Clinical trials: Limbal Stem-cell Deficiency
Glaucoma, Ocular Hypertension
Association Between Limbal Function and Tear Proteomics in Chronic Ocular Diseases: Focusing on Glaucoma
Background Intact corneal epithelium is important for the defense on the ocular surface, and the function of limbal stem cells is crucial to maintain its integrity.
- Conditions
- Glaucoma, Ocular Hypertension, Limbal Stem Cell Deficiency
- Trial name
- NCT07119580
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Aniridia
Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia
This study will examine specific gene changes in patients with aniridia, a disease in which the iris (colored part of the eye) is absent or partially absent, and will correlate the changes with clinical manifestations of the…
- Trial name
- NCT00265590
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Eye Institute (NEI)
Limbal Stem-cell Deficiency
Labial Mucosal Epithelium Grafting for Corneal Limbus Substitution
Earlier approaches for cornea reepithelization in patients with bilateral LSCD included allogeneic corneal limbus grafting from postmortem donor or livingrelated relatives with concomitant systemic immunosuppression (Cheung and…
- Trial name
- NCT04995926
- Testing
- Labial mucosal epithelium grafting for corneal limbus substitution
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Limbal Stem Cell Deficiency
Multi-Center, Prospective, Non-Interventional Study in Subjects With Limbal Stem Cell Deficiency
The goal of this non-interventional, observational study is to describe the natural history, clinical course, and management patterns of subjects with limbal stem cell deficiency (LSCD).
- Trial name
- NCT07636590
- Testing
- Non-interventional
- Where
- 8 sites in United States
- Volunteers
- 500 people
- Sponsor
- Claris Biotherapeutics, Inc.
Limbal Stem-cell Deficiency, Congenital Aniridia
Treatment of LSCD With DM
Limbal Stem Cell Deficiency (LSCD) is a blinding disease that accounts for an estimated 15-20% of corneal blindness worldwide. Current treatments are limited.
- Trial name
- NCT05909735
- Testing
- transplantation of a Descemet's Membrane corneal onlay, partial LSCD, transplantation of a Descemet's Membrane corneal onlay, total/near-total LSCD
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Minnesota
Eyes Dry Chronic, Chronic Conjunctivitis of Both Eyes
CDL Validation Study
Ocular surface photography is significantly limited in standardization and reproducibility. This reduces its applicability for clinical monitoring of acute or chronic disease.
- Conditions
- Eyes Dry Chronic, Chronic Conjunctivitis of Both Eyes, Limbal Stem-cell Deficiency, Eye Lesion
- Trial name
- NCT05461469
- Where
- Austria
- Volunteers
- 104 people
- Sponsor
- Occyo GmbH
Limbal Deficiency
Cell Therapy in Failure Syndromes in Limbal Stem Cells
Transplantation of allogeneic or autologous limbal epithelial stem cells cultured on human amniotic membrane with no feeders in eyes with total limbal deficiency. Prospective non-comparative monocentric study.
- Trial name
- TC181 (NCT01619189)
- Testing
- epithelial stem cells cultured, transplantation of cultured cells
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Limbal Stem Cell Deficiency
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency
This study will enroll subjects with qualifying limbal stem cell deficiency (LSCD). All subjects will receive CSB-001 investigational drug in either one or both study eyes.
- Trial name
- NCT06452316
- Testing
- CSB-001 Ophthalmic Solution 0.1%
- Where
- 6 sites in United States
- Volunteers
- 75 people
- Sponsor
- Claris Biotherapeutics, Inc.
Neurotrophic Keratitis
Nerve Growth Factor for the Treatment of Cornea Disease
To determine the efficacy and safety of nerve growth factor in the treatment of limbal stem cell deficiency (LSCD) associated with neurotrophic cornea.
- Trial name
- NCT04552730
- Testing
- Cenegermin-Bkbj
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stanford University
Ocular Surface Disease
Transplantation of Cultivated Limbal Epithelium on Amniotic Membrane for Limbal Stem Cell Deficiency
To evaluate the effectiveness of autologous (tissue from fellow eye) transplantation of cultivated limbal epithelium on amniotic membrane to treat severe surface irregularity and scarring of the corneal surface.
