Clinical trials: Limb Loss
Lower Limb Amputation
Evaluation of a Novel Transfemoral Prosthetic Socket System
The purpose of the study is to evaluate residual limb circulation and skin health associated with the use of a novel prosthetic transfemoral socket system.
- Trial name
- NCT01846845
- Testing
- Conventional Prosthetic Transfemoral Socket System, Novel Prosthetic transfemoral socket system
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Ohio Willow Wood
Lower-Limb Strength, Muscular Endurance
Study of 15% Versus 30% Velocity Loss Thresholds During Bodyweight Squats and Their Effects on Strength and Endurance in Young Women
The goal of this clinical trial is to learn how two different velocity loss thresholds (15% and 30%) during bodyweight squats affect strength and endurance in non-athletic young women aged 18-25 years.
- Conditions
- Lower-Limb Strength, Muscular Endurance, Velocity-Based Resistance Training
- Trial name
- NCT07461701
- Testing
- Body-weight squat training (15% velocity loss threshold), Body-weight squat training (30% velocity loss threshold)
- Where
- Pakistan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Lahore
Amputation
Active Knee Prosthesis Study for Improvement of Locomotion for Above Knee Amputees
The purpose of this study is to develop a robust, low-power, stable, and light weight, active knee prosthetic device that can dramatically increase gait symmetry and walking economy of a transfemoral amputee during walking.
- Trial name
- NCT00771589
- Testing
- Active Knee Prosthesis
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Providence VA Medical Center
Hydrostatic Vacuum Casting
Qualitative & Quantitative Comparison of Hydrostatic vs Vacuum Casting Methods in Trans-Tibial Amputees
The purpose of this graduate research study is to compare hydrostatic and vacuum casting techniques using patient mobility indicators, volume displacement, comfort, and overall satisfaction outcomes in trans-tibial amputees.
- Trial name
- NCT03891017
- Testing
- vacuum casting, hydrostatic casting
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Amputation
Clinical Trial of Tensegrity Prosthetics K3 Promoter Foot Prosthesis
The purpose of this clinical trial is to determine if the experimental Tensegrity prosthetic foot offers a reduction of the amount of oxygen used while walking, if stability is improved over current prosthetic feet, and whether…
- Trial name
- NCT00888199
- Testing
- Experimental prosthetic foot (K3 Promoter)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tensegrity Prosthetics
Amputation, Surgical
Improving Prosthetic Arms for Amputee: A Better Fit and More Functionality
This research and development will improve upon and investigate the potential validity of an innovative new transradial socket and harness design (the KSH system) that offers an alternative to standard hard sockets and rubber…
- Trial name
- KSH (NCT05990062)
- Testing
- K-Socket-Harness
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Amniotic Band Syndrome, Upper Extremity Deformities, Congenital
Assessment of Neural and Motor Performance
The neural basis underlying motor performance in children using a prosthesis has been severely understudied resulting in minimal empirical evidence.
- Trial name
- NCT04241588
- Testing
- 3D Printed Upper-limb Prosthesis, Control
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Socket Designs of Transfemoral Amputees.
Southern Bone & Joint Study - Brimless Sockets
The investigators are comparing a new type of prosthetic socket for above knee amputees to the standard of care. The hypothesis is that the new type of socket will show equivalence to the standard of care using our designated…
- Trial name
- NCT01416129
- Testing
- Standard of care socket, Prosthetic brimless socket
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Amputation, Ultrasonography
Core Muscle Function and Postural Control in Lower Extremity Amputees
The primary aim of this study is to determine the effect of amputation on core muscle groups by comparing core muscle thickness in individuals with lower extremity amputation to both their intact side and a healthy control group…
- Conditions
- Amputation, Ultrasonography, Postural Control, Balance
- Trial name
- usg (NCT07875075)
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Amputation
Mirror Therapy for Phantom Limb Pain
This study, conducted at the National Institutes of Health (NIH) and at Walter Reed Army Medical Center (WRAMC), will explore the phenomenon of phantom limb pain (a continued feeling of pain in an amputated limb) and will use…
- Trial name
- NCT00623818
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Upper Limb Amputees
The Effect of Amputation on Spatial Visual Representation in Peripersonal Space
In this study, we wish to find behavioral evidence for the question whether an amputation of the arm can lead to changes in visual perception or motor responses to objects in peripersonal space.
