NCT02106468
- Testing
- Prednisone tablet 5mg, Omega-3 soft capsules 1000 mg
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- October 6 University
Oral Lichen Planus, Oral Cancer
the Oncogenic Potential of Salivary miRNA-93 and miRNA-412-3P in Oral Lichen Planus Patients
Assessment The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus
- Trial name
- NCT05400057
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Moataz Mahmoud
Oral Lichen Planus
Metagenomic Analysis of the Oral Microbiome in Patients With Oral Lichen Planus: A Pilot Study in the Turkish Population
Lichen planus is a common chronic mucocutaneous inflammatory disease that affects the skin, nails, eyes, urogenital system, and oral mucosa. Oral lichen planus (OLP) specifically occurs in the oral cavity.
- Trial name
- NCT07137156
- Testing
- cytobrush, next-generation sequencing
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Oral Lichen Planus, Tumor Necrosis Factor-alpha
Efficacy of Aloe Vera Compared to Corticosteroid in Topical Treatment of Oral Lichen Planus and on Salivary Levels of Tumor Necrosis Factor Alpha
Aloe Vera Herbal treatment has been widely used as an anti-inflammatory and antioxidant the objective of this study was to evaluate the clinical efficacy of Aloevera gel compared to corticosteroid gel o for symptomatic oral…
- Trial name
- NCT07792512
- Testing
- aloevera gel, Topical Corticosteroid Creams (Triamcinolone acetonide 0.1% and Hydrocortisone 2.5%)
- Where
- 5 sites in Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Oral Lichen Planus
Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus
60 individuals were subdivided into 2 groups, 30 patients with oral lichen planus, 30 control individuals. Expression of miRNA-138 and cyclin D1 were evaluated in oral mucosa utilizing Quantitative real-time polymerase chain…
- Trial name
- NCT02834520
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus, Leptin Levels
Salivary and Serum Leptin Levels in Oral Lichen Planus Patients: A Case-control Study.
This study aims to evaluate the levels of leptin in both saliva and serum samples of patients diagnosed with oral lichen.
- Trial name
- NCT06078579
- Testing
- Leptin
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
The Regulatory Role of Immune Response in Oral Lichen Planus
Oral lichen planus (OLP) is a common chronic inflammatory disease of Oral mucosa. The pathogenesis of OLP is not clear, and there is no effective method to cure it.
- Trial name
- NCT05997173
- Testing
- Control, Non erosive OLP, Erosive OLP
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Oral Lichen Planus, Vitamin D Deficiency
Vitamin D Deficiency As a Risk Factor for the Development and Malignant Transformation of Oral Lichen Planus
To examine how a lack of vitamin D may increase the risk of developing oral lichen planus and its malignant progression while accounting for sex, food habits, sunlight, socioeconomic level, and psychological variables.
- Trial name
- NCT06033105
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Saliva, Oral Lichen Planus
Unveiling the Protein Expression Patterns in Oral Lichen Planus and Leukoplakia Through Comparative Salivary Proteomics
The goal of this observational study is to compare salivary proteome profiles in patients with Oral Lichen Planus (OLP), Oral Leukoplakia (OL), and healthy individuals without oral mucosal disease.
- Conditions
- Saliva, Oral Lichen Planus, Oral Leukoplakia, Proteomics
- Trial name
- NCT07416318
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Oral Lichen Planus
Efficacy of Topical Treatment With Clobetasol in Symptomatic Oral Lichen Planus.
The investigators want to study the effect of clobetasol in symptomatic oral lichen planus. The investigators will include 90 patients and randomly allocate them in three groups.
- Trial name
- NCT04364555
- Testing
- Clobetasol Propionate
- Where
- 2 sites in Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Malmö University
Oral Lichen Planus
Management of Pain in Oral Lichen Planus
Treating Oral Lichen Planus (OLP) is a big challenge for clinicians. Despite numerous existing remedies, to date no effective cure has been found, which is mainly attributed to the lack of understanding of the pathogenesis of the…
- Trial name
- NCT03572959
- Testing
- 0.1 % topical triamcinolone acetonide, SIROIaser
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sherine Adel Nasry
Oral Lichen Planus
Pimecrolimus Cream for Oral Lichen Planus
Study investigating the use of pimecrolimus 1% cream for oral lichen planus
- Trial name
- NCT00297037
- Testing
- Pimecrolimus 1% cream
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Utah
Oral Lichen Planus
Effect of Oral Zinc Supplementation as an Adjuvant to Topical Corticosteroid in Oral Lichen Planus Patients
Lichen planus is an auto-immune, chronic inflammatory disease that affects mucosal and cutaneous tissue. Erosive and atrophic oral lichen planus (OLP) are difficult to manage because patients present with symptoms ranging from…
- Trial name
- NCT04278599
- Testing
- Oral Zinc supplementation
- Where
- India
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Oral Cancer, Oral Leukoplakia
Oral Cancer Screening and Education in Hong Kong
This study will be conducted to obtain data on oral cancer risk factors to generate machine learning models with good predictive accuracy for stratifying individuals with high-oral cancer risk and delineating high-risk and…
- Conditions
- Oral Cancer, Oral Leukoplakia, Oral Submucous Fibrosis, Proliferative Verrucous Leukoplakia
- Trial name
- NCT04487938
- Testing
- No intervention utilised
- Volunteers
- 3,190 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Oral Lichen Planus, Periodontitis
Periodontal Status in Patients With Oral Lichen Planus
This case-control study will enroll 176 patients age- and sex- matched at the Oral Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome.
- Trial name
- NCT07597616
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Lichen Planus, Oral
Evaluation of Desmoglein-3 Autoantibodies in the Tissues of Oral Lichen Planus and Correlation with Disease Severity
1. evaluate the level of Dsg3 autoantibodies in tissue biopsy of Atrophic/Bullous Erosive (A/BE) OLP (Primary Objective). 2. correlate the severity of the disease with the level of tissue Dsg3 autoantibodies (Secondary Objective).
- Trial name
- NCT06652477
- Testing
- ELISA
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Oral Lichen Planus
Oral Lichen Planus and Systemical Oncological Comorbidities
Lichen planus (LP) is a chronic mucocutaneous inflammatory disease of unknown etiology. In its oral variant, oral lichen planus (OLP) has a reported prevalence ranging from 0.5% to 2.2% in the general population.
- Trial name
- NCT06449248
- Testing
- Checking of appropriateness of OLP diagnosis
- Where
- Italy
- Volunteers
- 1,517 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Oral Potentially Malignant Disorders, Oral Lichen Planus
Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-Smokers
The goal of this observational study is to learn whether two inflammatory proteins, interleukin-8 (IL-8) measured in saliva and interleukin-6 (IL-6) measured in blood serum, can help distinguish adults with oral potentially…
- Conditions
- Oral Potentially Malignant Disorders, Oral Lichen Planus, Oral Leukoplakia, Oral Squamous Cell Carcinoma
- Trial name
- NCT07915570
- Testing
- Salivary IL-8 and Serum IL-6 Measurement
- Where
- Egypt
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- British University In Egypt