Clinical trials: Lipid-induced Insulin Resistance
Metabolic Syndrome, Hypertriglyceridemia
Nutritional Transitions to More Plant Proteins and Less Animal Proteins: Understanding the Induced Metabolic Reorientations and Searching for Their Biomarkers (ProVegOmics)
The dietary shift from animal to plant protein sources is one of the key aspects of the nutritional transition towards more sustainable food system and diets.
- Conditions
- Metabolic Syndrome, Hypertriglyceridemia, Fasting Blood Sugar Above Normal, Lower Than Standard HDL-cholesterol Level
- Trial name
- ProVegOmics (NCT04236518)
- Testing
- Diets with either predominantly animal protein sources., Diets with predominantly plant protein sources
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Obesity, Metabolic Syndrome X
Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity
Obesity is common (>30% of US adults), contributes to substantial morbidity and mortality, but is difficult to treat. Partly this is due to the transient, arduous and modest nature of lifestyle interventions.
- Trial name
- REVIVE (NCT01351753)
- Testing
- Metformin, Orlistat, Topiramate
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Iowa
Insulin Resistance, NAFLD
Reversal of Lipid-Induced Insulin Resistance
The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have…
- Trial name
- NCT02193295
- Testing
- Caloric Restriction
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Yale University
Hyperlipidemia, Insulin Resistance
Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling
Background: There is general agreement that statin-treatment of patients to lower plasma cholesterol levels can increase the incidence of type 2 diabetes mellitus (T2D) in some individuals1-5.
- Conditions
- Hyperlipidemia, Insulin Resistance, Type 2 Diabetes
- Trial name
- NCT02437084
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Stanford University
Wildtype, Polymorphism Liver FABP
Potential Association of a Common L-FABP Polymorphism With Lipid-induced Hepatic Insulin Resistance
The investigators hypothesise that a common A277G polymorphism of the liver fatty acid binding protein (L-FABP) gene, which leads to an amino acid exchange, may be associated with alterations of lipid-induced hepatic insulin…
- Trial name
- NCT00277342
- Testing
- measurement of lipid-induced hepatic insulin resistance
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Lipid-induced Insulin Resistance
Fat and Transcapillary Insulin Transport
There is a current debate whether impaired insulin-mediated microvascular perfusion limits the delivery of hormones and nutrients to muscle and whether short term FFA elevation affects transcapillary transport of insulin and…
- Trial name
- FATRAIN (NCT01482455)
- Testing
- Elevation of FFA during OGTT, Elevation of FFA during Clamp
- Where
- Austria
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Insulin Sensitivity
The Effect of Lowered Physical Activity on Insulin Sensitivity and Lipid and Glucose Metabolism
The purpose of this study is to investigate the effects of lowered physical activity (resulting in decreased muscle mitochondrial oxidative capacity) alone and together with increased plasma free fatty acid availability (by…
- Trial name
- NCT01576250
- Testing
- unilateral lower limb suspension
- Where
- Netherlands
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Overfeeding
Polyphenols and Overfeeding
Obesity is a complex and multifactorial disease representing a major public health challenge. Indeed, overweight and obese people carry a major risk of developing insulin resistance and type 2 diabetes mellitus.
- Trial name
- Poly-Nut (NCT02145780)
- Testing
- 2g of grape polyphenol extract
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Preeclampsia, Gestational Diabetes Mellitus (GDM)
Cardiometabolic Disease and Substrate Metabolism
This study's primary purpose is to determine the potential relationship between cardiometabolic disease, specifically insulin resistance (HOMA-IR), and maternal lipid oxidation.
- Conditions
- Preeclampsia, Gestational Diabetes Mellitus (GDM), Preeclampsia (PE), Preeclampsia (PE) Risk
- Trial name
- CAP (NCT07565727)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Insulin Resistance
Free Fatty Acid Induced Insulin Resistance
This study aims to explore time-dependent effects of lipid infusion an intramyocellular lipid metabolites and the induction of impaired insulin signaling.