- Trial name
- NCT00348114
- Testing
- Transplantation of cultivated limbal epithelium
- Volunteers
- 8 people
- Sponsor
- Singapore National Eye Centre
Rare Diseases, Aniridia
Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
The cross-sectional observational clinical study related to rare eye diseases is a multi-center study in which the hypothesis is that neurokinin 1 receptor and/or substance P expression is increased in REDs associated with…
- Conditions
- Rare Diseases, Aniridia, Neurotrophic Keratopathy, Limbal Stem Cell Deficiency
- Trial name
- NCT06412718
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Limbal Stem-cell Deficiency
Autologous Oral Mucosa Transplantation for Limbal Stem Cell Deficiency
PURPOSE: To report clinical and histochemical results of oral mucosa graft transplantation in eyes with limbal stem cell deficiency. DESIGN: Prospective observational study.
- Trial name
- NCT03226015
- Volunteers
- 27 people
- Sponsor
- Klinikum Chemnitz gGmbH
Limbal Stem Cell Deficiency
ABCB5 as a Prognostic Marker in Survival of Cultivated Limbal Stem Cell Transplantation
In this study the prognostic value of ABCB5 in survival of the limbal stem cell transplantation expanded in vitro on amniotic membrane for corneal surface reconstruction in patients with limbal stem cell deficiency will be…
- Trial name
- NCT02579993
- Testing
- Pannus and conjunctival dissection, Human cultivated limbal stem cell transplantation
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Limbal Stem-cell Deficiency
Multiple Noninvasive Examination Modality to Evaluate the Severity of Ocular Surface Disorders
Here the investigators proposed this study to collect cases of different etiologies of ocular surface diseases. With at least one of these four non-invasive examination modalities, the investigators aim to analyze and compare the…
- Trial name
- NCT03594370
- Where
- Taiwan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Limbal Stem-cell Deficiency
The Effects of Autologous SLET
This study aims to prospectively evaluate the therapeutic effects of autologous simple limbal epithelial transplantation for patients with limbal stem cell deficiency.
- Trial name
- NCT04021875
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Limbus Corneae
Limbal Stem Cell Deficiency of Genetic Origin: Genotype-phenotype Correlation
The study aims at searching for a genotype-phenotype correlation in patients with a genetic pathology of the ocular surface, in order to identify genetic abnormalities associated with the most severe clinical situations.
- Trial name
- SILOG (NCT02886611)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Limbal Stem Cell Deficiency
Autologous Transplantation of Cultivated Limbal Stem Cells on Amniotic Membrane in Limbal Stem Cell Deficiency (LSD) Patients
The purpose of this study is to evaluate the efficacy, safety, and long term outcomes of ex vivo cultured limbal stem cell on amniotic membrane transplantation for corneal surface reconstruction in cases of partial and sever…
- Trial name
- NCT00736307
- Testing
- Cultured limbal stem cells Transplantation
- Where
- 2 sites in Iran
- Volunteers
- 10 people
- Sponsor
- Royan Institute
Limbal Stem Cell Deficiency
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
The main aim of the study is to determine the safety and feasibility of a cultivated autologous limbal epithelial cell (CALEC) transplantation in the treatment of limbal stem cell deficiency.
- Trial name
- CALEC (NCT02592330)
- Testing
- Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Severe Ocular Surface Damage, Limbal Deficiency
Efficacy of Cultivated Corneal Epithelial Stem Cell for Ocular Surface Reconstruction
The purpose of this study is to elucidate the appropriate condition of developing cultivated corneal epithelial graft and evaluate the surgical outcome of transplantation of the cultivated corneal epithelial stem cell in the…
- Trial name
- NCT01237600
- Testing
- Cultivated limbal transplantation
- Where
- Thailand
- Volunteers
- 19 people
- Sponsor
- Mahidol University
Persistent Corneal Epithelial Defect, Corneal Epithelial Disorders
Efficacy of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease
In this phase II randomized double-masked clinical trials, subjects with non-resolving corneal epithelial disease/defect (i.e., refractory to standard treatments for at least two weeks) will receive 8 weeks treatment of topical…
- Trial name
- NCT06919081
- Testing
- Allogeneic Bone-Marrow Derived Mesenchymal Stromal Cells Secretome, Vehicle Control
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Illinois at Chicago