- Trial name
- NCT00458757
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Phantom Limb Pain
Peripheral Magnetic Stimulation (PMS) Effects on Somatosensory Perception in Patients with Upper Limb Amputation
The study investigates the capabilities of peripheral magnetic stimulation (PMS) as a tool for creating somatosensory sensations of various submodalities and analyzing the dynamics of bioelectric signals of the brain (using…
- Trial name
- NCT06813937
- Testing
- Procedure: Peripheral Magnetic Stimulation (PMS), Electroencephalography (EEG)
- Where
- Russia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Phantom Limb Pain
Phantom Limb Pain Triggered by Micturition
Phantom Limb Pain ( PLP) is pain that is perceived and referred to a region of the body that is no longer present. in most patients, severity and frequency of phantom pain attacks gradually decrease over several weeks to 2 years…
- Trial name
- NCT03855930
- Testing
- functional MRI
- Where
- 2 sites in Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loewenstein Hospital
Amputation, EMG
The Dynamic Postural Changes in Transtibial and Transfemoral Amputees
This research was planned to examine how unpredictable movements on the support surface will affect muscle activation and kinematic parameters in individuals with transtibial and transfemoral amputations.
- Conditions
- Amputation, EMG, Balance, Perturbation
- Trial name
- NCT05301270
- Testing
- EMG Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Amputation
Massage on Pain Levels, Range of Motion, and Muscle Strength in Unilateral Lower Limb Amputees
The purpose of this graduate research study is to explore the therapeutic benefits of Myofascial Release massage on lower limb amputees with pain levels, range of motion, and muscle strength.
- Trial name
- NCT03389334
- Testing
- massage
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Neuroma Amputation
Evaluation of Ultrasonic Neuroma Size With Residual Limb Pain in Above-Knee Amputees
Background: The formation of neuromas, a fusiform swelling of a nerve or nerve ending, is a well documented response to limb amputation.
- Trial name
- NCT00686764
- Testing
- Observational
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Weakness, Muscle, Muscle Weakness
Short Term Immobilization of the Lower Limb
The purpose of this study is to determine the effects of one week of knee-joint immobilization on muscle size, strength, neuromuscular function, and brain function.
- Conditions
- Weakness, Muscle, Muscle Weakness, Muscle Loss, Muscle Atrophy
- Trial name
- STILL (NCT05072652)
- Testing
- Neuromuscular Electrical Stimulation, Action Observation + Mental Imagery
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Amputation
A Unique Body-Powered Terminal Device With Enhanced Grasping Capabilities for Individuals With Upper Limb Loss
We have developed a novel terminal device for a prosthetic arm that eliminates the functional tradeoffs seen in body-powered voluntary open devices.
- Trial name
- NCT07254247
- Testing
- Novel Prosthetic Hook, Control Hook (Light Spring), Control Hook (Heavy Spring)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Little Room Innovations, LLC
Lower Limb Amputation Below Knee (Injury)
Human-Prosthetic Interaction: Brain & Technology After Lower-Limb Loss
This study evaluates brain neuroplasticity and functional performance in people with unilateral lower limb amputation.
- Trial name
- HumanIT (NCT05818410)
- Testing
- Prosthetic device (Lunaris), No prosthetic device, Prosthetic device (Sach foot)
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Amputees
Physical Activity in Adults With Amputation
This cross-sectional study explores physical activity and energy expenditure among inactive adults with a unilateral transtibial amputation.
- Trial name
- NCT03722797
- Testing
- Metabolic Cost Testing Procedures
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Delaware