- Trial name
- FFAIR (NCT01229059)
- Testing
- Lipovenös lipid infusion
- Where
- Germany
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Metabolic Syndrome, Hypercholesterolemia
Metformin in Preventing Androgen Deprivation Therapy Induced Insulin Resistance and Metabolic Syndrome
The main purpose of this study is to assess the efficacy of metformin in abrogating androgen deprivation therapy (ADT) induced insulin resistance as measured by homeostasis model assessment (HOMAIR) in men with non-metastatic…
- Trial name
- MVENT (NCT01077479)
- Testing
- Metformin
- Where
- Australia
- Volunteers
- 28 people
- Sponsor
- Western Sydney Local Health District
Insulin Resistance
Dietary Lipid Induced Insulin Resistance
The overall goal of the proposal is to use a saturated fatty acid (SFA)- enriched, high fat diet to rapidly induce insulin resistance (IR) to provide insight into underlying proximal mechanisms of reduced insulin signaling.
- Trial name
- NCT02757560
- Testing
- SFA diet, MUFA diet, CARB diet
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Phoenix VA Health Care System
Pre-eclampsia, Obesity
ESTEEM - Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pregnancy Outcomes
Obesity is a growing problem in East London and every other woman who enters pregnancy is obese or overweight. In addition to obesity, other metabolic risk factors such as raised lipids, high blood pressure and diabetes increase…
- Conditions
- Pre-eclampsia, Obesity, Raised Lipids, High Blood Pressure
- Trial name
- ESTEEM (NCT02218931)
- Testing
- Targeted ESTEEM diet, Non-randomised cohort
- Where
- United Kingdom
- Volunteers
- 3,442 people
- Sponsor
- Queen Mary University of London
Insulin Resistance
The Effect of Liraglutide on Dietary Lipid Induced Insulin Resistance in Humans
In this research study, investigators will test the effects of an approved medication for diabetes,Liraglutide, to reduce insulin resistance that develops from eating a diet high in saturated fats.
- Trial name
- NCT02403284
- Testing
- Liraglutide, Sugar Pill
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Phoenix VA Health Care System
Glucose Intolerance
Carnitine Infusion and Insulin Resistance
Insulin resistant subjects and type 2 diabetic patients are characterized by a decreased metabolic flexibility: a reduced capability to switch from fat oxidation in the basal state to carbohydrate oxidation in the…
- Trial name
- NCT02722902
- Testing
- Carnitor, IntraLipid
- Where
- Netherlands
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
HAART-induced Lipodystrophy and Metabolic Syndrome
Randomized, Placebo-Controlled Study of Leptin for the Treatment of HIV Lipodystrophy and Metabolic Syndrome
The purpose of this study is to examine whether replacing leptin to normal levels can reverse the changes in fat distribution, lipid profile, and other metabolic problems associated with highly active antiretroviral therapy…
- Trial name
- NCT00140244
- Testing
- r-metHuLeptin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Beth Israel Deaconess Medical Center
Metabolic Syndrome X
Telmisartan-Induced Reduction in Intra-Myocellular Lipids Trial
The purpose of this study is to determine whether telmisartan and/or a low-glycemic index diet are effective in reducing intra-myocellular lipid (muscle fat) content.
- Trial name
- NCT00147264
- Testing
- Low-Glycemic Index Diet vs. Control Diet
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- McMaster University
Pancreatitis, Acute, Hypertriglyceridemia
Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis
To investigate an economical and effective way to reduce the level of serum triglyceride in patients with hypertriglyceridemia-induced acute pancreatitis.
- Trial name
- NCT03342807
- Testing
- Insulin, Aphesis
- Volunteers
- 220 people
- Sponsor
- Peking Union Medical College Hospital
Healthy
Postprandial Insulin Secretion and Appetite Regulation After Moderate Alcohol Consumption
A body of epidemiologic studies show that moderate alcohol consumption is associated with a protective effect against type 2 diabetes.
- Trial name
- NCT00524550
- Testing
- moderate alcohol consumption
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
PI3K Gene Mutation, AKT Gene Mutation
Bile Acids in Acute Insulin Resistance
This is a prospective observational study with a primary goal of monitoring changes in circulating bile acid profiles and parameters of glucose and lipid metabolism prior, during, and after cancer treatment with agents that…
- Conditions
- PI3K Gene Mutation, AKT Gene Mutation, MTOR Gene Mutation, Cancer
- Trial name
- NCT05571670
- Testing
- Drug-induced acute insulin resistance due to PI3K inhibitor, AKT inhibitor, or mTOR inhibitor
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Columbia University